TWI587876B - Moisturizer composition with hyaluronic acid - Google Patents

Description

Hyaluronic acid moisturizing composition

The present invention relates to a care product composition, particularly a skin care composition having a moisturizing effect.

Whenever winter comes, the skin is exposed to a low-temperature and dry environment for a long time, and it is easily affected by external stimuli and caused by dry peeling and peeling. In addition, combined with the pressure of modern life, the pollution of living environment, etc., it often accelerates the degree of dryness and damage of the skin.

If the skin is dry and damaged due to lack of moisture, it will cause dullness, fine lines and wrinkles, and poor repair ability. Hyaluronic acid/Hyaluronan, also known as hyaluronic acid or uronic acid, is a disaccharides polymer with a basic structure of D-glucuronic acid and DN-acetamidine. Made up of glucosamine (DN-acetylglucosaminc). Hyaluronic acid is widely present in connective tissues, epithelial tissues and nerve tissues of organisms, and has the function of supporting and moisturizing. In particular, hyaluronic acid, which is present in epithelial tissues, maintains moisture in the skin, supports skin structure, and maintains an elastic and glossy skin texture. Hyaluronic acid is generally degradable and resynthesized with the function of physiological natural metabolism. However, affected by the external environment, if it is not possible to make up from the outside, the rate of degradation of hyaluronic acid in the body will be higher than the rate of formation, thus causing the rapid loss of hyaluronic acid. Unable to provide muscle at this time The skin's good moisturizing function causes the skin to gradually dry and damage. In order to maintain the normal function of the skin, it is necessary to externally supplement the moisturizing product containing hyaluronic acid.

The hyaluronic acid produced today has a relatively large molecular weight of up to 20,000,000 Da, which is disadvantageous for the moisturizing product containing the hyaluronic acid to be absorbed into the subcutaneous tissue through the skin, so that the moisturizing effect cannot be effectively achieved. In addition, the hyaluronic acid moisturizing products currently generally used have only a single hyaluronic acid component, and the moisturizing effect which can be improved is limited.

Therefore, in order to improve the external environment to make the skin dry and dry, and in view of the above problems, the object of the present invention is to provide a composite moisturizing skin care composition to increase the skin's absorption of hyaluronic acid. , greatly enhances the moisturizing effect.

According to an object of the present invention, there is provided a moisturizing skin care composition comprising sodium hyluronate, hyaluronic acid oligomer, oligosaccharides and galangal leaf extract ( Alpinia galangal leaf extracts); wherein the content ratio of sodium hyaluronate, hyaluronic acid oligomer, oligosaccharide and galangal leaf extract is 1:0.1:5:1 to 1:0.5:5:1.

Preferably, the content ratio of sodium hyaluronate, hyaluronic acid oligomer, oligosaccharide and galangal leaf extract may be 1:0.1:5:1 to 1:0.25:5:1.

Preferably, the hyaluronic acid oligomer in the skin care composition provided by the present invention may have a molecular weight of less than 10,000 Da.

Preferably, the oligosaccharide in the skin care composition provided by the present invention may comprise 12-24 glucuronic acid polymers, and 8-10% of the glucuronic acid polymer is acetylated (acetylated) ).

The present invention provides a skin care composition having a moisturizing effect, having one or more of the following advantages:

(1) The skin care composition of the present invention can achieve the effect of smoothing the skin texture (reducing the roughness) by the synergistic action between the components.

(2) The skin care composition of the present invention, which can improve skin elasticity and increase gloss by synergistic action between the ingredients.

(3) The skin care composition of the present invention can enhance the moisturizing degree of the skin and increase the water content of the skin surface layer by the synergistic action between the components.

Fig. 1 is a skin diagram before and after the use of the skin care composition of the embodiment of the present invention.

The invention will be further described in detail by the following preferred embodiments and the accompanying drawings.

The present invention provides a moisturizing skin care composition comprising sodium hyaluronate, hyaluronic acid oligomer, oligosaccharide and galangal leaf extract. The composition of the skin care product is similar to the composition of hyaluronic acid in human skin, and can promote the formation of hyaluronic acid in the human body, and can effectively achieve the effect of moisturizing the skin.

The present invention provides Example 1, wherein the components of the skin care product composition are sodium hyaluronate (HA-LQH), hyaluronic acid oligomer (Hyalo-Oligo ^® ), oligosaccharide (Optim Hyal ^TM ), and galangal leaf extract. (Hyalufix), and water.

According to Example 1 of the present invention, wherein the skin care composition is based on the total weight, the weight ratio of the above components is: sodium hyaluronate (HA-LQH) 0.1 wt%, hyaluronic acid oligomer (Hyalo-Oligo ^® ) 0.01wt%, oligosaccharides (Optim Hyal ^TM) 0.5wt% and 0.1wt% Alpinia leaf extract (Hyalufix), and the balance water.

According to an embodiment of the present invention, wherein the HA-LQH based fermentation made from high-purity sodium hyaluronate granules; Hyalo-Oligo ^® based powder is of high purity after treatment (over 95%) of the small molecule hyaluronan acid polymers having an average molecular weight less than 10000 Da, in this embodiment, the average molecular weight of about 7000Da; Optim Hyal ^TM intron "saccharide activin" (Glycokines ^TM), which is 18 glucuronic acid polymer, and the glucose 9% of the uronic acid polymer is acetylated; Hyalufix is effective in inducing the activity of the Hyaluronan synthase family.

According to the embodiment 1 of the present invention, the skin care composition according to the embodiment 1 of the present invention is actually subjected to the efficacy test, and the skin care composition according to the embodiment 1 of the present invention is first subjected to the subject having the more obvious skin dryness damage. After confirming the allergic reaction on the medial side of the upper arm of the hand (20 in total, numbered 1 to 20, respectively), the composition was administered to each subject once a day in the morning and evening. , use for four weeks in a row. Before the use of the care product composition (W0), the skin condition of the subject was observed after one week (W1), two weeks later (W2), three weeks later (W3), and four weeks later (W4). It also detects the skin texture, skin elasticity and skin moisture level of the skin, as an indicator of efficacy.

The above-mentioned skin texture roughness, skin elasticity value and skin moisturization were measured by a multi-functional skin analyzer Aramo TS (Aramhuvis, Korea). Multifunctional Skin Analyzer Aramo TS5 Using optical and contact sensors to analyze skin's seven major problems, skin roughness, wrinkles, oils, cuticle moisture, melanin, elasticity and keratin metabolism can be tested.

The principle of testing skin texture with a multi-functional skin analyzer is to convert the optical image obtained by binarization into black and white images and calculate the number of dark spots and white spots in all black and white images. The number of dark spots indicates that the number of skin furrows and white spots indicates pebbles. If the number of bright spots measured is lower, the skin is less and the skin is rougher.

On the other hand, the skin elasticity value is a vacuum suction method for detecting the respective elastic indexes of the skin surface. The principle is that, based on the principle of suction and stretching, a negative pressure is generated on the surface of the skin being tested to draw the skin into a specific test probe. The depth of the skin being sucked into the test probe is through a non-contact optical test. System measured. The transmitter and receiver are included in the test probe. The ratio of light (the ratio of the emitted light to the received light) is proportional to the depth of the skin being inhaled, and then the elasticity index of the skin is determined by MPA software analysis. There are three kinds of elastic indexes, namely R2=(Ua/Uf), also known as gross elasticity; R5=(Ur/Ue), which represents net-elasticity when the skin is not deformed; and R7= (Ur/Ut), also known as biological elasticity (Ua: total retraction; Uf: total distension; Ur: immediate retraction; Ue: immediate expansion ( Immediate distension)). The closer the above three elastic indices are to one, the better the skin elasticity. The total elasticity index is the average of the three elastic indices, expressed as a percentage to represent the skin elasticity value.

Finally, the moisture content of the skin can be measured by optical analysis of the skin to determine the water content of the surface layer (the stratum corneum).

Please refer to Table 1. Table 1 shows the skin texture roughness results detected by the multi-functional skin analyzer of Example 1. Wherein, W0 indicates that the skin care composition according to Embodiment 1 of the present invention has not been used, W1 to W4 indicate after one week of application, two weeks later, three weeks later, and four weeks later. The average roughness of the skin texture was the average of the bright spot index and the detected value of 20 subjects, both expressed as a percentage. The improvement rate is calculated as: [(Qe)/e]*100%, where Q is the average bright spot value or detected value of W1, W2, W3 or W4; e is the average bright spot value or detection before smearing (W0) value. As can be seen from Table 1, after four weeks of application of the skin care composition provided by the examples of the present invention, the skin roughness was significantly improved, and the improvement rate was about 29%.

Next, please refer to Table 2, which is the detection result of the skin elasticity value detected by the multifunctional skin analyzer of Example 1. Here, W0 indicates that before the skin care composition according to Example 1 of the present invention has been used, W1 to W4 indicate after one week of application, two weeks later, three weeks later, and four weeks later. The mean elasticity value is the average of the total skin elasticity index of 20 subjects and expressed as a percentage. The improvement rate is calculated as: [(X-a)/a]*100%, where X is the average elastic value of W1, W2, W3 or W4; a is the average elastic value before application. It can be seen from the results of Table 2 that after applying the care product composition provided in the present embodiment, the skin elasticity is improved, and the improvement rate can be improved by more than 20%.

Please refer to Table 3, which is the test result of skin moisturization detected by the multifunctional skin analyzer of Example 1. Wherein W0 indicates that the skin care composition according to Embodiment 1 of the present invention has not been used, W1 to W4 indicate after one week of application, two weeks later, three weeks later, and four weeks later. The mean skin moisturization test values were the average of the test values of 20 subjects, expressed as a percentage. The improvement rate is calculated as: [(Y-b)/b]*100%, where Y is the average moisture test value of W1, W2, W3 or W4; b is the average moisture test value before (W0). According to the results of Table 3, after the composition of the skin care product provided by the embodiment is applied, the skin water-blocking ability can be obviously improved, the skin moisturizing degree can be improved, and the improvement rate can be improved by more than 25 percent.

In summary, reference is also made to Fig. 1 which is a skin diagram before and after the use of the skin care composition of Example 1 of the present invention. Three of the 20 subjects (subject Nos. 9, No. 10, and No. 13) were selected, respectively, before the use of the skin care composition of Example 1 of the present invention, and the photos of the skin after four weeks of use. . It can be seen that after the use of the skin care composition according to Example 1 of the present invention, the unevenness of the unevenness of the skin is remarkably improved, the gloss is improved, and the moisture content of the skin is increased, and the skin care composition of the embodiment of the present invention is shown to have an improved skin condition. Texture roughness, enhances skin elasticity and enhances the moisture content of the skin's stratum corneum.

The present invention also provides 2 embodiment, the composition of the components of skin care products which sodium hyaluronate (HA-LQH), hyaluronic acid oligomer of Example (Hyalo-Oligo ^®), oligosaccharides (Optim Hyal ^TM) leaf and galangal Extract (Hyalufix), and water.

According to Example 2 of the present invention, wherein the skin care composition is based on the total weight, the weight ratio of the above components is: sodium hyaluronate (HA-LQH) 0.1 wt%, hyaluronic acid oligomer (Hyalo-Oligo ^® ) 0.025wt%, oligosaccharides (Optim Hyal ^TM) 0.5wt% and 0.1wt% Alpinia leaf extract (Hyalufix), and the balance water.

Respective components provided in Example 2 of the present invention the composition care products, as compared with Example 1, except that Hyalo-Oligo ^® different percentage proportions by weight, the remaining proportion of the respective components are the same as in Example 1.

According to the embodiment 2 of the present invention, the skin care composition is actually tested for efficacy in the same manner as the above, and the detection method and process are the same as those in the first embodiment. For the detailed detection process and principle, please refer to the embodiment 1. This is not covered here.

Please refer to Table 4. Table 4 shows the skin texture roughness results detected by the multifunctional skin analyzer of Example 2. Here, W0 indicates that before the skin care composition according to Example 2 of the present invention has been used, W1 to W4 indicate after one week of application, two weeks later, three weeks later, and four weeks later. The average roughness of the skin texture was the average of the bright spot index and the detected value of 20 subjects, both expressed as a percentage. The improvement rate is calculated as: [(Qe)/e]*100%, where Q is the average bright spot value or detected value of W1, W2, W3 or W4; e is the average bright spot value or detection before smearing (W0) value. As can be seen from Table 4, after four weeks of application of the skin care composition provided by the embodiment of the present invention, the skin roughness is significantly improved, and the improvement rate can exceed 30%.

Next, please refer to Table 5, which is the detection result of the skin elasticity value detected by the multi-functional skin analyzer of Example 2. Wherein W0 indicates that the skin care composition according to Embodiment 2 of the present invention has not been used. Before, W1 to W4 indicate after one week of application, two weeks later, three weeks later, and four weeks later. The mean elasticity value is the average of the total skin elasticity index of 20 subjects and expressed as a percentage. The improvement rate is calculated as: [(X-a)/a]*100%, where X is the average elastic value of W1, W2, W3 or W4; a is the average elastic value before application. It can be seen from the results of Table 5 that after applying the care product composition provided in the present embodiment, the skin elasticity is improved, and the improvement rate can be improved by more than 20%.

Please refer to Table 6, which is the result of detecting the skin moisturization detected by the multifunctional skin analyzer of Example 2. Wherein W0 indicates that the skin care composition according to Example 2 of the present invention has not been used, and W1 to W4 indicate after one week of application, two weeks, three weeks, and four weeks. The mean hydration test values were the average of the test values of 20 subjects, expressed as a percentage. The improvement rate is calculated as: [(Y-b)/b]*100%, where Y is the average moisture test value of W1, W2, W3 or W4; b is the average moisture test value before (W0). According to the results of Table 6, it can be seen that after the composition of the skin care product provided by the embodiment is applied, the skin lock water can be obviously improved, and the improvement rate can be improved by more than 20%.

In conclusion, the skin care composition provided by the present invention can be well absorbed by the human body by using the synergistic action between hyaluronic acid, small molecule hyaluronic acid oligomer and auxiliary substances, and obviously improves the skin after use. Texture roughness, enhance skin moisture retention, and increase skin elasticity.

On the other hand, the present invention further provides Comparative Example 1 for comparison with the efficacy of Example 1 and Example 2. The components of the skin care composition provided in Comparative Example 1 were also sodium hyaluronate (HA-LQH), hyaluronic acid oligomer (Hyalo-Oligo ^® ), oligosaccharide (Optim Hyal ^TM ), and galangal leaf extract. (Hyalufix), and water.

The difference from the first embodiment and the second embodiment is that the content ratio of each component of the skin care product composition provided in Comparative Example 1 of the present invention is 1:0.1:3:0.5. The total weight ratio of the above components is: sodium hyaluronate (HA-LQH) 0.1 wt%, hyaluronic acid oligomer (Hyalo-Oligo ^® ) 0.01 wt%, oligosaccharide (Optim Hyal ^TM) 0.3 wt% and galena leaf extract (Hyalufix) 0.05 wt%, and the balance being water.

According to the comparative example 1 of the present invention, the efficacy test is performed on the subject different from the first embodiment and the second embodiment, and the detection method and process are the same as those in the first embodiment and the second embodiment. For detailed detection procedures and principles, please refer to Embodiment 1 and Embodiment 2, and details are not described herein.

Please refer to Table 7. Table 7 shows the skin texture roughness results detected by the multifunctional skin analyzer of Comparative Example 1. Here, W0 indicates that before the skin care composition of Comparative Example 1 according to the present invention has been used, W1 to W4 indicate one week after the application, two weeks, three weeks, and four weeks. The average roughness of the skin texture was the average of the bright spot index and the detected value of 20 subjects, both expressed as a percentage. The improvement rate is calculated as: [(Qe)/e]*100%, where Q is the average bright spot value or detected value of W1, W2, W3 or W4; e is the average bright spot value or detection before smearing (W0) value. It can be seen from Table 7 that after applying the composition of the skin care product provided by the embodiment of the present invention, the skin roughness is not obvious after four weeks. Improvement, improvement rate is only 17.79%. The skin texture roughness test results of the skin care composition of Comparative Example 1 of the present invention were less effective than the results of Example 1 and Example 2.

Next, please refer to Table 8, which is the detection result of the skin elasticity value detected by the multifunctional skin analyzer of Comparative Example 1. Here, W0 indicates that before the skin care composition of Comparative Example 1 according to the present invention has been used, W1 to W4 indicate one week after the application, two weeks, three weeks, and four weeks. The mean elasticity value is the average of the total skin elasticity index of 20 subjects and expressed as a percentage. The improvement rate is calculated as: [(X-a)/a]*100%, where X is the average elastic value of W1, W2, W3 or W4; a is the average elastic value before application. According to the results of Table 8, it can be seen that after applying the skin care composition provided in the present embodiment, although the skin elasticity can be improved (the improvement rate is about 12%), the maintenance with the embodiment 1 and the embodiment 2 is carried out. Compared with the improvement rate of the composition of the product, the skin care effect of the skin care composition provided in Comparative Example 1 was limited.

Please refer to Table 9, which is the result of detecting the skin moisturization detected by the multifunctional skin analyzer of Comparative Example 1. Wherein W0 indicates that the skin care composition of Comparative Example 1 according to the present invention has not been used, and W1 to W4 indicate one week after the application, two weeks later, three weeks later, and four weeks later. The mean hydration test values were the average of the test values of 20 subjects, expressed as a percentage. The improvement rate is calculated as: [(Y-b)/b]*100%, where Y is the average moisturization detection value of W1, W2, W3 or W4; b is the average moisture retention detection value before the application (W0). According to the results of Table 9, it can be seen that after the application of the skin care composition provided in the present embodiment, the skin moisturizing degree is improved, and the improvement rate is about 15%. However, the moisturizing effect which can be attained by the skin care composition of Comparative Example 1 as compared with Example 1 or Example 2 is still less than that achieved by the skin care composition of Example 1 or Example 2.

The results of the efficacy test of the skin care composition of the above three examples can be inferred. The ingredients in the composition provided by the present invention must be blended in a specific ratio to achieve an excellent skin moisturizing effect. Further, in the skin care composition provided by the present invention, sodium hyaluronate (HA-LQH), hyaluronic acid oligomer (Hyalo-Oligo ^® ), oligosaccharide (Optim Hyal ^TM ), and galangal leaf extract are provided. (Hyalufix) The content of these four components should be between 1:0.1:5:1 and 1:0.5:5:1, which can have better moisturizing effect. Preferably, particularly when the ratio of the components of the composition is 1:0.1:5:1, a considerable moisturizing effect can be achieved.

According to the experimental results of the above embodiments, when the skin care composition provided by the present invention is applied to the skin, the apparent shape change improves the texture roughness of the skin, increases the brightness of the skin, enhances the gloss, and increases the water content of the stratum corneum. , thereby slowing down the phenomenon of dry skin and peeling. Further, it can also be understood from the ratio of the respective components that the skin care composition provided by the present invention can achieve a remarkable moisturizing effect by only a small proportion of the total composition of the product. Therefore, the skin care composition provided by the present invention can have a moisturizing effect only with a small amount of components, thereby reducing production cost and increasing production.

The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims.

Claims (3)

A moisturizing skin care composition comprising sodium hyluronate, hyaluronic acid oligomer, oligosaccharides, and Alpinia galangal leaf extracts Wherein the content ratio of sodium hyaluronate, hyaluronic acid oligomer, oligosaccharide and galangal leaf extract is 1:0.1:5:1 to 1:0.5:5:1; wherein the oligosaccharide comprises 12 - 24 glucuronic acid polymers, and 8-10% of the glucuronic acid polymer is acetylated. The skin care composition according to claim 1, wherein the content ratio of sodium hyaluronate, hyaluronic acid oligomer, oligosaccharide and galangal leaf extract is 1:0.1:5:1 to 1: 0.25:5:1. The skin care composition according to claim 1 or 2, wherein the hyaluronic acid oligomer has a molecular weight of less than 10,000 Da.