TWI710397B - Blood filtration device - Google Patents

Abstract

The blood filter device of the present invention includes: a hollow sleeve, wherein an injection tube is arranged above the hollow sleeve, a first discharge tube and a second discharge tube are arranged below the hollow sleeve; a hollow filter tube, which The lower end has an opening, the hollow filter tube is located inside the hollow sleeve, the lower end of the hollow filter tube is installed in the first discharge tube of the hollow sleeve, wherein the hollow filter tube has a plurality of holes; a collection tank, the A joint is provided above the collection tank for connecting with the first discharge pipe of the hollow sleeve, wherein a connection pipe is provided above the collection tank; and an air extraction device connected with the connection tube of the collection tank, The air extraction device is used to make the pressure inside the hollow filter tube smaller than the pressure outside the hollow filter tube.

Description

Blood filtration device

The invention relates to a blood filtering device, in particular to a blood filtering device capable of separating blood cells and platelet-rich plasma.

Platelet Rich Plasma (PRP) is a platelet concentrate separated from blood. Platelet Rich Plasma is rich in a variety of growth factors. These growth factors can provide raw materials for self-repair, allow tissue regeneration, and stop chondrocytes. Necrosis and abrasion prevent inflammation and relieve pain. Therefore, platelet-rich plasma is used in clinical research, inspection, surgery, medical cosmetology, orthopedic surgery, hair regeneration, sports injury treatment, and accelerated burn wound healing. If it can go deep Discussion, I believe it will definitely make a great contribution to human health.

At present, the most common method for separating platelet rich plasma (PRP) is to use centrifugation technology, through the characteristic of the high proportion of blood cells, put whole blood in a test tube, and use the centrifugal force generated by high-speed rotation to separate the blood. Then the upper layer of platelet rich plasma (Platelet Rich Plasma, PRP) is drawn. Please refer to the following patents or products that use centrifugal technology to obtain platelet-rich plasma: Taiwan Patent No. I531401 uses one of the upper bottle body and the lower bottle body to be joined correspondingly. The top of the lower bottle body is closed and has a predetermined number of convection holes. The lower part of the upper bottle body is equipped with an isolation plate, which can be driven to change the relative relationship with the convection hole by rotating the upper and lower bottle bodies to determine whether the upper and lower bottles are connected. , A suspension plug and a screw cap are arranged at the lower part of the lower bottle body, the height of the suspension plug can be changed by the adjustment of the screw cap, and a cylinder sleeve is set on the top of the upper bottle body, inside the cylinder sleeve It is equipped with a pipe string and a one-way valve, and a rotating seat and a control valve are assembled on the top of the sleeve, and sealed with an upper cover, and two independent nozzles are provided on the upper cover, by which the rotating seat And the control of the control valve determines whether the two pipe columns on the upper cover are connected or not, and a cap is also provided to cover the two pipe ports at the same time, thereby forming the closed platelet concentrator of the present invention, so that it can be performed by a centrifuge. This centrifugal operation separates and concentrates the blood into three layers of different components: plasma layer, platelet-rich plasma, and blood cells.

Chinese Mainland Patent No. CN202478263U and CN201469752U patents both proposed methods using a traditional syringe as a blood drawing device. After the blood is taken, the injection needle is removed, and a container with a piston is used to cover the opening of the syringe ( That is, the original injection needle socket), and then the assembled syringe and the container sleeved on it are centrifuged together. During centrifugation, the syringe is on the top and the container is on the bottom; therefore, the plasma collection method after centrifugation is The blood layer at the bottom is discharged downward from the syringe to the container, so that the platelet-rich plasma drops to the opening of the syringe, and then an injection needle is installed to directly inject the platelet-rich plasma back into the patient from the blood source.

U.S. Patent Application Publication No. 20100025342A1 proposed a blood separation device, which is also based on the principle of a traditional syringe. It uses two syringes, one of which is the first syringe, which is used to install an injection needle and draw whole blood. After obtaining the whole blood, replace the injection needle with a cap to seal the opening, and then apply a weaker centrifugation procedure to preliminarily separate the blood with the injection opening facing down. After that, a second syringe with an injection needle is used Put it into the pipe reserved by the push handle of the first syringe to absorb most of the plasma that is preliminarily separated (that is, to obtain the upper layer liquid by preliminary centrifugation); then replace the injection needle with another cap, seal the opening of the second syringe, and then Stronger centrifugation is performed to facilitate more precise layering of the plasma, and downward (that is, the direction of gravity) to discharge the specific blood layer to obtain platelet-rich plasma.

The product of platelet-rich plasma obtained by centrifugal separation technology: GLO PRP kit: Product operation video website

https://www.youtube.com/watch? v=XJrOrCm8h2w

T-LAB PRP Kit: Product operation video URL

https://www.youtube.com/watch? v=C68Mcug01X8

Proteal PRP Kit: Product operation video URL

https://www.youtube.com/watch? v=lQV2h4OWOwo

Dr.PRP Kit

Product operation video URL

https://www.youtube.com/watch? v=e1IgqdeBtYo

GENESIS PRP

Product operation video URL

https://www.youtube.com/watch? v=494YeLv6mZE

However, the above patents or products that obtain platelet rich plasma (PRP) by centrifugal separation technology have the following disadvantages

1. The operating procedures are complicated. The current method for obtaining platelet-rich plasma is still centrifuge tube extraction. After the blood is centrifuged, in order to extract the platelet-rich plasma from the upper layer and avoid drawing the lower part, multiple procedures and tools must be used (Please refer to the above-mentioned products and videos) in order to successfully complete the extraction of platelet-rich plasma.

2. Manual operation is required. After the blood is centrifuged, the subsequent extraction of platelet-rich plasma must be processed manually, which is quite labor intensive.

3. The operation time is long. Because the operation procedure of extracting the upper layer of platelet-rich plasma is complicated and needs to be performed manually, it takes more time to obtain platelet-rich plasma by centrifugation technology.

4. Mass production is not possible. Because the operation procedure of extracting the upper platelet rich plasma (Platelet Rich Plasma, PRP) is complicated and needs to be carried out manually, mass production is impossible.

In view of the above-mentioned technical deficiencies and requirements, the present invention provides a blood filtration device with a simplified structure and convenient operation. In addition to simplifying complicated procedures, it also greatly reduces the steps required for manual operation, thus greatly shortening the operation time, and the present invention The blood filtration equipment uses the hollow filter tube to filter blood, which is different from the general centrifugal separation technology. It can also be used to separate a large amount of platelet-rich plasma from the blood to achieve the purpose of mass production.

One object of the present invention is to provide a blood filtration device.

Another object of the present invention is to provide a blood filtration device capable of separating platelet-rich plasma.

Another object of the present invention is to provide a blood filter device that uses a hollow filter tube to filter blood.

Another object of the present invention is to provide a blood filter device that uses a metal hollow filter mesh tube to filter blood.

Another object of the present invention is to provide a blood filtration device that uses a pressure difference to filter blood.

Another object of the present invention is to provide a blood filter device with a suction device.

Another object of the present invention is to provide a blood filter device that can filter a large amount of blood.

The blood filter device of the present invention includes: a hollow sleeve, wherein an injection pipe is arranged above the hollow sleeve, and a first discharge pipe and a second discharge pipe are arranged under the hollow sleeve, wherein the injection pipe is used for injection For blood, the first drain tube is used to drain platelet-rich plasma, the second drain tube is used to drain blood cells; a hollow filter tube with an opening at the lower end for draining platelet-rich plasma, the hollow filter tube is located inside the hollow sleeve , Wherein the lower end of the hollow filter tube is mounted on the first discharge tube of the hollow sleeve, the position of the lower end opening of the hollow filter tube at least partially overlaps the opening of the upper end of the first discharge tube of the hollow sleeve, wherein the hollow The filter tube has a plurality of holes for filtering blood; a collection tank, wherein a joint part is provided above the collection tank for connecting with the first discharge pipe of the hollow sleeve, wherein a connection tube is provided above the collection tank; and An air extraction device connected to the connecting pipe of the collection tank, wherein the air extraction device is used to make the pressure inside the hollow filter tube lower than the pressure outside the hollow filter tube.

The above-mentioned blood filter device uses an air suction device to pump air into the collection tank, so that the pressure in the hollow filter tube is lower than the pressure outside the hollow filter tube. With this pressure difference, the blood injected into the hollow sleeve is sent to the hollow filter tube. Then the blood is separated and filtered by the pore size of the hollow filter tube, so that the platelet rich plasma (PRP) with a diameter smaller than the pore diameter of the hollow filter tube can enter the hollow filter tube and pass through the first The drain tube flows into the collection tank; and the blood cells (such as red blood cells, white blood cells) with a diameter larger than the hole diameter of the hollow filter tube are blocked outside the hollow filter tube and discharged through the second drain tube of the hollow sleeve to achieve the blood The purpose of separating platelet rich plasma (Platelet Rich Plasma, PRP).

The above-mentioned blood filtering device can filter human or different animal blood, such as human blood, pig blood, bovine blood, etc., through a hollow filter tube. The hole size of the hollow filter tube can be selected according to the size of blood cells of different animals. For example, the diameter of human red blood cells is 6~8μm, and the diameter of platelets is 2~4μm, in order to effectively block red blood cells. A hollow filter tube with a pore size smaller than 6 μm but larger than 4 μm can be selected, such as a 5 μm hollow filter tube, so that Platelet Rich Plasma (PRP) can flow smoothly through the hollow filter tube into the collection tank.

The above-mentioned provision of an injection pipe above the hollow sleeve means that an injection pipe is provided at the upper end of the hollow sleeve, or an injection pipe is provided on the side of the hollow sleeve near the upper end.

The above-mentioned so-called having a first discharge pipe under the hollow sleeve means that a first discharge pipe is provided at the lower end of the hollow sleeve, or a first discharge pipe is provided on the side of the hollow sleeve near the lower end.

The above-mentioned so-called a second discharge pipe under the hollow sleeve means that a second discharge pipe is provided at the lower end of the hollow sleeve, or a second discharge pipe is provided on the side of the hollow sleeve near the lower end.

The internal space of the hollow filter tube is hollow, and the lower end has an opening. The opening position is set at the opening position of the upper end of the first discharge tube of the hollow sleeve, so that the position of the lower end opening of the hollow filter tube at least partially overlaps the hollow sleeve. For the opening at the upper end of the first discharge tube, it is preferable that the position of the lower end opening of the hollow filter tube completely overlaps the opening at the upper end of the first discharge tube of the hollow sleeve, so that when the blood is filtered, the platelet rich plasma (PRP ) Can pass through the hollow space in the hollow filter tube, flow through the lower end of the hollow filter tube, the first discharge tube of the hollow sleeve, and then enter the collection tank.

The lower end of the above-mentioned hollow filter tube may further include a combined portion, which may be connected to the bottom of the hollow sleeve in any conventional manner, such as bonding, screwing, locking, or snapping.

The above-mentioned hollow filter tube can be a hollow filter tube of any conventional shape, such as a cylindrical shape, a square column shape, a polygonal column shape, a cone shape, and a fan-shaped column shape, and a cylindrical hollow filter tube is preferred.

The above-mentioned hollow filter tube may be a full-tube type hollow filter tube, and the upper end of the full-tube type hollow filter tube can be connected to the top of the hollow sleeve in any conventional manner, such as bonding, screwing, locking, and locking.

The above-mentioned hollow filter tube can be further equipped with a rotating device, so that the hollow filter tube can be rotated in the hollow sleeve, so as to reduce the filter cake caused by the clogging of blood cells on the outside of the hollow filter tube when filtering blood.

The above-mentioned hollow filter tube includes a filter part, which can be a filter mesh made of any conventional material, such as a metal mesh, a nylon (NYLON) mesh, a polypropylene (Polypropylene, PP for short) mesh, Polyethylene (Polyethylene) net, polyethylene terephthalate ( PET or PETE) net, the above-mentioned multiple materials can be made into single-layer or multi-layer filter nets. The filter part can be a filter screen made by any conventional method, such as sintering (for metal), non-woven filter cloth (such as PP, PE), plain woven filter cloth (such as NYLON, PET). Among them, hydrophilic filter mesh and metal mesh are preferred.

The above-mentioned hollow filter tube may further include a bracket installed on the inner side of the hollow filter tube to support the hollow filter tube. The bracket may be any conventionally shaped bracket, such as cylindrical, square column, polygonal column. , Cone, fan-shaped column, etc.

The above-mentioned hollow sleeve may be a hollow sleeve of any shape, such as a cylindrical shape, a square column shape, a polygonal column shape, and a cone shape, and a cylindrical hollow sleeve is preferred. The injection tube of the hollow sleeve can be further equipped with a valve to adjust the flow of blood into the injection tube. The injection tube of the hollow sleeve can be further connected to a continuous blood supply device, which can be a siphon type continuous blood supply device, and the continuous blood supply device is used to continuously deliver blood to the hollow sleeve. The first discharge pipe of the hollow sleeve can be further equipped with a valve to adjust the flow of platelet-rich plasma into the collection tank. The second discharge pipe of the hollow sleeve can be further equipped with a valve to adjust the discharge flow of blood cells.

The above-mentioned hollow sleeve may be a detachable hollow sleeve. With the detachable hollow sleeve, the hollow filter tube or the upper end of the first discharge pipe located in the hollow sleeve can be detached or installed.

The above-mentioned first discharge pipe of the hollow sleeve is connected to the joint part of the collection tank, and the connection method can be any conventional connection method, such as bonding, screwing, locking, and snapping.

The above-mentioned collection tank may be a detachable collection tank to facilitate the processing of the filtrate in the collection tank.

The above-mentioned collection tank may further include a third discharge pipe arranged below the collection tank or on a side near the bottom to discharge the filtrate in the collection tank.

The above-mentioned air extraction device is connected with the connecting pipe of the collecting tank, and the connecting method can be any conventional connecting method, such as bonding, screwing, locking, and snapping. The air extraction device may be any conventional air extraction device, such as a vacuum extraction device.

The aforementioned air extraction device may be any conventional air extraction device, such as a vacuum extraction device.

10‧‧‧Blood filtration device

100‧‧‧Hollow sleeve

110‧‧‧Injection tube

111‧‧‧First valve

120‧‧‧First discharge pipe

121‧‧‧Second valve

130‧‧‧Second discharge pipe

131‧‧‧The third valve

210‧‧‧Hollow filter tube

211‧‧‧Combination Department

212‧‧‧Open

213‧‧‧Filter

220‧‧‧Full tube hollow filter tube

221‧‧‧First Combination Department

222‧‧‧Open

223‧‧‧Filter

224‧‧‧The second combination department

300‧‧‧Collection tank

310‧‧‧Connecting pipe

320‧‧‧Joint

400‧‧‧Air extraction device

Fig. 1 is a perspective view of a preferred embodiment of the blood filter device of the present invention.

Fig. 2 is a schematic cross-sectional view of the preferred embodiment shown in Fig. 1.

Fig. 3 is a perspective schematic view of the hollow filter tube of the preferred embodiment shown in Fig. 1.

Fig. 4 is a perspective view of another preferred embodiment of the blood filter device of the present invention.

Fig. 5 is a schematic cross-sectional view of the preferred embodiment shown in Fig. 4.

Fig. 6 is a three-dimensional schematic diagram of the full-tube hollow filter tube of the preferred embodiment shown in Fig. 4.

Fig. 7 is another perspective schematic view of the full-tube hollow filter tube shown in Fig. 6.

Hereinafter, the preferred specific example of the present invention is further illustrated with the following diagrams: FIG. 1 is a perspective view of a preferred specific example of the blood filter device of the present invention. The blood filter device 10 uses the air extraction device 400 to extract air from the collection tank 300 so that the pressure inside the hollow filter tube 210 is lower than the pressure outside the hollow filter tube 210. With this pressure difference, the injection tube 110 will be injected into the hollow The blood in the sleeve 100 flows in the direction of the hollow filter tube 210, and the blood is separated and filtered by the holes on the hollow filter tube 210, so that the platelet rich plasma (PRP Rich Plasma, PRP) has a diameter smaller than the hole diameter of the hollow filter tube 210. ) Can pass through the hollow filter tube 210 and flow into the collection tank 300 through the first discharge tube 120; and blood cells (such as red blood cells and white blood cells) with a diameter larger than the hole diameter of the hollow filter tube 210 are blocked from the hollow filter tube 210, Then, the hollow sleeve 100 flows out through the second discharge pipe 130 of the hollow sleeve 100 to achieve the purpose of separating platelet rich plasma (PRP) from the blood.

The injection tube 110 of the hollow sleeve 100 is equipped with a first valve 111 to adjust the flow of blood into the injection tube 110. The first discharge pipe 120 of the hollow sleeve 100 is equipped with a second valve 121 to adjust the flow of platelet-rich plasma into the collection tank. The second discharge pipe 130 of the hollow sleeve 100 is provided with a third valve 131 for adjusting the discharge flow of blood cells.

FIG. 2 is a schematic cross-sectional view of the preferred embodiment shown in FIG. 1. FIG. The inner space of the hollow filter tube 210 is hollow, and the lower end has an opening 212 (see FIG. 3). The hollow filter tube 210 is arranged on the first discharge tube 120 of the hollow sleeve 100 and connected with the first discharge tube 120 to allow the hollow filter The position of the lower end opening 212 of the tube 210 is completely overlapped with the upper end opening of the first discharge tube 120 of the hollow sleeve 100. Therefore, when the suction device 400 starts to operate to filter blood, platelets with a diameter smaller than the hole diameter of the hollow filter tube 210 Thick plasma (Platelet Rich Plasma, PRP) can pass through the hollow space in the hollow filter tube 210, flow through the lower end opening 212 of the hollow filter tube 210, the first discharge tube 120, and enter the collection tank 300, and the diameter is larger than the hole on the hollow filter tube 210 Blood cells with a pore size (such as red blood cells, white blood cells) are blocked outside the hollow filter tube 210 and flow out of the hollow sleeve 100 through the second discharge tube 130 of the hollow sleeve 100.

Fig. 3 is a perspective schematic view of the hollow filter tube of the preferred embodiment shown in Fig. 1. The filter portion 213 of the hollow filter tube 210 is a metal mesh, and the size of the mesh is larger than the diameter of Platelet Rich Plasma (PRP) and smaller than the diameter of blood cells (such as red blood cells and white blood cells). The position of the lower end opening 212 of the hollow filter tube 210 is at least partially overlapped with the upper end opening of the first discharge tube 120 of the hollow sleeve 100. The combined portion 211 at the lower end of the hollow filter tube 210 is connected to the bottom of the hollow sleeve 100 in a screw-fit manner. In the figure, the upper end of the hollow filter tube 210 is closed, but those skilled in the art can easily infer that the upper end of the hollow filter tube 210 can also be a metal mesh.

Fig. 4 is a perspective view of another preferred embodiment of the blood filter device of the present invention. The blood filter device 10 uses the air extraction device 400 to extract air from the collection tank 300, so that the pressure in the full-tube hollow filter tube 220 is lower than the pressure outside the full-tube hollow filter tube 220. This pressure difference will make The blood injected into the hollow sleeve 100 from the injection tube 110 flows in the direction of the full-tube hollow filter tube 220, and the blood is separated and filtered by the pore size of the full-tube hollow filter tube 220 to make the diameter smaller than the full-tube type. The platelet rich plasma (PRP) with the pore size of the hollow filter tube 220 can flow into the collection tank 300 through the full-tube hollow filter tube 220; and blood cells with a diameter larger than the pore size of the full-tube hollow filter tube 220 (Such as red blood cells, white blood cells) are blocked outside the full-tube hollow filter tube 220, and then flow out of the hollow sleeve 100 through the second discharge tube 130 of the hollow sleeve 100 to separate the platelet rich plasma from the blood. The purpose of Plasma, PRP).

Fig. 5 is a schematic cross-sectional view of the preferred embodiment shown in Fig. 4. The internal space of the full-tube hollow filter tube 220 is hollow, and the lower end has an opening 222. The full-tube hollow filter tube 220 is arranged above the first discharge tube 120 of the hollow sleeve 100 and connected with the first discharge tube 120. The position of the lower end opening 222 of the hollow filter tube 220 is completely overlapped with the opening of the upper end of the first discharge tube 120 of the hollow sleeve 100. Therefore, when the pumping device 400 is turned on to pump air and begin to filter blood, the platelet rich plasma (Platelet Rich Plasma) , PRP) can pass through the hollow space in the full-tube hollow filter tube 220, flow through the lower end opening 222 of the full-tube hollow filter tube 220, the first discharge pipe 120, and enter the collection tank 300, and the diameter is larger than the full-tube hollow filter The blood cells (such as erythrocytes and white blood cells) with the holes on the tube 220 are blocked outside the full-tube hollow filter tube 220 and flow out of the hollow sleeve 100 through the second discharge tube 130 of the hollow sleeve 100.

Fig. 6 is a three-dimensional schematic diagram of the full-tube hollow filter tube of the preferred embodiment shown in Fig. 4. The filter part 223 of the full-tube hollow filter tube 220 is a metal mesh. The position of the lower end opening 222 of the full-tube hollow filter tube 220 is at least partially overlapped with the upper end opening of the first discharge tube 120 of the hollow sleeve 100. The first combined part 221 at the lower end of the full-tube hollow filter tube 220 is connected to the bottom of the hollow sleeve 100 by screwing; the second combined part 224 at the upper end of the full-tube hollow filter tube 220 is connected by screwing At the top of the hollow sleeve 100.

Fig. 7 is another perspective schematic view of the hollow filter tube shown in Fig. 6.

10‧‧‧Blood filtration device

100‧‧‧Hollow sleeve

110‧‧‧Injection tube

111‧‧‧First valve

120‧‧‧First discharge pipe

121‧‧‧Second valve

130‧‧‧Second discharge pipe

131‧‧‧The third valve

210‧‧‧Hollow filter tube

300‧‧‧Collection tank

310‧‧‧Connecting pipe

320‧‧‧Joint

400‧‧‧Air extraction device

Claims (10)

A blood filtering device comprising: a hollow sleeve, an injection tube is arranged above the hollow sleeve, a first discharge tube and a second discharge tube are arranged below the hollow sleeve, wherein the injection tube is used for injecting blood, the The first discharge tube is used to discharge platelet-rich plasma, and the second discharge tube is used to discharge blood cells; a hollow filter tube with an opening at the lower end to discharge platelet-rich plasma, the hollow filter tube is located inside the hollow sleeve, wherein the The lower end of the hollow filter tube is installed on the upper end of the first discharge tube of the hollow sleeve, and the position of the lower end opening of the hollow filter tube at least partially overlaps the upper end of the first discharge tube of the hollow sleeve, wherein the hollow filter tube It has a plurality of holes for filtering blood; a collection tank with a joint portion above the collection tank for connecting with the first discharge pipe of the hollow sleeve, wherein a connection pipe is disposed above the collection tank; and an air suction The device, wherein the air extraction device is connected with the connecting pipe of the collection tank, and the air extraction device is used to make the pressure inside the hollow filter tube lower than the pressure outside the hollow filter tube. According to the blood filter device described in item 1 of the scope of patent application, the hole diameter of the hollow filter tube is larger than the diameter of platelets and smaller than the diameter of red blood cells. The blood filter device described in item 2 of the scope of patent application, wherein the hollow filter tube includes a filter part, and the filter part is a metal mesh, a non-woven mesh or a filter cloth. According to the blood filter device described in item 3 of the scope of patent application, the filter part of the hollow filter tube is a single-layer or multi-layer metal mesh, non-woven mesh or filter cloth. The blood filter device according to item 4 of the scope of patent application, wherein the filter part of the hollow filter tube is made of a multilayer metal mesh. According to the blood filter device described in item 3 of the scope of patent application, the hollow filter tube further includes a bracket on the inner side to support the hollow filter tube. The blood filter device described in the first item of the patent application further includes a rotating device, wherein the rotating device is connected with the hollow filter tube to rotate the hollow filter tube in the hollow sleeve. The blood filter device according to claim 1, wherein the blood filter device further includes a continuous blood supply device, wherein the continuous blood supply device is connected to the injection tube of the hollow sleeve, and the continuous blood supply device is used for continuous blood supply To the hollow sleeve. For the blood filter device described in item 1 of the scope of patent application, the hollow sleeve is detachable for replacing the hollow filter tube installed in the hollow sleeve. According to the blood filter device described in item 1 of the scope of patent application, the injection pipe, the first discharge pipe, the second discharge pipe or the connecting pipe of the collection tank of the hollow sleeve further include a valve.

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