TWI457141B - 雙組分口腔保健產品 - Google Patents
雙組分口腔保健產品 Download PDFInfo
- Publication number
- TWI457141B TWI457141B TW098103784A TW98103784A TWI457141B TW I457141 B TWI457141 B TW I457141B TW 098103784 A TW098103784 A TW 098103784A TW 98103784 A TW98103784 A TW 98103784A TW I457141 B TWI457141 B TW I457141B
- Authority
- TW
- Taiwan
- Prior art keywords
- component
- composition
- arginine
- calcium
- phosphate
- Prior art date
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- 230000009977 dual effect Effects 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims description 59
- 239000004475 Arginine Substances 0.000 claims description 22
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 21
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 239000011575 calcium Substances 0.000 claims description 14
- 229910052791 calcium Inorganic materials 0.000 claims description 14
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 11
- 210000003298 dental enamel Anatomy 0.000 claims description 10
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 206010020751 Hypersensitivity Diseases 0.000 claims description 8
- 150000001450 anions Chemical class 0.000 claims description 8
- 208000002925 dental caries Diseases 0.000 claims description 7
- 208000026935 allergic disease Diseases 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 229910001424 calcium ion Inorganic materials 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000005115 demineralization Methods 0.000 claims description 5
- 230000002328 demineralizing effect Effects 0.000 claims description 5
- 230000009610 hypersensitivity Effects 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 229940085991 phosphate ion Drugs 0.000 claims description 4
- 239000011737 fluorine Substances 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 229910004261 CaF 2 Inorganic materials 0.000 claims description 2
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- 230000003902 lesion Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- GUYBGCBOZOALMT-UHFFFAOYSA-J dicalcium;fluoride;phosphate Chemical compound [F-].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O GUYBGCBOZOALMT-UHFFFAOYSA-J 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 239000000551 dentifrice Substances 0.000 description 39
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- -1 fluoride ions Chemical class 0.000 description 11
- 239000000047 product Substances 0.000 description 11
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- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 10
- 239000002562 thickening agent Substances 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000003242 anti bacterial agent Substances 0.000 description 9
- 230000036541 health Effects 0.000 description 9
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
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- 210000005239 tubule Anatomy 0.000 description 8
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- 239000000975 dye Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000049 pigment Substances 0.000 description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 6
- 230000000675 anti-caries Effects 0.000 description 6
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 5
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- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
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- 201000002170 dentin sensitivity Diseases 0.000 description 4
- 239000003906 humectant Substances 0.000 description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 230000007815 allergy Effects 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 230000003139 buffering effect Effects 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 229910000420 cerium oxide Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
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- 208000015181 infectious disease Diseases 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 235000019832 sodium triphosphate Nutrition 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
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- 235000019354 vermiculite Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2742208P | 2008-02-08 | 2008-02-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200948385A TW200948385A (en) | 2009-12-01 |
| TWI457141B true TWI457141B (zh) | 2014-10-21 |
Family
ID=40952695
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098103784A TWI457141B (zh) | 2008-02-08 | 2009-02-06 | 雙組分口腔保健產品 |
| TW103121297A TWI552762B (zh) | 2008-02-08 | 2009-02-06 | 雙組分口腔保健產品 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW103121297A TWI552762B (zh) | 2008-02-08 | 2009-02-06 | 雙組分口腔保健產品 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110059029A1 (enExample) |
| EP (1) | EP2249770A4 (enExample) |
| JP (2) | JP5584629B2 (enExample) |
| CN (2) | CN102764271B (enExample) |
| AR (1) | AR070586A1 (enExample) |
| AU (1) | AU2009212324B2 (enExample) |
| BR (1) | BRPI0907102A2 (enExample) |
| CA (1) | CA2710604C (enExample) |
| CO (1) | CO6300924A2 (enExample) |
| MX (1) | MX2010007740A (enExample) |
| MY (1) | MY157315A (enExample) |
| RU (1) | RU2476200C2 (enExample) |
| TW (2) | TWI457141B (enExample) |
| WO (1) | WO2009100268A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012017707B1 (pt) * | 2010-01-29 | 2021-11-09 | Colgate-Palmolive Company | Composição para higiene oral para cuidado do esmalte sensível |
| WO2013036229A1 (en) | 2011-09-08 | 2013-03-14 | Colgate-Palmolive Company | Oral and skin care compositions based on a 3, 3 ' - dialkyl - 1, 1 ' - biphenyl - 2, 2 ' - diol or a 3, 3 ' -dialkenyl- 1, 1 ' -biphenyl- 2, 2 ' -diol |
| JP2013163656A (ja) * | 2012-02-10 | 2013-08-22 | Gc Corp | 歯磨剤 |
| RU2524614C1 (ru) * | 2013-08-01 | 2014-07-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ увеличения прочности цементов для медицины |
| JP6092751B2 (ja) * | 2013-10-25 | 2017-03-08 | ライオン株式会社 | 歯磨組成物 |
| CA2927611C (en) * | 2013-12-03 | 2020-11-17 | Colgate-Palmolive Company | Oral care compositions |
| CA2961376A1 (en) * | 2014-09-15 | 2016-03-24 | Vizuri Health Sciences Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
| WO2016105389A1 (en) | 2014-12-23 | 2016-06-30 | Colgate-Palmolive Company | Oral care compositions |
| BR112017012629B1 (pt) | 2014-12-23 | 2021-06-08 | Colgate-Palmolive Company | composição para higiene bucal e uso da mesma |
| AU2015374240B2 (en) | 2014-12-29 | 2021-11-11 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
| JP6523002B2 (ja) * | 2015-03-20 | 2019-05-29 | 東洋エアゾール工業株式会社 | ２液混合型エアゾール歯磨剤 |
| MX365971B (es) * | 2015-04-29 | 2019-06-21 | Colgate Palmolive Co | Composiciones para el cuidado bucal. |
| WO2017048617A1 (en) * | 2015-09-15 | 2017-03-23 | Vizuri Health Sciences Llc | Polyphenol/flavonoid compositions and methods of formulating oral hygienic products |
| WO2020252501A1 (en) * | 2019-06-13 | 2020-12-17 | The Procter & Gamble Company | Kits comprising unit-dose oral care compositions |
| CN110693724B (zh) * | 2019-11-05 | 2020-10-30 | 浙江大学 | 一种牙齿矿化液及其矿化方法 |
| CN112336634B (zh) * | 2020-11-02 | 2022-03-22 | 浙江大学 | 基于微环境诱导纳米粒子再沉积的牙本质粘接预处理组合物及用途 |
| EP4014948A1 (de) * | 2020-12-18 | 2022-06-22 | Ivoclar Vivadent AG | Zusammensetzung zur remineralisation von zähnen |
| CN114939073A (zh) * | 2022-06-07 | 2022-08-26 | 云南白药集团健康产品有限公司 | 一种提高牙釉质再矿化效率的口腔护理用品及其制备方法与应用 |
| EP4292665A1 (en) * | 2022-06-16 | 2023-12-20 | Koninklijke Philips N.V. | An instantly formed cationic acp gel for treatment of tooth hypersensitivity |
| CN119421699A (zh) * | 2022-06-16 | 2025-02-11 | 皇家飞利浦有限公司 | 用于治疗牙齿过敏症的原位形成的阳离子acp凝胶 |
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| US5476647A (en) * | 1993-09-13 | 1995-12-19 | American Dental Association Health Foundation | Complex calcium and fluoride containing mouth rinses, dentifrices, and chewable tablets |
| GB2354441A (en) * | 1999-08-06 | 2001-03-28 | Mccormack Ltd | Composition for treating dentine hypersensitivity |
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| GB1352420A (en) * | 1971-06-18 | 1974-05-08 | Ajinomoto Kk | Arginine derivatives their production and their use |
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| GB1408922A (en) * | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
| US3932605A (en) * | 1972-06-12 | 1976-01-13 | Jaroslav Vit | Dental treatment |
| US3988434A (en) * | 1972-08-07 | 1976-10-26 | Schole Murray L | Dental preparation |
| US3863006A (en) * | 1973-01-29 | 1975-01-28 | Milton Hodosh | Method for desensitizing teeth |
| US4025616A (en) * | 1973-03-06 | 1977-05-24 | The Procter & Gamble Company | Oral compositions for plaque, caries and calculus retardation with reduced staining tendencies |
| US4100269A (en) * | 1973-06-28 | 1978-07-11 | Lever Brothers Company | Anticalculus dentifrice |
| US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
| US3925543A (en) * | 1973-11-01 | 1975-12-09 | Colgate Palmolive Co | Antibacterial oral compositions containing preservative-antioxidants |
| US4011309A (en) * | 1975-01-20 | 1977-03-08 | Marion Laboratories, Inc. | Dentifrice composition and method for desensitizing sensitive teeth |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
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| US4108981A (en) * | 1976-08-02 | 1978-08-22 | Indiana University Foundation | Alkaline oral compositions comprising aluminum and a carboxylic acid |
| US4042680A (en) * | 1976-08-02 | 1977-08-16 | Indiana University Foundation | Anticariogenic maloaluminate complexes |
| US4108979A (en) * | 1976-08-02 | 1978-08-22 | Indiana University Foundation | Dentifrice preparations comprising aluminum and a compatible abrasive |
| US4146607A (en) * | 1977-11-07 | 1979-03-27 | Lever Brothers Company | Synergistic anti-plaque mixture with tetradecylamine plus aluminum and/or zinc |
| US4160821A (en) * | 1978-02-27 | 1979-07-10 | Johnson & Johnson | Treatment for gingivitis |
| GB1573727A (en) * | 1978-05-19 | 1980-08-28 | Colgate Palmolive Co | Dentifrices |
| US4216961A (en) * | 1978-08-04 | 1980-08-12 | Mcquillan Mary J | Table baseball apparatus |
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| US4532124A (en) * | 1981-08-19 | 1985-07-30 | Development Finance Corporation Of New Zealand | Dental rinse |
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| JPS58118509A (ja) * | 1981-12-29 | 1983-07-14 | Lion Corp | 口腔用組成物 |
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| US4725576A (en) * | 1983-12-29 | 1988-02-16 | Research Foundation Of State University Of New York | Fungicidal polypeptide compositions containing L-histidine and methods for use therefore |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
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| JP2006069990A (ja) * | 2004-09-03 | 2006-03-16 | Kao Corp | 口腔用組成物 |
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-
2009
- 2009-02-06 CA CA2710604A patent/CA2710604C/en not_active Expired - Fee Related
- 2009-02-06 RU RU2010137324/15A patent/RU2476200C2/ru not_active IP Right Cessation
- 2009-02-06 WO PCT/US2009/033295 patent/WO2009100268A2/en not_active Ceased
- 2009-02-06 TW TW098103784A patent/TWI457141B/zh not_active IP Right Cessation
- 2009-02-06 US US12/866,639 patent/US20110059029A1/en not_active Abandoned
- 2009-02-06 TW TW103121297A patent/TWI552762B/zh not_active IP Right Cessation
- 2009-02-06 AU AU2009212324A patent/AU2009212324B2/en not_active Ceased
- 2009-02-06 EP EP20090707335 patent/EP2249770A4/en not_active Ceased
- 2009-02-06 CN CN201210249396.4A patent/CN102764271B/zh not_active Expired - Fee Related
- 2009-02-06 AR ARP090100432A patent/AR070586A1/es unknown
- 2009-02-06 MY MYPI2010002607A patent/MY157315A/en unknown
- 2009-02-06 MX MX2010007740A patent/MX2010007740A/es unknown
- 2009-02-06 JP JP2010546019A patent/JP5584629B2/ja not_active Expired - Fee Related
- 2009-02-06 BR BRPI0907102A patent/BRPI0907102A2/pt active Search and Examination
- 2009-02-06 CN CN2009801046404A patent/CN101938975B/zh not_active Expired - Fee Related
-
2010
- 2010-09-02 CO CO10108727A patent/CO6300924A2/es not_active Application Discontinuation
-
2014
- 2014-07-18 JP JP2014147534A patent/JP2014221814A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5476647A (en) * | 1993-09-13 | 1995-12-19 | American Dental Association Health Foundation | Complex calcium and fluoride containing mouth rinses, dentifrices, and chewable tablets |
| GB2354441A (en) * | 1999-08-06 | 2001-03-28 | Mccormack Ltd | Composition for treating dentine hypersensitivity |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009212324B2 (en) | 2011-12-08 |
| BRPI0907102A2 (pt) | 2016-05-03 |
| EP2249770A2 (en) | 2010-11-17 |
| JP2014221814A (ja) | 2014-11-27 |
| TW201442734A (zh) | 2014-11-16 |
| CN101938975A (zh) | 2011-01-05 |
| WO2009100268A3 (en) | 2009-11-05 |
| CN101938975B (zh) | 2012-09-05 |
| JP5584629B2 (ja) | 2014-09-03 |
| CN102764271A (zh) | 2012-11-07 |
| AR070586A1 (es) | 2010-04-21 |
| EP2249770A4 (en) | 2014-02-19 |
| CA2710604A1 (en) | 2009-08-13 |
| TWI552762B (zh) | 2016-10-11 |
| AU2009212324A1 (en) | 2009-08-13 |
| TW200948385A (en) | 2009-12-01 |
| CA2710604C (en) | 2014-07-08 |
| RU2010137324A (ru) | 2012-03-20 |
| CO6300924A2 (es) | 2011-07-21 |
| WO2009100268A2 (en) | 2009-08-13 |
| CN102764271B (zh) | 2016-03-02 |
| MY157315A (en) | 2016-05-31 |
| JP2011511795A (ja) | 2011-04-14 |
| RU2476200C2 (ru) | 2013-02-27 |
| US20110059029A1 (en) | 2011-03-10 |
| MX2010007740A (es) | 2010-08-06 |
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| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |