TWI602912B - Contact lenses care solution - Google Patents

Description

Contact lens maintenance solution

The present invention relates to a contact lens maintenance solution, and more particularly to a maintenance liquid having a cleaning function which can improve the moisturization of a contact lens.

In the process of wearing contact lenses, when the wearer's eye surface is in contact with the contact lens, protein or/and lipid precipitation will begin to occur. In the case of wearing contact lenses for a long time, the wearer's eyes are easy to feel. Drying, thus reducing wearing comfort. When the protein gradually accumulates, it will cause the wearer to have unclear vision, corneal congestion, conjunctivitis, corneal neovascularization, corneal ulcer and other problems. More serious, the bacteria will be born, making the wearer's eyeball susceptible to infection. Therefore, daily cleaning of contact lenses is quite important.

In order to effectively clean the contact lens, the contact lens should be immersed in the maintenance liquid for a period of time, so that the protein or/and the lipid on the lens are decomposed to achieve the cleaning effect. However, when the contact lens is immersed in the cleaning solution for a long time, the surface of the lens absorbs the components in the cleaning liquid and causes irritation to the eyes, and the wearing comfort is not as good as before. Therefore, the contact lens maintenance solution has been added with additives such as a soothing agent, a moisturizer or an isotonic agent to alleviate the discomfort generated during wearing. Among the aforementioned additives, it is known to add 0.2 to 1.5% by weight to the maintenance liquid. Glycerin acts as a humectant.

The invention provides a cleaning liquid with a cleaning function capable of improving the moisturizing property of a contact lens to solve the above problem, that is, a novel moisturizing agent is added to the maintenance liquid. It contains a polymer with ethylene acetamide, alginic acid and glycerin. This humectant provides biocompatibility and low cytotoxicity, reduces eye irritation or redness, and has good wettability after contact lens cleaning. Improve dry eyes and soreness caused by long-term wear.

The maintenance liquid for contact lenses provided by the invention comprises a buffer, a chelating agent, a surfactant and a humectant, the humectant comprising 100 parts by weight of glycerin and 0.5 to 40 parts by weight of ethylene-containing B A polymer of guanamine and 5 to 40 parts by weight of alginic acid.

The humectant for the contact lens maintenance solution of the present invention needs to contain a specific ratio of ethylene acetamide, alginic acid and glycerin, on the one hand, having good biocompatibility and low cytotoxicity and promoting humectant Adsorption on contact lenses, on the other hand, due to the low use of glycerin, it can prevent the moisturizing layer formed by the moisturizer in the eyeball and lens from excessively adsorbing water molecules on the surface of the eyeball, thereby affecting the secretion of lacrimal gland.

The humectant for contact lens maintenance liquid of the present invention preferably contains 1 to 35 parts by weight of a polymer containing ethylene acetamide and 10 to 35 parts by weight of alginic acid in 100 parts by weight of glycerin.

The ethylene acetamide polymer used in the humectant for contact lens maintenance liquid of the present invention may be ethylene acetamide homopolymer or ethylene acetamide copolymer, ethylene acetamide homopolymer system. It is formed by polymerization of ethylene acetylamine monomer. The ethylene acetamide copolymer is obtained by polymerizing a vinyl acetamide monomer and other monomers having a crosslinkable functional group, and the other monomer having a crosslinkable functional group may be, for example, sodium acrylate.

In one embodiment of the present invention, the amount of the humectant added to the contact lens maintenance solution of the present invention is from about 0.01 part by weight to 0.20 part by weight, preferably from 0.04 part by weight to 0.14 part by weight, based on 100 parts by weight of the buffer.

In an embodiment of the present invention, the humectant in the contact lens maintenance solution of the present invention may further comprise hyaluronic acid.

In one embodiment of the present invention, the contact lens maintenance solution of the present invention is moisturized Further, 20 to 70 parts by weight of hyaluronic acid may be added to the agent.

In an embodiment of the present invention, in the contact lens maintenance solution of the present invention, the components of the humectant may be added to the buffer after mixing or may be separately added to the buffer.

In one embodiment of the present invention, the buffer solution in the contact lens maintenance solution of the present invention is selected from the group consisting of deionized water and selected from the group consisting of sodium chloride, boric acid and salts thereof, phosphoric acid and salts thereof, nitric acid and salts thereof, tartaric acid and salts thereof. And consisting of carbonic acid and its salts, hydrogencarbonate, lactic acid and its salts, citric acid and its salts, acetic acid and its salts, polyols and their derivatives, and sulfonic acids and their derivatives. The aforementioned salts may be, for example, an alkali metal salt such as a sodium salt or a potassium salt, but are not limited thereto.

In one embodiment of the present invention, the chelating agent in the contact lens maintenance solution of the present invention is selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, polyphosphates and salts thereof, and succinic acid. And a group consisting of salts, tartaric acid and salts thereof, tetraacetic acid and salts thereof. The aforementioned salts may be, for example, an alkali metal salt such as a sodium salt or a potassium salt, but are not limited thereto.

In one embodiment of the present invention, the surfactant in the contact lens maintenance solution of the present invention is selected from the group consisting of poloxamer, poloxamer derivatives, poloxamine, and poloxa A group consisting of a derivative of the formula, sodium citrate, and a cationic surfactant.

In one embodiment of the present invention, the amount of the chelating agent added to the contact lens maintenance solution of the present invention is from about 0.01 part by weight to 1.0 part by weight, preferably from 0.02 part by weight to 0.05 part by weight, per 100 parts by weight of the buffer solution. .

In one embodiment of the present invention, the amount of the surfactant added in the contact lens maintenance solution of the present invention is from about 0.1 part by weight to 1.0 part by weight, preferably from 0.6 part by weight to 0.7% by weight based on 100 parts by weight of the buffer solution. Share.

In an embodiment of the present invention, the contact lens maintenance solution of the present invention further comprises an antibacterial agent, an antioxidant, a thickener, a tonicity adjuster, a lubricant or a combination thereof.

In an embodiment of the present invention, the antibacterial agent in the contact lens maintenance solution of the present invention is selected from the group consisting of polyhexamethylene biguanide (PHMB), water-soluble salt of polyhexamethylene biguanide, and polyaminopropyl biguanide (PAPB). ), a water-soluble salt of polyaminopropyl biguanide, Protamine sulfate or Melitin.

In one embodiment of the present invention, the antibacterial agent is added in the contact lens maintenance solution of the present invention in an amount of about 0.0001 part by weight to 0.1 part by weight, preferably 0.0001 part by weight to 0.03 part by weight, per 100 parts by weight of the buffer solution. .

In an embodiment of the present invention, the antioxidant in the contact lens maintenance solution of the present invention is selected from the group consisting of sulfite, ascorbate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and shrimp. A group of erythropoietin and vitamin C.

In one embodiment of the present invention, the antioxidant is added in the contact lens maintenance solution of the present invention in an amount of about 0.001 part by weight to 0.1 part by weight based on 100 parts by weight of the buffer solution.

The above and other objects, features, and advantages of the present invention will become more apparent and understood.

In one aspect of the invention, the invention provides a maintenance fluid for a contact lens comprising a buffer, a chelating agent, a surfactant, and a humectant, the humectant comprising a polymerization with ethylene acetamide And alginic acid and glycerin, wherein the humectant comprises 100 parts by weight of glycerin, 0.5 to 40 parts by weight of a polymer containing ethylene acetamide, and 5 to 40 parts by weight of alginic acid.

The contact lens maintenance liquid with cleaning function provided by the invention can provide biocompatibility and low cytotoxicity, and reduce eye allergy or redness due to the addition of a humectant of ethylene glycol amine polymer, alginic acid and glycerin. Phenomenon, and good wettability after contact lens cleaning to improve dry eyes and soreness caused by long-term wear.

The humectant for the contact lens maintenance liquid of the present invention needs to contain a specific amount of a polymer having ethylene acetamide, alginic acid and glycerin, on the one hand, having good biocompatibility and low cytotoxicity and promoting humectant Adsorption on contact lenses, on the other hand, due to the low amount of glycerin added, it can prevent the moisturizing layer formed by the moisturizer in the eyeball and the lens from excessively adsorbing water molecules on the surface of the eyeball, thereby affecting the secretion of lacrimal gland.

The amount of the humectant for the contact lens maintenance liquid of the present invention is from about 0.01 part by weight to 0.20 part by weight based on 100 parts by weight of the buffer. It is preferably from about 0.04 parts by weight to 0.14 parts by weight.

The ethylene acetamide polymer used in the humectant for the contact lens maintenance liquid of the present invention may be a vinyl acetamide homopolymer or a vinyl acetamide copolymer. The ethylene acetamide homopolymer is polymerized from a vinyl acetamide monomer, and may be, for example, a product of the GE-191 series of SHOWA DENKO of Japan, and its product model is as follows: GE-191-053, GE-191-103 , GE-191-104GE-191-107 or GE-191-108, but not limited to this. The ethylene acetamide copolymer is obtained by polymerizing a vinyl acetamide monomer and another monomer having a crosslinkable functional group, and the other monomer having a crosslinkable functional group may be, for example, sodium acrylate. This ethylene acetamide copolymer is, for example, a product of GE-167 of Japan SHOWA DENKO. In order to make the humectant evenly adsorbed on the contact lens, the viscosity of the polymer containing ethylene acetamide is between 100 mPa. s to 20,000mPa. Between s, preferably between 100mPa. s to 3,000mPa. Between s. The humectant of the contact lens maintenance liquid of the present invention preferably contains 1 to 35 parts by weight of 100 parts by weight of glycerin. A polymer of ethylene acetamide.

The algal acid suitable for use in the humectant of the contact lens maintenance liquid of the present invention has a weight average molecular weight ranging from 1,000 to 30,000, preferably from 5,000 to 20,000. When the average molecular weight of alginic acid is greater than or less than the foregoing range, the cleaning ability of the contact lens maintenance solution for proteins or lipids is lowered. The humectant of the contact lens maintenance liquid of the present invention preferably contains 10 to 35 parts by weight of alginic acid in 100 parts by weight of glycerin.

Furthermore, in the contact lens maintenance solution of the present invention, the humectant may further comprise hyaluronic acid.

The hyaluronic acid suitable for use in the humectant of the contact lens maintenance liquid of the present invention has a weight average molecular weight ranging from 100,000 to 8,000,000, preferably from 100,000 to 1,300,000. When the average molecular weight of hyaluronic acid is greater than or less than the foregoing range, the cleaning ability of the contact lens maintenance solution is also lowered. Further, 20 to 70 parts by weight of hyaluronic acid may be further added to the humectant, preferably 20 to 67 parts by weight of hyaluronic acid.

In the moisturizing agent for the invisible eye care solution proposed by the present invention, the components forming the moisturizing agent may be added to the buffer after mixing or may be separately added to the buffer.

The buffer of the contact lens maintenance solution of the present invention is used to control the pH of the contact lens maintenance solution within a preferred range, for example, within an acceptable range of 6 to 8. Since the contact lens maintenance solution is adsorbed on the contact lens, the closer the pH value of the contact lens maintenance solution is to the pH value of the body tissue fluid 7.4, the eye comfort is improved. In one embodiment of the invention, the buffer in the contact lens maintenance fluid consists of water, sodium chloride, boric acid, and borate.

The buffer used in the contact lens maintenance solution can be used as long as it is compatible with a physiologically compatible buffer, for example, a group consisting of borate, phosphate, citrate, boric acid, carbonate, and acetate. The aforementioned salts may be, for example, an alkali metal salt such as sodium. Salt or potassium salt. The concentration of the salt in the buffer is generally between 0.001% and 5% by weight.

The chelating agent for the contact lens maintenance solution of the present invention is selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, polyphosphates and salts thereof, succinic acid and salts thereof, and tartaric acid. And a group of its salts, tetraacetic acid and its salts. The aforementioned salts may be, for example, an alkali metal salt such as a sodium salt or a potassium salt. The amount of the chelating agent added is from about 0.01 part by weight to 1.0 part by weight, preferably from about 0.02 part by weight to 0.05 part by weight, per 100 parts by weight of the buffer.

In one embodiment of the invention, the chelating agent in the contact lens maintenance solution uses disodium edetate.

The surfactant of the contact lens maintenance solution of the present invention may be selected from poloxamer, poloxamer derivatives, poloxamine, poloxamer derivatives, sodium citrate and A group consisting of cationic surfactants. The poloxamer may be, for example but not limited to, Poloxamer 407, Pluronic® L35, L43, L44, L62, L62D, L62LF, L64, L92, F108, F123, F88, F98, F68, F68LF, F127, F87, F77, P84, P85, P75, P103, P104 or P105. A derivative of poloxamer means a poloxamer having a functional group modification. The poloxamine can be, for example but not limited to, Tetronic® 707, 1107, 1307, 908 or 1304, and the poloxamine derivative means a poloxaamine having a functional group modification. The amount of the surfactant added is from about 0.1 part by weight to 1.0 part by weight, preferably from 0.6 part by weight to 0.7 part by weight, per 100 parts by weight of the buffer.

In one embodiment of the invention, the surfactant in the contact lens maintenance fluid uses poloxamer and sodium citrate.

Moreover, the contact lens maintenance solution of the present invention further comprises an antibacterial agent and an antioxidant. a chemical, a thickener, a tonicity modifier, a lubricant, or a combination thereof.

Suitable antibacterial agents are, for example, polyhexamethylene biguanide (PHMB), water-soluble salts of polyhexamethylene biguanide, polyaminopropyl biguanide (PAPB), water-soluble salts of polyaminopropyl, protamine sulfate Or melittin. The antibacterial agent proposed by the present invention is added in an amount of about 0.0001 to 0.1 part by weight, preferably about 0.0001 to 0.03 part by weight, per 100 parts by weight of the buffer.

Suitable antioxidants are, for example, the group consisting of sulfites, ascorbates, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), astaxanthin and vitamin C. The antioxidant proposed in the present invention is added in an amount of about 0.001 part by weight to 0.1 part by weight based on 100 parts by weight of the buffer.

Suitable tonicity adjusting agents can be, for example, sodium chloride, potassium chloride or mannitol.

The following examples are intended to further illustrate the invention, but the invention is not limited thereto.

[Method for preparing contact lens maintenance solution]

For detailed components of the contact lens maintenance liquids of Preparation Examples 1-8, please refer to Table 1.

Example 1

40 parts by weight of water was heated to 50 ° C, followed by the addition of 0.001 parts by weight of a vinyl acetamide polymer (trade name: adHERO GE167, available from SHOWA DENKO, Japan) polymerized with ethylene acetamide and sodium acrylate. 0.1 parts by weight of glycerin, 0.01 parts by weight of alginic acid (CAS No 9005-38-3, average molecular weight 222, available from Spectrum Chemical MFG CORP, US), and 0.02 parts by weight of disodium edetate, uniformly Stir until completely dissolved.

Next, after cooling the solution to room temperature, 0.6 parts by weight of sodium chloride, 0.05 parts by weight of sodium borate, 0.59 parts by weight of boric acid, and 0.6 parts by weight of lemon were added. Sodium, 0.1 parts by weight of poloxamer (trade name poloxamer 407, CAS No. 9003-11-6, available from Sigma Aldrich, USA), followed by the addition of 60 parts by weight of water, with uniform stirring until complete dissolution.

Further, 0.0001 part by weight of polyhexamethylene biguanide (PHMB, trade name COSMOCIL CQ, CAS No. 32289-58-0, available from LONZA, Switzerland) was added to the above solution, and uniformly stirred until completely dissolved.

Finally, the solution in which the antibacterial agent has been added is aseptically filtered and then stored in a package to complete the preparation of the contact lens maintenance solution.

Example 2

The preparation method of Example 2 was the same as that of Example 1, except that the amount of glycerin added and the amount of poloxamer added were different.

Example 3

40 parts by weight of water was heated to 50 ° C, followed by the addition of 0.001 parts by weight of ethylene acetamide copolymer (trade name: adHERO GE167, available from SHOWA DENKO, Japan) polymerized with ethylene acetamide and sodium acrylate, 0.1 weight Parts of glycerin, 0.01 parts by weight of alginic acid (CAS No. 9005-38-3, average molecular weight 222, available from Spectrum Chemical MFG CORP, US), 0.02 parts by weight of hyaluronic acid (CAS No. 9067-32-7, The average molecular weight was 325,000, available from Carbomer, Inc., US) and 0.02 parts by weight of disodium edetate, uniformly stirred until completely dissolved.

Next, after cooling the solution to room temperature, 0.6 parts by weight of sodium chloride, 0.05 parts by weight of sodium borate, 0.59 parts by weight of boric acid, 0.6 parts by weight of sodium citrate, and 0.1 parts by weight of poloxamer were added. (trade name: poloxamer 407, CAS No. 9003-11-6, available from Sigma Aldrich, USA), and finally 60 parts by weight of water was added and uniformly stirred until completely dissolved.

Further, 0.0001 part by weight of polyhexamethylene biguanide (PHMB, trade name COSMOCIL CQ, CAS No. 32289-58-0, available from LONZA, Switzerland) was added to the above solution, and uniformly stirred until completely dissolved.

Example 4

The preparation method of Example 4 was the same as that of Example 3, except that the amount of glycerin, poloxamer, and the polymer containing ethylene acetamide added was different.

Example 5

The preparation method of Example 5 was the same as that of Example 3, except that the amounts of glycerin, poloxamer, and hyaluronic acid added were different.

Example 6

The preparation method of Example 6 was the same as that of Example 5, except that the antibacterial agent of Example 6 was protamine, which was purchased from Sigma Aldrich Co., USA (CAS No. 53594-25-4) and ethylenediamine used. The amount of disodium tetraacetate added is different.

Example 7

The preparation method of Example 7 was the same as that of Example 5, except that the antibacterial agent used in Example 7 was a melittin which was purchased from Sigma Aldrich Co., Ltd. (CAS No. 20449-79-0) and the used E2. The amount of disodium edetate added is different.

Example 8

40 parts by weight of water was heated to 50 ° C, followed by the addition of 0.001 parts by weight of a vinyl acetamide polymer (trade name: adHERO GE167, available from SHOWA DENKO, Japan) polymerized with ethylene acetamide and sodium acrylate. 0.03 parts by weight of glycerin, 0.01 parts by weight of alginic acid (CAS No. 9005-38-3, average molecular weight 222, available from Spectrum Chemical MFG CORP, US), 0.01 parts by weight of hyaluronic acid (CAS No. 9067-32- 7, an average molecular weight of 325,000, available from Carbomer, Inc., US) and 0.05 parts by weight of disodium edetate, Stir well until completely dissolved.

Next, after cooling the solution to room temperature, 0.6 parts by weight of sodium chloride, 0.05 parts by weight of sodium borate, 0.59 parts by weight of boric acid, 0.6 parts by weight of sodium citrate, and 0.01 parts by weight of poloxamer are added. (trade name: poloxamer 407, CAS No. 9003-11-6, available from Sigma Aldrich, USA) and 0.001 parts by weight of astaxanthin (purchased from Mosch Industrial Co., Ltd., Taiwan), and finally added 60 parts by weight of water. Stir well until completely dissolved.

Further, 0.0001 part by weight of polyhexamethylene biguanide (PHMB, trade name COSMOCIL CQ, CAS No. 32289-58-0, available from LONZA, Switzerland) was added to the above solution, and uniformly stirred until completely dissolved. .

Next, the contact lens maintenance liquid prepared in Examples 1-8 was subjected to the characteristic evaluation and the bactericidal efficacy test according to the following methods. For the evaluation results, please refer to Table 2 and Table 3.

[contact angle test]

Commercially available hydrophobic plastic lenses (trade name Oasys, purchased from Taiwan Jiaosheng Co., Ltd.) and commercially available water gel lenses (trade name TICON55, purchased from Taiwan Essence Optical Co., Ltd.) were respectively immersed in Examples 1 to 1 In the prepared contact lens maintenance solution, the soaking time was 24 hours, and then the lens was taken out for the contact angle test.

[Test method for protein removal rate]

The commercially available hydrophobic plastic lens (trade name Oasys, purchased from Taiwan Jiaosheng Co., Ltd.) and the commercially available water plastic lens (trade name TICON55, purchased from Taiwan Essence Optical Co., Ltd.) were respectively immersed in 3 ml of lysozyme. The polypropylene sample tube of the solution was sealed with a polypropylene protective cap and incubated for 12 hours in a 37 ° C constant temperature oven. Then, the lens was taken out, and the lysozyme solution on the surface of the lens was adsorbed by a paper towel, and the solution in the sample tube was used for the lysozyme content experiment, and the measured lysozyme was measured as W1. The removed lens is then immersed in a lens extraction solution with 2 ml (acetonitrile volume: trifluoroacetic acid volume: water volume = 100:0.2:100) in a polypropylene sample tube, and shake the sample tube with a rotary shaker (Red Rotor) at 37 ° C for 24 hours, finally take out the lens, and perform a lysozyme content measurement experiment on the extraction solution. The measured lysozyme measurement was W2. The protein removal rate is calculated as [W1/(W1+W2)]*100%.

[Test method for delipidation rate]

The commercially available hydrophobic gel lens (trade name Oasys, purchased from Taiwan Jiaosheng Co., Ltd.) and commercially available water gel lens (trade name TICON55, purchased from Taiwan Essence Optics Co., Ltd.) were respectively immersed in a 3 ml cholesterol solution. The polypropylene sample tube was sealed with a polypropylene protective cap and incubated for 12 hours in a 37 ° C constant temperature oven. The lens is then removed, the cholesterol solution on the surface of the lens is adsorbed by a paper towel, and the solution in the sample tube is used for the cholesterol content test, and the measured cholesterol value is P1. The removed lens was then immersed in a polypropylene sample tube with 2 ml of lens extraction solution (chloroform volume: methanol volume = 2:1), and the sample tube was shaken at 37 ° C with a rotary shaker (Red Rotor). After 24 hours, the lens was finally taken out, and the extraction solution was subjected to a cholesterol content measurement experiment. At this time, the measured cholesterol value was P2. The lipid removal rate was calculated as [P1/(P1+P2)]*100%.

[Bactericidal efficacy test]

Commercially available hydrophobic plastic lenses (trade name Oasys, purchased from Taiwan Jiaosheng Co., Ltd.) and commercially available water plastic lenses (trade name TICON55, purchased from Taiwan Essence Optical Co., Ltd.) according to International Standards for Ophthalmic Optics ISO 14729 (International Standards) For Ophthalmic Optics) For bactericidal efficacy testing, the test time is divided into 6 hours and 24 hours. "○" means that the test results conform to the ISO standard, and "X" means that the test results are not up to the ISO standard.

From the results of the characteristic data of Table 2, it is known that the hydrophobic gel lens is soaked by the contact lens maintenance solution of Examples 1 to 8 of the present invention, and the contact angle is 10.1 to 15.1 °, and the protein The cleaning rate was 55% to 63.2%, and the lipid cleaning rate was 45.9% to 60.1%.

When the hydrocolloid lens is immersed in the contact lens maintenance liquid of Examples 1 to 8 of the present invention, the contact angle is 10.5° to 11.8°, the protein cleaning rate is 47.7% to 56.0%, and the lipid cleaning rate is 44.9% to 58.5%. . Therefore, the contact lens maintenance solution proposed by the present invention can maintain the contact angle of 15.8° or less regardless of the cleaning and maintenance of the water-repellent lens or the water-based lens. Therefore, the surface of the lens has a good moisturizing effect, and then The protein cleaning rate and lipid cleaning rate are all about 45%.

From the antibacterial efficacy test of Table 3, it is understood that the contact lens maintenance solutions of Examples 1 to 8 can comply with the ISO sterilization standard for Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa.

While the present invention has been described in its preferred embodiments, the present invention is not intended to limit the invention, and the present invention may be modified and modified without departing from the spirit and scope of the invention. The scope of protection is subject to the definition of the scope of the patent application.

Claims (12)

A maintenance fluid for a contact lens comprising: a buffer; a chelating agent; a surfactant; and a humectant comprising 100 parts by weight of glycerin and 0.5 to 40 parts by weight of a polymer containing ethylene acetamide And 5 to 40 parts by weight of alginic acid. The maintenance liquid for contact lenses according to the above aspect of the invention, wherein the humectant is added in an amount of from 0.01 to 0.2 parts by weight based on 100 parts by weight of the buffer. The maintenance solution for contact lenses according to claim 1, wherein the humectant further comprises hyaluronic acid. The maintenance solution for contact lenses according to claim 3, wherein the humectant further comprises 20 to 70 parts by weight of hyaluronic acid. The maintenance solution for a contact lens according to any one of claims 1 to 4, wherein each component in the humectant formed may be added to the buffer after mixing or may be separately added to In the buffer. The maintenance solution for contact lenses according to claim 1, wherein the chelating agent is selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, polyphosphates and salts thereof, and succinic acid ( Succinic acid) and its salt, tartaric acid and its salts, tetraacetic acid and its salts. For contact lens maintenance fluid as described in claim 1 of the patent application, Wherein the surfactant is selected from the group consisting of sodium citrate, poloxamer, poloxamer derivatives, poloxamine, poloxamer derivatives, and cationic surfactants. Group. The maintenance liquid for contact lenses according to the above aspect of the invention, wherein the chelating agent is added in an amount of 0.01 to 1.0 part by weight based on 100 parts by weight of the buffer. The maintenance liquid for contact lenses according to claim 1, wherein the surfactant is added in an amount of 0.1 to 1.0 part by weight based on 100 parts by weight of the buffer. The maintenance fluid for contact lenses according to claim 1, which further comprises an antibacterial agent, an antioxidant, a thickener, a tonicity modifier, a lubricant or a combination thereof. The maintenance liquid for contact lenses according to claim 10, wherein the antibacterial agent is selected from the group consisting of polyhexamethylene biguanide, water-soluble salt of polyhexamethylene biguanide, polyaminopropyl biguanide, polyamine a water-soluble salt of propyl biguanide, protamine sulfate or melittin. The maintenance solution for contact lenses according to claim 10, wherein the antioxidant is selected from the group consisting of sulfite, ascorbate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT). , astaxanthin, vitamin C or a combination thereof.