TWI671361B - Hydrogel composition and hydrogel contact lenses made of the composition - Google Patents

Abstract

The invention provides a hydrogel composition for preparing hydrogel lenses. The hydrogel composition includes a hydrophilic monomer, a blue light blocking monomer, a crosslinking agent, and an initiator. Wherein, the hydrophilic monomer is 30 to 99.68 parts by weight; the blue light blocking monomer is 0.02 to 0.5 part by weight, and it contains a yellow dye; the crosslinking agent is 0.1 to 1 part by weight; and the initiator is 0.2 to 2 parts by weight.

Description

Hydrogel composition and hydrogel lens prepared therefrom

The invention relates to a hydrocolloid composition, in particular to a hydrocolloid composition that blocks blue light.

Because contact lenses made of hydrogel have good moisturizing function, even if worn for a long time, the cornea can have sufficient water content, and it is not easy to cause eye discomfort due to dry cornea. Therefore, hydrogel has become one of the better components of contact lens.

In the past two decades, many electronic display devices, such as TV screens, computer screens, tablets, and mobile phones, have used light emitting diodes (LEDs) as light sources, and the blue light emitted by LEDs (wavelengths from 380nm to 500nm) ) Easy to cause eye diseases. In the case of using a tablet or a mobile phone for a long time, the eyes may be damaged by the long-term exposure to blue light, which may even cause early detection of cataracts and macular lesions.

However, high-water contact lenses that block blue light to protect the eyes are still lacking on the market. Therefore, there is a great need for a hydrogel lens that can simultaneously provide good blue light blocking and high water content.

In view of the problems faced by the prior art, the present invention discloses a hydrogel composition capable of isolating blue light. The hydrogel lens made by the hydrogel composition has high water content and isolates blue light.

The invention provides a hydrogel composition for preparing hydrogel lenses. The hydrogel composition includes a hydrophilic monomer, a blue light blocking monomer, a crosslinking agent, and an initiator. Wherein, the hydrophilic monomer is 30 to 99.68 parts by weight; the blue light blocking monomer is 0.02 to 0.5 part by weight, and it contains a yellow dye; the crosslinking agent is 0.1 to 1 part by weight; and the initiator is 0.2 to 2 parts by weight.

In various embodiments of the present invention, the hydrophilic monomer is 96.5 to 99.68 parts by weight.

In various embodiments of the present invention, the hydrocolloid composition further includes a silicone compound, selected from the group consisting of a silicon monomer, a silicon polymer, and a silicon prepolymer, and the silicone compound is 5 to 59 parts by weight, and 30 to 60 parts by weight of the hydrophilic monomer.

In various embodiments of the present invention, the silicon monomer has a structure of formula (1): Where V ₁ is , or , L ₁ is an alkylene group of C3 ~ C7 or , R ₁ is methyl or , Where * is the bonding position in formula (1).

In various embodiments of the present invention, the silicon polymer has a structure of formula (2): Where L ₂ is an alkylene group of C3 ~ C10, , S ₂ is or , Where R ₂ is an alkyl group of C3 to C5, n is an integer of 3 to 20, and * is a bonding position in formula (2).

In various embodiments of the present invention, the silicon prepolymer has a structure of formula (3): Where V ₃ is , or , L ₃ is an alkylene group of C2 to C5, and m is an integer of 10 to 50, where * is a bonding position in formula (3).

In various embodiments of the present invention, the yellow dye has a structure of formula (4): Wherein R ₃ is -OH or -CH ₃ and R ₄ is -O- or -CH ₂ CH ₂ NH-.

In various embodiments of the present invention, when R ₃ of formula (4) is -OH and R ₄ is -CH ₂ CH ₂ NH-, the yellow dye has a structure of formula (5):

In various embodiments of the present invention, when R ₃ of formula (4) is -CH ₃ and R ₄ is -O-, the yellow dye has the structure of formula (6):

In various embodiments of the present invention, the yellow dye has a sulfonyl group or a sulfonate group.

In various embodiments of the present invention, when the yellow dye has a sulfonic acid group, the yellow dye has a structure of formula (7):

In various embodiments of the present invention, when the yellow dye has a sulfonate group and the sulfonate group is -SO ₃ Na, the yellow dye has a chemical structure of formula (8):

In various embodiments of the present invention, the yellow dye has an amide group.

In various embodiments of the present invention, when the yellow dye has an amidino group, the yellow dye has a structure of formula (9):

In various embodiments of the present invention, the hydrophilic single system is selected from the group consisting of N-vinyl pyrrolidone (NVP), 2-hydroxyethyl methacrylate (HEMA), Glyceryl methacrylate (GM), methacrylic acid, acrylic acid, N, N-dimethyl acrylamide (DMA), N, N -A group consisting of N, N-dimethyl methacrylamide and N-vinyl-N-methyl acetamide.

In various embodiments of the present invention, the cross-linking agent is selected from the group consisting of ethylene glycol dimethacrylate, diethylene glycol dimethacrylate ), Triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, allyl methacrylate, Vinyl glycol dially ether, triethylene glycol dially ether, triethylene glycol dially ether tetraethylene glycol dially ether), triallyl-s-triazine-2,4,6 (1H, 3H, 5H) -trione (triallyl-s-triazine-2,4,6 (1H, 3H, 5H) -trione) and trimethylolpropane trimethacrylate (1,1,1-trimethylolpropane trimethacrylate).

In various embodiments of the invention, the initiator is a photo-initiator.

In various embodiments of the present invention, the photoinitiator is a phosphine-oxide-based initiator, a metallocene titanium compound initiator (titanium metallocene-based initiator) or a combination thereof.

In various embodiments of the present invention, the phosphine oxide initiator is selected from the group consisting of diphenyl (2,4,6-triphenyl) phosphine oxide, Bis (2,4,6-trimethylbenzoyl) -phenylphosphine oxide (bis (2,4,6-trimethylbenzoyl) phenyl phosphine oxide) and bis (2,6-dimethoxybenzoyl) A group consisting of fluorenyl) (2,4,4-trimethylpentyl) phosphine oxide (bis (2,6-dimethoxylbenzoyl) (2,4,4-trimethylpentyl) phosphine oxide).

In various embodiments of the invention, the metallocene titanium compound initiator comprises dicyclopentadienyl bis [2,4-difluoro-3 -(1-pyrrolyl) phenyl] titanium).

In various embodiments of the present invention, the hydrocolloid composition further comprises a UV blocking monomer, and is 0.5 to 2 parts by weight.

In various embodiments of the present invention, the UV-blocking monomer is a monomer having a benzophenone, a monomer having a benzotriazole, or a combination thereof.

In various embodiments of the present invention, a single system having benzophenone is selected from the group consisting of 4-methacryloxy-2-hydroxydiphenyl ketone (4-methacryloxy-2- hydroxy benzophenone) and 4- (2-acryloxyethoxy) -2-hydroxydiphenyl ketone (4- (2-acryloxyethoxy-2-hydroxy benzophenone).

In various embodiments of the present invention, the single system having benzotriazole is selected from the group consisting of 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-benzo Triazole (2- (2-hydroxy- 5-methacryloxyethylphenyl) -2H-benzotriazole), 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-chlorobenzotriazole (2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-chloro-benzotria zole), 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-methoxy 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-methoxybenzotriazole, 2- [3'- t -butyl-5 '-(3 ”-dimethylethylsilyl) (Propoxy) -2'-hydroxyphenyl] -5-methoxybenzotriazole (2- [3'- t -butyl-5 '-(3 ”-dimethylvinylsilylpropoxy) -2'-hydroxyph enyl)- 5-methoxybenzotriazole), 2- [3'- t -butyl-2'-hydroxy-5 '-(3 "-methacrylfluorenylpropyl) -5-chlorobenzotriazole (2- [3' -t -butyl-5 '-(3 ”-methacryloyloxypropyl) phenyl] -5-chlorobenzotriazole) and 2- [2'-hydroxy-5'-(γ-methacryloxypropoxy) -3'- t -butylphenyl] -5-methoxy-2H-benzotriazole (2- [2'-hydroxy-5 '-(γ-methacryloyloxy propoxy) -3'-tert-butylphenyl] -5-methoxy-2H-benzotriazole).

In various embodiments of the present invention, the hydrogel composition further comprises a hydrophobic monomer, and is 1 to 10 parts by weight.

In various embodiments of the present invention, the hydrophobic single system is selected from the group consisting of methyl methacrylate, butyl methacrylte, n-hexyl methacrylate, and A group of isobornyl methacrylate.

In various embodiments of the present invention, the hydrocolloid composition further includes an organic solvent in an amount of 1 to 30 parts by weight.

In various embodiments of the present invention, the organic solvent is selected from the group consisting of A group consisting of glycerol, n-butanol, t-butanol, t-amyl alcohol, and n-hexanol.

The invention provides a hydrogel lens. The hydrogel lens includes a lens body, which is formed of the hydrogel composition in any one of the above embodiments.

With reference to the following description and the scope of the appended patent applications, the features, aspects, and advantages of this disclosure can be better understood.

It should be understood that the above general description and the following detailed description are examples and are intended to provide further explanation of the claimed invention.

Several embodiments of the present invention are disclosed below. For the sake of clarity, many practical details will be described in the following description. It should be understood, however, that these practical details should not be used to limit the invention. That is, in some embodiments of the present invention, these practical details are unnecessary. In addition, the chemical structural formula shown in the text will be illustrated in a simple and schematic manner.

In this article, unless the article specifically restricts the article, "a" and "the" can refer to a single or multiple. It will be further understood that the terms "including", "including", "having" and similar words used in this document indicate the features, regions, integers, steps, operations, elements and / or components recorded therein, but do not exclude It describes or additionally one or more of its other features, regions, integers, steps, operations, elements, components, and / or groups thereof.

According to the aforementioned problems, it can be known that when the eyes are exposed to blue light for a long time, it is easy to cause eye diseases. However, blocking all blue light, while providing the best protection for the eyes, can lead to poor vision, especially at night. Therefore, how to protect the eyes while maintaining good visual effects, especially night vision, has become a problem that needs to be solved.

In view of this, the present invention provides a hydrogel composition for preparing a hydrogel lens. The hydrogel lens manufactured by the invention can block part of blue light to protect the eyes, and has good visual effects, especially night vision capabilities.

The invention provides a hydrogel composition for preparing hydrogel lenses. The hydrogel composition includes a hydrophilic monomer, a blue light blocking monomer, a crosslinking agent, and an initiator. Wherein, the hydrophilic monomer is 30 to 60 parts by weight; the blue light blocking monomer is 0.02 to 0.5 part by weight, and it contains a yellow dye; the cross-linking agent is 0.1 to 1 part by weight; and the initiator is 0.2 to 2 parts by weight.

In various embodiments of the present invention, the hydrophilic monomer is 96.5 to 99.68 parts by weight.

For example, the hydrophilic single system is selected from the group consisting of N-vinyl pyrrolidone (NVP), 2-hydroxyethyl methacrylate (HEMA), and glycerol methacrylate (glyceryl methacrylate, GM), methacrylic acid, acrylic acid, N, N-dimethyl acrylamide (DMA), N, N-dimethylformamide A group consisting of N, N-dimethyl methacrylamide and N-vinyl-N-methyl acetamide.

In various embodiments of the present invention, the hydrocolloid composition is more Silicone-containing compounds are selected from the group consisting of silicon monomers, silicon polymers, and silicon prepolymers. When the hydrogel composition includes a silicone compound, the hydrogel composition includes: 5 to 59 parts by weight of a silicone compound, 30 to 60 parts by weight of a hydrophilic monomer, 0.02 to 0.5 parts by weight of a blue light blocking monomer, and 0.1 of a crosslinking agent To 1 part by weight and 0.2 to 2 parts by weight of the initiator.

Specifically, the silicon compound can be selected from the group consisting of silicon monomers, silicon polymers, and silicon prepolymers. The silicon monomers, silicon polymers, and silicon prepolymers can be selected from Table 1. List of various compounds:

In various embodiments of the present invention, the yellow dye may have an ethylenically-based polymerizable group, a sulfonyl group, a sulfonate group, or an amide group. group) compounds, as shown in Table 2:

In various embodiments of the present invention, the cross-linking agent is selected from the group consisting of ethylene glycol dimethacrylate, diethylene glycol dimethacrylate ), Triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, allyl methacrylate, Vinyl glycol dially ether, triethylene glycol dially ether dially ether), tetraethylene glycol dially ether, triallyl-s-triazine-2,4,6 (1H, 3H, 5H) -trione -s-triazine-2,4,6 (1H, 3H, 5H) -trione) and trimethylolpropane trimethacrylate (1,1,1-trimethylolpropane trimethacrylate).

In various embodiments of the present invention, the initiator is a photo-initiator, and the photo-initiator is a phosphine-oxide-based initiator, a titanium metallocene- based initiator) or a combination thereof.

In various embodiments of the present invention, the phosphine oxide initiator is selected from the group consisting of diphenyl (2,4,6-triphenyl) phosphine oxide, Bis (2,4,6-trimethylbenzoyl) -phenylphosphine oxide (bis (2,4,6-trimethylbenzoyl) phenyl phosphine oxide) and bis (2,6-dimethoxybenzoyl) A group consisting of fluorenyl) (2,4,4-trimethylpentyl) phosphine oxide (bis (2,6-dimethoxylbenzoyl) (2,4,4-trimethylpentyl) phosphine oxide).

In various embodiments of the invention, the metallocene titanium compound initiator comprises dicyclopentadienyl bis [2,4-difluoro-3 -(1-pyrrolyl) phenyl] titanium).

In various embodiments of the present invention, the hydrocolloid composition further comprises a UV-blocking monomer, 0.5 to 2 parts by weight, a monomer having a benzophenone, a monomer having a benzotriazole ( benzotriazole) or a combination thereof.

In various embodiments of the present invention, The single system of (benzophenone) is selected from the group consisting of 4-methacryloxy-2-hydroxy benzophenone and 4- (2-propenyloxyethoxy) A group consisting of 4- (2-acryloxyethoxy-2-hydroxy benzophenone).

In various embodiments of the present invention, the single system having benzotriazole is selected from the group consisting of 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-benzo Triazole (2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-benzotriazole), 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-chlorobenzotriazole (2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-chloro-benzotria zole), 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-methoxy 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-methoxybenzotriazole, 2- [3'- t -butyl-5 '-(3 ”-dimethylethylsilyl) (Propoxy) -2'-hydroxyphenyl] -5-methoxybenzotriazole (2- [3'- t -butyl-5 '-(3 ”-dimethylvinylsilylpropoxy) -2'-hydroxyph enyl)- 5-methoxybenzotriazole), 2- [3'- t -butyl-2'-hydroxy-5 '-(3 "-methacrylfluorenylpropyl) -5-chlorobenzotriazole (2- [3' -t -butyl-5 '-(3 ”-methacryloyloxypropyl) phenyl] -5-chlorobenzotriazole) and 2- [2'-hydroxy-5'-(γ-methacryloxypropoxy) -3'- t -butylphenyl] -5-methoxy-2H-benzotriazole (2- [2'-hydroxy-5 '-(γ-methacryloyloxyp ropoxy) -3'-tert-butylphenyl] -5-methoxy-2H-benzotriazole).

In various embodiments of the present invention, the hydrocolloid composition further comprises a hydrophobic monomer, which is 1 to 10 parts by weight, and is selected from the group consisting of methyl methacrylate. (methyl methacrylate), butyl methacrylte, n-hexyl methacrylate, and isobornyl methacrylate.

In various embodiments of the present invention, the hydrocolloid composition further comprises an organic solvent in an amount of 1 to 30 parts by weight, and is selected from glycerol, n-butanol, and tertiary A group of t-butanol, t-amyl alcohol, and n-hexanol.

The hydrogel composition is placed in a pair of polypropylene molds, and a curing reaction is performed through visible light irradiation to make a hydrogel lens, and the hydrogel lens is removed from the mold by a dry removal method. Next, after extraction with hot water, the hydrogel lens was placed in a polypropylene blister package containing a boric acid saline buffer solution, sealed with aluminum foil, and then sterilized at 120 ° C for 30 minutes under high pressure.

The hydrogel lenses made by the above manufacturing methods all have a water content of 38 to 80%, preferably a water content of 40 to 70%, and can block blue light with a wavelength of 380 to 500nm from 10% to 55%.

The following hydrogel compositions are merely examples and are not intended to limit the present invention. Specifically, the hydrogel composition 1-8 includes: 95 parts by weight of 2-hydroxyethyl methacrylate (HEMA), 1.9 parts by weight of methacrylic acid, and vinyl ethylene glycol 0.8 parts by weight of ethylene glycol dimethacrylate, 0.15 parts by weight of (1,1,1-trimethylolpropane trimethacrylate), and bis (2,4,6-trimethylbenzyl) -phenylphosphine oxidation 0.5 parts by weight of bis (2,4,6-trimethylbenzoyl) phenyl phosphine oxide, 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-benzotriazole (2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-benzotriazole) 1.0 parts by weight, blue dye (reactive blue 19, RB19) 0.03 parts by weight, and yellow dyes with different structures and contents (as shown in Table 3). Table 3 shows the penetration of hydrogel lenses made from hydrogel compositions 1-8 for blue light (380 ~ 500nm):

As can be seen from Table 3, when the yellow dye in the hydrocolloid composition is 0.02-0.15 parts by weight, its blue light transmittance is 45-85%, in other words, it can block 15-55% of blue light, and in this case Next, when wearing hydrogel lenses made of the hydrogel composition, users can protect their eyes from blue light damage, and also have good visual effects, especially night vision capabilities.

Next, a comprehensive test of visual acuity and contract sensitivity is performed. Test the number of letters that the subject can correctly recognize under different levels of light and contrast.

The test was completed by 30 subjects aged 25-40, and the visual acuity of these testers when wearing their custom lenses was 20/25, where "20/25" represents The visual target can be seen by ordinary people at 25 feet. The test subject must be seen at a distance of 20 feet from the visual target. Therefore, the visual acuity value is expressed as 20/25. First, the test subject is required to wear a hydrogel lens (experimental group lens) made of the aforementioned hydrogel composition 7 and capable of blocking 25% blue light, and a contact lens (control group lens) which generally does not have blue light blocking function. The experimental group lens and the control group lens have the same curvature and diameter. Next, ask the subject to recognize 60 letters to be tested at a distance of 4 meters under different levels of light and contrast (referring to the color contrast between the font and the background). Contrast sensitivity, the results ( p value <0.05) are shown in Table 4:

From the above test results, it can be known that the lenses of the experimental group (which can block 25% blue light) are not in the environment of sunlight, general indoor light or dim light, or high contrast, medium contrast, or low contrast. Affects the subject's ability to correctly recognize letters. Moreover, compared with wearing the lens of the control group, the subjects can correctly recognize more letters when wearing the lens of the experimental group, and have better visual acuity and contrast sensitivity. Even when wearing the experimental group lens in a dim light environment, it can still improve its visual acuity and contrast sensitivity.

It can be known from the foregoing embodiments of the present invention that the hydrogel lens made by the hydrogel composition provided by the present invention is superior to the conventional contact lens, and summarizes these advantages as follows. The hydrogel composition provided by the present invention is made by The hydrogel lens can block 10-55% of the blue light to reduce the eye's exposure to harmful blue light, thereby avoiding eye diseases such as cataract or macular disease. At the same time, it does not affect the visual acuity and contrast sensitivity, and even makes the user have better visual acuity and contrast sensitivity. Therefore, the user has good visual ability even under dim light.

The invention has described certain embodiments in considerable detail, but other embodiments are possible. Therefore, the spirit and scope of the appended claims should not be limited to the embodiments described herein.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Any person skilled in the art can make various modifications and retouches without departing from the spirit and scope of the present invention. Therefore, the protection of the present invention The scope shall be determined by the scope of the attached patent application.

Claims (21)

A hydrogel composition for preparing hydrogel lenses, comprising: a hydrophilic monomer at 30 to 99.68 parts by weight; a blue light blocking monomer at 0.02 to 0.5 parts by weight, and comprising a yellow dye, said The yellow dye has the structure of formula (7), formula (8) or formula (9): One crosslinking agent is 0.1 to 1 part by weight; and one initiator is 0.2 to 2 parts by weight. For example, the hydrocolloid composition according to item 1 of the application, wherein the hydrophilic monomer is 96.5 to 99.68 parts by weight. For example, the hydrocolloid composition of the first patent application scope further includes a silicone compound selected from the group consisting of a silicon monomer, a silicon polymer, and a silicon prepolymer, and the silicone compound is 5 to 59 parts by weight, and the hydrophilic monomer is 30 to 60 parts by weight. For example, the hydrocolloid composition of the scope of application for patent No. 3, wherein the silicon monomer has the structure of formula (1): Where V ₁ is , or , L ₁ is an alkylene group of C3 ~ C7 or , R ₁ is methyl or , Where * is the bonding position in formula (1). For example, the hydrogel composition of the third scope of the application for a patent, wherein the silicon polymer has a structure of formula (2): Where L ₂ is an alkylene group of C3 ~ C10, , S ₂ is or , Where R ₂ is an alkyl group of C3 to C5, n is an integer of 3 to 20, and * is a bonding position in formula (2). For example, the hydrocolloid composition of the scope of application for patent No. 3, wherein the silicon prepolymer has the structure of formula (3): Where V ₃ is , or , L ₃ is an alkylene group of C2 to C5, and m is an integer of 10 to 50, where * is a bonding position in formula (3). For example, the hydrocolloid composition according to item 1 of the application, wherein the hydrophilic single system is selected from the group consisting of N-vinyl pyrrolidone (NVP), 2-hydroxyethyl methacrylate (2- hydroxyethyl methacrylate (HEMA), glyceryl methacrylate (GM), methacrylic acid, acrylic acid, N, N-dimethyl acrylamide, DMA), N, N-dimethyl methacrylamide, and N-vinyl-N-methyl acetamide group. For example, the hydrocolloid composition according to item 1 of the patent application, wherein the crosslinking agent is selected from the group consisting of ethylene glycol dimethacrylate, divinyl glycol dimethacrylate Diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, allyl methacrylic acid Esters (allyl methacrylate), vinyl glycol dially ether, triethylene glycol dially ether, tetravinyl glycol Tetraethylene glycol dially ether, triallyl-s-triazine-2,4,6 (1H, 3H, 5H) -trione (triallyl-s-triazine-2,4,6 ( 1H, 3H, 5H) -trione) and trimethylolpropane trimethacrylate (1,1,1-trimethylolpropane trimethacrylate). For example, the hydrocolloid composition according to item 1 of the application, wherein the initiator is a photoinitiator. For example, the hydrocolloid composition according to item 9 of the application, wherein the photo-initiator is a phosphine-oxide-based initiator, a titanium metallocene-based initiator Or a combination. For example, the hydrocolloid composition of claim 10, wherein the phosphine oxide initiator is selected from the group consisting of diphenyl (2,4,6-triphenyl) phosphine oxide (diphenyl (2,4,6- triphenyl) phosphine oxide), bis (2,4,6-trimethylbenzoyl) -phenylphosphine oxide (bis (2,4,6-trimethylbenzoyl) phenyl phosphine oxide), and bis (2,6- Dimethoxybenzyl) (2,4,4-trimethylpentyl) phosphine oxide (bis (2,6-dimethoxylbenzoyl) (2,4,4-trimethylpentyl) phosphine oxide) group. For example, the hydrocolloid composition of claim 10, wherein the metallocene titanium compound initiator comprises dicyclopentadienyl bis [2,4-difluoro-3- (1-pyrrole) phenyl] titanium (2 , 4-difluoro-3- (1-pyrrolyl) phenyl] titanium). For example, the hydrocolloid composition in the first item of the patent application scope further comprises a UV blocking monomer, which is 0.5 to 2 parts by weight. For example, the hydrocolloid composition according to item 13 of the application, wherein the ultraviolet blocking monomer is a monomer having benzophenone, a monomer having benzotriazole, or a combination thereof . For example, the hydrocolloid composition according to item 14 of the application, wherein the single system having benzophenone is selected from the group consisting of 4-methacryloxy-2-hydroxydiphenyl ketone ( Group consisting of 4-methacryloxy-2-hydroxy benzophenone and 4- (2-acryloxyethoxy) -2-hydroxydiphenyl ketone (4- (2-acryloxyethoxy-2-hydroxy benzophenone) . For example, the hydrocolloid composition according to item 14 of the application, wherein the single system having benzotriazole is selected from the group consisting of 2- (2-hydroxy-5-methacryloxyethylphenyl) ) -2H-benzotriazole (2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-benzotriazole), 2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6 -2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-chloro-benzotri azole, 2- (2-hydroxy-5-methacryloxyethylphenyl)- 2H-6-methoxybenzotriazole (2- (2-hydroxy-5-methacryloxyethylphenyl) -2H-6-methoxybenzotriazole), 2- [3'- t -butyl-5 '-(3 ”-di Methylethylsilylpropoxy) -2'-hydroxyphenyl] -5-methoxybenzotriazole (2- [3'- t -butyl-5 '-(3 ”-dimethylvinylsilylpropoxy) -2 '-hydroxyp henyl] -5-methoxybenzotriazole), 2- [3'- t -butyl-2'-hydroxy-5'-(3 ”-methacrylmethylpropyl) -5-chlorobenzotriazole (2- [3'- t -butyl-5 '-(3 ”-methacryloyloxypropyl) phenyl] -5-chlorobenzotriazole) and 2- [2'-hydroxy-5'-(γ-methacryloxypropoxy) ) -3'- t -butylphenyl] -5-methoxy-2H-benzotriazole (2- [2'-hydroxy- 5 '-(γ-methacryloyloxypropoxy) -3'-tert-butylphenyl] -5-methoxy-2H-benzotriazole). For example, the hydrocolloid composition according to the first patent application range further includes a hydrophobic monomer, which is 1 to 10 parts by weight. For example, the hydrocolloid composition according to item 17 of the application, wherein the hydrophobic single system is selected from the group consisting of methyl methacrylate, butyl methacrylte, and n-hexyl methacrylate ( n-hexyl methacrylate) and isobornyl methacrylate. For example, the hydrocolloid composition according to item 1 of the patent application scope further includes an organic solvent in an amount of 1 to 30 parts by weight. For example, the hydrogel composition according to item 19 of the application, wherein the organic solvent is selected from glycerol, n-butanol, t-butanol, and t-amyl alcohol (t -amyl alcohol) and n-hexanol. A hydrogel lens includes: a lens body, which is formed of the hydrogel composition according to any one of claims 1-20.