TWI532513B - Drug delivery device - Google Patents

Description

Drug delivery device

The invention relates to a quantitative drainage atomization spraying device, which can deliver a liquid medicine to a dropper through a pressure, and can be exchanged with a microporous oscillating plate to re-atomize the drug or directly enter the pressure tube in a droplet type to accelerate the ejection. The high-speed atomization transmission system can easily replace the required drug ampoules and the drug quantitative delivery device that selects the micro-hole oscillating plate atomization.

According to the current, there are many kinds of injection devices in beauty and medicine, but the real needle-free dermal layer drug delivery system is very few. Most of the liquid syringes used today have a gun-type body with a chamber or a casing. For loading drugs, and connected with high-pressure gas, and using the principle of high pressure, the syringe is pressed against the patient's skin. When the trigger is pushed, the liquid will be sprayed from the muzzle in a column and injected into the skin to achieve the effect of delivery, thus causing skin wounds and Pain, and if you need to change the drug, you must have a full range of sterilization procedures. Another type is to spray the drug directly under pressure. This method of delivery still cannot meet the speed and accurate quantitative requirements for dermal delivery.

Needle-free syringes are the future development trend due to their convenience and practicability. However, there are still some defects in the current structural design, and there are still some shortcomings to be used for improvement. The analysis is as follows:

1. The general needle-free liquid drug delivery device is still mainly delivered by liquid column.

2, the general needle-free liquid drug spray conveyor produces a certain amount of uneven particle size is not accurate, and can not reach the speed of more than 100m / sec.

3, the general drug delivery device is usually non-removable, can not be dismantled for cleaning or maintenance work, especially in the tube cleaning, can not be perfect.

Generally, the liquid atomizer is extremely inconvenient to fill the medicine or install or replace the medicine bottle. The process is time consuming and laborious; often the medicine used in the previous time will have residual liquid in the tube, such as improper cleaning or replacement. The use of this device by other drugs will result in a patient's therapeutic risk.

In view of this, the creator specially designed to solve the above problems, and after continuous experimentation and improvement, this innovative, convenient and practical "drug delivery device" will be produced, which will benefit the industry and the public.

One object of the present invention is to provide a drug delivery device for continuous micro-control of liquid drug atomization high-speed ejection of a replaceable canister.

Another object of the present invention is to provide a detachable drug delivery assembly device for achieving the function of detachable cleaning or replacement of individual components.

A third object of the present invention is to provide a drug delivery device that can be selectively replaced with a canister container type, and includes a replaceable canister connector design, by adjusting or replacing a dropper diameter or a microporous atomization oscillation plate. Enhance the atomization efficiency to achieve a more detailed homogeneous spray atomization effect.

According to a preferred embodiment of the above items, the drug delivery device comprises: a drug delivery pressure tube, wherein the venturi tube is used to form a conical hole at both ends and a throat is formed in the middle. One of the conical holes is a mainstream gas inlet, and the other conical hole is a drug outlet. A medicine tank fixing base is formed on a circumferential surface of the drug delivery pressure tube near the main gas inlet, and two opposite holes are arranged on the surface thereof. a through hole is communicated with the tapered hole; a medicine tank fixing seat is a rectangular flat plate type, and the above-mentioned medicine tank fixing base can be anastomosed and closed, and a socket opposite to the above-mentioned through hole is provided, and the medicine is further provided The can holder is formed on the surface of the can fixed base to form two opposite fixed and leakproof cassettes; and a canister is replaceable and can be any shape, has an unoriented drug delivery tube, and the edge is formed A card edge can be inserted into the jack to form a positioning, and the drug delivery tube is provided with an adjustable drug delivery inner tube protruding from a microneedle tube at one end, and a certain distance from the drug delivery tube is formed. Drainage hole pressure input; order to achieve the pressurized liquid medicament and metering atomizing effect of emission.

According to another preferred embodiment of the above items, the drug delivery device comprises: a drug delivery pressure tube, wherein the venturi tube is used to form the conical holes at both ends and the throat is formed in the middle. One tapered hole is a mainstream gas inlet, and the other tapered hole is a drug outlet. A medicine tank fixing base is formed on a circumferential surface of the drug delivery pressure pipe near the mainstream gas inlet, and a surface thereof is provided with a rectangular concave oscillation. a slot for placing the slot, and a socket on the opposite sides of the oscillating plate receiving slot, wherein the oscillating plate receiving slot is embedded with an oscillating plate with an oscillating plate substrate, and the bottom surface is provided with a through hole and a cone The oscillating plate is a thin sheet body and a plurality of micropores are uniformly arranged on the surface; a medicine tank fixing seat is a rectangular flat plate type, and the oscillating plate placing groove can be anastomosed and closed, and a through hole is provided a hole opposite the hole, and the surface of the canister fixing seat facing the oscillating plate receiving groove is formed with a slightly convex oscillating plate fixed pressing plate, which can press the oscillating substrate of the oscillating plate, and two opposite fixed and leakproof cards Oh, can The canister fixing seat is fixed in the corresponding socket when the medicine tank fixing base is fixed; and a medicine tank is in any shape of a replaceable type, which has an unoriented drug delivery tube, and a card is formed at the end edge. The edge can be inserted into the jack to form a positioning, and the drug delivery tube is provided with an adjustable drug delivery inner tube with a microneedle nozzle at one end, and a certain amount of pressure input drainage hole is formed away from the drug delivery tube. And a medicine tank amp bottle holder; pushing the liquid medicine to the micro needle tube drip by the quantitative pressure pushing source or by the oscillating piece covered with the micro hole, entering the drug delivery pressure tube to form the atomization, or reaching two The effect of secondary atomization.

Further, in conjunction with the drawings, the preferred embodiments of the drug delivery device of the present invention will be described, and the Applicant has a deeper and more specific understanding of the present invention.

Referring to the first drawing, a composition of a drug delivery device according to a preferred embodiment of the present invention is disclosed. As shown in the figure, the drug delivery device (1) comprises: a drug delivery pressure tube (10). The inside is made by using the venturi principle to form the conical holes at both ends and the throat is formed in the middle, wherein one conical hole is the main gas inlet (11), and the other conical hole is the drug outlet (12), and the drug is pressurized. a tube fixing base (13) is formed on the circumferential surface of the tube (10) near the mainstream gas inlet (11), and a through hole (16) having a hole edge in a step shape is communicated with the tapered hole; the through hole 16) The diameter is preferably less than 10 mm in actual practice; a canister (30) is replaceable and can be of any shape, and has a non-oriented drug delivery tube (31) for drug delivery plus The combination of the pressure tube (10) is convenient and self-changing, and the end edge is formed with a card edge, which can be inserted into the through hole (16) to form a positioning, and an adjustable drug delivery inner tube is arranged in the drug delivery tube (31) ( 32), one end of the adjustable drug delivery inner tube (32) protrudes with a microneedle nozzle drip (321), and the microneedle tube Preferably, the diameter of the mouth (321) is less than 1 mm in practice, and the canister (30) is shaped away from the drug delivery tube (31) to form a certain amount of pressure input drainage holes (33) and a canister. The bottle holder (34); further, the circumferential surface of the adjustable drug delivery inner tube (32) is simultaneously adhered to the inner wall surface of the drug delivery tube (31) and the inner wall surface of the through hole (16), and has a positioning The effect can also be adopted to form a design that increases the friction and the anti-slip effect, such as a regular or irregular rough surface, so that it is not easy to fall from the drug delivery tube (31).

Referring to the second figure, a schematic cross-sectional view of a partial structure according to the first figure is disclosed; according to the above units, in combination, the medicine can (30) is inserted into the drug delivery pressure tube by using a drug delivery tube (31). (10) in the through hole (16) of the canister fixing base (13), the card edge of the end of the drug delivery tube (31) is closely matched to the stepped hole edge of the through hole (16) to form Fixing action, at the same time, the two ends of the adjustable drug delivery inner tube (32) are respectively inserted into the inner wall surface of the drug delivery tube (31) and the through hole (16), so that the end of the drug delivery tube (31) protrudes slightly. The needle drop (321) can be located at the junction of the through hole (16) and the tapered hole, so that the liquid can be directly dropped into the drug delivery pressure tube (10), so as to complete the assembly of the entire drug delivery device (1).

Referring to the third drawing, a composition of a drug delivery device comprising an oscillating plate according to another preferred embodiment of the present invention is disclosed. As shown in the figure, the drug delivery device (1) comprises: a drug delivery pressure tube. (10), in which the venturi tube principle is used to form the conical holes at both ends and the throat is formed in the middle, wherein one conical hole is the mainstream gas inlet (11), and the other conical hole is the drug outlet (12). A medicine tank fixing base (13) is formed on the circumferential surface of the drug delivery pressurizing tube (10) near the main gas inlet (11), and a swash plate receiving groove (131) having a rectangular recess is disposed on the surface thereof, and the oscillation is located at the oscillation The accommodating plate (131) is provided with an oscillating plate (15) with an oscillating plate substrate (151), and the bottom surface is adapted to be placed on the opposite side of the slot (131). A through hole (16) is disposed in communication with the tapered hole. The oscillating plate (15) is a pole piece and the surface is evenly distributed with a plurality of micro holes. In addition, the thickness of the oscillating plate substrate (151) is slightly larger than that of the oscillating plate (15). Therefore, when the oscillating plate (15) is placed in the oscillating plate setting groove (131), the oscillating plate (15) is in a suspended state, and the oscillating plate substrate (15) 1) Electrically connecting a control board (not shown) by means of a wire external connection, and controlling the vibration plate (15) to achieve high-speed vibration effect by controlling the control plate; a medicine tank fixing seat (20), In the form of a rectangular flat plate, the oscillating plate placing groove (13) can be anastomosed, and a jack (21) corresponding to the through hole (16) and having an end hole edge forming a class shape is provided, and the medicine is further provided. The surface of the tank fixing seat (20) facing the oscillating plate placing groove (13) is formed with a slightly convex oscillating plate fixing platen (22), and the oscillating substrate (151) of the oscillating plate (15) can be pressed, and the two opposite sides The fixed and leak-proof cassette (23) can be positioned and embedded in the corresponding socket (14) when the can holder (20) closes the can fixing base (12); The diameter of the fixed and leak-proof cassette (23) is equivalent to the diameter of the socket (14), or the diameter of the fixed and leak-proof cassette (23) is slightly larger than the diameter of the socket (14), so that the two are combined It can have a certain degree of tightness and can not be easily separated, and the surface of the oscillating plate fixing platen (22) can form a design to increase friction and anti-slip effect, such as regular or irregular shape. a rough surface; a canister (30), which is replaceable and can be of any shape, has a non-oriented drug delivery tube (31) and the end edge is formed with a card edge, which can be inserted into the above-mentioned socket (21) Forming a positioning, the drug delivery tube (31) is provided with an adjustable drug delivery inner tube (32), one end of the adjustable drug delivery inner tube (32) protrudes with a microneedle tube drip (321), and a distance away from the The drug delivery tube (31) is oriented to form a certain amount of pressure input drainage hole (33) and a medicine tank ampoule holder (34); further, the circumferential surface of the adjustable drug delivery inner tube (32) is in the production process. At the same time, it is closely adhered to the inner wall surface of the drug delivery tube (31) and the inner wall surface of the through hole (16), and has a positioning effect; and a design that increases the friction and the anti-slip effect, such as a rough surface of regular or irregular shape, can be used. It is not easy to fall from the drug delivery tube (31), and can maintain an adjustment distance of 0.2 to 5 mm from the oscillating plate (15).

Please refer to the fourth and fifth figures together to disclose the appearance and cross-section of the drug delivery device according to the third figure; on the combination of the drug delivery compression tube (10) and the canister holder (20), The oscillating plate (15) is placed in the oscillating plate setting groove (131) on the surface of the canister fixing base (13) on the circumferential surface of the drug delivery pressing tube (10), and the medicinal can holder (20) is fitted The oscillating plate placing groove (131) is closed, and the oscillating plate substrate (151) of the oscillating plate (15) is pressed by the oscillating plate fixing platen (22), and the fixing and the leakage preventing cassette (23) are embedded correspondingly. The jack (14) is firmly positioned to form a fixed position, and the oscillating piece (15) is suspended in the oscillating plate placing groove (131) to facilitate vibration; when the combination is completed, the medicinal can (30) is In combination, the drug delivery tube (31) of the canister (30) is combined with the drug canister fixing seat (20) on the peripheral surface of the drug canister fixing base (13) to make the medicine. The canister (30) is in communication with the drug delivery pressure tube (10), and the microneedle nozzle drip (321) in the drug delivery tube (31) can be located at the junction of the through hole (16) and the tapered hole to facilitate Direct injection of drug into the drug The pressurization tube (10) is sent to complete the assembly of the other type of drug delivery device (1).

6 is a schematic view showing the action of the drug delivery device according to another preferred embodiment of the present invention; as shown in the figure, the right side (in the direction of the drawing) of the drug delivery pressure tube (10) is a mainstream gas inlet. (11), external pressure high-pressure input is externally connected, and the quantitative pressure input drainage hole (33) of the medicine tank (30) is connected with a quantitative pressure pushing source (35), and the function is an adjustable quantitative pressure input. The pressure pushes the liquid medicine in the quantitative medicine tank (30) through the drug delivery tube (31), the adjustable drug delivery inner tube (32), and the microneedle tube drip (321) at the end edge falls down in a small amount of water droplets. As for the high-vibration oscillating plate (15), an atomized fine molecular state is formed, and then the micropores covered by the surface of the oscillating plate (15) enter the drug delivery pressurizing tube (10), at which time the mainstream gas high pressure input pushes the The atomized liquid is ejected by atomization from the drug outlet (12). This method of atomizing the drug solution and then spraying it by pressurized atomization can make the atomization effect of the drug liquid more uniform.

Please refer to the seventh embodiment, which is a schematic cross-sectional view showing a partial structure of a drug delivery device without an oscillating plate according to still another preferred embodiment of the present invention; wherein the drug delivery tube (31) of the medicine tank (30) and the drug delivery pressure tube (10) The canister fixing seat (20) on the circumferential surface of the upper pot fixing base (13) is combined to form a medicine tank (30) which is connected with the drug delivery pressurizing tube (10), the drug delivery tube (31) has an adjustable drug delivery inner tube (32) with a microneedle tube drip (321), so that the liquid medicine contained in the medicine tank (30) is used by the quantitative pressure pushing source (35) from the drainage hole (33) The introduction into the microneedle nozzle drip (321) is output in a small amount of droplets, except that the oscillating plate is not disposed in the space between the canister fixing base (13) and the canister fixing seat (20). ), that is, the high-speed vibration atomization effect is not provided, and the position of the adjustable drug delivery inner tube (32) in the drug delivery tube (31) is adjusted, so that the micro-needle tube drip (321) is located in the through-hole (16) and the drug delivery plus At the junction of the pressure tube (10), a small amount of droplet-shaped output liquid can be directly delivered into the drug delivery pressure tube (10).

Referring to FIG. 8 , a schematic diagram of the action of the drug delivery device according to still another preferred embodiment of the present invention is disclosed. As shown in the figure, the right side (the direction of the drawing) of the drug delivery pressure tube (10) is the mainstream. The gas inlet (11) is externally connected with a high-pressure input of the mainstream gas, and the quantitative pressure pushing source in the canister (30) is provided by a quantitative pressure pushing source (35) connected to the outside of the quantitative pressure input drainage hole (33). Quantitative pressure input, whereby the pressure is transferred to the drug solution in the medicine tank (30) through the drug delivery tube (31), the adjustable drug delivery inner tube (32), and the micro-needle tube drip (321) at the end edge with a small amount of water droplets The drop directly flows into the drug delivery pressurizing tube (10) through the through hole (16). At this time, the high-pressure input of the mainstream gas pushes the atomized liquid, and is sprayed by the drug outlet (12). This method of discharging the drug solution in a quantitative drop shape and then re-pressurizing the atomization spray can also form a gas-liquid mixing atomization effect, but the drug selection must be a low-viscosity material to obtain a more atomized atomization. Delivery effect.

FIG. 9 is a schematic view showing the actual implementation of a preferred embodiment of the present invention, and FIG. 10 is a schematic view showing the actual implementation of a preferred embodiment of the present invention; wherein the drug delivery device (1) Regardless of the type of the first, second or third embodiment, in practical use, a set of mutually cooperating outer casings (3) can be combined so that the entire drug delivery device (1) is completely covered. Thereby, on the one hand, the drug delivery device (1) is protected and fixed, and the hand grip property is better, and on the other hand, the stability of the liquid atomization pressure discharge is ensured.

Feature Description:

1. The drug delivery device of the invention mainly comprises a detachable drug delivery pressure tube, a medicine tank holder and a medicine tank, and the micro-needle tube drip of the desired diameter can be selected according to the difference of the viscosity of the medicine liquid to provide different fog. Squirting effect.

2. In addition to the design of the first point structure, the drug delivery device of the present invention can also be selected to provide a different atomization spray effect with the microporous oscillating plate design.

3. The units in the drug delivery device of the present invention are integrated into a single unit by combination, so that it is convenient to replace, disassemble and clean, and can be reused after being disinfected, thereby reducing the cost.

In summary, the "drug delivery device" of the present invention is as described above, achieves the intended purpose and efficacy, and has not been found to have the same or similar approximation after checking the relevant materials, fully complying with the positive requirements of the patent application, and Application.

However, the above description is only for the preferred embodiment of the present invention, and is not intended to limit the scope of the present invention; the equivalent variation or modification of the spirit of the scope of the present invention should be applied for. Covered by the scope.

(1). . . Drug delivery device

(10). . . Drug delivery pressure tube

(11). . . Mainstream gas inlet

(12). . . Drug outlet

(13). . . Canister fixing base

(131). . . Oscillating film

(14). . . Jack

(15). . . Oscillator

(151). . . Oscillating plate substrate

(16). . . Through hole

(20). . . Canister holder

(twenty one). . . Jack

(twenty two). . . Oscillating plate fixed platen

(twenty three). . . Fixed and leakproof cassettes

(30). . . Medicine tank

(31). . . Drug delivery tube

(32). . . Adjustable drug delivery inner tube

(321). . . Microneedle drip

(33). . . Quantitative pressure input drain

(34). . . Medicament bottle holder

(35). . . Quantitative pressure push source

(3). . . Outer casing

The first drawing is a structural diagram of a drug delivery device according to a preferred embodiment of the present invention;

The second drawing is a schematic cross-sectional view of a partial structure according to the first figure;

The third drawing is a structural diagram of a drug delivery device according to another preferred embodiment of the present invention;

The fourth figure is a schematic view of the appearance of the drug delivery device composed of the contents of the third figure;

The fifth figure is a schematic cross-sectional view of a partial structure according to the fourth figure;

Figure 6 is a schematic view showing the action of the drug delivery device according to another preferred embodiment of the present invention;

7 is a schematic cross-sectional view showing a partial structure of a drug delivery device according to still another preferred embodiment of the present invention;

Figure 8 is a schematic view showing the action of the drug delivery device according to still another preferred embodiment of the present invention;

Figure 9 is a schematic view showing the actual implementation of a preferred embodiment of the present invention;

The tenth embodiment is a schematic diagram of the actual implementation of a preferred embodiment of the present invention.

(1). . . Drug delivery device

(10). . . Drug delivery pressure tube

(11). . . Mainstream gas inlet

(12). . . Drug outlet

(13). . . Canister fixing base

(131). . . Oscillating film

(14). . . Jack

(15). . . Oscillator

(151). . . Oscillating plate substrate

(16). . . Through hole

(20). . . Canister holder

(twenty one). . . Jack

(twenty two). . . Oscillating plate fixed platen

(twenty three). . . Fixed and leakproof cassettes

(30). . . Medicine tank

(31). . . Drug delivery tube

(32). . . Adjustable drug delivery inner tube

(321). . . Microneedle drip

(33). . . Quantitative pressure input drain

(34). . . Medicament bottle holder

Claims (6)

A drug delivery device comprises: a drug delivery pressure tube, which is formed by the venturi principle, and has a conical hole formed at each end thereof and a throat portion formed therein, wherein a conical hole is a mainstream gas inlet, and a conical hole is a drug outlet; wherein a high-pressure mainstream gas can be input into the drug delivery pressure tube via the main gas inlet; a canister is fixed to the base, and the drug is formed near the inlet of the mainstream gas The surface of the pressurized tube is transported, and the surface of the pot fixing base is provided with an oscillating plate receiving groove in a rectangular recess shape; the two jacks are disposed on opposite sides of the oscillating plate placing groove; a through hole is disposed on a bottom surface of the oscillating plate placement groove and communicates with the inside of the drug delivery pressure tube; an oscillating plate is embedded in the oscillating plate placement groove and has an oscillating plate substrate, wherein The oscillating plate is a pole piece, and a plurality of micro holes are evenly arranged on the surface thereof; wherein the oscillating plate substrate has a thickness slightly larger than the oscillating plate, so that the oscillating plate is placed on the oscillating plate. The oscillation when the groove Presenting a suspended state; a canister fixing seat is a rectangular flat plate type, and is covered on the oscillating plate placing groove, the canister fixing seat has a corresponding socket formed on the medicine a bottom surface of the tank fixing seat corresponding to the through hole; and two fixing and leakage preventing latches disposed on opposite sides of the bottom surface of the medicine tank fixing seat for covering and closing the medicine tank fixing seat When the canister is fixed to the base, the correspondingly embedded in the corresponding base The canister is positioned to position the canister holder on the canister fixing base; and an alternative canister includes: a drug delivery tube having a non-orientation formed in the replaceable One end of the medicine tank, and the edge of the drug delivery tube is formed with a card edge for inserting into the corresponding socket; an adjustable drug delivery inner tube is disposed in the drug delivery tube And a microneedle nozzle is protruded at one end thereof; wherein, when combined, the drug delivery tube of the replaceable canister is coupled to the canister holder, and the canister is passed through the drug delivery tube and the drug delivery tube The adjustable drug delivery inner tube is in communication with the inside of the drug delivery pressure tube, and the microneedle tube drip enters the inside of the drug delivery pressure tube through the through hole; and a certain amount of pressure input drainage hole is formed in the The other end of the alternative canister; wherein the quantitative pressure input drainage hole is externally connected with a certain amount of pressure pushing source to provide a certain amount of pressure to the replaceable canister by the quantitative pressure pushing source, This way makes The liquid medicine in the replaceable medicine tank is dripped into the drug delivery pressure tube through the microneedle tube drip of the edge of the adjustable drug delivery inner tube, and is driven by the high pressure of the mainstream gas. The atomization is further ejected from the drug outlet. The drug delivery device of claim 1, which is completely covered in two outer casings that can be assembled with each other. The drug delivery device of claim 1, wherein the oscillating plate substrate is electrically connected to an external control panel through a wire to cause the oscillating plate to vibrate at a high speed by the control of the control panel. The drug delivery device of claim 1, wherein the cartridge holder further comprises an oscillating plate fixing platen disposed on the bottom surface of the can holder and slightly convex, and is used for pressing The oscillating plate substrate of the oscillating plate is fixed. The drug delivery device of claim 1, wherein the replaceable canister further comprises a canister ampoules, which are also formed at the other end of the replaceable canister, adjacent to the Quantitative pressure input drain. The drug delivery device of claim 1, wherein the distance between the microneedle nozzle and the oscillating plate is between 0.2 and 5 mm, and the diameter of the through hole must be less than 10 mm in diameter, and The diameter of the microneedle drip must be less than 1 mm in diameter.