TWI707852B - Tyk2 抑制劑及其用途 - Google Patents

Tyk2 抑制劑及其用途 Download PDF

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Publication number
TWI707852B
TWI707852B TW105128290A TW105128290A TWI707852B TW I707852 B TWI707852 B TW I707852B TW 105128290 A TW105128290 A TW 105128290A TW 105128290 A TW105128290 A TW 105128290A TW I707852 B TWI707852 B TW I707852B
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Taiwan
Prior art keywords
compound
disease
vii
pharmaceutically acceptable
nitrogen
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TW105128290A
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English (en)
Chinese (zh)
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TW201718576A (zh
Inventor
卡格 E 瑪斯
傑諾米 羅伯特 葛林伍德
多娜 L 羅曼羅
吉瑞狄恩 C 哈瑞瑪
羅納德 T 威斯特
蜜 莎麗
約書亞 傑米爾 甘迺迪-史密斯
馬庫斯 道葛林
薩揚 莫代爾
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美商林伯士拉克許米公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW105128290A 2015-09-02 2016-09-01 Tyk2 抑制劑及其用途 TWI707852B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562213475P 2015-09-02 2015-09-02
US62/213,475 2015-09-02
US201562214018P 2015-09-03 2015-09-03
US62/214,018 2015-09-03

Publications (2)

Publication Number Publication Date
TW201718576A TW201718576A (zh) 2017-06-01
TWI707852B true TWI707852B (zh) 2020-10-21

Family

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Family Applications (1)

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TW105128290A TWI707852B (zh) 2015-09-02 2016-09-01 Tyk2 抑制劑及其用途

Country Status (5)

Country Link
US (4) US10023571B2 (enExample)
EP (2) EP4327809A3 (enExample)
JP (3) JP6802263B2 (enExample)
TW (1) TWI707852B (enExample)
WO (1) WO2017040757A1 (enExample)

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US12479816B2 (en) * 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
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WO2022033544A1 (zh) * 2020-08-13 2022-02-17 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
KR20240070634A (ko) 2021-09-30 2024-05-21 브리스톨-마이어스 스큅 컴퍼니 Tyk2 억제제에 대한 반응성을 결정하는 방법
US20250051338A1 (en) 2021-10-25 2025-02-13 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
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CN114674813B (zh) * 2022-03-21 2025-02-07 同济大学 一种利用芳基丙酸类药物半定量检测硫酸根自由基的方法
CN117886669A (zh) * 2024-01-10 2024-04-16 中国农业大学 一种将酰氯还原氘化为氘代醇的方法
CN118955546A (zh) * 2024-07-31 2024-11-15 上海毕得医药科技股份有限公司 一种化合物1-异丙基吡唑-3-硼酸频哪醇酯的合成方法

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Publication number Priority date Publication date Assignee Title
US20070088163A1 (en) * 2003-09-12 2007-04-19 Kemia, Inc. Modulators of calcitonin and amylin activity
EP2108642A1 (en) * 2006-10-17 2009-10-14 Kyowa Hakko Kirin Co., Ltd. Jak inhibitor
WO2011079051A1 (en) * 2009-12-23 2011-06-30 Takeda Pharmaceutical Company Limited Fused heteroaromatic pyrrolidinones as syk inhibitors

Also Published As

Publication number Publication date
US20210047319A1 (en) 2021-02-18
EP3344624A1 (en) 2018-07-11
US10781204B2 (en) 2020-09-22
EP3344624A4 (en) 2019-01-16
TW201718576A (zh) 2017-06-01
US20180354949A1 (en) 2018-12-13
JP2019172690A (ja) 2019-10-10
HK1256997A1 (en) 2019-10-11
JP2018532706A (ja) 2018-11-08
EP3344624B1 (en) 2023-10-25
JP2021130712A (ja) 2021-09-09
EP3344624B8 (en) 2023-11-29
US10023571B2 (en) 2018-07-17
EP4327809A3 (en) 2024-04-17
EP4327809A2 (en) 2024-02-28
JP6802263B2 (ja) 2020-12-16
US20170066763A1 (en) 2017-03-09
US11434240B2 (en) 2022-09-06
WO2017040757A1 (en) 2017-03-09
US20230074228A1 (en) 2023-03-09

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