TWI680761B - 尿酸性或痛風性疾病的預防或治療 - Google Patents

尿酸性或痛風性疾病的預防或治療 Download PDF

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Publication number
TWI680761B
TWI680761B TW105102935A TW105102935A TWI680761B TW I680761 B TWI680761 B TW I680761B TW 105102935 A TW105102935 A TW 105102935A TW 105102935 A TW105102935 A TW 105102935A TW I680761 B TWI680761 B TW I680761B
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TW
Taiwan
Prior art keywords
purine
dione
chloro
dihydro
uric acid
Prior art date
Application number
TW105102935A
Other languages
English (en)
Chinese (zh)
Other versions
TW201628623A (zh
Inventor
張倩
振華 黃
劉金榮
遲雙雙
Original Assignee
大陸商上海珊頓醫藥科技有限公司
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Publication of TW201628623A publication Critical patent/TW201628623A/zh
Application granted granted Critical
Publication of TWI680761B publication Critical patent/TWI680761B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW105102935A 2015-01-30 2016-01-29 尿酸性或痛風性疾病的預防或治療 TWI680761B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
CN201510048096 2015-01-30
CN201510048096.3 2015-01-30
CN201510080714 2015-02-13
CN201510079809.2 2015-02-13
CN201510080714.2 2015-02-13
CN201510079809 2015-02-13
CN201510216089 2015-04-30
CN201510216089.X 2015-04-30

Publications (2)

Publication Number Publication Date
TW201628623A TW201628623A (zh) 2016-08-16
TWI680761B true TWI680761B (zh) 2020-01-01

Family

ID=56542370

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105102935A TWI680761B (zh) 2015-01-30 2016-01-29 尿酸性或痛風性疾病的預防或治療

Country Status (26)

Country Link
US (1) US10322132B2 (cg-RX-API-DMAC10.html)
EP (1) EP3251675B1 (cg-RX-API-DMAC10.html)
JP (1) JP6678685B2 (cg-RX-API-DMAC10.html)
KR (1) KR102128810B1 (cg-RX-API-DMAC10.html)
CN (1) CN107206002B (cg-RX-API-DMAC10.html)
AU (1) AU2016212625B2 (cg-RX-API-DMAC10.html)
BR (1) BR112017016065A2 (cg-RX-API-DMAC10.html)
CA (1) CA2973746C (cg-RX-API-DMAC10.html)
CY (1) CY1124383T1 (cg-RX-API-DMAC10.html)
DK (1) DK3251675T3 (cg-RX-API-DMAC10.html)
EA (1) EA034139B1 (cg-RX-API-DMAC10.html)
ES (1) ES2881872T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20211007T1 (cg-RX-API-DMAC10.html)
HU (1) HUE054741T2 (cg-RX-API-DMAC10.html)
IL (1) IL253726B2 (cg-RX-API-DMAC10.html)
LT (1) LT3251675T (cg-RX-API-DMAC10.html)
MA (1) MA41431B1 (cg-RX-API-DMAC10.html)
MX (1) MX380301B (cg-RX-API-DMAC10.html)
PL (1) PL3251675T3 (cg-RX-API-DMAC10.html)
PT (1) PT3251675T (cg-RX-API-DMAC10.html)
SG (2) SG11201705889VA (cg-RX-API-DMAC10.html)
SI (1) SI3251675T1 (cg-RX-API-DMAC10.html)
SM (1) SMT202100359T1 (cg-RX-API-DMAC10.html)
TW (1) TWI680761B (cg-RX-API-DMAC10.html)
WO (1) WO2016119570A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201704600B (cg-RX-API-DMAC10.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12566174B2 (en) 2017-05-11 2026-03-03 The Research Foundation For The State University Of New York Method and kit for determining the presence of monosodium urate crystals in joint synovial fluid
AU2024229006A1 (en) 2023-02-27 2025-09-18 Shanton Pharma Pte. Ltd. Crystal form of 8-chloro-3-pentyl-3,7-dihydro-1h-purin-2,6-dione compound and preparation method therefor
CN116650490B (zh) * 2023-06-07 2025-05-20 中国人民解放军海军军医大学 化合物mt-1207在降低尿酸方面的应用
EP4497439A1 (en) * 2023-07-28 2025-01-29 Universitat de les Illes Balears Compounds for the treatment or prevention of gout
TWI902254B (zh) * 2024-05-16 2025-10-21 新加坡商珊頓醫藥科技新加坡公司 化合物8-氯-3-戊基-3,7-二氫-1h-嘌呤-2,6-二酮的晶型及其製備方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016699A1 (en) * 1992-02-21 1993-09-02 Smithkline Beecham Corporation Tnf inhibitors
CN101103030A (zh) * 2004-02-14 2008-01-09 史密丝克莱恩比彻姆公司 具有hm74a受体活性的药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906792D0 (en) 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
AR015966A1 (es) 1997-10-17 2001-05-30 Smithkline Beecham Corp Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito
AR061626A1 (es) * 2006-06-23 2008-09-10 Incyte Corp Derivados de purinona como agonistas de hm74a
CN101479273B (zh) 2006-06-23 2011-11-30 英赛特股份有限公司 作为hm74a激动剂的嘌呤酮衍生物
WO2010071865A1 (en) * 2008-12-19 2010-06-24 Nuon Therapeutics, Inc. Pharmaceutical compositions and methods for treating hyperuricemia and related disorders
US20110136835A1 (en) * 2009-09-14 2011-06-09 Nuon Therapeutics, Inc. Combination formulations of tranilast and allopurinol and methods related thereto
WO2011057110A1 (en) 2009-11-06 2011-05-12 Ruprecht-Karls-Universitat-Heidelberg Gpr109a agonists for the treatment of cerebral ischemia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016699A1 (en) * 1992-02-21 1993-09-02 Smithkline Beecham Corporation Tnf inhibitors
CN101103030A (zh) * 2004-02-14 2008-01-09 史密丝克莱恩比彻姆公司 具有hm74a受体活性的药物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
辛雅雯等,痛風治療藥物及其研究進展,中國藥物化學雜誌,第22卷,2012年,第416-423頁 *

Also Published As

Publication number Publication date
US10322132B2 (en) 2019-06-18
KR102128810B1 (ko) 2020-07-02
PT3251675T (pt) 2021-05-25
EP3251675B1 (en) 2021-04-21
WO2016119570A1 (zh) 2016-08-04
HK1244434A1 (zh) 2018-08-10
EA034139B1 (ru) 2020-01-09
CA2973746A1 (en) 2016-08-04
SMT202100359T1 (it) 2021-07-12
AU2016212625B2 (en) 2020-03-26
EP3251675A4 (en) 2018-06-20
HRP20211007T1 (hr) 2021-09-17
IL253726B2 (en) 2023-07-01
CN107206002A (zh) 2017-09-26
JP6678685B2 (ja) 2020-04-08
MA41431B1 (fr) 2021-05-31
IL253726A0 (en) 2017-09-28
MX2017009853A (es) 2017-11-01
KR20170106485A (ko) 2017-09-20
TW201628623A (zh) 2016-08-16
SI3251675T1 (sl) 2021-08-31
JP2018503691A (ja) 2018-02-08
EA201791714A1 (ru) 2017-11-30
DK3251675T3 (da) 2021-06-28
MA41431A (fr) 2017-12-06
SG10201907026RA (en) 2019-09-27
ES2881872T3 (es) 2021-11-30
BR112017016065A2 (pt) 2018-04-03
US20170326148A1 (en) 2017-11-16
MX380301B (es) 2025-03-12
ZA201704600B (en) 2020-07-29
HUE054741T2 (hu) 2021-09-28
CA2973746C (en) 2020-03-24
SG11201705889VA (en) 2017-08-30
IL253726B1 (en) 2023-03-01
AU2016212625A1 (en) 2017-07-27
EP3251675A1 (en) 2017-12-06
CY1124383T1 (el) 2022-07-22
CN107206002B (zh) 2019-07-16
LT3251675T (lt) 2021-07-12
PL3251675T3 (pl) 2021-11-02
HK1245146A1 (en) 2018-08-24

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