TWI798498B - Solution with high antimicrobial ability and lubricating effect - Google Patents
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本發明係關於一種具有高效抗微生物能力與潤滑效果的溶液,尤其指一種具有1ppm/3ppm/10ppm濃度之抗微生物成分,且於接觸目標的至少300秒/60秒/10秒時,可殺除大於90%微生物的一種具有高效抗微生物能力與潤滑效果的溶液。 The present invention relates to a solution with high anti-microbial ability and lubricating effect, especially an anti-microbial component with a concentration of 1ppm/3ppm/10ppm, which can kill the target at least 300 seconds/60 seconds/10 seconds A solution with high antimicrobial ability and lubricating effect with more than 90% microorganisms.
在隱形眼鏡的市場中,如何有效地消毒鏡片以及保持鏡片的潤滑度為兩大重要的議題。過去於隱形眼鏡溶液中所添加的潤滑成分主要是使用多元醇、糖胺聚糖、纖維素混合醚、羥甲纖維素鈉、羧甲基纖維素(carboxymethyl cellulose,CMC)、羥丙基甲基纖維素(hydroxypropyl methylcellulose,HPMC)、聚乙烯吡咯烷酮(polyvinylpyrrolidone,PVP)、聚乙二醇(polyethylene glycol,PEG)、丙二醇、甘油、玻尿酸、乳酸乙酯或油性物質等。當潤滑成分單獨存在時,因缺乏抗微生物的成分,使其較容易受微生物汙染,而可能導致使用者的眼部遭感染。然而,有多數的潤滑成分難以與殺菌成分相容,當同時混合潤滑成分與殺菌成分時,常見的問題為殺菌成分受潤滑成分的干擾,導致殺菌功效下降。 In the contact lens market, how to effectively disinfect the lens and maintain the lubricity of the lens are two important issues. In the past, the lubricating ingredients added to contact lens solutions mainly used polyols, glycosaminoglycans, cellulose mixed ethers, sodium hydroxymethylcellulose, carboxymethylcellulose (CMC), hydroxypropylmethylcellulose, etc. Cellulose (hydroxypropyl methylcellulose, HPMC), polyvinylpyrrolidone (polyvinylpyrrolidone, PVP), polyethylene glycol (polyethylene glycol, PEG), propylene glycol, glycerin, hyaluronic acid, ethyl lactate or oily substances, etc. When the lubricating component exists alone, due to the lack of anti-microbial components, it is more likely to be contaminated by microorganisms, which may cause eye infections of users. However, most of the lubricating ingredients are difficult to be compatible with the bactericidal ingredients. When the lubricating ingredients and the bactericidal ingredients are mixed at the same time, the common problem is that the bactericidal ingredients are interfered by the lubricating ingredients, resulting in a decrease in the bactericidal efficacy.
再者,使用者除了重視隱形眼鏡的消毒程度之外,亦重視安全性與抗微生物的效率。其中一種隱形眼鏡的消毒液,其抗微生物成分為苯扎氯銨(benzalkonium chloride,BAC)。苯扎氯銨雖具有抗微生物效果,卻有毒性與刺激性,若使用者長期使用將易引起角膜損傷與病變。其中一種隱形眼鏡的消毒液,其抗微生物成分為聚六亞甲基雙胍(polyhexamethylene biguanide,PHMB)。聚六亞甲基雙胍的毒性低,然而若欲滿足在短時間內有足夠的殺除微生物之效果,則其濃度至少需要500ppm,且有易殘留的問題。其中一種隱形眼鏡的消毒液,其抗微生物成分為過氧化氫,此種消毒液在抗微生物的過程中,需耗費4-8小時才可透過鉑將過氧化氫完全轉化成氧氣與水,以避免未轉化的過氧化氫對人體眼部產生刺激。其他隱形眼鏡的消毒液之種類如聚維酮碘(povidone-iodine,PVP-I)、氯己定,所述二者的濃度至少需要達250、1000ppm,才具有足夠的殺除微生物之能力,然而抗微生物成分的濃度若無法有效地降低,則可能對使用者造成不良影響。 Furthermore, in addition to the degree of disinfection of contact lenses, users also attach importance to safety and antimicrobial efficiency. One of the disinfectants for contact lenses has an antimicrobial component of benzalkonium chloride (BAC). Although benzalkonium chloride has an antimicrobial effect, it is toxic and irritating. If the user uses it for a long time, it will easily cause corneal damage and pathological changes. One of the disinfectants for contact lenses has an antimicrobial component of polyhexamethylene biguanide (PHMB). The toxicity of polyhexamethylene biguanide is low. However, if it is desired to have a sufficient effect of killing microorganisms in a short period of time, its concentration needs to be at least 500 ppm, and there is a problem of easy residue. One of the disinfectants for contact lenses has an antimicrobial component of hydrogen peroxide. During the antimicrobial process, it takes 4-8 hours for this disinfectant to completely convert hydrogen peroxide into oxygen and water through platinum. Avoid unconverted hydrogen peroxide irritating to human eyes. Other types of disinfectant for contact lenses such as povidone-iodine (PVP-I) and chlorhexidine, the concentration of the two needs to be at least 250, 1000ppm to have sufficient ability to kill microorganisms. However, if the concentration of antimicrobial ingredients cannot be effectively reduced, it may cause adverse effects on users.
因此,為了克服習知技術的不足之處,透過抗微生物成分與潤滑成分的特定比例組成,本發明實施例提供一種具有高效抗微生物能力與潤滑效果的溶液,且在溶液接觸目標後的至少一特定時間後,溶液可殺除大於90%的微生物。 Therefore, in order to overcome the deficiencies of the conventional technology, the embodiment of the present invention provides a solution with high antimicrobial ability and lubricating effect through the specific ratio of antimicrobial components and lubricating components, and at least one time after the solution contacts the target After a certain time, the solution can kill more than 90% of microorganisms.
基於前述目的的至少其中之一者,本發明提供之溶液具有高效抗微生物能力與潤滑效果。所述溶液包括抗微生物成分與潤滑成分,其中抗微生 物成分的濃度為1-3000ppm,且溶液的抗微生物能力為:於抗微生物成分的濃度為1ppm時,溶液在接觸目標的至少300秒時,可殺除大於90%的微生物;或者於抗微生物成分的濃度為3ppm時,溶液在接觸目標的至少60秒時,可殺除大於90%的微生物;或者於抗微生物成分的濃度為10ppm時,溶液在接觸目標的至少10秒時,可殺除大於90%的微生物。 Based on at least one of the aforementioned purposes, the solution provided by the present invention has high-efficiency antimicrobial ability and lubricating effect. The solution includes an antimicrobial component and a lubricating component, wherein the antimicrobial The concentration of the substance component is 1-3000ppm, and the antimicrobial ability of the solution is: when the concentration of the antimicrobial component is 1ppm, the solution can kill more than 90% of the microorganisms when it contacts the target for at least 300 seconds; When the concentration of the ingredient is 3ppm, the solution can kill more than 90% of the microorganisms when it contacts the target for at least 60 seconds; or when the concentration of the antimicrobial ingredient is 10ppm, the solution can kill when it contacts the target for at least 10 seconds More than 90% of microorganisms.
可選地,所述微生物為細菌、真菌或病毒。 Optionally, the microorganisms are bacteria, fungi or viruses.
可選地,所述潤滑成分的濃度為0.01-30毫克/毫升(mg/ml)。 Optionally, the lubricating component has a concentration of 0.01-30 mg/ml.
基於前述目的的至少其中之一者,本發明提供之溶液係由二氧化氯與潤滑成分組成,且具有高效抗微生物能力與潤滑效果,其中二氧化氯的濃度為1-3000ppm,以及潤滑成分的濃度為0.01-30毫克/毫升。 Based on at least one of the aforementioned purposes, the solution provided by the present invention is composed of chlorine dioxide and lubricating ingredients, and has high antimicrobial ability and lubricating effect, wherein the concentration of chlorine dioxide is 1-3000ppm, and the lubricating ingredients The concentration is 0.01-30 mg/ml.
可選地,所述潤滑成分包括多元醇、多元醇的鹽類、糖胺聚糖、糖胺聚糖的鹽類、纖維素混合醚以及纖維素混合醚之鹽類的至少其中一者。 Optionally, the lubricant component includes at least one of polyols, salts of polyols, glycosaminoglycans, salts of glycosaminoglycans, mixed cellulose ethers, and salts of mixed cellulose ethers.
可選地,在所述潤滑成分為多元醇與/或其鹽類的情況下,多元醇與/或其鹽類的濃度為0.4-30毫克/毫升;在所述潤滑成分為糖胺聚糖與/或其鹽類的情況下,糖胺聚糖以及其鹽類的濃度為0.01-5毫克/毫升;以及在所述潤滑成分為纖維素混合醚與/或其鹽類的情況下,纖維素混合醚以及其鹽類的濃度為0.24-10毫克/毫升。 Optionally, in the case where the lubricating component is a polyol and/or its salt, the concentration of the polyol and/or its salt is 0.4-30 mg/ml; when the lubricating component is a glycosaminoglycan and/or its salts, the concentration of glycosaminoglycan and its salts is 0.01-5 mg/ml; and when the lubricating component is cellulose mixed ether and/or its salts, fiber The concentration of plain mixed ethers and their salts is 0.24-10 mg/ml.
可選地,在所述潤滑成分為多元醇與/或其鹽類的情況下,多元醇與/或其鹽類的濃度為10-30毫克/毫升;在所述潤滑成分為糖胺聚糖與/或其鹽類的情況下,糖胺聚糖與/或其鹽類的濃度為0.05-5毫克/毫升;以及在所述潤滑 成分為纖維素混合醚與/或其鹽類的情況下,纖維素混合醚與/或其鹽類的濃度為1.2-10毫克/毫升。 Optionally, in the case where the lubricating component is a polyol and/or its salt, the concentration of the polyol and/or its salt is 10-30 mg/ml; when the lubricating component is a glycosaminoglycan and/or its salts, the concentration of glycosaminoglycan and/or its salts is 0.05-5 mg/ml; and in said lubricating When the component is cellulose mixed ether and/or its salts, the concentration of cellulose mixed ether and/or its salts is 1.2-10 mg/ml.
可選地,前述任一個溶液,其中多元醇為甘油、丙二醇、辛二醇、乙基己基甘油、己二醇、木糖醇、聚乙二醇、聚丙二醇或戊二醇。 Optionally, any one of the aforementioned solutions, wherein the polyhydric alcohol is glycerin, propylene glycol, caprylyl glycol, ethylhexylglycerin, hexanediol, xylitol, polyethylene glycol, polypropylene glycol or pentanediol.
可選地,前述任一個溶液,其中糖胺聚糖為透明質酸(Hyaluronic Acid,HA)、硫酸軟骨素(Chondroitin Sulfate,CS)、硫酸皮膚素(Dermatan Sulfate,DS)、硫酸角質素(Keratan sulfate,KS)、硫酸乙醯肝素(Heparan sulfate,HS)或肝素(Heparin,HP)。 Optionally, any of the aforementioned solutions, wherein the glycosaminoglycan is hyaluronic acid (Hyaluronic Acid, HA), chondroitin sulfate (Chondroitin Sulfate, CS), dermatan sulfate (Dermatan Sulfate, DS), keratan sulfate (Keratan sulfate, KS), heparan sulfate (Heparan sulfate, HS) or heparin (Heparin, HP).
可選地,前述任一個溶液,其中纖維素混合醚為甲基纖維素、羥丙基甲基纖維素、羥乙基甲基纖維素、羧甲基纖維素或羥乙基纖維素。 Optionally, any one of the aforementioned solutions, wherein the cellulose mixed ether is methylcellulose, hydroxypropylmethylcellulose, hydroxyethylmethylcellulose, carboxymethylcellulose or hydroxyethylcellulose.
簡言之,本發明實施例提供的溶液同時具有高效抗微生物能力與潤滑效果。所述溶液的抗微生物成分之濃度低,故當用於生醫材料(例如,隱形眼鏡)時,對使用者的傷害程度亦十分低。再者,溶液可在短時間內殺除90%以上的微生物,具有抗微生物效率高的優點。所述溶液之雙效合一的效果對有需求之各種市場(例如隱形眼鏡的保養液、無菌機台的潤滑液等)具有優勢。 In short, the solution provided by the embodiment of the present invention has both high-efficiency antimicrobial ability and lubricating effect. The solution has a low concentration of antimicrobial components, so when used in biomedical materials (eg, contact lenses), the degree of harm to the user is also very low. Furthermore, the solution can kill more than 90% of microorganisms in a short time, and has the advantage of high antimicrobial efficiency. The combined effect of the solution has advantages for various markets in need (such as maintenance solution for contact lenses, lubricating solution for sterile machines, etc.).
為讓本發明之上述和其他目的、特徵及優點能更明顯易懂,配合所附圖示,做詳細說明如下。 In order to make the above and other objects, features and advantages of the present invention more comprehensible, a detailed description is given below with reference to the accompanying drawings.
圖1是本發明實施例6之丙二醇濃度與摩擦係數關係圖。 Figure 1 is a graph showing the relationship between the concentration of propylene glycol and the coefficient of friction in Example 6 of the present invention.
圖2是本發明實施例7之甘油濃度與摩擦係數關係圖。 Figure 2 is a graph showing the relationship between glycerin concentration and friction coefficient in Example 7 of the present invention.
圖3是本發明實施例8之玻尿酸濃度與摩擦係數關係圖。 Fig. 3 is a graph showing the relationship between hyaluronic acid concentration and friction coefficient in Example 8 of the present invention.
圖4是本發明實施例9之羥丙基甲基纖維素濃度與摩擦係數關係圖。 Figure 4 is a graph showing the relationship between the concentration of hydroxypropyl methylcellulose and the coefficient of friction in Example 9 of the present invention.
為充分瞭解本發明之目的、特徵及功效,茲藉由下述具體之實施例,並配合所附之圖式,對本發明做一詳細說明,說明如後。 In order to fully understand the purpose, features and effects of the present invention, the present invention will be described in detail through the following specific embodiments and accompanying drawings, as follows.
本發明實施例提供一種具有高效抗微生物能力與潤滑效果的溶液,其包括抗微生物成分以及潤滑成分。所述溶液的抗微生物成分選自二氧化氯,當抗微生物成分的濃度為1ppm時,溶液在接觸目標的300秒後可殺除90%以上的微生物;或者當抗微生物成分的濃度為3ppm時,溶液在接觸目標的60秒後可殺除90%以上的微生物;或者當抗微生物成分的濃度為10ppm時,溶液在接觸目標的10秒後可殺除90%以上的微生物。在此請注意,雖然上述抗微生物成分選自二氧化氯,但本發明不限制抗微生物成分,其他具上述抗微生物能力的抗微生物成分亦可以使用。 An embodiment of the present invention provides a solution with high antimicrobial ability and lubricating effect, which includes an antimicrobial component and a lubricating component. The antimicrobial component of the solution is selected from chlorine dioxide, when the concentration of the antimicrobial component is 1ppm, the solution can kill more than 90% of microorganisms after contacting the target for 300 seconds; or when the concentration of the antimicrobial component is 3ppm , the solution can kill more than 90% of microorganisms after 60 seconds of contact with the target; or when the concentration of antimicrobial ingredients is 10ppm, the solution can kill more than 90% of microorganisms after 10 seconds of contact with the target. Please note here that although the above-mentioned antimicrobial ingredients are selected from chlorine dioxide, the present invention is not limited to the antimicrobial ingredients, and other antimicrobial ingredients with the above-mentioned antimicrobial ability can also be used.
本發明所述溶液的抗微生物成分「二氧化氯」具有強氧化劑的特性,其用於對抗微生物的原理是使微生物的胺基酸斷鍵並失去活性,以使微生物最終因無法代謝而死亡。二氧化氯被世界衛生組織(WHO)列為A1級安全高效的消毒劑,即使少量誤食也不易對人體產生危害。再者,二氧化氯具有遇光分解的特性,即,當二氧化氯照光之後,會隨時間自行分解為對人體無危害之氧氣與氯離子,因此,可隨著使用時間愈長,使危害程度愈低。二氧化氯的分解情形請參照表1。表1為1ppm之二氧化氯水溶液於氙燈照射下的濃度趨勢表。 氙燈係用於模擬太陽光的照射情形,其中氙燈的型號為UHAO所供售的YS03。二氧化氯濃度之檢測儀器的型號為Photometer所供售的DT1B。如表1所示,當二氧化氯水溶液隨著氙燈照射時間愈長,所偵測到的二氧化氯濃度愈低,且當二氧化氯水溶液在氙燈照射120分鐘後,二氧化氯的濃度可降至檢測儀器的最低偵測極限之濃度(低於0.02ppm)。 The antimicrobial component "chlorine dioxide" in the solution of the present invention has the characteristics of a strong oxidizing agent. The principle of its use against microorganisms is to break the amino acid bonds of microorganisms and lose their activity, so that the microorganisms will eventually die due to inability to metabolize. Chlorine dioxide is listed by the World Health Organization (WHO) as an A1-level safe and efficient disinfectant, and it is not easy to cause harm to the human body even if a small amount is accidentally ingested. Furthermore, chlorine dioxide has the characteristic of decomposing when exposed to light, that is, when chlorine dioxide is exposed to light, it will decompose into oxygen and chloride ions that are harmless to the human body over time. Therefore, the longer the use time, the harmful the lower the degree. Please refer to Table 1 for the decomposition of chlorine dioxide. Table 1 is the concentration trend table of 1 ppm chlorine dioxide aqueous solution under the irradiation of xenon lamp. The xenon lamp system is used to simulate the irradiation of sunlight, and the model of the xenon lamp is YS03 sold by UHAO. The model of the chlorine dioxide concentration detection instrument is DT1B sold by Photometer. As shown in Table 1 , when the chlorine dioxide aqueous solution is irradiated with the xenon lamp for a longer time, the detected chlorine dioxide concentration is lower, and when the chlorine dioxide aqueous solution is irradiated by the xenon lamp for 120 minutes, the concentration of chlorine dioxide can be Drop to the concentration of the lowest detection limit of the detection instrument (less than 0.02ppm).
再者,本發明將二氧化氯導入所述溶液的方法,係採用單步驟(One-step)系統,即直接將二氧化氯以錠劑、水溶液或其他形式加入所述溶液中。One-step系統的優點為便利性與安全性高,用以取代傳統二步驟(Two-step)系統(投入亞氯酸鈉與鹽酸反應以產生二氧化氯)可能產生的風險與危害(例如,產生鹵烷類、氯胺類與溴酸鹽類等致癌性的副產物)。二氧化氯在溶液中是以氣態存在,因此容易從溶液中逸散至空氣,傳統Two-step系統的優點為可降低二氧化氯因容易快速逸散至空氣所造成的高損失率,然而,由於本發明所述溶液可以在短時間內(例如,300秒)達成殺除微生物的效果,故可採用更方便且安全的One-step系統,而較無須擔心二氧化氯快速逸散的問題。 Furthermore, the method for introducing chlorine dioxide into the solution of the present invention adopts a one-step system, that is, directly adds chlorine dioxide into the solution in tablet, aqueous solution or other forms. The advantage of the One-step system is that it is convenient and safe, and it is used to replace the risks and hazards (for example, produce carcinogenic by-products such as haloalkanes, chloramines and bromates). Chlorine dioxide exists in a gaseous state in the solution, so it is easy to escape from the solution to the air. The advantage of the traditional Two-step system is that it can reduce the high loss rate caused by the easy and rapid escape of chlorine dioxide to the air. However, Since the solution of the present invention can achieve the effect of killing microorganisms in a short time (for example, 300 seconds), a more convenient and safe One-step system can be used, and there is no need to worry about the problem of rapid chlorine dioxide escape.
接著,將進一步透過實施例說明具有高效抗微生物能力與潤滑效果的溶液的條件及其效果。首先,請參照表2以知悉僅含有二氧化氯之溶液的殺除微生物之效果,表2是二氧化氯的濃度與其殺除微生物之時間的對應表。如表2所示,溶液中的抗微生物成分為二氧化氯,當二氧化氯的濃度為1-3000ppm時具有抗微生物的效果。實施例1與2皆使用濃度為1ppm的二氧化氯,並分別於600/300秒下以進行殺除微生物的試驗,以及實施例3-5是分別使用濃度為3/10/3000ppm的二氧化氯,並分別於60/10/10秒下以進行殺除微生物的試驗,其中微生物例如但不限制為細菌、真菌或病毒。於實施例1-5的結果可得知實施例1-5的條件皆可有效地殺除微生物。實施例1、2的比較結果顯示濃度為1ppm之二氧化氯溶液僅需花費300秒即具有合格的殺除微生物之效果,以及實施例4、5的結果顯示濃度為10ppm之二氧化氯溶液僅需花費10秒即具有合格的殺除微生物之效果,其中二氧化氯的添加濃度愈高則可在愈短的時間內殺除微生物,即二氧化氯的添加濃度與殺除微生物的效果成正比。於本發明實施例中,合格的殺除微生物效果被定義為可殺除大於90%的微生物。本發明實施例中,做為測試對象的微生物為細菌與真菌,另外,2ppm的二氧化氯可於120秒內殺除93.7%的病毒,其條件範圍落於較佳實施例2、4之間,故本發明所述之溶液可用於殺除細菌、真菌或病毒等微生物。
Next, the conditions and effects of the solution with high antimicrobial ability and lubricating effect will be further illustrated through examples. First, please refer to Table 2 to know the effect of killing microorganisms of a solution containing only chlorine dioxide. Table 2 is a correspondence table between the concentration of chlorine dioxide and the time for killing microorganisms. As shown in Table 2 , the antimicrobial component in the solution is chlorine dioxide, which has an antimicrobial effect when the concentration of chlorine dioxide is 1-3000ppm.
接著,請繼續參照以下實施例以知悉溶液同時包括抗微生物成分與潤滑成分時的條件與效果。本發明所述溶液的潤滑成分可以是多元醇、多元醇的鹽類、糖胺聚糖、糖胺聚糖的鹽類、纖維素混合醚或纖維素混合醚之鹽類,其中多元醇例如但不限制為甘油、丙二醇、辛二醇、乙基己基甘油、己二醇、木糖醇、聚乙二醇、聚丙二醇或戊二醇,糖胺聚糖例如但不限制為透明質酸(Hyaluronic Acid,HA)、硫酸軟骨素(Chondroitin Sulfate,CS)、硫酸皮膚素(Dermatan Sulfate,DS)、硫酸角質素(Keratan sulfate,KS)、硫酸乙醯肝素(Heparan sulfate,HS)或肝素(Heparin,HP),以及纖維素混合醚例如但不限制為甲基纖維素、羥丙基甲基纖維素、羥乙基甲基纖維素、羧甲基纖維素或羥乙基纖維素。 Next, please continue to refer to the following examples to know the conditions and effects when the solution includes both antimicrobial ingredients and lubricating ingredients. The lubricating component of the solution of the present invention can be polyol, salt of polyol, glycosaminoglycan, salt of glycosaminoglycan, cellulose mixed ether or salt of cellulose mixed ether, wherein polyhydric alcohol such as but Glycosaminoglycans such as but not limited to hyaluronic acid (Hyaluronic Acid, HA), Chondroitin Sulfate (CS), Dermatan Sulfate (DS), Keratan Sulfate (KS), Heparan Sulfate (HS) or Heparin (Heparin, HP), and cellulose mixed ethers such as but not limited to methylcellulose, hydroxypropylmethylcellulose, hydroxyethylmethylcellulose, carboxymethylcellulose or hydroxyethylcellulose.
表3是潤滑成分與二氧化氯相容性測試表,其中於實施例6中,係以多元醇作為潤滑成分並選用丙二醇,於實施例7中,係以多元醇作為潤滑成分並選用甘油,於實施例8中,係以糖胺聚糖作為潤滑成分並選用透明質酸(即,玻尿酸),以及於實施例9中,係以纖維素混合醚作為潤滑成分並選用羥丙基甲基纖維素。如表3所示,於實施例6-9中,在二氧化氯的濃度皆為1ppm的情況下,實施例6-9中的潤滑成分之濃度分別為丙二醇30毫克/毫升(mg/ml);甘油30毫克/毫升;玻尿酸5毫克/毫升;羥丙基甲基纖維素10毫克/毫升的條件下,實施例6-9的結果皆顯示具有合格的殺除微生物之效果。實施例6-9的結果顯示本發明提供的溶液,其抗微生物成分與潤滑成分之特定組合可保有抗微生物的效果,且僅需使用低濃度的抗微生物成分即可達到功效。
Table 3 is a lubricating component and chlorine dioxide compatibility test table, wherein in embodiment 6, polyhydric alcohol is used as lubricating component and propylene glycol is selected for use, and in embodiment 7, polyhydric alcohol is used as lubricating component and glycerin is selected for use, In Example 8, glycosaminoglycan was used as the lubricating component and hyaluronic acid (i.e., hyaluronic acid) was selected, and in Example 9, cellulose mixed ether was used as the lubricating component and hydroxypropyl methylcellulose was selected. white. As shown in Table 3 , in Examples 6-9, when the concentration of chlorine dioxide is 1ppm, the concentrations of the lubricating components in Examples 6-9 are respectively 30 mg/ml (mg/ml) of
當抗微生物成分與潤滑成分混合以形成溶液時,潤滑成分的濃度並非沒有限制。當潤滑成分被添加至一定濃度時,將使溶液的黏度快速上升,並將造成其摩擦係數(COF)上升。摩擦係數與兩個表面之間的摩擦力有關,當溶液的摩擦係數愈小,可使使用者在使用溶液時的舒適度愈高,即摩擦係數愈小愈好。相反的,當溶液的摩擦係數上升,將導致使用者在使用上的舒適度下降且不便利。實施例6-9亦測試各組溶液中,在所屬潤滑成分與其濃度條件的情況下,各組溶液之摩擦係數的變化,試驗中以Bruker供售的型號CETR UMT-2之摩擦力檢驗機進行測試,並以1ppm二氧化氯水溶液之摩擦係數為對照組,其中對照組的摩擦係數為0.0184。請參照圖1至圖4,圖1是本發明實施例6之丙二醇濃度與摩擦係數關係圖,圖2是本發明實施例7之甘油濃度與摩擦係數關係圖,圖3是本發明實施例8之玻尿酸濃度與摩擦係數關係圖,以及圖4是本發明實施例9之羥丙基甲基纖維素濃度與摩擦係數關係圖。請參照實施例6-9與圖1至圖4之結果以知悉不同條件的溶液其潤滑成分濃度與摩擦係數的關係以及其潤滑效果。 When the antimicrobial ingredient is mixed with the lubricating ingredient to form a solution, the concentration of the lubricating ingredient is not without limitation. When the lubricating component is added to a certain concentration, the viscosity of the solution will increase rapidly, which will cause its coefficient of friction (COF) to increase. The coefficient of friction is related to the friction force between two surfaces. The smaller the coefficient of friction of the solution, the higher the user's comfort when using the solution, that is, the smaller the coefficient of friction, the better. On the contrary, when the coefficient of friction of the solution increases, the user's comfort level in use will decrease and it will be inconvenient. Examples 6-9 also tested the changes in the coefficient of friction of each group of solutions under the condition of the lubricating components and their concentration conditions in each group of solutions. In the test, the friction testing machine of the model CETR UMT-2 sold by Bruker was used. Test, and take the friction coefficient of 1ppm chlorine dioxide aqueous solution as the control group, wherein the friction coefficient of the control group is 0.0184. Please refer to Fig. 1 to Fig. 4, Fig. 1 is the graph of the relationship between the concentration of propylene glycol and the coefficient of friction in Example 6 of the present invention, Fig. 2 is the graph of the relationship between the concentration of glycerol and the coefficient of friction in Embodiment 7 of the present invention, and Fig. 3 is the graph of the relationship between the concentration of glycerol and the coefficient of friction in Embodiment 8 of the present invention Figure 4 is a relationship diagram between hyaluronic acid concentration and friction coefficient in Example 9 of the present invention. Please refer to the results of Examples 6-9 and Figures 1 to 4 to know the relationship between the concentration of lubricating components and the coefficient of friction and the lubricating effect of solutions under different conditions.
實施例6之條件對照表3,其試驗結果如圖1所示,在抗微生物成分「二氧化氯」為1ppm的情況下,潤滑成分「丙二醇」其濃度介於0.4-30毫克/ 毫升時,溶液的摩擦係數皆小於對照組的摩擦係數0.0184,故於實施例6之條件下的結果顯示,溶液中的潤滑成分為多元醇與/或其鹽類時,濃度為0.4-30毫克/毫升之多元醇「丙二醇」可與二氧化氯形成具有抗微生物能力與潤滑效果的溶液。如圖1所示,隨著丙二醇的濃度由0.4毫克/毫升增加到20毫克/毫升時,溶液的摩擦係數達到最低值0.0019。當丙二醇的濃度往上增加時,溶液的摩擦係數轉而往上增加。實施例6中,當溶液中的潤滑成分之濃度介於0.4-30毫克/毫升,溶液具有好的潤滑效果,當潤滑成分之濃度介於10-30毫克/毫升,溶液具有較佳的潤滑效果。 The condition control table 3 of embodiment 6, its test result is as shown in Figure 1, under the situation that antimicrobial component " chlorine dioxide " is 1ppm, when its concentration of lubricating component " propylene glycol " is between 0.4-30 mg/ml, The friction coefficients of the solutions are all less than the friction coefficient 0.0184 of the control group, so the results under the conditions of Example 6 show that when the lubricating components in the solution are polyhydric alcohols and/or their salts, the concentration is 0.4-30 mg/ml. Polyol "propylene glycol" can form a solution with chlorine dioxide that has antimicrobial ability and lubricating effect. As shown in Figure 1, as the concentration of propylene glycol increased from 0.4 mg/ml to 20 mg/ml, the friction coefficient of the solution reached a minimum value of 0.0019. As the concentration of propylene glycol increases upwards, the coefficient of friction of the solution in turn increases upwards. In Example 6, when the concentration of the lubricating component in the solution is between 0.4-30 mg/ml, the solution has a good lubricating effect, and when the concentration of the lubricating component is between 10-30 mg/ml, the solution has a better lubricating effect .
實施例7之條件對照表3,其試驗結果如圖2所示,在抗微生物成分「二氧化氯」為1ppm的情況下,潤滑成分「甘油」其濃度介於0.4-30毫克/毫升時,溶液的摩擦係數皆小於對照組的摩擦係數0.0184,故於實施例7之條件下的結果顯示,溶液中的潤滑成分為多元醇與/或其鹽類時,濃度為0.4-30毫克/毫升之多元醇「甘油」可與二氧化氯形成具有抗微生物能力與潤滑效果的溶液。圖2結果顯示,隨著甘油的濃度由0.4毫克/毫升增加到25毫克/毫升時,溶液的摩擦係數達到最低值0.0037。當甘油的濃度往上增加時,溶液的摩擦係數轉而往上增加。實施例7中,當溶液中的潤滑成分之濃度介於0.4-30毫克/毫升,溶液具有好的潤滑效果,當潤滑成分之濃度介於10-30毫克/毫升,溶液具有較佳的潤滑效果。 The condition comparison table 3 of embodiment 7, its test result is as shown in Figure 2, under the situation of 1ppm in antimicrobial component " chlorine dioxide ", when its concentration of lubricating component " glycerin " is between 0.4-30 mg/ml, The friction coefficients of the solutions are all less than the friction coefficient of the control group 0.0184, so the results under the conditions of Example 7 show that when the lubricating components in the solution are polyhydric alcohols and/or their salts, the concentration is 0.4-30 mg/ml. Polyol "glycerin" can form a solution with chlorine dioxide which has antimicrobial ability and lubricating effect. The results in Figure 2 show that as the concentration of glycerol increases from 0.4 mg/ml to 25 mg/ml, the friction coefficient of the solution reaches the lowest value of 0.0037. As the concentration of glycerol increases upwards, the coefficient of friction of the solution in turn increases upwards. In Example 7, when the concentration of the lubricating component in the solution is between 0.4-30 mg/ml, the solution has a good lubricating effect, and when the concentration of the lubricating component is between 10-30 mg/ml, the solution has a better lubricating effect .
實施例8之條件對照表3,其試驗結果如圖3所示,在抗微生物成分「二氧化氯」為1ppm的情況下,潤滑成分「玻尿酸」其濃度介於0.01-5毫克/毫升時的摩擦係數皆小於對照組的摩擦係數0.0184,故於實施例8之條件下的結 果顯示,溶液中的潤滑成分為糖胺聚糖與/或其鹽類時,濃度為0.01-5毫克/毫升之糖胺聚糖「玻尿酸」可與二氧化氯形成具有抗微生物能力與潤滑效果的溶液。如圖3所示,隨著玻尿酸的濃度由0.01毫克/毫升增加到1毫克/毫升時,溶液的摩擦係數達到最低值0.0033。當玻尿酸的濃度往上增加時,溶液的摩擦係數轉而往上增加。實施例8中,當溶液中的潤滑成分之濃度介於0.01-5毫克/毫升,溶液具有好的潤滑效果,當潤滑成分之濃度介於0.05-5毫克/毫升,溶液具有較佳的潤滑效果。 The condition control table 3 of embodiment 8, its test result is as shown in Figure 3, under the situation that antimicrobial ingredient " chlorine dioxide " is 1ppm, the lubricating ingredient " hyaluronic acid " when its concentration is between 0.01-5 mg/ml The friction coefficients are all less than the friction coefficient of the control group 0.0184, so the results under the conditions of Example 8 show that when the lubricating components in the solution are glycosaminoglycans and/or their salts, the concentration is 0.01-5 mg/ml Glycosaminoglycan "hyaluronic acid" can form a solution with chlorine dioxide that has antimicrobial ability and lubricating effect. As shown in Figure 3, as the concentration of hyaluronic acid increased from 0.01 mg/ml to 1 mg/ml, the friction coefficient of the solution reached the lowest value of 0.0033. When the concentration of hyaluronic acid increases upwards, the friction coefficient of the solution increases upwards in turn. In Example 8, when the concentration of the lubricating component in the solution is between 0.01-5 mg/ml, the solution has a good lubricating effect, and when the concentration of the lubricating component is between 0.05-5 mg/ml, the solution has a better lubricating effect .
實施例9之條件對照表3,其試驗結果如圖4所示,在抗微生物成分「二氧化氯」為1ppm的情況下,潤滑成分「羥丙基甲基纖維素」其濃度介於0.24-10毫克/毫升時的摩擦係數皆小於對照組的摩擦係數0.0184,故於實施例9之條件下的結果顯示,溶液中的潤滑成分為纖維素混合醚與/或其鹽類時,濃度為0.24-10毫克/毫升之纖維素混合醚「羥丙基甲基纖維素」可與二氧化氯形成具有抗微生物能力與潤滑效果的溶液。如圖4所示,隨著羥丙基甲基纖維素的濃度由0.24毫克/毫升增加到5毫克/毫升時,溶液的摩擦係數達到最低值0.0020。當羥丙基甲基纖維素的濃度往上增加時,溶液的摩擦係數轉而往上增加。實施例9中,當溶液中的潤滑成分之濃度介於0.24-10毫克/毫升,溶液具有好的潤滑效果,當潤滑成分之濃度介於1.2-10毫克/毫升,溶液具有較佳的潤滑效果。 The condition control table 3 of embodiment 9, its test result is shown in Figure 4, under the situation that antimicrobial component " chlorine dioxide " is 1ppm, its concentration of lubricating component " hydroxypropyl methylcellulose " is between 0.24- The coefficients of friction at 10 mg/ml are all less than the coefficient of friction 0.0184 of the control group, so the results under the conditions of Example 9 show that when the lubricating component in the solution is cellulose mixed ether and/or its salts, the concentration is 0.24 -10 mg/ml of cellulose mixed ether "hydroxypropyl methylcellulose" can form a solution with chlorine dioxide that has antimicrobial ability and lubricating effect. As shown in Figure 4, as the concentration of hydroxypropyl methylcellulose increases from 0.24 mg/ml to 5 mg/ml, the friction coefficient of the solution reaches the lowest value of 0.0020. As the concentration of hydroxypropyl methylcellulose increases upwards, the coefficient of friction of the solution in turn increases upwards. In Example 9, when the concentration of the lubricating component in the solution is between 0.24-10 mg/ml, the solution has a good lubricating effect, and when the concentration of the lubricating component is between 1.2-10 mg/ml, the solution has a better lubricating effect .
由實施例6-9的結果得知,本發明提供的溶液同時具有抗微生物成分與潤滑成分,其中潤滑成分不限制為多元醇與/或其鹽類、糖胺聚糖與/或其鹽類或者是纖維素混合醚與/或其鹽類,以及本發明所述之溶液不限制其用途,例如可用於隱形眼鏡保養液或是無菌機台的潤滑溶液。於本發明實施例中,由 於不同類型的潤滑成分其分子大小不同,故分別有不同的合適之添加濃度。舉例而言,分子較小的潤滑成分如多元醇與/或其鹽類可具有較高的添加濃度,分子較大的潤滑成分如糖胺聚糖與/或其鹽類或者如纖維素混合醚與/或其鹽類則具有較低的添加濃度。 From the results of Examples 6-9, it is known that the solution provided by the present invention has both antimicrobial components and lubricating components, wherein the lubricating components are not limited to polyols and/or their salts, glycosaminoglycans and/or their salts Or cellulose mixed ether and/or its salts, and the solution described in the present invention does not limit its use, for example, it can be used as a contact lens maintenance solution or a lubricating solution for a sterile machine. In the embodiment of the present invention, by Different types of lubricating ingredients have different molecular sizes, so there are different appropriate addition concentrations. For example, lubricating ingredients with smaller molecules such as polyols and/or their salts can have a higher concentration, and lubricating ingredients with larger molecules such as glycosaminoglycans and/or their salts or mixed ethers such as cellulose And/or its salts have a lower concentration.
綜合以上所述,相較於習知技術,本發明實施例所述之具有高效抗微生物能力與潤滑效果的溶液之技術效果,係說明如下。 Based on the above, compared with the conventional technology, the technical effect of the solution with high antimicrobial ability and lubricating effect described in the embodiment of the present invention is explained as follows.
習知技術中,隱性眼鏡溶液的消毒成分與潤滑溶液難以結合使用,其原因為抗微生物成分與潤滑成分之間難以相容,兩者甚至會互相抵銷彼此的功效,導致抗微生物與潤滑效果打折。反觀本發明實施例所述之具有高效抗微生物能力與潤滑效果的溶液,可同時包括抗微生物成分與潤滑成分,且僅需低濃度的抗微生物成分即有效果,在多個產業(例如隱形眼鏡、機械用具)具有足夠的競爭性。 In the prior art, it is difficult to use the disinfecting components of the contact lens solution and the lubricating solution in combination because the antimicrobial components and the lubricating components are incompatible, and the two may even cancel each other's efficacy, resulting in antimicrobial and lubricating components. The effect is discounted. In contrast, the solution with high antimicrobial ability and lubricating effect described in the embodiments of the present invention can include antimicrobial components and lubricating components at the same time, and only a low concentration of antimicrobial components is required to be effective. In many industries (such as contact lenses) , mechanical appliances) are sufficiently competitive.
本發明在上文中已以較佳實施例揭露,然熟習本項技術者應理解的是,上述實施例僅用於描繪本發明,而不應解讀為限制本發明之範圍。應注意的是,舉凡與前述實施例等效之變化與置換,均應設為涵蓋於本發明之範疇內。 The present invention has been disclosed above with preferred embodiments, but those skilled in the art should understand that the above embodiments are only for describing the present invention and should not be interpreted as limiting the scope of the present invention. It should be noted that all changes and substitutions equivalent to those of the foregoing embodiments should be included within the scope of the present invention.
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CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
TWI602912B (en) * | 2016-04-19 | 2017-10-21 | 明基材料股份有限公司 | Contact lenses care solution |
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CN1794973A (en) * | 2003-03-27 | 2006-06-28 | 阿勒根公司 | Preserved ophthalmic compositions |
CN101669518A (en) * | 2009-09-30 | 2010-03-17 | 北京欧凯纳斯科技有限公司 | Germicidal antiviral composite containing chlorine dioxide |
TWI602912B (en) * | 2016-04-19 | 2017-10-21 | 明基材料股份有限公司 | Contact lenses care solution |
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