TWI735246B - Improved needleless injection device - Google Patents

Abstract

The present invention provides an improved needleless injection device, which features: quick disassembly of the venturi atomization injection module and pop-up nozzle cover of the medicine tank, replaceable piston pressurized water jet injection module, and replaceable A limited number of microporous sheets, and the biological material in the improved liquid container enters the eccentric circulation slot in the venturi atomization injection module, which can quickly replace the venturi atomization injection module and prevent the separation of the operation process. The fixed part of the shaft and the fixed seat, as well as the detachable handle with the built-in power supply and air source; this combination can enhance the user-friendly operation of the needle-free injection device, and can achieve a more efficient and stable quantitative output of aerosol liquid Efficacy; In addition, the needle-free injection device has a power supply device that can be connected to an external power source and a sufficient gas source to achieve a longer-lasting and stable pressurized gas pressure output.

Description

Improved needleless injection device

The present invention is an improved needleless injection device, especially it is required to have the functions of quicker selection of the piston pressurized water jet injection module, replacement of the venturi atomization injection module, and liquid container in the implementation and use. Provide a more stable and long-lasting quantitative spray liquid output effect, but also can have practical effects such as convenient portability.

Since the use of needles to inject drugs is likely to cause discomfort to patients, and the disposal of needles after use and accidental puncture infections, a "needle-free injection" technique is developed accordingly. The so-called "needle-free injection" is in progress. The needle is not used for drug injection, but the liquid drug is ejected in a straight line with a very fine diameter at a high speed, and the drug penetrates the skin through its own kinetic energy in the water column penetration mode or in the atomized penetration mode to enter the organism (such as the human body or animal ) Of the body. Due to the characteristics of the fluid itself, when the liquid drug enters the internal tissues of the organism, it can diffuse and distribute along the gaps of the tissue fibers, so the entry process causes minimal damage to the tissue, and the drug can be effectively distributed and diffused to facilitate absorption. However, most of the drugs injected at present are mainly in the form of liquid water column. If you want to use the atomized form as an injection drug, the problem that the drug cannot enter the skin effectively due to the excessive molecular weight and poor permeability of the drug will affect it. To reach the depth and effect of the drug injection into the target, that is to say, the atomization type must have an excellent atomization effect to effectively penetrate the muscle membrane, muscles or joints under the human skin, and enhance the body's absorption effect of the drug. Therefore, when the atomization type is used as the drug injection method, the needle-free injection device needs to be The volume of atomized gas and the accuracy of drug quantification and injection time are well controlled to take into account the efficiency and safety and convenience of quantification requirements.

The conventional needle-free injection system, such as the Taiwan Announcement No. I670096 Invention Patent, discloses a needle-free injection device, which mainly uses a gas transmission tube, a gas tank, a cylinder, and a piston module as the main introduction components of pressurized gas. At the same time, it includes a venturi module and a piston module; any existing fluid substance containing bottle can be combined with the needle-free injection device, so that the needle-free injection device can be used to complete the needle-free injection procedure of the fluid substance. This needle-free injection device is suitable for the injection procedure of biological materials, and experimental data has confirmed that the biological materials (fibroblasts) ejected by the atomized needle-free injection device of the venturi module can still be used. It has a survival rate of up to 80%, and at the same time, the survival rate of the ejected fibroblasts is even more than 90% after receiving subsequent transplantation and culture. Therefore, the needle-free injection device is particularly suitable for one-way use of cell therapy.

However, although the needle-free injection device has its desired function, it has many flaws in its operation and use, and the applicant has found the following imperfections to be improved, including: the SOC nozzle cover and SC of the injection device The nozzle hood is opened in a rotating manner to take out the Venturi module. It takes more time to open; secondly, the through hole of the Venturi module of the needle-free injection device is provided with an oscillating plate to atomize and flow into the Venturi. Use, a through hole with a large diameter of 0.5mm to 1.5mm. The size of the through hole will cause the oscillating plate to stagnate due to the gas pressure released by the cylinder piston in the vent tube and the gas filled into the liquid container will also be It affects the stability of biological materials; in addition, the needle-free injection device is limited by gravity when in use, and can only be drawn out by siphoning when the liquid storage tank contains biological materials, so the liquid material contains When used at an angle above the vertical opening, it will be restricted, so that the biological materials cannot flow smoothly to the circulation tank for use; in addition, the fixing part is completely separated from the fixing seat when the liquid container is replaced, so there is a problem of the fixing part falling off, which affects Even In addition, the Venturi tube module uses the atomized high-speed jet method to penetrate into the tissue, so it must be administered several times to achieve the effect, and the needle-free injection device is fixedly connected to the power supply and the air source, resulting in a space for use The upper limit is limited, and it cannot be carried and used, which greatly reduces the convenience and practicability.

One object of the present invention is to provide a needleless injection device of a combined water jet type piston pressurized water jet injection module.

The second objective of the present invention is to provide an improved needle-free injection device, thereby achieving the effect that the venturi atomizing injection module can be removed and replaced more quickly and conveniently.

The third objective of the present invention is to provide an improved needle-free injection device. With a replaceable microporous sheet with a limited aperture, the operator can set the cylinder at ( 1~50mS) fast switch, the fixed pressure gas of the gas storage tank is sprayed out a quantitative gas in a constant speed pulse mode, and the gas is pressurized to the restricted aperture position through the venturi tube while the upper liquid containing the biological material in the tank is siphoned A quantitative biological material is extracted by the method, and mixed with the ejected gas, and ejected through the front end of the venturi in an atomized intermittent pulse ejection mode, which can achieve the best percutaneous penetration effect.

The fourth object of the present invention is to provide an improved needle-free injection device, by forming a straight-line communication design between the outlet of the improved eccentric circulation groove and the through hole entering the venturi module, the biological material can be injected in the needle-free type. A higher utilization rate is achieved from the perspective of device use.

The fifth object of the present invention is to provide an improved needle-free injection device, which uses a fixed part to design a movable axis, which can be restricted to the fixed seat to solve the problem of the fixed part falling off during insertion and removal, and to achieve a faster replacement of the liquid container The efficacy of the biological materials in the tank.

The sixth object of the present invention is to provide an improved and efficient needleless injection device, A power supply device is connected to a detachable handle to achieve the effect of integrating power and air source, which will be more convenient to carry and use. At the same time, the power supply device can also be connected to an external power source and a larger air source to achieve longer-term use benefits. .

In order to solve the conventional problem, the present invention provides an improved needle-free injection device in one embodiment, which mainly has an exterior and an interior composition. The exterior includes an injection device body composed of a set of relatively fitted casings, and an A detachable handle composed of a set of relatively combined handle shells; the inside of the body includes: an injection module and an air cylinder, the injection module includes: a venturi atomization injection module, which provides biological The material is mixed with high-pressure gas and then sprayed out, and a replaceable piston pressurized water jet injection module is driven by high-pressure gas. It can be used alternately with the venturi atomization injection module to provide biological materials. High-pressure water jet ejection; the cylinder provides high-pressure gas output, and one end is a gas storage chamber, and the other end is connected with a gas transmission pipe to connect to the casing end to form an external gas transmission connection seat for connecting external gas; The nozzle cover is a pop-up type for quicker and more convenient removal and replacement of the spray module; and a power supply device that provides connection to the built-in battery or external power source to control the power output.

The shape of the body and the detachable handle is not limited to any geometric shape, and the shape after composition is not limited, such as a gun-shaped design.

The above-mentioned venturi atomization injection module further includes: a venturi tube with two conical holes connected to the small diameter end of the pipe, and the two large diameter ends are respectively an outlet/inlet hole on the upper circumference of the venturi tube A circular fixed base is set on the surface, and a through hole penetrates through the center to communicate with the pipe connecting the small diameter ends of the two conical holes; a microporous sheet, a thin sheet with a hole in the center, is set in the fixed base; The fixing seat is fixed on the fixing base, and is matched with a fixing member that can be opened and closed quickly, so as to quickly replace the liquid storage tank, and there is a liquid storage tank inside the fixing seat, and has The outlet of an eccentric circulation groove body is in straight line communication with the through hole.

The aperture of the hole in the center of the microporous sheet is limited to the range of 0.01mm~0.5mm.

The liquid containing tank is provided with biological materials with a molecular weight of at least not higher than 2000kDa.

The above-mentioned fixing member can be connected to the fixing seat by using a movable shaft design on either side.

The above-mentioned nozzle cover further includes: a bracket covering the lower half of the end edge to connect with the casing; a front cover with a hollow nozzle and a joint and a cover; a row of teeth, one end of which is connected to the joint Connection, the other end has a hook, and the two sides are attached with opposite reduction wheels; a spring is fixed in the central groove of the tooth row and one end is fixed to provide the purpose of ejecting the front cover; a snap, with a fixed The shaft is connected and fixed with one end of the spring, and a snap hook provides a snap hook to fix one end of the tooth row.

The above-mentioned piston pressurized water jet injection module further includes: a movable plug thruster, the specific structure sequentially includes the piston air barrel connected to the air source, the tapered rear pillar, the movable plug pillar, and the movable plug front of the end edge Conical head, with a return air hole at the junction of the movable plug column and the tapered rear column and an exhaust port column on the peripheral surface of the tapered rear column; The tank is connected with a feed channel and a main pipe. The acceleration channel of the piston gas barrel at one end is connected with the tapered rear column groove, the movable column channel, the tapered front column injection groove, the compression channel and the injection hole in sequence. A length adjustment cover is provided on the outer cover of the injection hole, and a vent hole is provided on the tapered rear column stopper groove corresponding to the sealed exhaust port column; the main pipe provides the movable plug thruster to be pushed in by the rapid push of high-pressure gas , And use the tail section supply of high-pressure gas to be discharged from the return hole to the exhaust port, Will push the movable plug thruster back to its original position.

The above-mentioned power supply device further includes: a setting device, which can select the battery power display icon; a display, which provides the current battery power; a battery embedded in the power supply device and closed by a battery box cover, Provides the power source required for the normal operation of the power supply device; a cable set is used to seal the electrical connector on one surface with a cable buckle cover, and integrate with the power transmission line on the opposite side to provide a connection to the outside Power purpose.

The above-mentioned power supply device further includes a fixing member that can be connected to a larger external pressure source, including a pressure regulator and a high-pressure gas cylinder, to provide a more sufficient gas supply effect.

(1): Injection device body

(10): Chassis

(11): Tenon seat

(12): Card groove

(2): Detachable handle

(20): Handle shell

(21): Tenon groove

(211): Tenon

(22): Card hook

(23): High pressure gas cylinder

(24): Pressure regulator

(25): Battery

(3): Venturi atomizing spray module

(30): Venturi

(31): Outlet/inlet holes

(32): Through hole

(321): fixed base

(33): Microporous sheet

(331): Hole

(34): fixed seat

(341): fixed parts

(342): Liquid Holder

(343): Liquid Storage Tank

(345): Activity Axis

(4): Cylinder

(40): Air storage chamber

(41): Gas transmission tube

(5): Nozzle cover

(51): Front cover

(511): Joint

(512): Hood

(52): Tooth row

(521): Reduction wheel

(522): hook

(53): Spring

(54): Seizure

(541): fixed axis

(542): Seizure hook

(6): Power supply device

(60): Setter

(61): Display

(62): Battery

(621): Battery box cover

(63): Cable set

(631): Cable tie cover

(632): Power Transmission Line

(64): Fixed parts

(7): Piston pressurized water jet injection module

(70): Movable plug thruster

(701): Piston Air Bucket

(702): tapered rear post

(703): Movable plug

(704):The front tapered head of the movable plunger

(71): Return Hole

(72): Sealing exhaust port post

(73): Pressurized drug administration group

(731): medicinal solution container

(732): Feed channel

(74): Supervisor

(741): Piston Air Bucket Acceleration Channel

(742):Tapered rear post groove

(743): movable column channel

(744):Tapered front pillar injection slot

(745): Compression Road

(746): Ejection hole

(747): length adjustment cover

(75): Vent

The first figure is an overall appearance view of a needleless injection device according to an embodiment.

The second figure is a mostly exploded view of the needleless injection device of an embodiment.

The third figure is an overall cross-sectional view of a needleless injection device according to an embodiment.

The fourth figure is an exploded view of the venturi atomizing spray module of the needleless injection device according to an embodiment.

The fifth figure is an assembly diagram of the venturi atomization injection module of the needleless injection device of an embodiment.

Figure 6 is a schematic diagram of a piston-pressurized water jet injection module of a needleless injection device according to another embodiment.

The seventh figure is a schematic diagram of the operation of the nozzle cover of the needleless injection device according to an embodiment.

The eighth figure is an exploded view of the power supply device of the needleless injection device according to an embodiment.

The ninth figure is a combined diagram of the power supply device of the needleless injection device, the external high-pressure gas cylinder, and the pressure regulator of an embodiment.

The embodiments of the present invention are described in conjunction with the drawings. Please also refer to Figures 1 to 5, which discloses an improved needleless injection device provided by an embodiment of the present invention, which mainly has an exterior and an interior composition, and the exterior includes a set of relatively fitted casings (10) A detachable handle (2) composed of an injection device body (1) and a set of relatively combined handle shells (20), wherein the shape of the injection device body (1) and the detachable handle (2) are different The limit can be any geometric shape, and the shape after composition is not limited. In this example, a gun-shaped design is adopted. The inside of the body includes an injection module and a cylinder (4); as shown in the fourth and fifth figures, the injection module is a venturi atomization injection module (3) mainly includes: a venturi ( 30), the inside is a pipe connecting the small diameter ends of two conical holes; an air outlet/inlet hole (31) is formed at the large diameter end of the conical hole at both ends of the venturi (30); a through hole (32) , Set in the center of the circular fixed base (321) on the venturi (30), and a pipe connected by the small diameter ends of the two conical holes of the venturi (30) from the outside to form an internal and external communication; a micro-hole The sheet (33) is a sheet with a hole (331) in the center, which is set in the fixed base (321), and the aperture is limited between 0.01mm and 0.5mm; a fixed base (34) is fixed on the fixed base On the seat (321), there is a fast-opening and closing fixing member (341) to quickly replace the liquid containing tank (342). The liquid containing tank (342) is equipped with a biological material with a molecular weight of not higher than 2000kDa. The flexible material has a liquid storage tank (343) inside the fixing seat (34). One end of the cylinder (4) is an air storage chamber (40), and the other end is connected with a gas transmission pipe (41) and connected to the end of the casing (10) for connecting external air.

The above-mentioned detachable handle (2) composed of two opposing handle shells (20) further includes: a tenon groove (21) to provide a tenon seat (11) on the opposite housing (10). And use the tenon (211) to insert and fix it; and a hook (22) is provided to be embedded in the groove (12) on the opposite casing (10) to achieve the detachable handle (2) It is combined and fixed on the injection device body (1). The detachable handle (2) is provided with a connected high-pressure gas cylinder (23), pressure regulator (24) and battery (25) to provide adjustable air pressure and power sources to supply the injection device, respectively The action of the body (1).

As shown in Figures 4 and 5, the aforementioned fixing element (341) can be designed with a movable shaft (345) on either side to restrict the connection to the fixing seat (34), so as to solve the problem of the fixing element ( 341) has the problem of falling off, and can further achieve the effect of quickly replacing the liquid container (342).

Please refer to Figure 6, the above-mentioned injection module, namely the venturi atomization injection module, can be replaced and combined with a piston pressurized water jet injection module (7), which is It can be replaced and used according to the needs of the user. The specific structure includes: a movable plug thruster (70), the structure of which is connected to the high-pressure gas end of the piston gas barrel (701), the cone-shaped rear pillar (702), and the movable plug thruster (70). The plug plunger (703), and the front tapered head (704) of the movable plug plunger at the end edge, and there is a return air hole (71) at the junction of the movable plug plunger (703) and the tapered rear pillar (702). An exhaust port post (72) on the peripheral surface of the tapered rear post (702); and a pressurized dosing group (73) including: a liquid storage tank (731), a feed channel (732) ), and a main pipe (74) which is connected with the tapered rear column stop groove (742), the movable column passage (743) and the tapered front column injection groove (744) by the acceleration channel (741) of the piston gas barrel at one end in sequence , Compression channel (745) and injection hole (746), and the injection hole (746) is covered with a length adjustment cover (747), and the tapered rear post groove (742) corresponds to the exhaust port column (72) A vent (75) is provided; the main pipe (74) provides the activity The plug thruster (70) uses the rapid push of high-pressure gas to enter the propulsion, and uses the tail section of the high-pressure gas to be discharged when the return hole (71) corresponds to the exhaust port (75), which will push the movable plug thruster ( 70) Return to the original position.

Please refer to the seventh figure, there is a pop-up nozzle cover (5) at one end of the injection device body (1), which is designed to be quicker and easier to take out and replace the venturi atomizing spray module (3); this The nozzle cover (5) mainly includes: a bracket (not shown in the figure), which covers the lower half of the end edge and is connected to the casing (10); a front cover (51) with a hollow nozzle and a joint ( 511) and cover part (512); a tooth row (52), one end is connected with the joint (511), the other end has a hook (522), and the two sides are attached with opposite reduction wheels (521); A spring (53) is fixed in the central groove of the tooth row (52) and one end is fixed to provide the purpose of ejecting the front cover (51); a snap button (54) with a fixed axis (541) and the One end of the spring (53) is connected and fixed, and a snap hook (542) provides the snap hook (522) at one end of the tooth row (52) for interlocking and fixing. In practice, the front cover (51) is closed when the two snap hooks are fixed, and the snap hook (522) of the tooth row (52) is released from the snap hook (542) when the snap hook (54) is pressed. The speed of ejection is controlled by the reduction wheel (521) through the spring (53). The front cover and the gear row are connected by the joint (511) and can be bent downward to facilitate the venturi atomization injection module (3). )take out.

Please continue to refer to the eighth and ninth figures. The injection device body (1) further includes a power supply device (6) coupled to the upper side of the opposite casing (10) (as shown in the direction of the figure); the power supply The supply device (6) mainly includes: a setting device (60), which can select the display icon of the storage capacity (percentage%, or countdown and recording the use time); a display (61), which provides information about the current storage capacity of the battery; Battery (62), embedded in the power supply device (6) Inside, it is closed with a battery box cover (621) to provide the power source required for the normal operation of the power supply device (6); a cable set (63), which uses a cable buckle cover for the existing electrical connections (631) is closed and integrated with the power transmission line (632) on the opposite side to provide connection to external power; and a fixing piece (64) that can be connected to a larger external air pressure source, including a pressure adjustment A device (24) and a high-pressure gas cylinder (23) to provide a more sufficient qigong supply effect.

According to the operation of the above-mentioned needle-free injection device, the required biological material is selected and installed in the liquid containing tank (342), and the fixing seat (34) with the function of fast fixing and fixing is used with the fixing member (341) to Complete the installation; in implementation, the fixed pressure of the air storage chamber (40) is released through the internal cylinder (4) controlled by the timing switch to spray out the same volume of gas, and the organisms in the liquid containing tank (342) on the restricted aperture will be ejected The sexual material is drawn out in a siphon manner, and mixed with the ejected gas, and a stable and quantitative volume is ejected through the front end of the venturi atomization ejection module (3).

By replacing the above-mentioned venturi atomization spray module (3) with a piston pressurized water jet module (7), the water jet effect can be obtained. In action, when the high-pressure gas enters, it will touch and push the piston gas barrel (701), so that the front tapered head (704) of the movable plunger at the end of the piston propeller (70) will advance rapidly, because the micro-holes are larger than the injection Hole (746), so high-pressure gas is first poured into the liquid medicine containing tank (731), and the biological material is sprayed into the movable column channel (743) through the feed channel (732), and then the tapered head ( 704) is pushed to the compression channel (745), and then squeezed to the injection hole (746) for pressure injection. On the contrary, when the movable plug thruster (70) is retracted, the tail section supply of high-pressure gas is discharged from the air return hole (71) corresponding to the exhaust port (75), which will push the movable plug thruster (70) back To the original position.

Here is an experiment to verify the percutaneous spray of the needleless injection device of the present invention Shoot actual results.

The following figure shows the actual effect of the atomized spray of the present invention.

下表為定量功能測試(氣體壓力100psi；微孔孔徑0.25mm；開關時間3ms)

比較結果如下所示：

The following table is a quantitative function test (gas pressure 100psi; micropore diameter 0.25mm; switching time 3ms)

The comparison results are as follows:

Pigskin penetration results

下圖為本發明之無針注射裝置以B孔徑0.25mm及150psi之壓力施打(250mg/ml)螢光蛋白於鼠皮，經切片以共軛焦顯微鏡觀察，可完整觀察到皮層中的螢光反應。

The following figure shows the needle-free injection device of the present invention applying fluorescent protein (250mg/ml) to mouse skin with a B aperture of 0.25mm and 150psi pressure. After the section is observed with a conjugate focus microscope, the fluorescent protein in the cortex can be completely observed Light response.

下表為本發明無針注射裝置施打螢光蛋白及螢光玻尿酸於鼠皮，經切片以共軛焦顯微鏡觀察，皮膚組織完整且以徑0.25mm及150psi與100psi之壓力皆可於皮層中觀察到螢光反應。

The following table shows that the needle-free injection device of the present invention administers fluorescent protein and fluorescent hyaluronic acid to mouse skin. Observed by sectioning with a conjugate focus microscope, the skin tissue is intact and can be in the cortex with a diameter of 0.25 mm and pressures of 150 psi and 100 psi. Fluorescence reaction was observed.

以下為無針注射裝置之實驗施打條件：

實驗結果如下圖：經無針注射裝置每日10次連續施打在大鼠皮層4週，由切片觀察，皮膚組織完整且無發炎反應，無破損皮膚。實驗證實經改良限量微孔片之無針注射裝置有更穩定的定量輸出及更好霧化經皮吸收效果。

The following are the experimental conditions for the needle-free injection device:

The results of the experiment are shown in the figure below: 10 times a day for 4 weeks of continuous injection on the rat cortex via a needle-free injection device. Observed by the section, the skin tissue is intact and has no inflammatory reaction and no damaged skin. Experiments have confirmed that the needle-free injection device of the modified limited-quantity microporous tablet has a more stable quantitative output and a better atomized transdermal absorption effect.

From the above description, the features of the needle-free injection device of the present invention are: (1.) The injection module can be selected according to the injection requirements, including the high-pressure atomization injection effect of the venturi atomization injection module, or the piston plus The high-pressure water jet effect of the pressurized water jet module. (2.) The pop-up nozzle cover design improves the conventional needle-free injection device. The nozzle cover of the conventional needleless injection device is opened in a rotating manner, which leads to time-consuming opening of the venturi atomization spray module, and the pop-up nozzle cover design can Take out and replace the venturi atomizing spray module more quickly and conveniently. (3.) Replaceable limited-edition microporous sheet, by simply replacing the microporous pore size on the microporous sheet (the pore size is limited to the range of 0.01mm~0.5mm), and then matching with biological materials with a molecular weight of at least 2000kDa Quantitative injection can be used according to the molecular weight of biological materials. The intermittent pulse injection method can be changed. The cylinder is set to (1~50mS) fast switch, and the gas in the gas storage chamber is injected with a fixed speed pulse method. After the venturi atomization spray module is pressurized to the position of the restricted aperture, the biological material in the upper liquid containing tank is siphoned out, and mixed with the ejected gas to atomize through the front end of the venturi atomization spray module The type of intermittent pulse jet injection can achieve the best percutaneous penetration and depth. (4.) The improved design of the circulation tank for biological materials. Because the needle-free injection device is limited by gravity, it can only be drawn out by siphon when the liquid storage tank contains biological materials, so liquid substances When the accommodating port is used at an angle above the vertical angle, the biological material cannot flow into the circulation tank for use. Through the improved eccentric circulation tank outlet and the through hole to form a straight line connection, the biological material can be used in a needle-free injection device Increase the utilization rate from the perspective. (5.) The movable fixing part design allows the fixing part to be restricted to the fixing seat through a movable axis to be incompletely separated, which can solve the problem of the fixing part falling off when plugging and unplugging, and it can replace the liquid containing tank more quickly The biological material. (6.) Movable detachable handle with built-in power supply and air supply. Through the connection of the built-in power supply and air supply, the needleless injection device will be integrated into a type with both power supply and air supply, which is more convenient. Carry At the same time, the detachable handle can be quickly removed and connected to an external power source and a more atmospheric source to achieve a longer-term use benefit.

In summary, this invention clearly achieves the expected purpose and effect, and after checking the relevant information, there is no similarity or similarity, which fully meets the requirements of an invention patent application, and the application is filed in accordance with the law.

Although the present invention is disclosed as above in specific embodiments, it is not intended to limit the present invention. Anyone who is familiar with the art can still make some simple changes and modifications without departing from the spirit and scope of the present invention. Therefore, the present invention The scope of protection defined in the attached patent scope shall prevail.

(1): Injection device body

(10): Chassis

(11): Tenon seat

(2): Detachable handle

(20): Handle shell

(21): Tenon groove

(211): Tenon

(22): Card hook

(23): High pressure gas cylinder

(24): Pressure regulator

(25): Battery

(3): Venturi atomizing spray module

(4): Cylinder

(40): Air storage chamber

(41): Gas transmission tube

(5): Nozzle cover

(52): Tooth row

(521): Reduction wheel

(54): Seizure

Claims (10)

An improved needleless injection device, which has an exterior and an interior composition. The exterior includes a set of relatively fitted casings of the injection device body, and a set of relatively combined handles that are composed of a detachable handle; the The inside of the body includes: a venturi atomization injection module and a cylinder. The venturi atomization injection module provides for simultaneous mixing of biological materials and high-pressure gas before ejection. The cylinder provides high-pressure gas output. And one end is a gas storage chamber, and the other end is connected with a gas transmission tube to connect to the end of the casing to form an external gas transmission connection seat for connecting external gas; a nozzle cover is a pop-up type for faster and more convenient Take out and replace the venturi atomizing spray module; and a power supply device that provides connection to the built-in battery or external power source to control the power output. The improved needle-free injection device according to claim 1, wherein the venturi atomization injection module further comprises: a venturi tube, a pipe with two conical holes connected to the small diameter end, and the two large diameter ends are respectively An air outlet/inlet, a circular fixed base is provided on the upper peripheral surface of the venturi, and a through hole penetrates through the center to form a communication with the pipe connecting the small diameter ends of the two conical holes; a replaceable limited microporous sheet , Set in the fixed base; and a fixed seat, set on the fixed base, and inside the fixed seat there is an eccentric flow groove body outlet and the through hole in line communication. The improved needle-free injection device according to claim 2, wherein the aperture of the hole in the center of the microporous sheet is limited to a range of 0.01 mm to 0.5 mm. The improved needleless injection device according to claim 2, wherein the liquid containing tank is provided with a biological material with a molecular weight of not higher than 2000kDa. The improved needle-free injection device according to claim 2, wherein the fixing member can utilize a movable The moving shaft design can limit the connection to the fixed seat. The improved needle-free injection device according to claim 1, wherein the nozzle cover further comprises: a bracket covering the lower half of the end edge and connecting with the casing; a front cover with a hollow nozzle, and a joint and Cover; a tooth row, one end is connected with the joint, the other end has a hook, and two sides are attached with opposite reduction wheels; a spring is fixed in the central groove of the tooth row and one end is fixed, Provides the purpose of ejecting the front cover; a snap button with a fixed axis and one end of the spring connected and fixed, and a snap hook provides a snap hook fixing at one end of the tooth row. The improved needleless injection device according to claim 1, wherein the venturi atomization injection module can be replaced by a piston pressurized water jet injection module. The improved needle-free injection device according to claim 7, wherein the piston pressurized water jet injection module further includes: a movable plug thruster, and the specific structure sequentially includes a piston air barrel connected to the gas source and a tapered back column , The movable plug, and the front tapered head of the movable plug at the end, and there is a return hole at the junction of the movable plug and the tapered rear pillar and an exhaust port on the peripheral surface of the tapered rear pillar; With a pressurized drug administration group, it includes a drug solution containing tank connected with a feed channel, and a main pipe. The acceleration channel of the piston gas barrel at one end is connected to the tapered rear column groove, the movable column channel, and the cone in sequence. It is composed of an injection groove, a compression channel and an injection hole in the front column, and a length adjustment cover is arranged on the outer cover of the injection hole, and an exhaust hole is provided in the tapered rear column stopper groove corresponding to the exhaust port column; the main pipe provides the The movable plug thruster uses the rapid push of high-pressure gas to enter the propulsion, and uses the tail section of the high-pressure gas to be discharged when the return hole corresponds to the exhaust port, which will push the movable plug thruster back to the original position. The improved needle-free injection device according to claim 1, wherein the power supply device further includes: a setting device, which can select the display icon of the storage capacity; a display, which provides the current storage of the battery A battery, embedded in the power supply device, and closed with a battery box cover to provide the power source required for the normal operation of the power supply device; a cable set, which uses a cable for electrical connections on a surface The cable buckle cover is closed and integrated with the power transmission line on the opposite side to provide connection to external power. The improved needle-free injection device according to claim 1, wherein the power supply device further includes a fixing member that can be connected to a larger external air pressure source, including a pressure regulator and a high-pressure gas cylinder, to provide more sufficient Gas supply effect.

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