CN115215963B - Blue light resistant cornea contact lens and preparation method thereof - Google Patents
Blue light resistant cornea contact lens and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a blue light resistant cornea contact lens and a preparation method thereof, wherein the blue light resistant cornea contact lens is obtained by adding a blue light resistant agent into a raw material of a contact lens of the cornea contact lens for direct polymerization, and the blue light resistant agent is tetra [4- (methacryloyloxy) phenyl ] porphyrin. The cornea contact lens can effectively absorb harmful blue light with the wavelength band of 385-445 nm, and the spectral transmittance is lower than 80%; and for the beneficial blue light with the wavelength band of 4476-505 nm, the transmittance is higher than 90%, and the transmittance of the blue light in the visible light band is higher than 80%.
Description
Technical Field
The invention belongs to the technical field of cornea contact lenses, and particularly relates to a blue-ray-resistant cornea contact lens and a preparation method thereof.
Background
Along with the progress of technology, people have more opportunities to use electronic products such as computers, mobile phones and flat panels, and in order to make white light of an electronic screen whiter, the picture color is brighter, the color contrast is higher, and the dosage and intensity of blue light need to be increased, so that the electronic products which are located in the same time as the people in the morning always hide blue light with high intensity.
However, blue light is not harmful, the wavelength range of the blue light harmful to human eyes is 385-445 nm, the blue light of the wave band aggravates the maculopathy of retina, can cause eyeground injury after cataract surgery, causes vision blurring, causes visual fatigue, glare, inhibits melatonin secretion, disturbs sleep, and improves the occurrence rate of serious diseases of the eye; the wavelength of blue light beneficial to human body is 446-505 nm, and the beneficial blue light can excite spirit and alleviate depression, so that the blue light is irradiated to treat seasonal affective disorder (winter depression) and improve sleep quality.
Contact lenses, also known as corneal contact lenses, are lenses that are worn on the cornea of an eyeball to correct vision or protect the eye. Some functional contact lenses, such as photochromic contact lenses, blue-ray resistant contact lenses, ultraviolet-resistant contact lenses, and particularly blue-ray resistant contact lenses, have also been developed in recent years. However, the existing blue-light-resistant cornea contact lens is mainly prepared by adding yellow dye into a lens raw material directly or is coated, and has the defects of complex preparation process, yellow lens color, total absorption of blue light wavelength range and the like. For example: the patent CN201310303179.3 uses a polymerizable yellow dye to copolymerize with a lens forming material to prepare a contact lens that blocks or reduces the blue light penetration intensity, but the use of the yellow dye can yellow the lens, which is less acceptable to consumers; the method for preparing the coated contact lens consisting of the upper layer lens, the middle layer lens and the lower layer lens by using an interlayer coating method in the colored contact lens with blue light filtering and UV resisting functions in the patent CN201420321055.8 has complex preparation process.
At present, many blue-ray-resistant cornea contact lenses are all prepared by adopting an ink coating method, and blue-ray-resistant materials are likely to be separated out, so that compared with the traditional yellow-appearing blue-ray-resistant lens, development of the blue-ray-resistant cornea contact lens which is simple in preparation process, free of risks such as raw material separation and capable of being accepted by consumers is urgently needed.
Disclosure of Invention
The invention aims to: the invention aims to solve the technical problem of providing a blue light resistant cornea contact lens and a preparation method thereof.
The technical scheme is as follows: in order to solve the technical problems, the invention provides a blue light resistant cornea contact lens, which is obtained by adding a blue light resistant agent into a raw material of a contact lens of the cornea contact lens to be directly polymerized, wherein the blue light resistant agent is tetra [4- (methacryloyloxy) phenyl ] porphyrin, and the structure is shown as a formula I:
the blue-ray resistant cornea contact lens comprises one of a blue-ray resistant hydrogel cornea contact lens, a blue-ray resistant silicon hydrogel cornea contact lens, a blue-ray resistant hard lens or a blue-ray resistant air-permeable hard lens.
Wherein, the blue light resistant film contact lens raw material also comprises two or more of reaction monomers, cross-linking agents and initiators.
The blue light resistant film contact lens is formed by polymerizing a reaction monomer, a blue light resistant agent, a crosslinking agent and an initiator.
The reaction monomers of the blue light resistant hydrogel cornea contact lens comprise one or more of hydroxyethyl methacrylate, N-vinyl pyrrolidone, methacrylic acid, glycidyl methacrylate, N-dimethyl acrylamide, N-methyl-N-vinylacetamide and methyl methacrylate.
Wherein the reactive monomers of the blue light resistant silicone hydrogel contact lens comprise organic silicon monomers and other monomers, wherein the organic silicon monomers comprise one or more of 2-methyl-2-hydroxy-3- [3- [1, 3-tetramethyl-1- [ trimethylsilyl) oxy ] disiloxy ] propoxy ] propyl ester of 2-acrylic acid, (3-methacryloxy-2-hydroxypropoxy) propyltris (trimethylsiloxy) silane, (2-methacryloxy-3-hydroxypropoxy) propylbis (trimethylsiloxy) methylsilane, methacryloxymethyltris (trimethylsiloxy) silane, 3-methacryloxypropyltris (trimethylsiloxy) silane, di-3-methacryloxy2-hydroxypropoxypropyl polydimethylsiloxane of 2-acrylic acid, mono-N-butyl terminated polydimethylsiloxane of mono-methacryloxypropyl end caps, fluorinated siloxane methacrylate, and the other monomers comprise one or more of hydroxyethyl methacrylate, N-vinyl pyrrolidone, methyl acrylate, N-vinyl amide or N-methyl acrylate.
Wherein, the reaction monomer of the blue light resistant hard mirror comprises methyl methacrylate; the reactive monomer of the anti-blue light air-permeable hard mirror comprises one or more of siloxane methacrylate, mono-n-butyl-terminated polydimethylsiloxane terminated by mono-methacryloxypropyl, fluorinated siloxane methacrylate and cellulose acetate butyrate.
Further, the blue light resistant contact lens material includes commercially available materials for corneal contact lens hydrogel materials, the names of which include Polymacon, hioxifilcon, mafilcon, hefilcon, nesofilcon, omafilcon, droxifilcon, deltafilcon, etafilcon, etc.
Further, the blue light resistant film contact lens raw material comprises a cross-linked material polymerized by an organic silicon monomer, other monomers, a cross-linking agent and an initiator, and further comprises raw materials of commercially available silicon hydrogel contact lens materials, wherein the raw materials comprise Balafilcon, delefilcon, lotrafilcon, enfilcon, comfilcon, senefilcon, narafilcon, somofilcon and the like.
The blue light resisting agent is tetra [4- (methacryloyloxy) phenyl ] porphyrin (compound I), has double bond in structure and can be polymerized with the raw materials of the materials.
Wherein the weight percentage of the blue light resistant agent is 0.001-1%. When the addition amount of the blue light resisting agent is low (lower than 0.05 percent), the color of the cornea contact lens can be colorless; at higher levels of anti-blue agent added (above 0.05%), the color of the contact lens appears light pink; when more than 0.05% of the anti-blue agent and the blue dye are added simultaneously, the color of the contact lens is light purple.
Wherein, the raw material of the contact lens can also comprise an anti-UV agent, which comprises one or more of 2, 4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-benzyloxy benzophenone, 2-hydroxy-4-n-octoxybenzophenone, phenyl o-hydroxybenzoate, p-octyl phenyl salicylate, p-isopropylidene bisphenol bissalicylate, resorcinol monobenzoate, 2- (4-benzoyl-3-hydroxyphenoxy) ethyl 2-acrylic acid ester and 2- (2 '-hydroxy-4' -methacryloyl chlorophenyl) benzotriazole, and the addition amount of the anti-UV agent accounts for 0.001 to 5 percent of the total weight of the raw material of the contact lens.
The invention also discloses a preparation method of the blue light resistant film contact lens, which comprises the following steps: the blue light resistant film contact lens is prepared by adding a blue light resistant agent into a raw material of a contact lens of the contact lens, mixing, injecting into a contact lens mold, and photo-or thermal-initiated polymerization curing and hydration.
The blue light resistant cornea contact lens is prepared by polymerizing a blue light resistant agent and other reactive monomers; the raw materials are not separated out, the lens is colorless or light pink, harmful blue light can be effectively absorbed, and beneficial blue light is transmitted. The content of the blue light resistant agent is regulated to prepare a colorless cornea contact lens or a purple cornea contact lens prepared by mixing the blue light resistant agent with blue dye, and compared with the traditional blue light resistant lens with yellow color, the colorless or purple color is more easily accepted by consumers. The blue light resistant film contact lens has certain selectivity on blue light absorption, and mainly absorbs harmful blue light in 385-445 nm wave bands.
The beneficial effects are that: compared with the prior art, the invention has the following advantages:
1. the blue light resistant cornea contact lens prepared by the invention is formed by directly polymerizing the blue light resistant agent and the lens monomer, and the risk of raw material precipitation is avoided;
2. the color of the lens is not yellow, so that the lens is more acceptable to consumers; when the addition amount of the blue light resisting agent is low, the color of the cornea contact lens can be colorless; when the amount of the anti-blue light agent is higher, the color of the contact lens is light pink; when the blue light resisting agent and the blue dye are added simultaneously, the color of the contact lens is light purple.
3. The blue light resistant cornea contact lens can filter harmful blue light and transmit beneficial blue light, and simultaneously meets the requirement of the lens on light transmittance when worn: the average spectral transmittance of the blue light resistant cornea contact lens is lower than 80% or even lower than 60% at 385-445 nm, and is higher than 90% at 446-505 nm, and the visible light wave band transmittance can reach more than 80%; UV-resistant agents can also be added to blue-resistant cornea contact lenses so that the average spectral transmittance of the lenses at 285-315 nm is less than 5% or even less than 1%, and the average spectral transmittance at 316-380 nm is less than 50% or even less than 10%.
Drawings
FIG. 1 is an anti-blue hydrogel contact lens of example 2 with 0.05% anti-blue agent (Compound I);
FIG. 2 is a blue-light resistant silicone hydrogel contact lens of example 4 with 0.05% blue-light resistant agent (compound I) added.
Detailed Description
The present invention will be described in further detail with reference to the following examples.
EXAMPLE 1 Synthesis of tetrakis [4- (methacryloyloxy) phenyl ] porphyrin (Compound I)
0.41g of methacrylic acid and 0.932g of Dicyclohexylcarbodiimide (DCC) are dissolved in 30mL of dichloromethane at the temperature of 0 ℃ and stirred for reaction for 0.5h, then 0.75g of tetra (4-hydroxyphenyl) porphyrin and 4-Dimethylaminopyridine (DMAP) are added, stirring is continued for 1.5h, stirring is continued for 24h after the temperature is raised to room temperature, concentration is carried out, and separation and purification are carried out through column chromatography, thus obtaining a purple solid compound I.
Example 2 preparation of blue-light resistant hydrogel lenses
39.60g of hydroxyethyl methacrylate (HEMA), 0.02g of blue light resistant agent (compound I), 0.2g of Azobisisobutyronitrile (AIBN) and 0.2g of Ethylene Glycol Dimethacrylate (EGDMA) are mixed and stirred for 5 hours at room temperature, filtered, dropwise added into a mold, reacted in an oven at 70 ℃ for 12 hours, demolded after the reaction, put into pure water for hydration, and then transferred into standard saline to prepare the blue light resistant hydrogel cornea contact lens.
Comparative example 1
39.60g of hydroxyethyl methacrylate (HEMA), 0.2g of Azobisisobutyronitrile (AIBN) and 0.2g of Ethylene Glycol Dimethacrylate (EGDMA) are mixed and stirred for 5 hours at room temperature, filtered, dropwise added into a mold, reacted for 12 hours in an oven at 70 ℃, demolded after the reaction, put into pure water for hydration, and then transferred into standard saline to prepare the hydrogel cornea contact lens.
Example 3 preparation of blue-light resistant hydrogel lenses
20.01g of hydroxyethyl methacrylate (HEMA), 19.69g of g N-vinyl pyrrolidone (NVP), 0.36g of a blue light inhibitor (compound I), 0.1g of Azobisisoheptonitrile (ABVN) and 0.2g of Ethylene Glycol Dimethacrylate (EGDMA) are mixed and stirred at room temperature for 6 hours, filtered, dropwise added into a mold, airtight reacted for 8 hours in a 90 ℃ oven, demolded after the reaction, hydrated in standard saline, and the blue light-proof hydrogel cornea contact lens is prepared.
Comparative example 2
20.01g of hydroxyethyl methacrylate (HEMA), 19.69g of g N-vinylpyrrolidone (NVP), 0.1g of Azobisisoheptonitrile (ABVN) and 0.2g of triethylene glycol dimethacrylate (EGDMA) are mixed and stirred for 6 hours at room temperature, filtered, dropwise added into a mold, hermetically reacted for 8 hours in an oven at 90 ℃, and after the reaction, demolded, hydrated in standard saline, and the hydrogel cornea contact lens is prepared.
Example 4 preparation of blue-resistant silica hydrogel lenses
23.76g of 3-methacryloxypropyl TRIS (trimethylsiloxy) silane (TRIS), 15.84g N-methyl-N-Vinylacetamide (VMA), 0.02g of anti-blue light agent (compound I), 0.2g of Azobisisobutyronitrile (AIBN) and 0.2g of Ethylene Glycol Dimethacrylate (EGDMA) are mixed and stirred for 12 hours at room temperature, filtered, dropwise added into a mold, hermetically reacted for 12 hours at 70 ℃, demolded after the reaction is finished, hydrated for 1 hour in 20% ethanol solution, then transferred into pure water for hydration for 12 hours, and finally put into standard saline to prepare the blue light prevention silicon hydrogel cornea contact lens.
Comparative example 3
23.76g of 3-methacryloxypropyl TRIS (trimethylsiloxy) silane (TRIS), 15.84g N-methyl-N-Vinylacetamide (VMA), 0.2g of Azobisisobutyronitrile (AIBN) and 0.2g of Ethylene Glycol Dimethacrylate (EGDMA) are mixed and stirred for 12 hours at room temperature, filtered, dropwise added into a mold, hermetically reacted for 12 hours in a 70 ℃ oven, demolded after the reaction is finished, hydrated for 1 hour in a 20% ethanol solution, then transferred into pure water for hydration for 12 hours, and finally put into standard saline to prepare the silicon hydrogel cornea contact lens.
Example 5 preparation of blue-resistant silica hydrogel lenses
23.81g 2-methyl-2-hydroxy-3- [3- [1, 3-tetramethyl-1- [ trimethylsilyl) oxy ] disiloxy ] propyl ] acrylate (SIGMA), 15.84g N, N-Dimethylacrylamide (DMA), 0.16g blue light resistant agent (compound I), 0.15g Azobisisobutyronitrile (AIBN) and 0.2g Ethylene Glycol Dimethacrylate (EGDMA), mixing and stirring for 5h at room temperature, filtering, dropwise adding into a mould, hermetically reacting for 8h in an oven at 90 ℃, demoulding after the reaction, hydrating for 1h in a 5% ethylene glycol solution, transferring into pure water for hydrating for 8h, and finally placing into standard saline to prepare the silicon hydrogel cornea contact lens.
Comparative example 4
23.81g of 2-methyl-2-hydroxy-3- [3- [1, 3-tetramethyl-1- [ trimethylsilyl) oxy ] disiloxy ] propoxy ] propyl ester (SIGMA), 15.84g of N, N-Dimethylacrylamide (DMA), 0.15g of Azobisisobutyronitrile (AIBN) and 0.2g of tetraethylene dimethacrylate (EGDMA) were mixed and stirred at room temperature for 5 hours, filtered, dropwise added into a preheated mold, hermetically reacted for 8 hours in an oven at 90 ℃, demolded after the reaction, hydrated for 1 hour in a 5% glycol solution, transferred into pure water and finally put into standard saline to prepare the silicon hydrogel cornea contact lens.
Example 6 preparation of blue light resistant air-permeable hard mirror
11.525g of mono-n-butyl-terminated polydimethylsiloxane terminated by mono-methacryloxypropyl, 28g of methyl methacrylate, 0.06g of blue light resistant agent (compound I), 0.075g of dibenzoyl peroxide (BPO) and 0.4g of tetraethyl glycol dimethacrylate, mixing and stirring for 8 hours at room temperature, filtering, dripping into a mold, hermetically reacting for 12 hours in an oven at 80 ℃, demolding after the reaction is finished, and turning and forming to obtain the blue light resistant breathable hard mirror.
Comparative example 5
11.525g of mono-n-butyl-terminated polydimethylsiloxane terminated by mono-methacryloxypropyl groups, 28g of methyl methacrylate, 0.075g of dibenzoyl peroxide (BPO) and 0.4g of tetraethylene glycol dimethacrylate, mixing and stirring for 8 hours at room temperature, filtering, dripping into a mold, hermetically reacting for 12 hours in an oven at 80 ℃, demolding after the reaction, and turning to obtain the air-permeable hard mirror.
Example 7 preparation of UV resistant Lan Guanggui hydrogel lenses
19.61g of 2-methyl-2-hydroxy-3- [3- [1, 3-tetramethyl-1- [ trimethylsilyl) oxy ] disiloxane ] propoxy ] propyl ester (SIGMA), 19.84g of N-vinylpyrrolidone (NVP), 0.2g of a blue light resistant agent (compound I), 0.72g of 2- (2 '-hydroxy-4' -methacryloyl chlorophenyl) benzotriazole, 0.15g of Azobisisobutyronitrile (AIBN) and 0.2g of Ethylene Glycol Dimethacrylate (EGDMA), 0.2g of triethylene glycol divinyl ether, mixing and stirring at room temperature for 8 hours, filtering, dropwise dripping into a mold, hermetically reacting in an oven at 80 ℃, demolding after the reaction is finished, hydrating in a 5% ethylene glycol solution for 1 hour, transferring into pure water for 8 hours, and finally putting into standard saline to prepare the blue light resistant silicon hydrogel contact lens.
Comparative example 6
19.61g of 2-methyl-2-hydroxy-3- [3- [1, 3-tetramethyl-1- [ trimethylsilyl) oxy ] disiloxane ] propoxy ] propyl ester (SIGMA), 19.84g of N-vinylpyrrolidone (NVP), 0.2g of blue light resistant agent (compound I), 0.15g of Azobisisobutyronitrile (AIBN) and 0.2g of ethylene dimethacrylate (EGDMA), 0.2g of triethylene glycol divinyl ether, mixing and stirring for 8 hours at room temperature, filtering, dropwise dripping into a mold, hermetically reacting for 8 hours in an oven at 80 ℃, demolding after the reaction, hydrating for 1 hour in a 5% ethylene glycol solution, then transferring into pure water for hydrating for 8 hours, and finally putting into standard saline to prepare the blue light resistant silicon hydrogel contact lens.
Example 8
The transmittance of the contact lens was measured at a wavelength of 220 to 800nm by closely contacting the lens with the light-transmitting surface of a cuvette optical glass containing physiological saline (standard saline reference GB 11417.4-2012), and the results are shown in tables 1 and 2.
Table 1 transmittance data for blue light resistant cornea contact lenses
| 380～780nm(％) | 385～445nm(％) | 446～505nm(％) | |
| Example 2 | 90.07 | 74.36 | 95.37 |
| Comparative example 1 | 96.10 | 96.44 | 96.76 |
| Example 3 | 86.17 | 59.02 | 92.89 |
| Comparative example 2 | 97.78 | 97.78 | 98.21 |
| Example 4 | 93.58 | 79.04 | 97.11 |
| Comparative example 3 | 98.06 | 97.39 | 98.08 |
| Example 5 | 92.3 | 72.34 | 96.58 |
| Comparative example 4 | 98.06 | 97.31 | 98.03 |
| Example 6 | 92.56 | 76.32 | 96.8 |
| Comparative example 5 | 99.64 | 99.39 | 99.51 |
Table 2 transmittance data for blue light-resistant UV-resistant corneal contact lenses
From the above examples and comparative examples, it can be seen that the blue light resistant contact lens of the present invention has an average spectral transmittance of less than 80%, even less than 60%, at 385-445 nm, and an average spectral transmittance of more than 90% at 446-505 nm, while the visible light band transmittance thereof can reach more than 80%; the blue light resistant cornea contact lens may also incorporate an anti-UV agent such that the average spectral transmittance of the lens at 285-315 nm is less than 5% or even less than 1%, and the average spectral transmittance at 316-380 nm is less than 50% or even less than 10%.
Claims (11)
1. A blue light resistant film contact lens is characterized in that the blue light resistant film contact lens is obtained by adding a blue light resistant agent into a raw material of a contact lens of the contact lens and directly polymerizing, wherein the blue light resistant agent is tetra [4- (methacryloyloxy) phenyl group]Porphyrin, the structure of which is shown in formula I:
。
2. the blue-ray resistant cornea contact lens of claim 1, wherein the blue-ray resistant cornea contact lens comprises one of a blue-ray resistant hydrogel cornea contact lens and a blue-ray resistant hard lens, and the equilibrium water content of a standard salt solution of the blue-ray resistant hydrogel is more than or equal to 10% at 20 ℃; the equilibrium water content of the standard salt solution of the blue light resistant hard lens at 20 ℃ is less than 10%.
3. The blue-resistant cornea contact lens of claim 1, wherein the blue-resistant cornea contact lens comprises one of a blue-resistant silicone hydrogel cornea contact lens or a blue-resistant air-permeable hard lens, the equilibrium water content of the standard salt solution of the anti-Lan Guanggui hydrogel at 20 ℃ is greater than or equal to 10%; the standard salt solution of the blue light resistant breathable hard mirror has an equilibrium water content of less than 10 percent at 20 ℃.
4. The blue-resistant cornea contact lens of claim 1 or 2, wherein the blue-resistant cornea contact lens material comprises two or more of a reactive monomer, a crosslinking agent, and an initiator.
5. The blue-resistant corneal contact lens of claim 2, wherein the reactive monomer of the blue-resistant hydrogel corneal contact lens comprises one or more of hydroxyethyl methacrylate, N-vinyl pyrrolidone, methacrylic acid, glycidyl methacrylate, N-dimethylacrylamide, N-methyl-N-vinylacetamide, methyl methacrylate.
6. The blue light resistant corneal contact lens of claim 3, wherein the reactive monomers of the anti-Lan Guanggui hydrogel corneal contact lens comprise silicone monomers and other monomers, the silicone monomers comprising one or more of 2-methyl-2-hydroxy-3- [3- [1, 3-tetramethyl-1- [ trimethylsilyl) oxy ] disiloxane ] propoxy ] propyl, (3-methacryloxy-2-hydroxypropoxy) propyltris (trimethylsiloxy) silane, (2-methacryloxy-3-hydroxypropoxy) propylbis (trimethylsiloxy) methylsilane, methacryloxymethyltri (trimethylsiloxy) silane, 3-methacryloxypropyltris (trimethylsiloxy) silane, di-3-methacryloxypropyl polydimethylsiloxane, mono-N-butyl terminated polydimethylsiloxane of mono-methacryloxypropyl-2-hydroxypropoxy propyl polydimethylsiloxane of 2-acrylic acid, fluorinated siloxane methacrylate, and monomers comprising methacrylic acid ethyl ester, N-vinyl pyrrolidone, N-methyl acrylate, N-vinyl methacrylate, and the like.
7. The blue light resistant cornea contact lens of claim 3, wherein said blue light resistant hard lens reactive monomer comprises methyl methacrylate and said blue light resistant air permeable hard lens reactive monomer comprises one or more of silicone methacrylate, mono n-butyl terminated polydimethylsiloxane, fluorinated silicone methacrylate, cellulose acetate butyrate.
8. The blue light resistant cornea contact lens of claim 4, wherein said initiator comprises a photoinitiator or a thermal initiator, wherein said photoinitiator comprises one or more of 2-hydroxy-2-methylbenzophenone, 1-hydroxycyclohexyl phenyl ketone, 2-hydroxy-2-methyl-1-phenyl-propan-1-one, and 2,4, 6-trimethylbenzyl diphenyl phosphine oxide, and said thermal initiator comprises one or more of azobisisobutyronitrile, benzoyl peroxide, azobisisoheptonitrile, diisopropyl peroxydicarbonate, dicyclohexyl peroxydicarbonate, and bis (2-phenylethoxy) peroxydicarbonate; the cross-linking agent comprises one or more of polyethylene glycol diacrylate, ethylene glycol dimethacrylate, triallyl isocyanurate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, diethylene glycol divinyl ether, vinyl methacrylate, divinyl polyethylene glycol ester and trimethylolpropane trimethacrylate.
9. The blue light resistant film contact lens of claim 1, wherein the blue light resistant agent comprises 0.001% -1% by weight of the lens material.
10. The blue light resistant film contact lens of claim 1, wherein the blue light resistant film contact lens material further comprises an anti-UV agent comprising one or more of 2,4 dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-benzyloxybenzophenone, 2-hydroxy-4-n-octoxybenzophenone, phenyl o-hydroxybenzoate, p-octylphenyl salicylate, p-isopropylidenebisphenol bissalicylate, resorcinol monobenzoate, 2- (4-benzoyl-3-hydroxyphenoxy) ethyl 2- (2 '-hydroxy-4' -methacryloyl chlorophenyl) benzotriazole, and the amount of 2- (2 '-hydroxy-4' -methacryloyl chlorophenyl) benzotriazole is 0.001% -5% based on the total weight of the lens material.
11. A method for producing a blue light resistant contact lens according to any one of claims 1 to 10, comprising the steps of: the blue light resistant film contact lens is prepared by adding a blue light resistant agent into a raw material of a contact lens of the contact lens, mixing, injecting into a contact lens mold, and photo-or thermal-initiated polymerization curing and hydration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110422671.7A CN115215963B (en) | 2021-04-19 | 2021-04-19 | Blue light resistant cornea contact lens and preparation method thereof |
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| CN115010742B (en) * | 2022-06-02 | 2024-03-22 | 苏州瑞尔康科技有限公司 | Blue light absorbent, silicon hydrogel cornea contact lens based on blue light absorbent and application of blue light absorbent |
| CN115991847B (en) * | 2022-11-03 | 2023-12-08 | 江苏海伦隐形眼镜有限公司 | Blue light resistant cornea contact lens based on tetraaryl metalloporphyrin compound and preparation method thereof |
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| WO2014055513A1 (en) * | 2012-10-02 | 2014-04-10 | High Performance Optics, Inc. | Selective blue light filtered optic |
| CN112346165A (en) * | 2020-11-06 | 2021-02-09 | 南京工业大学 | High-strength blue-light-proof and ultraviolet-proof PC lens and preparation method thereof |
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| US9683102B2 (en) * | 2014-05-05 | 2017-06-20 | Frontier Scientific, Inc. | Photo-stable and thermally-stable dye compounds for selective blue light filtered optic |
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| WO2014055513A1 (en) * | 2012-10-02 | 2014-04-10 | High Performance Optics, Inc. | Selective blue light filtered optic |
| CN112346165A (en) * | 2020-11-06 | 2021-02-09 | 南京工业大学 | High-strength blue-light-proof and ultraviolet-proof PC lens and preparation method thereof |
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| Improved contact lens disinfection by exposure to violet radiation;Katharina Hoenes等;《Technology and Health Care》;第24卷(第1期);第145-151页 * |
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