TWI710398B - Blood filtration device - Google Patents

Abstract

The blood filter device of the present invention includes: a hollow sleeve, an injection pipe and a connecting pipe are arranged above the hollow sleeve, a first discharge pipe and a second discharge pipe are arranged under the hollow sleeve; a hollow filter tube is located at the Inside the hollow sleeve, the upper end of the hollow filter tube is installed on the lower end of the injection pipe of the hollow sleeve, and the lower end of the hollow filter tube is installed on the upper end of the second discharge pipe of the hollow sleeve, wherein the hollow filter tube has A plurality of holes; and a suction device connected to the connecting pipe of the hollow sleeve, wherein the suction device is used to make the pressure outside the hollow filter tube less than the pressure inside the hollow filter tube; the blood filter device is used for filtering In the case of blood, the first valve of the connecting pipe, the second valve of the first discharge pipe and the third valve of the second discharge pipe are closed.

Description

Blood filtration device

The invention relates to a blood filtering device, in particular to a blood filtering device capable of separating blood cells and platelet-rich plasma.

Platelet Rich Plasma (PRP) is a platelet concentrate separated from blood. The platelet rich plasma contains a variety of growth factors. These growth factors can provide raw materials for self-repair, allow tissue regeneration, and stop chondrocytes. Necrosis and abrasion prevent inflammation and relieve pain. Therefore, platelet-rich plasma is used in clinical research, inspection, surgery, medical cosmetology, orthopedic surgery, hair regeneration, sports injury treatment, and accelerated burn wound healing. If it can go deep Discussion, I believe it will definitely make a great contribution to human health.

At present, the most common method for separating platelet rich plasma (PRP) is to use centrifugation technology, through the characteristic of the high proportion of blood cells, put whole blood in a test tube, and use the centrifugal force generated by high-speed rotation to separate the blood. Then the upper layer of platelet rich plasma (Platelet Rich Plasma, PRP) is drawn. Please refer to the following patents or products that use centrifugal technology to obtain platelet-rich plasma: Taiwan Patent No. I531401 uses one of the upper bottle body and the lower bottle body to be joined correspondingly. The top of the lower bottle body is closed and has a predetermined number of convection holes. The lower part of the upper bottle body is equipped with an isolation plate, which can be driven to change the relative relationship with the convection hole by rotating the upper and lower bottle bodies to determine whether the upper and lower bottles are connected. , A suspension plug and a screw cap are arranged at the lower part of the lower bottle body, the height of the suspension plug can be changed by the adjustment of the screw cap, and a cylinder sleeve is set on the top of the upper bottle body, inside the cylinder sleeve It is equipped with a pipe string and a one-way valve, and a rotating seat and a control valve are assembled on the top of the sleeve, and sealed with an upper cover, and two independent nozzles are provided on the upper cover, by which the rotating seat And the control of the control valve determines whether the two pipe columns on the upper cover are connected or not, and a cap is also provided to cover the two pipe ports at the same time, thereby forming the closed platelet concentrator of the present invention, so that it can be performed by a centrifuge. This centrifugal operation separates and concentrates the blood into three layers of different components: plasma layer, platelet-rich plasma, and blood cells.

Chinese Mainland Patent No. CN202478263U and CN201469752U patents both proposed methods using a traditional syringe as a blood drawing device. After the blood is taken, the injection needle is removed, and a container with a piston is used to cover the opening of the syringe ( That is, the original injection needle socket), and then the assembled syringe and the container sleeved on it are centrifuged together. During centrifugation, the syringe is on the top and the container is on the bottom; therefore, the plasma collection method after centrifugation is The blood layer at the bottom is discharged downward from the syringe to the container, so that the platelet-rich plasma drops to the opening of the syringe, and then an injection needle is installed to directly inject the platelet-rich plasma back into the patient from the blood source.

U.S. Patent Application Publication No. 20100025342A1 proposed a blood separation device, which is also based on the principle of a traditional syringe. It uses two syringes, one of which is the first syringe, which is used to install an injection needle and draw whole blood. After obtaining the whole blood, replace the injection needle with a cap to seal the opening, and then apply a weaker centrifugation procedure to preliminarily separate the blood with the injection opening facing down. After that, a second syringe with an injection needle is used Put it into the pipe reserved by the push handle of the first syringe to absorb most of the plasma that is preliminarily separated (that is, to obtain the upper layer liquid by preliminary centrifugation); then replace the injection needle with another cap, seal the opening of the second syringe, and then Stronger centrifugation is performed to facilitate more precise layering of the plasma, and downward (that is, the direction of gravity) to discharge the specific blood layer to obtain platelet-rich plasma.

The product of platelet-rich plasma obtained by centrifugal separation technology:

GLO PRP kit:

Product operation video URL

https://www.youtube.com/watch? v=XJrOrCm8h2w

T-LAB PRP Kit:

Product operation video URL

https://www.youtube.com/watch? v=C68Mcug01X8

Proteal PRP Kit:

Product operation video URL

https://www.youtube.com/watch? v=lQV2h4OWOwo

Dr.PRP Kit

Product operation video URL

https://www.youtube.com/watch? v=e1IgqdeBtYo

GENESIS PRP

Product operation video URL

https://www.youtube.com/watch? v=494YeLv6mZE

However, the above patents or products that obtain platelet rich plasma (PRP) by centrifugal separation technology have the following disadvantages

1. The operating procedures are complicated. The method currently used to obtain platelet-rich plasma is still centrifugal test tube extraction. After the blood is centrifuged, in order to extract the platelet-rich plasma from the upper layer and avoid drawing to the lower part, multiple procedures and tools must be used (Please refer to the above-mentioned products and videos) in order to successfully complete the extraction of platelet-rich plasma.

2. Manual operation is required. After the blood is centrifuged, the subsequent extraction of platelet-rich plasma must be processed manually, which is quite labor intensive.

3. The operation time is long. Because the operation procedure of extracting the upper layer of platelet-rich plasma is complicated and needs to be performed manually, it takes more time to obtain platelet-rich plasma by centrifugation technology.

4. Unable to mass production, because the operation procedure of extracting the upper platelet rich plasma (Platelet Rich Plasma, PRP) is complicated and needs to be carried out manually, so mass production is impossible.

In view of the above-mentioned technical deficiencies and requirements, the present invention provides a blood filtration device with a simplified structure and convenient operation. In addition to simplifying complicated procedures, it also greatly reduces the steps required for manual operation, thus greatly shortening the operation time, and the present invention The blood filtration equipment uses the hollow filter tube to filter blood, which is different from the general centrifugal separation technology. It can also be used to separate a large amount of platelet-rich plasma from the blood to achieve the purpose of mass production.

One object of the present invention is to provide a blood filtration device.

Another object of the present invention is to provide a blood filtration device capable of separating platelet-rich plasma.

Another object of the present invention is to provide a blood filter device that uses a hollow filter tube to filter blood.

Another object of the present invention is to provide a blood filter device that uses a metal hollow filter mesh tube to filter blood.

Another object of the present invention is to provide a blood filtration device that uses a pressure difference to filter blood.

Another object of the present invention is to provide a blood filter device with a suction device.

Another object of the present invention is to provide a blood filter device that can filter a large amount of blood.

The blood filter device of the present invention includes: a hollow sleeve, an injection pipe and a connecting pipe are arranged above the hollow sleeve, a first discharge pipe and a second discharge pipe are arranged under the hollow sleeve, wherein the injection pipe It includes a first valve, the first discharge tube includes a second valve, the second discharge tube includes a third valve, wherein the injection tube is used to inject blood, the first discharge tube is used to discharge platelet-rich plasma, and the second The drain tube is used to drain blood cells; a hollow filter tube with a first opening at its upper end and a second opening at its lower end. The hollow filter tube is located inside the hollow sleeve, and the upper end of the hollow filter tube is mounted on the hollow The lower end of the injection pipe of the sleeve, the position of the first opening of the hollow filter pipe at least partially overlaps the lower end of the injection pipe of the hollow sleeve, and the lower end of the hollow filter pipe is mounted on the second discharge pipe of the hollow sleeve The position of the second opening of the hollow filter tube at least partially overlaps the opening of the upper end of the first discharge tube of the hollow sleeve, wherein the hollow filter tube has a plurality of holes for filtering blood; and a suction device , Wherein the air extraction device is connected with the connecting pipe of the hollow sleeve, wherein the air extraction device is used to make the pressure outside the hollow filter tube smaller than the pressure inside the hollow filter tube; wherein the blood filter device is used for filtering blood, The first valve, the second valve and the third valve are closed.

The above-mentioned blood filter device uses an air suction device to draw air to the hollow sleeve so that the pressure outside the hollow filter tube is lower than the pressure inside the hollow filter tube. With this pressure difference, the blood injected into the hollow sleeve is filtered into the hollow Flow in the direction of the outside of the tube, and then separate and filter the blood by the hole diameter of the hollow filter tube, so that the platelet rich plasma (PRP) with a diameter smaller than the hole diameter of the hollow filter tube can be filtered to the outside of the hollow filter tube. Flow into the first discharge tube; and blood cells (such as red blood cells, white blood cells) with a diameter larger than the hole diameter of the hollow filter tube are blocked inside the hollow filter tube, flow through the second opening of the hollow filter tube, and enter the second discharge tube of the hollow sleeve , To achieve the purpose of separating platelet rich plasma (Platelet Rich Plasma, PRP) from the blood.

The above-mentioned blood filtering device can filter human or different animal blood, such as human blood, pig blood, bovine blood, etc., through a hollow filter tube. The hole size of the hollow filter tube can be selected according to the size of blood cells of different animals. For example, the diameter of human red blood cells is 6~8μm, and the diameter of platelets is 2~4μm, in order to effectively block red blood cells. A hollow filter tube smaller than 6 μm but larger than 4 μm can be selected, such as a hollow filter tube with a pore size of 5 μm, so that Platelet Rich Plasma (PRP) can flow smoothly into the collection tank through the hollow filter tube.

The above-mentioned so-called provision of an injection pipe above the hollow sleeve means that an injection pipe is provided at the upper end of the hollow sleeve, or an injection pipe is provided on the side of the hollow sleeve close to the upper end.

The above-mentioned so-called connecting pipe above the hollow sleeve means that a connecting pipe is provided on the upper end of the hollow sleeve, or a connecting pipe is provided on the side of the hollow sleeve near the upper end.

The above-mentioned so-called having a first discharge pipe under the hollow sleeve means that a first discharge pipe is provided at the lower end of the hollow sleeve, or a first discharge pipe is provided on the side of the hollow sleeve near the lower end.

The above-mentioned so-called a second discharge pipe under the hollow sleeve means that a second discharge pipe is provided at the lower end of the hollow sleeve, or a second discharge pipe is provided on the side of the hollow sleeve near the lower end.

The internal space of the hollow filter tube is hollow, the position of the first opening of the hollow filter tube at least partially overlaps the lower end opening of the injection tube of the hollow sleeve, and the position of the first opening of the hollow filter tube completely overlaps the hollow sleeve The lower end of the injection tube of the cartridge is preferably opened, so that when the blood is filtered, the blood can enter the hollow space inside the hollow filter tube through the injection tube of the hollow sleeve and the first opening of the hollow filter tube. The position of the second opening of the hollow filter tube at least partially overlaps the upper end opening of the second discharge tube of the hollow sleeve, and the position of the second opening of the hollow filter tube completely overlaps the upper end of the second discharge tube of the hollow sleeve The opening is better, so that when filtering blood, blood cells (such as red blood cells, white blood cells) with a diameter larger than the hole diameter of the hollow filter tube are blocked inside the hollow filter tube, flow through the second opening of the hollow filter tube, and enter the hollow sleeve. The second discharge pipe.

The above-mentioned hollow filter tube can be a hollow filter tube of any conventional shape, such as a cylindrical shape, a square column shape, a cone shape, a fan-shaped column shape, and a cylindrical hollow filter tube is preferred.

The upper end of the above-mentioned full-tube hollow filter tube may further include a first combination part, which can be connected with the injection tube of the hollow sleeve in any conventional manner, such as bonding, screwing, locking, and locking.

The lower end of the above-mentioned full-tube type hollow filter tube may further include a second assembly part, which can be connected to the second discharge tube of the hollow sleeve in any conventional manner, such as bonding, screwing, locking, and locking.

The above-mentioned hollow filter tube can be further equipped with a rotating device, so that the hollow filter tube can be rotated in the hollow sleeve, so as to reduce the filter cake generated when blood cells are blocked on the inner side of the hollow filter tube when filtering blood.

The above-mentioned hollow filter tube includes a filter part, and the filter part can be a filter mesh made of any conventional material, such as a metal mesh, a nylon (NYLON) mesh, a polypropylene ( PP ) mesh, Polyethylene (Polyethylene) net, polyethylene terephthalate ( PET or PETE) net, the above-mentioned multiple materials can be made into single-layer or multi-layer filter nets. The filter part can be a filter screen made by any conventional method, such as sintering (for metal), non-woven filter cloth (such as PP, PE), plain woven filter cloth (such as NYLON, PET). Among them, hydrophilic filter mesh and metal mesh are preferred.

The above-mentioned hollow filter tube may further include a bracket installed on the inner side of the hollow filter tube to support the hollow filter tube. The bracket may be any conventionally shaped bracket, such as cylindrical, square column, polygonal column. , Conical, fan-shaped column.

The above-mentioned hollow sleeve may be a hollow sleeve of any shape, such as a cylindrical shape, a square column shape, a polygonal column shape, and a cone shape, and a cylindrical hollow sleeve is preferred. The first valve of the injection pipe of the hollow sleeve is used to adjust the flow of blood into the injection pipe. The injection tube of the hollow sleeve can be further connected with a continuous blood supply device for continuously delivering blood to the hollow sleeve, and the continuous blood supply device can be a siphon type continuous blood supply device.

The second valve of the first discharge pipe of the hollow sleeve is used to adjust the flow of platelet-rich plasma out of the first discharge pipe. The third valve of the second discharge pipe of the hollow sleeve is used to adjust the flow of blood cells out of the second discharge pipe. The connecting pipe of the hollow sleeve can be further equipped with a fourth valve to adjust the flow of the air extraction device.

When the blood filter device filters blood, the first valve, the second valve and the third valve are closed, so that the platelet-rich plasma can be effectively separated and filtered by the hollow filter tube.

The above-mentioned hollow sleeve may be a detachable hollow sleeve. With the detachable hollow sleeve, the hollow filter tube, the second discharge tube or the injection tube in the hollow sleeve can be detached or installed.

The above-mentioned blood filtering device may further include a first collection tank, which may be connected with the first discharge pipe of the hollow sleeve, and the first collection tank may be a detachable first collection tank. The above-mentioned first collection tank may further include a third discharge pipe arranged below the first collection tank or on a side near the bottom to discharge the filtrate in the first collection tank.

The above-mentioned blood filtering device may further include a second collection tank, which can be connected with the second discharge pipe of the hollow sleeve, and the second collection tank may be a detachable second collection tank. The above-mentioned second collection tank may further include a fourth discharge pipe disposed below or near the side of the second collection tank to discharge the filtrate in the second collection tank.

The aforementioned air extraction device may be any conventional air extraction device, such as a vacuum extraction device.

10‧‧‧Blood filtration device

100‧‧‧Hollow sleeve

110‧‧‧Injection tube

111‧‧‧First valve

120‧‧‧First discharge pipe

121‧‧‧Second valve

130‧‧‧Second discharge pipe

131‧‧‧The third valve

140‧‧‧Connecting pipe

141‧‧‧Fourth valve

210‧‧‧Hollow filter tube

211‧‧‧Filter

212‧‧‧First opening

213‧‧‧Second opening

214‧‧‧First Combination Department

215‧‧‧The second combination department

220‧‧‧Hollow filter tube

221‧‧‧Filter

222‧‧‧First Combination Department

223‧‧‧The second combination department

300‧‧‧Air extraction device

410‧‧‧First collection tank

420‧‧‧Second collection tank

Fig. 1 is a perspective view of a preferred embodiment of the blood filter device of the present invention.

Fig. 2 is a schematic cross-sectional view of the preferred embodiment shown in Fig. 1.

Fig. 3 is a perspective schematic view of the hollow filter tube of the preferred embodiment shown in Fig. 1.

FIG. 4 is a schematic diagram of FIG. 3 from another perspective.

Fig. 5 is a perspective view of another preferred embodiment of the blood filter device of the present invention.

Fig. 6 is a schematic cross-sectional view of the preferred embodiment shown in Fig. 5.

Fig. 7 is a three-dimensional schematic diagram of the hollow filter tube of the preferred embodiment shown in Fig. 5.

Hereinafter, the preferred specific example of the present invention is further illustrated with the following diagrams: FIG. 1 is a perspective view of a preferred specific example of the blood filter device of the present invention. The blood filter device 10 uses an air extraction device 300 to extract air from the hollow sleeve 100 so that the pressure outside the hollow filter tube 210 is lower than the pressure inside the hollow filter tube 210. With this pressure difference, the injection tube 110 will be injected The blood in the hollow sleeve 100 flows to the outside of the hollow filter tube 210, and the blood is separated and filtered by the hole diameter of the hollow filter tube 210, so that the platelet rich plasma (Platelet Rich Plasma) whose diameter is smaller than the hole diameter of the hollow filter tube 210 Plasma (PRP) can flow into the first collection tank 410 through the hollow filter tube 210 and the first discharge tube; and blood cells (such as red blood cells and white blood cells) with a diameter larger than the hole diameter of the hollow filter tube 210 are blocked in the hollow filter tube 210 The inside, then flows into the second collection tank 420 through the second discharge pipe 130 of the hollow sleeve 100 to achieve the purpose of separating platelet rich plasma (PRP) from the blood. When the blood filtration device 10 filters blood, the first valve 111, the second valve 121 and the third valve 131 are closed, so that the platelet-rich plasma can be effectively separated and filtered by the hollow filter tube 210.

The first valve 111 of the injection tube 110 of the hollow sleeve 100 is used to adjust the flow of blood into the injection tube. The second valve 121 of the first discharge pipe 120 of the hollow sleeve 100 is used to adjust the flow of platelet-rich plasma out of the first discharge pipe 120. The third valve 131 of the second discharge pipe 130 of the hollow sleeve 100 is used to adjust the flow of blood cells out of the second discharge pipe 131. The fourth valve 141 of the connecting pipe 140 of the hollow sleeve 100 is used to adjust the flow of the air extraction device 300.

FIG. 2 is a schematic cross-sectional view of the preferred embodiment shown in FIG. 1. FIG. The inner space of the hollow filter tube 210 is hollow, and the upper end has a first opening 212 (see FIG. 3). The position of the first opening 212 of the hollow filter tube 210 completely overlaps with the lower end opening of the injection tube 110 of the hollow sleeve 100, so as to filter In the case of blood, the blood can enter the hollow space inside the hollow filter tube 210 through the first opening 212 of the hollow filter tube 210. The position of the second opening 213 (see FIG. 4) of the hollow filter tube 210 is completely overlapped with the second discharge tube 130 of the hollow sleeve 100. Therefore, when the suction device 300 starts to operate to filter blood, the diameter is larger than that of the hollow filter tube 210 The blood cells (such as red blood cells and white blood cells) with the upper hole diameter are blocked inside the hollow filter tube 210, flow through the second opening 213 of the hollow filter tube 210, and enter the second discharge tube 130 of the hollow sleeve 100.

Fig. 3 is a perspective schematic view of the hollow filter tube of the preferred embodiment shown in Fig. 1. The filter part 211 of the hollow filter tube 210 is a metal mesh, and the size of the mesh is larger than the diameter of Platelet Rich Plasma (PRP) and smaller than the diameter of blood cells (such as red blood cells and white blood cells). The position of the first opening 212 of the hollow filter tube 210 at least partially overlaps the injection tube 110 of the hollow sleeve 100. The first assembly portion 214 of the hollow filter tube 210 is connected to the top of the hollow sleeve 100 by screwing; the second assembly portion 215 of the hollow filter tube 210 is connected to the bottom of the hollow sleeve 100 by screwing.

FIG. 4 is a schematic diagram of FIG. 3 from another perspective. The position of the second opening 213 of the hollow filter tube 210 is at least partially overlapped with the second discharge tube 130 of the hollow sleeve 100.

Fig. 5 is a perspective view of another preferred embodiment of the blood filtration device of the present invention. The blood filter device 10 uses the air extraction device 300 to extract air from the hollow sleeve 100 so that the pressure outside the hollow filter tube 220 is lower than the pressure inside the hollow filter tube 220. With this pressure difference, the injection tube 110 is injected The blood in the hollow sleeve 100 flows to the outside of the hollow filter tube 220, and then the blood is separated and filtered by the hole diameter of the hollow filter tube 220, so that the platelet rich plasma (Platelet Rich Plasma) whose diameter is smaller than the hole diameter of the hollow filter tube 220 Plasma (PRP) can flow into the first collection tank 410 through the hollow filter tube 220 and the first discharge tube 120; and blood cells (such as red blood cells and white blood cells) with a diameter larger than the hole diameter of the hollow filter tube 220 are blocked in the hollow filter tube In 220, the second discharge pipe 130 of the hollow sleeve 100 flows into the second collection tank 420 to achieve the purpose of separating platelet rich plasma (PRP) from the blood.

Fig. 6 is a schematic cross-sectional view of the preferred embodiment shown in Fig. 5. The inner space of the hollow filter tube 220 is hollow, the injection tube 110 passes through the top surface of the hollow sleeve 100 and is connected to the top of the hollow filter tube 220, and the second discharge tube 130 passes through the bottom surface of the hollow sleeve 100 and is connected to the hollow filter tube The bottom of the 220.

Fig. 7 is a perspective view of the hollow filter tube of the preferred embodiment shown in Fig. 5. The filter part 221 of the hollow filter tube 220 is a metal mesh. The injection tube 110 is connected to the first combination part 222 of the hollow filter tube 220, and the second discharge tube 130 is connected to the second combination part 223 of the hollow filter tube 220.

10‧‧‧Blood filtration device

100‧‧‧Hollow sleeve

110‧‧‧Injection tube

111‧‧‧First valve

120‧‧‧First discharge pipe

121‧‧‧Second valve

130‧‧‧Second discharge pipe

131‧‧‧The third valve

140‧‧‧Connecting pipe

141‧‧‧Fourth valve

210‧‧‧Hollow filter tube

300‧‧‧Air extraction device

Claims (10)

A blood filtering device comprising: a hollow sleeve, an injection pipe and a connecting pipe are arranged above the hollow sleeve, and a first discharge pipe and a second discharge pipe are arranged below the hollow sleeve, wherein the injection pipe includes a The first valve, the first discharge pipe includes a second valve, the second discharge pipe includes a third valve, wherein the injection pipe is used to inject blood, the first discharge pipe is used to discharge platelet-rich plasma, and the second discharge pipe is used To discharge blood cells; a hollow filter tube with a first opening at its upper end and a second opening at its lower end. The hollow filter tube is located inside the hollow sleeve, and the upper end of the hollow filter tube is mounted on the hollow sleeve The position of the first opening of the hollow filter tube at least partially overlaps the lower end of the injection tube of the hollow sleeve, and the lower end of the hollow filter tube is mounted on the second discharge tube of the hollow sleeve. The hollow filter The position of the second opening of the tube at least partially overlaps the upper end of the first discharge tube of the hollow sleeve, wherein the hollow filter tube has a plurality of holes for filtering blood; and a suction device, wherein the suction device and The connecting tube of the hollow sleeve is connected, wherein the air suction device is used to make the pressure outside the hollow filter tube smaller than the pressure inside the hollow filter tube; wherein when the blood filter device is filtering blood, the first valve and the first valve The second valve and the third valve are closed. According to the blood filter device described in item 1 of the scope of patent application, the hole diameter of the hollow filter tube is larger than the diameter of platelets and smaller than the diameter of red blood cells. The blood filter device described in item 2 of the scope of patent application, wherein the hollow filter tube includes a filter part, and the filter part is made of a metal mesh, a non-woven mesh or a filter cloth. According to the blood filter device described in item 3 of the scope of patent application, the filter part of the hollow filter tube is made of a single-layer or multi-layer metal mesh, non-woven mesh or filter cloth. The blood filter device according to item 4 of the scope of patent application, wherein the filter part of the hollow filter tube is made of a multilayer metal mesh. According to the blood filter device described in item 3 of the scope of patent application, the hollow filter tube further includes a bracket on the inner side to support the hollow filter tube. The blood filter device described in the first item of the patent application further includes a rotating device, wherein the rotating device is connected with the hollow filter tube to rotate the hollow filter tube in the hollow sleeve. The blood filter device according to claim 1, wherein the blood filter device further includes a continuous blood supply device, wherein the continuous blood supply device is connected to the injection tube of the hollow sleeve, and the continuous blood supply device is used for continuous blood supply To the hollow sleeve. For the blood filter device described in item 1 of the scope of patent application, the hollow sleeve is detachable for replacing the hollow filter tube installed in the hollow sleeve. According to the blood filter device described in item 1 of the scope of patent application, the connecting pipe of the hollow sleeve further includes a fourth valve.

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