TWI576116B - 氟化物－安定化之含鋅組成物 - Google Patents
氟化物－安定化之含鋅組成物 Download PDFInfo
- Publication number
- TWI576116B TWI576116B TW102143629A TW102143629A TWI576116B TW I576116 B TWI576116 B TW I576116B TW 102143629 A TW102143629 A TW 102143629A TW 102143629 A TW102143629 A TW 102143629A TW I576116 B TWI576116 B TW I576116B
- Authority
- TW
- Taiwan
- Prior art keywords
- zinc
- fluoride
- composition
- sodium
- acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 145
- 239000011701 zinc Substances 0.000 title description 51
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title description 46
- 229910052725 zinc Inorganic materials 0.000 title description 45
- 229940091249 fluoride supplement Drugs 0.000 claims description 42
- -1 sodium fluoroantimonate Chemical compound 0.000 claims description 41
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 37
- 239000004475 Arginine Substances 0.000 claims description 32
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 32
- 210000003298 dental enamel Anatomy 0.000 claims description 30
- 229910019142 PO4 Inorganic materials 0.000 claims description 26
- 229910000420 cerium oxide Inorganic materials 0.000 claims description 21
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 20
- 239000010452 phosphate Substances 0.000 claims description 20
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 19
- 239000011746 zinc citrate Substances 0.000 claims description 19
- 235000006076 zinc citrate Nutrition 0.000 claims description 19
- 229940068475 zinc citrate Drugs 0.000 claims description 19
- 238000005260 corrosion Methods 0.000 claims description 12
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 11
- 230000007797 corrosion Effects 0.000 claims description 11
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 8
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 8
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 7
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 7
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 6
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 6
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 6
- 235000019800 disodium phosphate Nutrition 0.000 claims description 6
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 6
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 6
- 239000002585 base Substances 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- 229960000414 sodium fluoride Drugs 0.000 claims description 5
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 claims description 5
- 229910000165 zinc phosphate Inorganic materials 0.000 claims description 5
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 4
- 235000019797 dipotassium phosphate Nutrition 0.000 claims description 4
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims description 4
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 4
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 4
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical class S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims description 3
- 239000011698 potassium fluoride Substances 0.000 claims description 3
- 235000003270 potassium fluoride Nutrition 0.000 claims description 3
- 230000002087 whitening effect Effects 0.000 claims description 3
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 claims description 2
- XROWMBWRMNHXMF-UHFFFAOYSA-J titanium tetrafluoride Chemical class [F-].[F-].[F-].[F-].[Ti+4] XROWMBWRMNHXMF-UHFFFAOYSA-J 0.000 claims description 2
- 238000012546 transfer Methods 0.000 claims description 2
- 239000011576 zinc lactate Substances 0.000 claims description 2
- 235000000193 zinc lactate Nutrition 0.000 claims description 2
- 229940050168 zinc lactate Drugs 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 2
- 229960001763 zinc sulfate Drugs 0.000 claims description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- SOLUNJPVPZJLOM-UHFFFAOYSA-N trizinc;distiborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-][Sb]([O-])([O-])=O.[O-][Sb]([O-])([O-])=O SOLUNJPVPZJLOM-UHFFFAOYSA-N 0.000 claims 1
- 235000009697 arginine Nutrition 0.000 description 31
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 29
- 235000021317 phosphate Nutrition 0.000 description 25
- 235000001014 amino acid Nutrition 0.000 description 22
- 150000001413 amino acids Chemical class 0.000 description 22
- 238000009472 formulation Methods 0.000 description 20
- 239000011575 calcium Substances 0.000 description 19
- 239000006072 paste Substances 0.000 description 18
- 239000011734 sodium Substances 0.000 description 16
- 229920001864 tannin Polymers 0.000 description 15
- 239000001648 tannin Substances 0.000 description 15
- 235000018553 tannin Nutrition 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 239000000551 dentifrice Substances 0.000 description 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 11
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 11
- 239000000606 toothpaste Substances 0.000 description 11
- 239000003945 anionic surfactant Substances 0.000 description 10
- 208000002925 dental caries Diseases 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 9
- 239000003082 abrasive agent Substances 0.000 description 9
- 239000004094 surface-active agent Substances 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 239000003906 humectant Substances 0.000 description 8
- 150000002500 ions Chemical class 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 239000002324 mouth wash Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 229910052708 sodium Inorganic materials 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 229940034610 toothpaste Drugs 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 229920001577 copolymer Polymers 0.000 description 7
- 235000013355 food flavoring agent Nutrition 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 7
- 229940083542 sodium Drugs 0.000 description 7
- 239000002562 thickening agent Substances 0.000 description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- CETPSERCERDGAM-UHFFFAOYSA-N ceric oxide Chemical compound O=[Ce]=O CETPSERCERDGAM-UHFFFAOYSA-N 0.000 description 6
- 229910000422 cerium(IV) oxide Inorganic materials 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical group O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- 229940051866 mouthwash Drugs 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 6
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 5
- 229920006318 anionic polymer Polymers 0.000 description 5
- 230000001680 brushing effect Effects 0.000 description 5
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 5
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
- 239000004472 Lysine Substances 0.000 description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 229910052791 calcium Inorganic materials 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 238000005530 etching Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000006260 foam Substances 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 235000018977 lysine Nutrition 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000005498 polishing Methods 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 229960003500 triclosan Drugs 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 3
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960003121 arginine Drugs 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 159000000007 calcium salts Chemical class 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 229960002173 citrulline Drugs 0.000 description 3
- 235000013477 citrulline Nutrition 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
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- 208000007565 gingivitis Diseases 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229960003104 ornithine Drugs 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229960002799 stannous fluoride Drugs 0.000 description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 3
- 150000003460 sulfonic acids Chemical class 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
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- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 description 2
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- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
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- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940077935 zinc phosphate Drugs 0.000 description 1
- RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical group [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/067994 WO2014088572A1 (en) | 2012-12-05 | 2012-12-05 | Fluoride-stable zinc containing oral care compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201438748A TW201438748A (zh) | 2014-10-16 |
| TWI576116B true TWI576116B (zh) | 2017-04-01 |
Family
ID=47388682
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102143629A TWI576116B (zh) | 2012-12-05 | 2013-11-29 | 氟化物－安定化之含鋅組成物 |
| TW104143704A TW201626978A (zh) | 2012-12-05 | 2013-11-29 | 氟化物-安定化之含鋅組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104143704A TW201626978A (zh) | 2012-12-05 | 2013-11-29 | 氟化物-安定化之含鋅組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20150313813A1 (https=) |
| EP (2) | EP3195850A1 (https=) |
| KR (1) | KR20150092255A (https=) |
| CN (2) | CN108078798A (https=) |
| AR (1) | AR093792A1 (https=) |
| AU (1) | AU2012396294B2 (https=) |
| BR (1) | BR112015012918B1 (https=) |
| CA (1) | CA2890537C (https=) |
| HK (1) | HK1215159A1 (https=) |
| IL (1) | IL238841B (https=) |
| IN (1) | IN2015DN03990A (https=) |
| MX (1) | MX350566B (https=) |
| PH (1) | PH12015501186A1 (https=) |
| RU (1) | RU2015126801A (https=) |
| TW (2) | TWI576116B (https=) |
| WO (1) | WO2014088572A1 (https=) |
| ZA (1) | ZA201503925B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9763865B2 (en) | 2012-12-19 | 2017-09-19 | Colgate-Palmolive Company | Oral gel comprising zinc-amino acid complex |
| CN108210355B (zh) * | 2013-12-19 | 2022-02-18 | 高露洁-棕榄公司 | 口腔护理组合物 |
| CN104721063B (zh) | 2013-12-19 | 2018-05-08 | 高露洁-棕榄公司 | 包含氧化锌和柠檬酸锌的洁齿剂组合物 |
| AU2013408274B2 (en) * | 2013-12-19 | 2017-03-02 | Colgate-Palmolive Company | Anti-malodor oral care composition |
| CA2952669C (en) * | 2014-10-15 | 2021-08-31 | Colgate-Palmolive Company | Oral care compositions comprising zinc, arginine and serine |
| CN107106428B (zh) | 2014-12-26 | 2020-07-03 | 高露洁-棕榄公司 | 磷酸锌络合物 |
| WO2016105430A1 (en) | 2014-12-26 | 2016-06-30 | Colgate-Palmolive Company | Zinc phosphate complex |
| WO2016105429A1 (en) | 2014-12-26 | 2016-06-30 | Colgate-Palmolive Company | Zinc phosphate complex |
| MX376016B (es) | 2014-12-26 | 2025-03-07 | Colgate Palmolive Co | Composiciones para el cuidado personal con activo de fosfato de zinc. |
| MY182599A (en) | 2014-12-26 | 2021-01-26 | Colgate Palmolive Co | Oral care compositions and methods of use |
| MX383439B (es) | 2015-07-01 | 2025-03-14 | Colgate Palmolive Co | Composiciones para el cuidado bucal y métodos de uso. |
| EP3462900A4 (en) * | 2016-05-31 | 2020-01-22 | Wm. Wrigley Jr. Company | STAIN PROTECTION FORMULATIONS |
| US10576029B2 (en) * | 2016-06-24 | 2020-03-03 | Colgate-Palmolive Company | Oral care compositions |
| RU2703561C2 (ru) | 2016-06-24 | 2019-10-21 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
| CN110087614B (zh) | 2016-12-21 | 2022-07-22 | 高露洁-棕榄公司 | 口腔护理组合物 |
| BR112019012356B1 (pt) | 2016-12-21 | 2021-03-23 | Colgate-Palmolive Company | Composição para cuidado oral |
| WO2018118142A1 (en) | 2016-12-21 | 2018-06-28 | Colgate-Palmolive Company | Oral care compositions |
| US10058493B2 (en) * | 2016-12-21 | 2018-08-28 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| JP7064938B2 (ja) * | 2017-04-27 | 2022-05-11 | ライオン株式会社 | 口腔用組成物 |
| WO2019183876A1 (en) | 2018-03-29 | 2019-10-03 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| BR112020017909B1 (pt) | 2018-03-29 | 2021-08-24 | The Procter & Gamble Company | Composições para tratamento bucal para promover a saúde das gengivas |
| EP3773453B1 (en) | 2018-03-29 | 2026-04-01 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| MX385755B (es) | 2018-03-29 | 2025-03-18 | Procter & Gamble | Composiciones para el cuidado bucal para promover la salud de las encias |
| US11058617B2 (en) | 2018-12-20 | 2021-07-13 | Colgate-Palmolive Company | Methods |
| US20220071868A1 (en) | 2018-12-26 | 2022-03-10 | Colgate-Palmolive Company | Methods of Inhibiting Neutrophil Recruitment to the Gingival Crevice |
| MX2021007646A (es) | 2018-12-26 | 2021-08-11 | Colgate Palmolive Co | Inhibicion de la coagregacion especifica por arginina. |
| CN119792113A (zh) | 2018-12-26 | 2025-04-11 | 高露洁-棕榄公司 | 使用精氨酸降低病原性细菌 |
| HRP20210178T1 (hr) * | 2019-01-11 | 2021-04-16 | Meda Ab | Preparati za oralnu njegu koji sadrže klorheksidin i arginin ili njihove soli |
| EP3946639A4 (en) * | 2019-04-25 | 2023-07-05 | Colgate-Palmolive Company | ORAL CARE COMPOSITIONS AND METHODS OF USE |
| AU2020337430B2 (en) * | 2019-08-27 | 2023-11-02 | Colgate-Palmolive Company | Zinc phosphate containing compositions |
| KR102076353B1 (ko) * | 2019-09-24 | 2020-02-12 | 강윤구 | 천연 추출물, 구연산, 아연 및 ｌ-아르기닌을 포함하는 항염 또는 항균 조성물 |
| WO2021059215A2 (en) | 2019-09-25 | 2021-04-01 | Church & Dwight Co., Inc. | Oral care composition |
| JP2022549339A (ja) | 2019-09-30 | 2022-11-24 | ザ プロクター アンド ギャンブル カンパニー | ホップを含む口腔ケア組成物の使用方法 |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| JP2022549842A (ja) | 2019-09-30 | 2022-11-29 | ザ プロクター アンド ギャンブル カンパニー | 歯科用バイオフィルムの治療のための歯磨剤組成物 |
| EP4037637A1 (en) | 2019-09-30 | 2022-08-10 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| MX2022003867A (es) * | 2019-10-07 | 2022-04-18 | Colgate Palmolive Co | Composiciones para el cuidado oral y metodos de uso. |
| EP4084770B1 (en) * | 2019-12-31 | 2023-07-19 | 3M Innovative Properties Company | Aqueous zinc oral care compositions with fluoride |
| MX2022011672A (es) | 2020-03-27 | 2022-10-18 | Colgate Palmolive Co | Composiciones para el cuidado oral y metodos de uso. |
| EP4018196A1 (en) | 2020-04-02 | 2022-06-29 | Colgate-Palmolive Company | Compositions for and methods of neutralizing lipopolysaccharide toxicity and methods of identifying the same |
| US11701314B2 (en) | 2020-07-31 | 2023-07-18 | Colgate-Palmolive Company | Processes and methods |
| US20230355487A1 (en) * | 2020-12-18 | 2023-11-09 | Colgate-Palmolive Company | Compositions and Related Methods |
| CN115006276B (zh) | 2021-03-05 | 2025-07-22 | 高露洁-棕榄公司 | 口腔护理组合物及使用方法 |
| EP4203900A1 (en) | 2021-05-25 | 2023-07-05 | Colgate-Palmolive Company | Oral care compositions |
| CA3238021A1 (en) * | 2021-11-23 | 2023-06-01 | Melissa Martinetti | Oral care compositions based on fructans and thickening agent, and methods for the same |
| EP4514305A2 (en) * | 2022-04-27 | 2025-03-05 | New York University | Zinc-based materials for treatment of dental caries |
| WO2023247292A1 (en) * | 2022-06-23 | 2023-12-28 | Unilever Ip Holdings B.V. | Oral care composition for mitigation and/or reversion of erosion of tooth enamel caused by wearing an aligner |
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| US20030152527A1 (en) * | 1999-11-12 | 2003-08-14 | The Procter & Gamble Company | Stannous oral compositions |
| CN1993101A (zh) * | 2004-08-03 | 2007-07-04 | 荷兰联合利华有限公司 | 包含碳酸钙和柠檬酸锌的牙膏 |
| WO2011123123A1 (en) * | 2010-03-31 | 2011-10-06 | Colgate-Palmolive Company | Oral care composition |
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| US3959458A (en) | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
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-
2012
- 2012-12-05 EP EP17160198.2A patent/EP3195850A1/en not_active Withdrawn
- 2012-12-05 WO PCT/US2012/067994 patent/WO2014088572A1/en not_active Ceased
- 2012-12-05 CA CA2890537A patent/CA2890537C/en active Active
- 2012-12-05 EP EP12803522.7A patent/EP2928440B2/en active Active
- 2012-12-05 MX MX2015007011A patent/MX350566B/es active IP Right Grant
- 2012-12-05 CN CN201810072503.8A patent/CN108078798A/zh active Pending
- 2012-12-05 RU RU2015126801A patent/RU2015126801A/ru unknown
- 2012-12-05 KR KR1020157017687A patent/KR20150092255A/ko not_active Withdrawn
- 2012-12-05 HK HK16103091.4A patent/HK1215159A1/zh unknown
- 2012-12-05 CN CN201280077533.9A patent/CN104822362A/zh active Pending
- 2012-12-05 IN IN3990DEN2015 patent/IN2015DN03990A/en unknown
- 2012-12-05 BR BR112015012918A patent/BR112015012918B1/pt active IP Right Grant
- 2012-12-05 AU AU2012396294A patent/AU2012396294B2/en active Active
- 2012-12-05 US US14/649,109 patent/US20150313813A1/en not_active Abandoned
-
2013
- 2013-11-29 TW TW102143629A patent/TWI576116B/zh not_active IP Right Cessation
- 2013-11-29 TW TW104143704A patent/TW201626978A/zh unknown
- 2013-12-04 AR ARP130104489A patent/AR093792A1/es unknown
-
2015
- 2015-05-14 IL IL238841A patent/IL238841B/en active IP Right Grant
- 2015-05-27 PH PH12015501186A patent/PH12015501186A1/en unknown
- 2015-06-01 ZA ZA2015/03925A patent/ZA201503925B/en unknown
-
2018
- 2018-07-31 US US16/050,059 patent/US20190038531A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030152527A1 (en) * | 1999-11-12 | 2003-08-14 | The Procter & Gamble Company | Stannous oral compositions |
| CN1993101A (zh) * | 2004-08-03 | 2007-07-04 | 荷兰联合利华有限公司 | 包含碳酸钙和柠檬酸锌的牙膏 |
| WO2011123123A1 (en) * | 2010-03-31 | 2011-10-06 | Colgate-Palmolive Company | Oral care composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104822362A (zh) | 2015-08-05 |
| CA2890537A1 (en) | 2014-06-12 |
| EP3195850A1 (en) | 2017-07-26 |
| IL238841A0 (en) | 2015-06-30 |
| IN2015DN03990A (https=) | 2015-10-02 |
| CA2890537C (en) | 2020-01-21 |
| TW201438748A (zh) | 2014-10-16 |
| PH12015501186B1 (en) | 2015-08-17 |
| EP2928440B1 (en) | 2017-05-03 |
| WO2014088572A1 (en) | 2014-06-12 |
| US20150313813A1 (en) | 2015-11-05 |
| EP2928440B2 (en) | 2019-12-18 |
| AR093792A1 (es) | 2015-06-24 |
| BR112015012918A2 (pt) | 2017-07-11 |
| BR112015012918B1 (pt) | 2018-10-30 |
| EP2928440A1 (en) | 2015-10-14 |
| MX350566B (es) | 2017-09-11 |
| HK1215159A1 (zh) | 2016-08-19 |
| AU2012396294B2 (en) | 2015-06-11 |
| IL238841B (en) | 2019-12-31 |
| US20190038531A1 (en) | 2019-02-07 |
| RU2015126801A (ru) | 2017-01-13 |
| CN108078798A (zh) | 2018-05-29 |
| AU2012396294A1 (en) | 2015-05-28 |
| PH12015501186A1 (en) | 2015-08-17 |
| KR20150092255A (ko) | 2015-08-12 |
| TW201626978A (zh) | 2016-08-01 |
| MX2015007011A (es) | 2015-09-28 |
| ZA201503925B (en) | 2017-07-26 |
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| Date | Code | Title | Description |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |