TWI708617B - Herbal composition for increasing hair volune and manufacturing method - Google Patents

Herbal composition for increasing hair volune and manufacturing method Download PDF

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TWI708617B
TWI708617B TW106111740A TW106111740A TWI708617B TW I708617 B TWI708617 B TW I708617B TW 106111740 A TW106111740 A TW 106111740A TW 106111740 A TW106111740 A TW 106111740A TW I708617 B TWI708617 B TW I708617B
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劉玥劭
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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Abstract

The present invention provides a herbal composition for increasing hair volume, comprising a first medicinal including Lily, Barbed skullcap herb, Carica papaya Linn, Honeysuckle flower, or any combinations thereof; a second medicinal material including Saffron; a third medicinal material including Chinese Arborvitae Twig and Leaf having its root, bark, and leaf combined with Black sesame, Chinese Arborvitae Twig and Leaf having its root, bark, and leaf combined with Mulberry having its root, leaf, and twig, Purple grape, or any combinations thereof; wherein the first medicinal material is 2~40%, the second medicinal material is 2~40%, and the third medicinal material is 20~96% based on the total weight of the herbal composition.

Description

用於促進髮量增加之中草藥組成物(本草漢方)及其製備方法 Chinese herbal medicine composition (Chinese herbal medicine) for promoting hair volume increase and preparation method thereof

本揭露係有關於中草藥組成物及其製備方法。特定言之,係指用於促進毛髮生長及/或減少毛髮掉落、促進頭髮烏黑(亦即:促進毛髮整體的原來髮色比例增加)、減少頭皮發癢、及/或減少頭皮屑、改善精神狀況、明目及/或改善膚質之中草藥組成物及其製備方法。 This disclosure relates to Chinese herbal medicine composition and its preparation method. In particular, it means to promote hair growth and/or reduce hair fall, promote black hair (that is, increase the original hair color ratio of the entire hair), reduce itchy scalp, and/or reduce dandruff, and improve Chinese herbal medicine composition for mental condition, eyesight improvement and/or improvement of skin quality and its preparation method.

頭髮的生長需要血液供給養分,倘若一旦發生貧血,就會導致掉髮的危機。正因為頭髮是身體成長最快的部份之一,當供應頭髮營養的血液不足或有所缺損時,頭髮就會很快地呈現髮質變差、白髮,甚至脫髮的現象。掉髮約可能有下列診斷:雄性禿、圓禿、感染引起之禿髮、藥物引起之禿髮、休止期禿髮、瘢痕性禿髮等等。其中,雄性禿為最常見掉髮的原因,尤其現代人生活壓力大,飲食油膩、過度吹整頭髮、熬夜作息不正常,更加重了掉髮的危機。雄性禿比較多是荷爾蒙失調、藥物不良反應、營養不良、遺傳、疾病、壓力、接受癌症相關治療等產生,男女均會罹患。 The growth of hair requires blood to supply nutrients. If anemia occurs, it will lead to a crisis of hair loss. It is precisely because hair is one of the fastest growing parts of the body. When the blood supplying the hair is insufficient or missing, the hair will quickly show the phenomenon of poor hair quality, gray hair, and even hair loss. Hair loss may have the following diagnoses: male baldness, baldness, baldness caused by infection, baldness caused by drugs, telogen baldness, scarring baldness, etc. Among them, male baldness is the most common cause of hair loss. In modern people, life is under pressure, greasy diet, excessive blowing of the hair, and abnormal staying up late, which exacerbates the crisis of hair loss. Male baldness is mostly caused by hormonal imbalance, adverse drug reactions, malnutrition, genetics, disease, stress, and cancer-related treatments. Both men and women will suffer.

從中西醫的觀點來看,頭髮生長盛衰與否,似與血液有著密不可分的關係。根據中醫典籍「素問.六節臟象論」記載:「腎者,精之處也,其華在髮,其充在骨」。除了「腎之華在髮」的論述之外,尚有其他的中醫典籍也曾提到「血盛則髮潤、血衰則髮衰」的說法;所以中醫認為頭髮受到血液的滋養,而頭髮的好與壞,其關鍵在於腎臟。因為「腎藏精,精能化血,精盛血旺,則毛髮潤澤美麗」,故說「腎之華在髮」。中醫理論有「髮為血之餘」、「腎之華在髮」之說法,所以主要跟『中醫的腎』有密切的關係;也有「血盛則髮潤、血衰 則髮衰」、「營血虛損.....毛髮枯而不潤」的說法,也說明了與『中醫的血』息息相關。所以傳統醫學治療的原則以『固腎』、『補血』為主。年輕人精血充沛,毛髮自然光澤黑潤;而老年人精血虧虛,毛髮花白而易脫落,或久病體虛髮落稀疏,若能注意補腎、益精、養血,是可以改善落髮的情形。 From the point of view of Chinese and Western medicine, the growth and decline of hair seems to be closely related to blood. According to the "Suwen. Six-section Zangxiang Theory" in the classics of traditional Chinese medicine: "The kidney has the essence, its bloom is growing, and its filling is in the bone." In addition to the statement that "the flower of the kidney is in hair", there are other TCM classics also mentioning the saying that "blood is rich, and blood is decayed." Therefore, Chinese medicine believes that hair is nourished by blood, and hair is nourished by blood. The key to the good and bad lies in the kidneys. Because "the kidney stores the essence, the essence can transform the blood, the essence is full of blood, and the hair is moist and beautiful." Therefore, "the blossom of the kidney is growing." The theory of Chinese medicine has the sayings that "blood is left behind" and "the blossom of the kidney is growing", so it is mainly related to the "kidney of Chinese medicine"; The sayings of "decay" and "blood loss... the hair is dry but not moist" also shows that it is closely related to the "blood of Chinese medicine". Therefore, the principle of traditional medical treatment is mainly to "enhance the kidney" and "enrich blood". Young people have plenty of essence and blood, and their hair is naturally shiny and black; while the elderly are deficient in essence and blood, and their hair is gray and easy to fall off, or the body is weak for a long time, and the hair is sparse. If you can pay attention to nourishing kidneys, nourishing essence, and nourishing blood, you can improve hair loss. .

目前美國食品藥物管制局〈FDA〉核准的治療掉髮藥物有兩類,一是口服的,商品名為柔沛,但只使用於男性;一是外擦的,商品名為落健,男女皆可使用,但濃度有差別。治療上通常需3至6個月,才能停止掉髮,服用1至2年才會長頭髮。可是口服的藥物會有勃起硬度不足的副作用,會造成某些男性的困擾。 At present, the US Food and Drug Administration (FDA) approved two types of drugs for the treatment of hair loss. One is oral, with the trade name Propecia, but only for men; the other is external rubbing, with the trade name Rokin, both men and women. Used, but the concentration is different. It usually takes 3 to 6 months for treatment to stop hair loss, and it takes 1 to 2 years for hair to grow. However, oral medications have the side effect of insufficient erectile hardness, which can cause distress for some men.

柔沛及落健的活性成分為米諾地爾(minoxidil)。米諾地爾促進毛髮生長的機轉目前還未完全了解,咸信米諾地爾(minoxidil)藉由擴張血管及開通鉀離子通道,使更多的氧氣及養分到毛囊,會促使毛囊從休止期到生長期。但,其他的血管擴張劑並沒有像米諾地爾一樣有刺激頭髮生長的功效。由於米諾地爾促進毛髮生長的機轉不明,因此也對開發新的相關藥物或製劑造成阻礙。因此,效果快、持續且副作用低的藥物或製劑仍有需求。 The active ingredient of Propecia and Rogaine is minoxidil. The mechanism by which minoxidil promotes hair growth is not yet fully understood. It is believed that minoxidil dilates blood vessels and opens potassium ion channels to bring more oxygen and nutrients to the hair follicles, which will promote the hair follicles from resting. Period to growth period. However, other vasodilators are not as effective as minoxidil in stimulating hair growth. As the mechanism of minoxidil to promote hair growth is unknown, it also hinders the development of new related drugs or preparations. Therefore, there is still a need for drugs or preparations with fast effects, sustained effects and low side effects.

有鑑於上述之需求,本揭露係有關於一種用於促進髮量增加之中草藥組成物,其包含:第一類藥材,其係選自由百合(百合屬,學名:Lilium)、天麻(或名定風草,學名Gastrodia elata)、半枝蓮(又名再生草或大花馬齒莧,學名:Portulaca grandiflora)、宣木瓜(薔薇科落葉灌木貼梗海棠(Chaenomeles speciose(Sweet)Nakai)、金銀花(Honeysuckle flower,學名Lonicera japonica Thunb.)及其任何混合所組成的群組;第二類藥材,其係選自由熟地(又名熟地黃,學名:Rehmannia glutinosa)、菟絲子(又名龍鬚子,學名:Cuscuta austras R.Brown)、番紅花(又名西紅花(Saffron),學名:Crocus sativus)、及其任何混合所組成的群組;第三類藥材,其係選自由側柏(又名香柏(Chinese Arborvitae Twig and Leaf),學名:Platycladus orientalis;拉丁植物動物礦物名:latycladus orientalis(L.)Franco[Thuja orientalis L.;Biota orientalis(L.)Endl.])(包括柏根皮及嫩枝葉);桑樹(包括桑葚(桑椹)(Mulberry,又名文武實,學名:Fructus Mori)及其根白皮(桑白皮,學名:Morus alba L.,又名:CORTEX MORI)、葉(桑葉,Mulberry Leaf,學名:Morus alba L.)、幹枝(桑枝,Mulberry Twig,又名:RAMULUS MORI)之混合);黑芝麻(又名巨勝子或胡麻,學名:Semen Sesami Nigrum);紫葡萄(學名:Vitis romanetii Roman.du Caill.ex Planch.);及其任何混合所組成的群組。 In view of the above-mentioned needs, this disclosure is related to a Chinese herbal medicine composition used to increase hair volume, which includes: the first type of medicinal materials, which are selected from lily (Lilium, scientific name: Lilium ), gastrodia Windweed , scientific name Gastrodia elata ), Scutellaria barbata (also known as regenerated grass or Portulaca grandiflora , scientific name: Portulaca grandiflora ), Xuan papaya (Chaenomeles speciose (Sweet) Nakai), honeysuckle ( Honeysuckle flower, scientific name Lonicera japonica Thunb.) and any combination thereof; the second type of medicinal material, which is selected from Rehmannia glutinosa (also known as Rehmannia glutinosa, scientific name: Rehmannia glutinosa ), dodder (also known as Longxuzi, scientific name) : Cuscuta austras R.Brown ), saffron (also known as Saffron (Saffron), scientific name: Crocus sativus ), and any combination thereof; the third type of medicinal material, which is selected from Platycladus orientalis (also known as fragrant Cypress (Chinese Arborvitae Twig and Leaf), scientific name: Platycladus orientalis ; Latin plant animal mineral name: latycladus orientalis (L.) Franco [Thuja orientalis L.; Biota orientalis (L.) Endl.]) (including Cypress root bark and tender Branches and leaves); mulberry trees (including mulberry (mulberry) (Mulberry, also known as Wenwu Shi, scientific name: Fructus Mori) and its root white bark (mulberry, scientific name: Morus alba L., also known as: CORTEX MORI), leaf (mulberry) Leaf, Mulberry Leaf, scientific name: Morus alba L.), dried twigs (mixture of Mulberry Twig, also known as RAMULUS MORI); black sesame (also known as Jushengzi or flax, scientific name: Semen Sesami Nigrum ); purple grape (Scientific name: Vitis romanetii Roman.du Caill.ex Planch.); and any group consisting of a mixture.

本揭露之中草藥組成物中,第一類藥材、第二類藥材及第三類藥材之組成分比例不限,但以中草藥組成物總重量計,較佳為該第一類藥材占2~40%,該第二類藥材占2~40%,且該第三類藥材占20~96%;更佳為該第一類藥材占10~35%,該第二類藥材占10~30%,且該第三類藥材占35~80%;最佳為該第一類藥材占20~30%,該第二類藥材占20~25%,且該第三類藥材占45~60%。 In the Chinese herbal medicine composition of the present disclosure, the composition ratio of the first type of medicinal materials, the second type of medicinal materials and the third type of medicinal materials is not limited, but based on the total weight of the Chinese herbal medicine composition, it is preferable that the first type of medicinal materials account for 2-40 %, the second type of medicinal materials accounted for 2-40%, and the third type of medicinal materials accounted for 20-96%; more preferably, the first type of medicinal materials accounted for 10 to 35%, and the second type of medicinal materials accounted for 10 to 30%, And the third type of medicinal materials accounts for 35 to 80%; the best is that the first type of medicinal materials account for 20 to 30%, the second type of medicinal materials account for 20 to 25%, and the third type of medicinal materials account for 45 to 60%.

在一實施態樣中,該第三類藥材係側柏之柏根皮(柏根)及嫩枝葉及桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合),側柏之柏根皮及嫩枝葉對桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合)的重量比以比例示之,即,重量比係0.8~1.2:1,較佳為1:1。 In one embodiment, the third type of medicinal material is the root bark (cypress root) and tender leaves of Platycladus orientalis and the mulberry tree (including the mixture of mulberry and white bark, mulberry leaf, and mulberry branch) of Platycladus orientalis The weight ratio of root bark and tender leaves to the mulberry tree (including the mixture of mulberry and mulberry bark, mulberry leaf, and mulberry branch) is shown in proportion, that is, the weight ratio is 0.8 to 1.2:1, preferably 1:1.

在另一實施態樣中,該第三類藥材係側柏之柏根皮、嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);及黑芝麻,且側柏之柏根皮、嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);及黑芝麻的重量比以比例示之,即,重量比係1~4:1~4:1,較佳為2:2:1。 In another embodiment, the third type of medicinal material is the root bark and young branches of Platycladus orientalis; mulberry (including a mixture of mulberry and mulberry white bark, mulberry leaves, and mulberry branches); and black sesame, and Platycladus orientalis The weight ratio of cypress root bark, young branches and leaves; mulberry tree (including the mixture of mulberry and mulberry white bark, mulberry leaves, and mulberry branches); and black sesame seeds are shown in proportions, that is, the weight ratio is 1~4:1~4 :1, preferably 2:2:1.

在又一實施態樣中,該第三類藥材係桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);及紫葡萄,且桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合)對紫葡萄的重量比係0.8~1.2:1,較佳為1:1。 In another embodiment, the third type of medicinal material is mulberry (including a mixture of mulberry and mulberry bark, mulberry leaf, and mulberry branch); and purple grape, and mulberry tree (including mulberry and mulberry bark, mulberry leaf, The weight ratio of the mixture of mulberry branch) to purple grape is 0.8~1.2:1, preferably 1:1.

在又一實施態樣中,該第三類藥材係側柏之柏根皮及嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);紫葡萄;及黑芝麻,且側柏之柏根皮及嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);紫葡萄;及黑芝麻的重量比係1~5:1~5:1~5:1,較佳為3:3:3:1。 In another embodiment, the third type of medicinal material is the root bark and young branches and leaves of Platycladus orientalis; mulberry (including a mixture of mulberry and mulberry white bark, mulberry leaf, and mulberry branch); purple grape; and black sesame, The weight ratio of cypress root bark and young branches and leaves of Platycladus orientalis; mulberry tree (including a mixture of mulberry and mulberry white bark, mulberry leaf and mulberry branch); purple grape; and black sesame is 1~5:1~5:1~ 5:1, preferably 3:3:3:1.

在一實施態樣中,該第一類藥材中係百合、天麻、半枝蓮、宣木瓜、及金銀花,且百合、天麻、半枝蓮、宣木瓜、及金銀花的重量比係1:0.8:1:1:1.2,其中,該金銀花除提供療效之外,同時也可作為外用劑型天然防腐劑。 In one embodiment, the first type of medicinal materials are lily, Gastrodia, Scutellaria barbata, Scutellaria barbata, and honeysuckle, and the weight ratio of lily, Gastrodia, Scutellaria barbata, Scutellaria barbata, and honeysuckle is 1: 0.8:1:1:1.2, among them, the honeysuckle not only provides curative effect, but also can be used as a natural preservative for external preparation.

在一實施態樣中,該第二類藥材中係熟地、菟絲子、及番紅花,且熟地、菟絲子、及番紅花的重量比係1.5:1:0.5。 In one embodiment, the second type of medicinal materials are rehmannia, dodder, and saffron, and the weight ratio of rehmannia, dodder, and saffron is 1.5:1:0.5.

本揭露之中草藥組成物更可視狀況選擇性地添加解表藥材、利尿藥材、清熱藥材或健脾燥濕藥材。 According to the present disclosure, the Chinese herbal medicine composition can be selectively added with relieving medicinal materials, diuretic medicinal materials, heat-clearing medicinal materials or spleen-invigorating and damp-drying medicinal materials.

本揭露之中草藥組成物所添加之解表藥材、利尿藥材、清熱藥材或健脾燥濕藥材之添加量不限,較佳的是,解表藥材添加量為1~50重量%,利尿藥材添加量為1~50重量%,清熱藥材添加量為1~70重量%,健脾燥濕添加量為1~40重量%;更佳的是,解表藥材較佳添加量為5~30重量%,利尿藥材較佳添加量為5~30重量%,清熱藥材較佳添加量為5~50重量%,健脾燥濕較佳添加量為2~30重量。 There is no limitation on the addition amount of anti-episodic medicinal materials, diuretic medicinal materials, heat-clearing medicinal materials, or spleen-invigorating and damp-drying medicinal materials added to the Chinese herbal composition of the present disclosure. Preferably, the added amount of anti-episodic medicinal materials is 1-50% by weight, and diuretic medicinal materials are added The amount is 1-50% by weight, the amount of heat-clearing medicinal materials is 1~70% by weight, and the amount of spleen-invigorating and damp-drying materials is 1-40% by weight; more preferably, the preferred amount of anti-spleen medicinal materials is 5-30% by weight The preferred amount of diuretic medicinal materials is 5-30% by weight, the preferred amount of heat-clearing medicinal materials is 5-50% by weight, and the preferred amount of spleen-invigorating and damp-drying drugs is 2-30% by weight.

本揭露中選擇性使用之解表藥材可為任何一種習知解表藥材較佳係選自由下列藥材所組成之群組:淡豆豉(Fermented soybean)、桂枝(Ramulus cinamomi)、紫蘇(Perillae folium)、生薑(Zingiberis rhizoma)、麻黃(Ephedrae herba)、蔥白(Allii fistulosi Bulbus)、羌活(Notopterygii rhizoma)、及其組合物。 The medicinal materials selectively used in this disclosure can be any conventional medicinal materials that are preferably selected from the group consisting of the following medicinal materials: Fermented soybean, Ramulus cinamomi, Perillae folium ), ginger (Zingiberis rhizoma), ephedra (Ephedrae herba), green onion (Allii fistulosi Bulbus), Qianghu (Notopterygii rhizoma), and combinations thereof.

本揭露中選擇性使用之利尿藥材可為任何一種習知利尿藥材,較佳係選自由下列藥材所組成之群組:澤瀉(Alismatis rhizoma)、車前子(Semen plantaginis)、丁豎杇(Elephantopus scaber)、黃水茄(Solanum incanum)、茯苓(Indian buead)、路路通(Beartiful sweetgum Fruit)、及其組合物。 The diuretic medicinal materials selectively used in the present disclosure can be any conventional diuretic medicinal materials, preferably selected from the group consisting of the following medicinal materials: Alismatis rhizoma, Semen plantaginis, Ding Shu 杇 ( Elephantopus scaber), Solanum incanum, Poria (Indian buead), Beartiful sweetgum Fruit, and combinations thereof.

本揭露中選擇性使用之清熱藥材可為任何一種習知清熱藥材,較佳係選自由下列藥材所組成之群組:檉柳(Tamarix chinensis Lour.)、橄欖(Black Olive)、決明子(Cassia Seed)、谷精草(Flos Eriocauli)、淡竹葉(Sasagrass)、及其組合物。 The heat-clearing medicinal materials selectively used in this disclosure can be any conventional heat-clearing medicinal materials, preferably selected from the group consisting of the following medicinal materials: Tamarix chinensis Lour., Black Olive, Cassia Seed , Flos Eriocauli, Sasagrass, and combinations thereof.

本揭露中選擇性使用之健脾燥濕可為任何一種習知健脾燥濕藥材多具芳香之氣較佳係選自由下列藥材所組成之群組:芡實(Euryaleferox Salisb.)、白豆蔻(Amomum kravanh Piere ex Gagnep)、草果(Amomum tsao-ko Crevost et Lemaire)、厚朴(Magnolia officinalis Rehd.et Wils.)、佩蘭(Eupatorium fortunei Turcz)及其組合物。 The selective use of the spleen-invigorating and damp-drying medicinal materials used in this disclosure can be any of the traditionally known medicinal materials for invigorating the spleen and dampness. The more fragrant odor is preferably selected from the group consisting of the following medicinal materials: Gorgon (Euryaleferox Salisb.), White Cardamom (Amomum kravanh) Piere ex Gagnep), Amomum tsao-ko Crevost et Lemaire, Magnolia officinalis Rehd.et Wils., Eupatorium fortunei Turcz, and combinations thereof.

本揭露之中草藥組成物中,解表藥材較佳為防風萃取物、淡豆豉萃取物、羌活萃取物、或其組合物;利尿藥材較佳為澤瀉萃取物、川木通萃取物、車前子萃取物或其組合物;清熱藥材較佳為牡丹皮萃取物、敗醬草萃取物或其組合物;健脾燥濕藥材較佳為芡實萃取物、蒼朮萃取物、姜科植物萃取物或其組合物。 In the Chinese herbal medicine composition disclosed in the present disclosure, the anti-episodic medicinal material is preferably a windproof extract, a light tempeh extract, a Qianghuo extract, or a combination thereof; the diuretic medicinal material is preferably an Alisma orientalis extract, a Chuanmutong extract, and plantain Extract or composition thereof; the heat-clearing medicinal material is preferably Paeonia Suffruticosa bark extract, Patrinia vulgaris extract or a combination thereof; the spleen-invigorating and damp-drying medicinal material is preferably Gorgon extract, atractylodes extract, ginger plant extract or Its composition.

上述之藥材,可為中藥材、中藥材萃取物、或其混合物。若為中藥材萃取物,係水萃取物、酒精萃取物、或水萃取物及酒精萃取物,特定言之,該中藥材萃取物係水萃取物及酒精萃取物。該中藥材萃取物係以噴霧乾燥或冷凍乾燥造粒而獲得。 The aforementioned medicinal materials may be Chinese medicinal materials, Chinese medicinal materials extracts, or mixtures thereof. If it is a Chinese medicinal material extract, it is a water extract, an alcohol extract, or a water extract and an alcohol extract. Specifically, the Chinese medicinal material extract is a water extract and an alcohol extract. The Chinese herbal medicine extract is obtained by spray drying or freeze drying granulation.

如本文中所使用,用語「促進髮量增加」係藉由促進毛髮生長及/或減少毛髮掉落達成,其中,較佳的是,該毛髮生長係原來髮色毛髮生長,未欲受限於理論,咸信本揭露之中草藥組成物延緩老化及增進代謝,個體之白髮在進入毛髮生長周期休止期即自然掉落,接著,所新生的毛髮為原來髮色。進一步地,本揭露之中草藥組成物同時具有促進毛髮整體的原來髮色比例增加(舉例而言,個體若原為黑髮,則毛髮中的黑髮比例提高)、減少頭皮發癢、平衡頭皮油脂及去除異味、及/或減少頭皮屑之功效。如本文中所使用,用語「原來髮色」係指毛髮白化前所呈現之髮色,例如黑色、棕色、金色、紅色等等。又進一步地,本揭露之中草藥組成物同時具有改善精神狀況、明目及/或改善膚質之功效。 As used herein, the term "promoting increase in hair volume" is achieved by promoting hair growth and/or reducing hair fall. Preferably, the hair growth is the original color hair growth and is not intended to be limited to Theoretically, it is believed that the Chinese herbal composition delays aging and improves metabolism. The white hair of an individual will naturally fall off when it enters the cessation period of the hair growth cycle, and then the newly regenerated hair will be the original hair color. Furthermore, the Chinese herbal composition disclosed in the present disclosure can also promote the increase of the original hair color ratio of the entire hair (for example, if the individual is originally black, the ratio of black hair in the hair will increase), reduce scalp itching, balance scalp oil and The effect of removing odor and/or reducing dandruff. As used herein, the term "original hair color" refers to the hair color that appears before the hair becomes albino, such as black, brown, gold, red, etc. Furthermore, the Chinese herbal composition disclosed in the present disclosure also has the effects of improving mental condition, improving eyesight and/or improving skin quality.

本揭露之中草藥組成物係以外用劑型投予。 The Chinese herbal medicine composition of this disclosure is administered in an external dosage form.

本揭露之中草藥組成物亦可經調製為口服製劑,且亦可依需要加入其他醫藥可接受之載體。例如,用於口服之中草藥組合物,型式包括膠囊、錠劑、乳化劑與液狀懸浮液、分散劑與溶劑。以錠片為例,一般所使用的載體為乳糖或是玉米澱粉,潤滑劑,或硬脂酰鎂為基木忝加物。以口服膠囊投藥型式,可以如乳糖與乾燥玉米澱粉等作為有效的稀釋液。如果需要,可添加適度的甜味劑,風味劑。本揭露中較佳更可包括一賦型劑而適用之賦型劑可為任一種習用者,較佳為玉米澱粉。 The herbal composition of the present disclosure can also be formulated into an oral preparation, and other pharmaceutically acceptable carriers can also be added as needed. For example, for oral Chinese herbal medicine compositions, the forms include capsules, tablets, emulsifiers and liquid suspensions, dispersions and solvents. Taking tablets as an example, generally used carriers are lactose or corn starch, lubricants, or magnesium stearate as the base additives. In the form of oral capsule administration, lactose and dried corn starch can be used as effective diluents. If necessary, moderate sweeteners and flavors can be added. The present disclosure may preferably include an excipient and the applicable excipient may be any conventional one, preferably corn starch.

本揭露另提供一種口服生髮、養髮、健髮保健飲料,其包含上述之本揭露之中草藥組成物、水、及隨意之水果果汁或水果萃取液。在該口服生髮、養髮、健髮、增髮保健飲料的一實施態樣中,本揭露之中草藥組成物係藥材之混合製得或各別製得的蒸餾液,該水係滅菌水或純水,且該水果係桑葚或葡萄。在進一步之實施態樣中,以該口服生髮、養髮、健髮、增髮保健飲料總重量計,各組分之重量百分比可如表1所示。 The present disclosure also provides an oral health-care beverage for hair growth, nourishment and hair strengthening, which contains the above-mentioned herbal composition of the present disclosure, water, and optional fruit juice or fruit extract. In one embodiment of the oral health beverage for growth, nourishment, health, and growth enhancement, the disclosed Chinese herbal medicine composition is a distillate prepared by mixing or separately prepared medicinal materials, and the water-based sterilized water or pure Water, and the fruit is mulberry or grape. In a further embodiment, based on the total weight of the oral hair growth, hair nourishing, hair strengthening, and hair increasing health beverage, the weight percentage of each component can be as shown in Table 1.

Figure 106111740-A0305-02-0006-1
Figure 106111740-A0305-02-0006-1

在又一實施態樣中,上述口服生髮、養髮、健髮、增髮保健飲料可另加入天然調味劑以增進嗜口性。例如,上述混合液再按混合液每1000c.c.加入0.1~1c.c.的龍眼蜜。 In another embodiment, the above-mentioned oral hair growth, hair nourishing, hair strengthening, and hair increasing health beverages may be additionally added with natural flavoring agents to enhance palatability. For example, the above mixture is added with 0.1~1c.c. longan honey every 1000c.c. of the mixture.

本揭露另提供製備如上述之中草藥組成物之方法,其包含下列之步驟:(a)分別提供第一類藥材、第二類藥材、及第三類藥材, (b)將第一類藥材、第二類藥材、及第三類藥材混合以形成混合物,其中,以中草藥組成物總重量計,該第一類藥材占2~40%,該第二類藥材占2~40%,且該第三類藥材占20~96%,(c)萃取該混合物,其中該第一類藥材係選自由百合、天麻、半枝蓮、宣木瓜、金銀花及其任何混合所組成的群組,其中該第二類藥材係選自由熟地、菟絲子、番紅花、及其任何混合所組成的群組,其中該第三類藥材係選自由側柏之柏根皮及嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);紫葡萄;黑芝麻;及其任何混合所組成的群組。 The present disclosure further provides a method for preparing the above-mentioned Chinese herbal medicine composition, which includes the following steps: (a) providing the first type of medicinal materials, the second type of medicinal materials, and the third type of medicinal materials, respectively, (b) Mixing the first type of medicinal materials, the second type of medicinal materials, and the third type of medicinal materials to form a mixture, wherein, based on the total weight of the Chinese herbal medicine composition, the first type of medicinal materials account for 2-40%, and the second type of medicinal materials 2~40%, and the third category of medicinal materials accounted for 20~96%, (c) extract the mixture, wherein the first category of medicinal materials is selected from lily, gastrodia, barbata, xuan papaya, honeysuckle and any The second type of medicinal material is selected from the group consisting of rehmannia, dodder, saffron, and any mixture thereof, wherein the third type of medicinal material is selected from the root bark and tender root of Platycladus orientalis Branches and leaves; mulberry tree (including mulberry and mulberry white bark, mulberry leaf, and a mixture of mulberry branches); purple grapes; black sesame seeds; and any group of mixtures thereof.

此外,前述之步驟中,也可依不同藥材配比混合,而後分開萃取、同時萃取、濃縮而獲得。 In addition, in the aforementioned steps, different medicinal materials can also be mixed according to the ratio, and then separately extracted, simultaneously extracted, and concentrated.

本揭露亦提供如上述之中草藥組成物用於製造供促進髮量增加、促進毛髮整體的原來髮色比例增加、減少頭皮發癢及/或減少頭皮屑的製劑之用途。如本文中所使用,用語「促進髮量增加」係指促進毛髮生長、減少毛髮掉落、或同時有促進毛髮生長及減少毛髮掉落達成。 The present disclosure also provides the use of the above-mentioned Chinese herbal medicine composition in the manufacture of preparations for promoting the increase of hair volume, promoting the increase of the original hair color ratio of the whole hair, reducing scalp itching and/or reducing dandruff. As used herein, the term "promoting increase in hair volume" refers to promoting hair growth, reducing hair fall, or both promoting hair growth and reducing hair fall.

在一實施態樣中,該製劑係經由皮膚外用或口服投予。 In one aspect, the preparation is administered externally or orally via the skin.

在又一實施態樣中,該製劑係經由口服投予時,該製劑係另包含廣藿香萃取液。 In another embodiment, when the preparation is administered orally, the preparation additionally contains patchouli extract.

在一實施態樣中,該製劑係以水或精油作為溶劑。 In one aspect, the formulation uses water or essential oil as a solvent.

在一實施態樣中,該製劑中的金銀花係用以作為外用天然防腐劑。 In one aspect, the honeysuckle in the preparation is used as a natural preservative for external use.

圖1A至1B是試用者池先生試用配方A2前後之頭項部毛髮照片。圖1A與圖1B對照可看到長髮範圍,禿髮範圍縮小超過一半。 Figures 1A to 1B are photos of the head hair of the tester Mr. Chi before and after formula A2. Comparing Figure 1A with Figure 1B, you can see the range of long hair, and the range of baldness is reduced by more than half.

圖2A至2C分別為試用者黃先生試用配方A2後之頭頂及後腦勺毛髮照片。 Figures 2A to 2C are photos of the top and back of the head of the tester Mr. Huang after trying formula A2.

圖3A至3D分別為試用者劉小姐試用配方A3前額部毛髮照片。 Figures 3A to 3D are photos of the forehead hair of the tester Ms. Liu who tried formula A3.

圖4A至4H為試用者林小姐試用配方A4之頭項部毛髮照片;圖4G及4H為偏後腦頂部毛毛髮照片。 Figures 4A to 4H are photos of the hair on the nape of the tester, Miss Lin, who tried formula A4; Figures 4G and 4H are photos of the hair on the top of the head.

圖5A至5D為試用者廖小姐試用配方A4後之頭項部毛髮照片。 Figures 5A to 5D are photos of the head hair of the tester Ms. Liao after trying formula A4.

圖6A至6M分別為試用者王先生試用配方A5前後的毛髮照片。 Figures 6A to 6M are respectively the hair photos of the tester Mr. Wang before and after the formulation A5 was tested.

圖7A至7M為試用者蔡先生試用配方A5前後的毛髮照片及改善狀況。 Figures 7A to 7M are the hair photos of the tester Mr. Cai before and after formula A5 and the improvement.

圖8A至8G為試用者黃先生試用配方A5後的毛髮照片及改善狀況。 Figures 8A to 8G show the hair photos and improvement of the tester Mr. Huang after trying formula A5.

圖9A至9F為試用者鄭小姐試用配方A5後的毛髮照片及改善狀況。 Figures 9A to 9F are the hair photos and improvement of the tester Ms. Zheng after trying formula A5.

本揭露依照習知科學中藥的製備方式,熟習本技術領域者,依各藥材特性,選用酒精、水、或彼之混合物萃取。將自各藥材所獲得之萃取物,依不同藥材及配比組成六種配方(詳列如表2),再給予有落髮困擾之試用者噴在髮根並稍加按摩,進行試驗。 The present disclosure is based on the preparation methods of conventional scientific Chinese medicines, and those who are familiar with the technical field, according to the characteristics of each medicinal material, select alcohol, water, or their mixture for extraction. The extracts obtained from each medicinal material were combined into six formulas according to different medicinal materials and ratios (detailed in Table 2), and then the trial persons who were troubled by hair loss were sprayed on the hair roots and massaged for a little bit for testing.

Figure 106111740-A0305-02-0008-2
Figure 106111740-A0305-02-0008-2
Figure 106111740-A0305-02-0009-3
Figure 106111740-A0305-02-0009-3

每一噴灑量為0.25ml,每日至少3ml-5ml,每日施用4次(早、午、晚、睡前),如無法定時施用,可自行刪減次數,例如早上及睡前,但每次使用量為5ml時,則每日總次數為20噴次。如每日使用兩次則總和用量需相同。試用之效果以3個月並以使用量作為評量基準,以正規用量作為效用產生快不快速為指標(用量太少將效果反應時間拉長,須視個人髮禿面積情況加減用量);依試用者的個人感覺作為療效判定基準。為求科學化數據,茲將效果以0-5分級距呈現,且觀察指標計有防脫髮、生髮(新生細毛)黑髮、精神狀況、膚質氣色等四項。 Each spraying volume is 0.25ml, at least 3ml-5ml per day, applied 4 times a day (morning, lunch, evening, and before going to bed). If you can’t apply regularly, you can reduce the number of times, such as morning and before bed, but every When the usage amount is 5ml, the total number of times per day is 20 sprays. If used twice a day, the total amount must be the same. The effect of the trial is 3 months and the use amount is used as the evaluation standard, and the regular amount is used as the indicator of whether the effect is fast or not (too little amount will lengthen the effect response time, depending on the individual's bald area); The individual’s personal feeling is used as the criterion for the efficacy. In order to obtain scientific data, the effect is presented in a scale of 0-5, and the observation indicators include four items: hair loss prevention, hair growth (new hair) black hair, mental status, and skin tone.

《評分標準》 "Grading"

0分:完全沒有改善 0 points: No improvement at all

1分:似乎有改善,不是很確定 1 point: There seems to be an improvement, not very sure

2分:有改善 2 points: improved

3分:確有改善 3 points: There is indeed improvement

4分:明顯改善 4 points: Significant improvement

5分:極顯著改善或他人以肉眼可輕易判斷出不同 5 points: Very significant improvement or others can easily judge the difference with the naked eye

實施例1:單方Example 1: Unilateral

本實施例以5位志願試用者作測試,試用者連續試用桑葚萃取液,三個月後作統計(詳見表3)。觀察指標計有防脫髮、生髮(新生細毛)、黑髮、精神狀況、以及膚質氣色等五項。其各項得分分別為0.8、1、1、0.6、0.6、0.2分,「似乎有改善,不確定」之範圍內。本實施例驗證民間傳說桑葚烏髮、長髮明目於三個月間用量約270ml-450ml(每日3ml-5ml)效果並不明顯,必須考慮配合其他藥材方能有較明確之療效。 In this example, 5 volunteer trialists were used for the test, and the trialists continuously tried the mulberry extract and made statistics after three months (see Table 3 for details). The observation indicators include five items: hair loss prevention, hair growth (new hair), black hair, mental status, and skin tone. Its scores are 0.8, 1, 1, 0.6, 0.6, and 0.2, which are within the range of "seems to be improved, not sure". This example verifies that the effect of the folklore mulberry black hair and long hair follicles in the dosage of about 270ml-450ml (3ml-5ml per day) in three months is not obvious, and other medicinal materials must be considered to have a clearer effect.

Figure 106111740-A0305-02-0009-4
Figure 106111740-A0305-02-0009-4
Figure 106111740-A0305-02-0010-5
Figure 106111740-A0305-02-0010-5

實施例2:測試配方A1之效果Example 2: Test the effect of formula A1

本實施例以5位志願試用者作測試,試用者連續試用噴灑本發明配方A1(如表2),2個月後按用量約150-300ml作統計(詳見表4)。觀察指標計有防脫髮、生髮(新生細毛)、黑髮、精神狀況、以及膚質氣色等五項。其各項得分分別為3.8、3.0、1.8、2.6、2.0、1.8分,其中防脫髮之療效極為卓著;而生髮(新生細毛)、黑髮、精神狀況、以及膚質氣色等也確有改善的程度。本實施例證實本揭露之中草藥組成物具備遠優於單味桑葚藥材的療效。 In this example, 5 volunteer trialists were used for testing. The trialists continuously tried spraying the formula A1 of the present invention (see Table 2), and counted according to the amount of about 150-300ml after 2 months (see Table 4 for details). The observation indicators include five items: hair loss prevention, hair growth (new hair), black hair, mental status, and skin tone. Its various scores are 3.8, 3.0, 1.8, 2.6, 2.0, 1.8 points, among which the effect of preventing hair loss is extremely outstanding; and the hair growth (new hair), black hair, mental condition, and skin tone and complexion have also been improved. degree. This example demonstrates that the Chinese herbal medicine composition has much better efficacy than single-flavored mulberry medicinal materials.

Figure 106111740-A0305-02-0010-6
Figure 106111740-A0305-02-0010-6

實施例3:測試配方A2之效果Example 3: Test the effect of formula A2

本實施例以6位志願試用者作測試,試用者連續試用噴灑本發明配方A2(如表2),2個月後按用量約150-300ml作統計(詳見表5)。觀察指標計有防脫髮、生髮(新生細毛)、黑髮、精神狀況、以及膚質氣色等五項。其各項得分分別為4.3、3.8、2、2.7、2.8、2.4分,其中防脫髮之療效極為卓著;而生髮(新生細毛)、黑髮、精神狀況、以及膚質氣色等也確有改善的程度。本實施例證實本揭露之中草藥組成物具備遠優於單味桑葚藥材的療效。 In this example, 6 volunteer trialists were used for testing. The trialists continuously tried spraying the formula A2 of the present invention (see Table 2), and counted according to the amount of about 150-300ml after 2 months (see Table 5 for details). The observation indicators include five items: hair loss prevention, hair growth (new hair), black hair, mental status, and skin tone. The scores are 4.3, 3.8, 2, 2.7, 2.8, and 2.4 respectively. Among them, the effect of preventing hair loss is extremely outstanding; and the hair growth (new hair), black hair, mental condition, and skin tone and complexion have also been improved. degree. This example demonstrates that the Chinese herbal medicine composition has much better efficacy than single-flavored mulberry medicinal materials.

Figure 106111740-A0305-02-0010-7
Figure 106111740-A0305-02-0010-7

本實施例之試用者池先生59歲,從10多年前開始出現頭頂部不明原因脫髮,並出現腦溢型脫髮有頂禿現象,長期使用落建並服用柔沛。試用配方A2 150ml後,雖仍有掉髮但頂禿部分長出小細髮,大約75ml後頭髮長出約3.5-4cm。用到125ml禿髮範圍已都有細毛長出,落髮狀況也有改善,用到150ml禿的面積範圍縮小,細毛有變粗,長髮至6-7.8cm。頭部發癢情況改善,頭皮屑減少。(參見圖1A與1B)。 Mr. Chi, the trial person in this example, is 59 years old. He started to suffer from unexplained alopecia on the top of his head more than 10 years ago, as well as cerebral hemorrhage alopecia and alopecia areata. He has been using Luojian for a long time and taking Propectin. After trying the formula A2 150ml, although there is still hair loss, the bald part grows small fine hair. After about 75ml, the hair grows about 3.5-4cm. After 125ml of baldness is used, fine hairs have grown, and the hair loss condition has also been improved. When 150ml is used, the area of baldness is reduced, and the fine hairs become thicker, and the hair grows to 6-7.8cm. Itchy head improved and dandruff decreased. (See Figures 1A and 1B).

本實施例之試用者黃先生65歲,從20年前開始出現頭頂及後腦不明原因脫髮,頭髮越來越稀疏,開始中央及後中央呈現禿頭,長期使用落建及柔沛產品。使用A2 35ml,第一週狀況不是很明顯,有小細毛發生(如圖2A及2B),使用70ml較有感覺毛髮長出大約2-3cm。第三週,使用了125ml,頭頂上面部分頭髮生長較快長,後腦勺的右方毛囊發生,細毛較明顯,其他長髮長度約有8-9cm,如圖2C。禿頭部分確有改善。 The tester of this example, Mr. Huang, 65 years old, began to experience unexplained hair loss on the top and back of the head 20 years ago. His hair became thinner and thinner, and he began to show baldness in the center and back. Using A2 35ml, the condition is not obvious in the first week, and there are small fine hairs (as shown in Figure 2A and 2B). When using 70ml, it feels that the hair grows about 2-3cm. In the third week, after using 125ml, the hair on the top of the head grew faster, and the hair follicle on the right side of the back of the head appeared, and the fine hair was more obvious. Other long hairs were about 8-9cm in length, as shown in Figure 2C. The baldness has indeed improved.

實施例4:測試配方A3之效果Example 4: Test the effect of formula A3

本實施例以8位志願受測者做測試,試用者連續試用噴灑本發明配方A3(如表2),2個月後按用量約150-300ml作統計(詳見表6)。觀察指標計有防脫髮、生髮(新生細毛)、黑髮、精神狀況/膚質氣色以及止癢止屑等五項。其各項得分分別為4.5、4.125、3.875、3.375、3.5、3分,其中防脫髮以及精神狀況改善之療效極為卓著;而生髮(新生細毛、以及膚質氣色等也有改善。本實施例證實本揭露之中草藥組成物具備遠優於單味桑葚藥材的療效。 In this example, 8 volunteer test subjects were used for testing, and the testers continuously tried spraying formula A3 of the present invention (see Table 2), and counted according to the dosage of about 150-300ml after 2 months (see Table 6 for details). The observation indicators included five items: anti-hair loss, hair growth (new hair), black hair, mental condition/skin complexion, and anti-itching and anti-dandruff. The scores are 4.5, 4.125, 3.875, 3.375, 3.5, and 3 points respectively. Among them, the effect of preventing hair loss and improving mental status is extremely outstanding; and hair growth (new hair, and skin tone, etc.) are also improved. This example demonstrates this. It is revealed that the Chinese herbal medicine composition has much better efficacy than single-flavored mulberry medicinal materials.

Figure 106111740-A0305-02-0011-8
Figure 106111740-A0305-02-0011-8

本實施例之試用者劉小姐,50歲女性,從6年前子宮外肌瘤開刀手術治癒後開始出現頭項部不明原因脫髮,前額髮際線後移,髮際線越來越寬,脫髮部位的頭髮越長越細,且長度大約1-2cm左右就開始脫落。試用配方A2 50ml,自覺掉髮情況明顯減少,頭皮癢頭皮屑情 況改善,明目。試用該產品100ml後,自覺頭項部細毛有變粗,也有新生細毛,頭髮有生長3-4cm,前額部頭髮亦有變粗現象。試用該產品150ml後,掉髮數持續明顯減少,前額部及項部頭髮變粗,頭髮較有豐厚感,面色較兩週前紅潤。請參見圖3A-3D,其分別為試用者劉小姐試用配方A3前、試用150ml(平均每日5ml)後之頭項及前額部毛髮照片。 The probationer of this example, Ms. Liu, a 50-year-old woman, has experienced unexplained hair loss on the head and nape after surgical treatment of extrauterine fibroids 6 years ago. The forehead hairline moved back and the hairline became wider and wider. The longer and thinner the hair in the hair loss area, and the length of about 1-2cm, it begins to fall out. Trial formula A2 50ml, consciously reduced hair loss, itchy scalp and dandruff Improved condition and improved eyesight. After trying 100ml of this product, I felt that the fine hairs on the nape of the head became thicker, there were also new fine hairs, the hair grew 3-4cm, and the hair on the forehead also became thicker. After trying 150ml of the product, the number of hair loss continued to decrease significantly, the forehead and nape hair became thicker, the hair felt more plump, and the complexion was rosier than two weeks ago. Please refer to Figures 3A-3D, which are photos of the head and forehead hair of the tester Ms. Liu before trying formula A3 and after trying 150ml (average 5ml per day).

實施例5:測試配方A4之效果Example 5: Test the effect of formula A4

本實施例以8位志願受測者做測試,試用者連續試用噴灑本發明配方A4(如表2),2個月後按用量約150-300ml作統計(詳見表7)。觀察指標計有防脫髮、生髮(新生細毛)、黑髮、精神狀況、膚質氣色以及止癢止屑等五項。其各項得分分別為3.8、4、4.28、3.2、4、3.3分,其中防脫髮以及精神狀況改善之療效極為卓著;而生髮(新生細毛)、以及膚質氣色等也有改善。本實施例證實本揭露之中草藥組成物具備遠優於單味桑葚藥材的療效。 In this example, 8 volunteer subjects were used for testing, and the trialists continuously tried spraying formula A4 of the present invention (see Table 2), and counted according to the dosage of about 150-300ml after 2 months (see Table 7 for details). Observation indicators include five items: hair loss prevention, hair growth (new hair growth), black hair, mental condition, skin complexion, antipruritic and anti-dandruff. The scores are 3.8, 4, 4.28, 3.2, 4, and 3.3 respectively. Among them, the effects of preventing hair loss and improving mental status are extremely outstanding; and hair growth (new hair), and skin tone and complexion are also improved. This example demonstrates that the Chinese herbal medicine composition has much better efficacy than single-flavored mulberry medicinal materials.

Figure 106111740-A0305-02-0012-9
Figure 106111740-A0305-02-0012-9

本實施例之試用者林小姐26歲女性,4年前曾因卵巢問題停經並開始落髮,並在有停經問題由醫生醫治後其失去毛髮並未長回,髮際線縫開始越來越粗,中央有開始禿髮現象。近期至健髮中心檢測為毛囊萎縮以致頭髮不生。自願開始試用配方A4,使用約100ml(按正常用量約為20天)。圖片4A-4F及4G-4H可顯示其改善情況。 The 26-year-old female of the tester of this example, Miss Lin, had menopause due to ovarian problems 4 years ago and started to lose hair. After the menopause problem was treated by a doctor, her hair did not grow back and her hairline seams began to become thicker and thicker. , There is a baldness in the center. Recently, the hair follicles were atrophied and the hair did not grow. Voluntarily start to try formula A4, use about 100ml (about 20 days according to the normal dosage). Pictures 4A-4F and 4G-4H can show its improvement.

本實施例之試用者廖小姐58歲因老化原因,髮際線縫開始越來越粗,開始試用配方A4使用約50ml(按正常用量約為10天)圖5A及5B可看出使用後毛髮生長約5-6cm,濃密度仍須加強。圖5C-5D可顯示其改善情況;其髮際線較縮小,廖小姐表示,發現落髮減少,雖然每日用量很少,但覺得有效果。 The trial person of this example, Miss Liao, was 58 years old. Due to aging, her hairline seams began to become thicker and thicker. She started to try formula A4 and used about 50ml (about 10 days according to the normal dosage). Figures 5A and 5B show the hair after use. It grows about 5-6cm, and the density still needs to be strengthened. Figures 5C-5D can show the improvement; the hairline is narrower. Ms. Liao said that she found that the hair loss has been reduced. Although the daily dosage is very small, she thinks it is effective.

實施例6:測試配方A5之效果Example 6: Test the effect of formula A5

本實施例以8位志願受測者做測試,試用者連續試用噴灑本發明配方A5(表2),2個月後按用量約150-300ml作統計(詳見表8)。觀察指標計有防脫髮、生髮(新生細毛)、黑髮、精神狀況、膚質氣色以及止癢止屑等五項。其各項得分分別為4.375、4.375、4.625、3.875、3.5、3.75分,其中防脫髮以及精神狀況改善之療效極為卓著;而生髮(新生細毛)、以及膚質氣色等也有改善。本實施例證實本揭露之中草藥組成物具備遠優於單味桑葚藥材的療效。 In this example, 8 volunteer subjects were used for testing, and the trialists continued to spray the formula A5 of the present invention (Table 2). After 2 months, the amount was about 150-300ml for statistics (see Table 8 for details). Observation indicators include five items: hair loss prevention, hair growth (new hair growth), black hair, mental condition, skin complexion, antipruritic and anti-dandruff. The scores are 4.375, 4.375, 4.625, 3.875, 3.5, and 3.75 points. Among them, the effects of preventing hair loss and improving mental status are extremely outstanding; hair growth (new hair), and skin tone and complexion are also improved. This example demonstrates that the Chinese herbal medicine composition has much better efficacy than single-flavored mulberry medicinal materials.

Figure 106111740-A0305-02-0013-10
Figure 106111740-A0305-02-0013-10

本實施例之受試者王先生,54歲男性,從10多年前開始頭髮就漸漸稀疏,因為細毛無髮增長及脫落,頭頂毛髮稀少,並頭髮至一長度後,無法再長,後腦杓頂漸禿,健髮中心醫師診治認定為雄性禿。試用配方A5後100ml,覺得睡得很好,整個人覺得較有活力,掉髮數大為減少,頭皮癢、頭皮屑也減輕,照片放大可見毛囊有發生,頭髪確有增長。原本頭皮無法均勻長出細毛的部位已漸增長7-8cm。圖6A、6B及6C係王先生試用配方A5前及試用100ml後、及試用250ml(按正常用量約50天)的頭頂毛髮照片。他的後腦勺部位另參見圖6D、6E、6F、6G,其中,圖6D使用前,6E為試用量75ml(按正常用量約15天)的結果,圖6F為試用量100ml(按正常用量約20天)的結果,圖6G為試用量200ml(按正常用量約40天)的結果。圖6H-6M係毛髮生長情形。 The subject of this example, Mr. Wang, a 54-year-old male, has gradually thinning hair since more than 10 years ago. Because the fine hair did not grow and fall off, the hair on the top of the head was sparse, and when the hair reached one length, it could not grow any longer. Gradually bald, the doctor at the Health Hair Center diagnosed and treated it as male baldness. After trying 100ml of formula A5, I feel that I slept well, the whole person feels more energetic, the number of hair loss is greatly reduced, the scalp itching and dandruff are also alleviated, the magnification of the photo shows that the hair follicles are occurring, and the hair growth is indeed growing. The area where the scalp cannot grow fine hair has gradually grown 7-8cm. Figures 6A, 6B and 6C are photos of the hair on the top of the head of Mr. Wang before trial formulation A5, after trial 100ml, and trial 250ml (about 50 days according to normal dosage). See Figures 6D, 6E, 6F, and 6G for the back of his head. Figure 6D is the result of the trial volume of 75ml (about 15 days according to the normal dosage), and Figure 6F is the trial volume of 100ml (the normal dosage is about 20 Figure 6G shows the result of the trial amount of 200ml (about 40 days according to the normal amount). Figure 6H-6M hair growth situation.

本實施例之受試者蔡先生,65歲男性,從20多年前頭髮漸稀,已經落髮多年,整個頭項看起來已經沒有頭髮,但以頭皮毛檢測儀檢視仍可看到許多細毛,只是因為細毛無法增長即脫落,故導致禿髮,此為雄性禿及斑禿的典型症狀。請比較圖7A及7B之頭項部毛髮照片。圖7A與7B對照可看出頭部後方下頭髮長出較快,試用到75ml(約15天),蔡先生表示其白 髮減少,也有黑髮長出,請參見圖7C-7E。頭頂上方試用配方A5後50ml,精神變好,氣色紅潤變佳,拍照追蹤時發現頭項原光亮處有肉眼可見之細毛長出(比較使用前的圖7F,自圖7G、圖7H中可見生髮長度增長未脫落,自圖7K中可見黑髪生出)。使用至75ml後,發現頭項的細毛明顯變粗,這表示毛髮生長期已經延長,不會提早脫落。禿髮部分圖片放大參圖7L、圖7M已有黑細髮生出活化毛囊後,毛囊發出黑細毛。顯示本揭露之中草藥組成物對於頭髮毛髮有明顯修護的效果。 The subject of this example, Mr. Cai, a 65-year-old male, has had hair thinning more than 20 years ago and has been losing hair for many years. The entire head looks no longer hair, but a scalp hair detector can still see many fine hairs. Because the fine hair cannot grow and fall off, it leads to baldness, which is a typical symptom of male baldness and alopecia areata. Please compare the head hair photos in Figures 7A and 7B. Figure 7A and 7B compare, it can be seen that the hair grows faster under the back of the head, try to 75ml (about 15 days), Mr. Cai said its white Hair is reduced and black hair grows, please refer to Figure 7C-7E. After trying 50ml of formula A5 on the top of the head, the spirits improved, and the complexion became more ruddy. When taking pictures and tracking, it was found that there were fine hairs that were visible to the naked eye in the original bright part of the head (compare the picture 7F before use, and the hair growth can be seen in Fig. 7G and Fig. 7H. The length growth did not fall off, from Figure 7K, it can be seen that black hair grows). After using it to 75ml, it is found that the fine hair of the head item is obviously thicker, which means that the hair has been prolonged for a long time and will not fall off early. See Figure 7L and Figure 7M for enlarged pictures of baldness. After the hair follicles have been activated, the hair follicles have produced black hairs. It shows that the herbal composition disclosed in the present disclosure has an obvious repairing effect on the hair.

本實施例之試用者黃先生65歲於先前試用配方A3生出毛髮後(未圖示),但後腦勺部位毛囊萎縮較嚴重致使濃密度略顯不足,改適用配方A5 50ml(按正常用量約10天)後如圖8A-8E,圖8C顯示毛囊萎縮嚴重處開始生出細毛,頭髮可以繼續增長不再脫落,禿髮的面積縮小約1/2。如圖8F及8G,以側面部位來看,頭頂項生出的細毛變粗變黑見濃密。如圖8E,可看出側髮長度已超過15cm以上,往後梳至後方。 The tester of this example, Mr. Huang, was 65 years old after he had previously tried formula A3 to give birth to hair (not shown), but the hair follicles at the back of his head were atrophied and the density was slightly insufficient, so he changed to formula A5 50ml (normal dosage for about 10 days) ) Then, as shown in Figures 8A-8E, Figure 8C shows that fine hairs begin to grow in the severely atrophy of the hair follicle, the hair can continue to grow and no longer fall off, and the area of baldness is reduced by about 1/2. As shown in Figures 8F and 8G, when viewed from the side, the fine hairs born on the top of the head become thicker and darker and thicker. As shown in Figure 8E, it can be seen that the length of the side hair has exceeded 15cm, comb back to the back.

本實施例之試用者鄭小姐53歲也是頭頂白髮髮際線越來越粗,毛囊萎縮,工作壓力大(參見圖9A及9B)。落髮嚴重試用配方A5後約75ml(大約15天)可看到其黑髮生出並頭髮減少脫落增加了豐厚感(參見圖9C-9F)。 The 53-year-old probationer of this example, Ms. Zheng, also has white hair on the top of her head. The hairline is getting thicker, her hair follicles are shrinking, and her work pressure is high (see Figures 9A and 9B). For severe hair loss, about 75ml (about 15 days) after trying formula A5, it can be seen that the darkening occurs and the hair loss is reduced and the feeling of volume is increased (see Figure 9C-9F).

藉上述試驗結果可推知,本揭露中草藥組成物不僅可減少落髮,促使毛髮生長、黑髮,更可有效改善精神狀況以及膚質氣色,且超越一般認知用以烏髮生髮的桑葚、黑芝麻、紫葡萄單味補養藥甚多。 Based on the above test results, it can be inferred that the Chinese herbal composition disclosed in the present disclosure can not only reduce hair loss, promote hair growth and black hair, but also effectively improve the mental condition and skin tone and complexion, and it surpasses the general knowledge of mulberry, black sesame, and black sesame seeds used for black hair. There are many single nourishing medicines for purple grapes.

上述實施例僅係為了方便說明而舉例而已,本揭露所主張之權利範圍自應以申請專利範圍所述為準,而非僅限於上述實施例。 The above-mentioned embodiments are merely examples for the convenience of description, and the scope of rights claimed in this disclosure should be subject to the scope of the patent application, not limited to the above-mentioned embodiments.

Claims (11)

一種用於促進髮量增加之中草藥組成物,其包含:第一類藥材,其係百合(學名:Lilium)、天麻(學名:Gastrodia elata)、半枝蓮(學名:Scutellaria barbata D.Don)、宣木瓜(學名:Carica papaya Linn)及金銀花(學名:Lonicera japonica Thunb.);第二類藥材,其係番紅花(學名:Crocus sativus)、熟地(學名:Rehmannia glutinosa)及菟絲子(學名:Cuscuta chinensis);第三類藥材,其係桑樹(學名:Morus)(包括桑葚(學名:Fructus Mori)及桑白皮、桑葉及桑枝之混合);側柏(學名:Platycladus orientalis)(包括柏根皮及嫩枝葉(學名:Cacumen Platycladi))、黑芝麻(學名:Semen Sesami Nigrum)及桑樹(學名:Morus)(包括桑葚(學名:Fructus Mori)及桑白皮、桑葉及桑枝之混合);側柏(學名:Platycladus orientalis)(包括柏根皮及嫩枝葉(學名:Cacumen Platycladi))與桑樹(學名:Morus)(包括其果實桑葚(學名:Fructus Mori)及其根白皮、葉及幹枝之混合);紫葡萄(學名:Vitis romanetii Roman.du Caill.ex Planch.)及桑樹(學名:Morus)(包括桑葚(學名:Fructus Mori)及桑白皮、桑葉及桑枝之混合);或其任何組合,其中,以中草藥組成物總重量計,該第一類藥材占2~40%,該第二類藥材占2~40%,且該第三類藥材占20~96%。 A Chinese herbal medicine composition used to increase hair volume, which contains: the first type of medicinal materials, which are lily (scientific name: Lilium), gastrodia elata (scientific name: Gastrodia elata), Scutellaria barbata D.Don (scientific name: Scutellaria barbata D. Don), Xuan Papaya (scientific name: Carica papaya Linn) and honeysuckle (scientific name: Lonicera japonica Thunb.); the second type of medicinal materials, which are saffron (scientific name: Crocus sativus), rehmannia (Rehmannia glutinosa) and dodder (scientific name: Cuscuta) chinensis); the third type of medicinal material, which is mulberry (scientific name: Morus) (including mulberry (scientific name: Fructus Mori) and a mixture of mulberry bark, mulberry leaves and mulberry branches); Platycladus orientalis (scientific name: Platycladus orientalis) (including cypress Root bark and young branches (scientific name: Cacumen Platycladi), black sesame (scientific name: Semen Sesami Nigrum) and mulberry (scientific name: Morus) (including mulberry (scientific name: Fructus Mori) and a mixture of mulberry white bark, mulberry leaves and mulberry branches ); Platycladus orientalis (scientific name: Platycladus orientalis) (including cypress root bark and twigs and leaves (scientific name: Cacumen Platycladi)) and mulberry tree (scientific name: Morus) (including its fruit mulberry (scientific name: Fruitus Mori) and its root white bark and leaves And dry branches); purple grape (scientific name: Vitis romanetii Roman.du Caill.ex Planch.) and mulberry (scientific name: Morus) (including mulberry (scientific name: Fruitus Mori) and a mixture of mulberry white bark, mulberry leaves and mulberry branches ); or any combination thereof, wherein, based on the total weight of the Chinese herbal medicine composition, the first type of medicinal materials accounted for 2-40%, the second type of medicinal materials accounted for 2-40%, and the third type of medicinal materials accounted for 20-96% . 如請求項1之中草藥組成物,其中該第三類藥材係由側柏之柏根皮及嫩枝葉;及桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合)組成,且彼等重量比係0.8~1.2:1。 Such as claim 1 Chinese herbal medicine composition, wherein the third type of medicinal material is composed of cypress root bark and tender leaves of Platycladus orientalis; and mulberry tree (including a mixture of mulberry and mulberry white bark, mulberry leaf, and mulberry branch), and The equal weight ratio is 0.8~1.2:1. 如請求項1之中草藥組成物,其中該第三類藥材係由側柏之柏根皮、嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);及黑芝麻組成,且彼等重量比係1~4:1~4:1。 Such as claim 1 Chinese herbal medicine composition, wherein the third type of medicinal material is composed of cypress root bark, tender branches and leaves of Platycladus orientalis; mulberry (including a mixture of mulberry and mulberry white bark, mulberry leaves, and mulberry branches); and black sesame , And their weight ratio is 1~4:1~4:1. 如請求項1之中草藥組成物,其中該第三類藥材由桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);及紫葡萄組成,且彼等重量比係0.8~1.2:1。 Such as claim 1 Chinese herbal medicine composition, where the third type of medicinal material is composed of mulberry (including a mixture of mulberry and mulberry bark, mulberry leaf, and mulberry branch); and purple grape, and their weight ratio is 0.8~1.2: 1. 如請求項1之中草藥組成物,其中該第三類藥材係側柏之柏根皮及嫩枝葉;桑樹(包括桑葚及桑白皮、桑葉、及桑枝之混合);紫葡萄;及黑芝麻,且彼等之重量比係1~5:1~5:1~5:1。 Such as claim 1 Chinese herbal medicine composition, wherein the third type of medicinal material is the root bark and tender leaves of Platycladus orientalis; mulberry tree (including a mixture of mulberry and mulberry white bark, mulberry leaf, and mulberry branch); purple grape; and black Sesame, and their weight ratio is 1~5:1~5:1~5:1. 如請求項1之中草藥組成物,其中該藥材係中藥材、中藥材萃取物、或其混合物。 Such as claim 1, a Chinese herbal medicine composition, wherein the herbal medicine is a Chinese herbal medicine, a Chinese herbal medicine extract, or a mixture thereof. 如請求項6之中草藥組成物,其中該中藥材萃取物係水萃取物、酒精萃取物、或水萃取物及酒精萃取物。 Such as claim 6 Chinese herbal medicine composition, wherein the Chinese medicinal material extract is a water extract, an alcohol extract, or a water extract and an alcohol extract. 如請求項1之中草藥組成物,其中該中草藥組成物同時具有促進毛髮整體的原來髮色比例增加、減少頭皮發癢、及/或減少頭皮屑之功效。 For example, the Chinese herbal medicine composition of claim 1, wherein the Chinese herbal medicine composition also has the effects of promoting the increase of the original hair color ratio of the whole hair, reducing itching of the scalp, and/or reducing dandruff. 如請求項1之中草藥組成物,其中該中草藥組成物同時具有改善精神狀況、明目及/或改善膚質之功效。 For example, the Chinese herbal medicine composition of claim 1, wherein the Chinese herbal medicine composition has the effects of improving mental condition, improving eyesight and/or improving skin quality. 如請求項1之中草藥組成物,其中該中草藥組成物係以外用劑型投予。 Such as claim 1 Chinese herbal medicine composition, wherein the Chinese herbal medicine composition is administered in an external dosage form. 一種製備如請求項1所述之中草藥組成物之方法,其包含下列之步驟:(a)分別提供如請求項1所述之第一類藥材、第二類藥材、及第三類藥材, (b)將第一類藥材、第二類藥材、及第三類藥材混合以形成混合物,其中,以中草藥組成物總重量計,該第一類藥材占2~40%,該第二類藥材占2~40%,且該第三類藥材占20~96%,(c)萃取該混合物。 A method for preparing the Chinese herbal medicine composition according to claim 1, which comprises the following steps: (a) providing the first type of medicinal materials, the second type of medicinal materials, and the third type of medicinal materials as described in claim 1, respectively, (b) Mixing the first type of medicinal materials, the second type of medicinal materials, and the third type of medicinal materials to form a mixture, wherein, based on the total weight of the Chinese herbal medicine composition, the first type of medicinal materials account for 2-40%, and the second type of medicinal materials It accounts for 2-40%, and the third type of medicinal materials accounts for 20-96%. (c) Extract the mixture.
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