TWI457134B - Rheumatoid arthritis treatment - Google Patents
Rheumatoid arthritis treatment Download PDFInfo
- Publication number
- TWI457134B TWI457134B TW099108133A TW99108133A TWI457134B TW I457134 B TWI457134 B TW I457134B TW 099108133 A TW099108133 A TW 099108133A TW 99108133 A TW99108133 A TW 99108133A TW I457134 B TWI457134 B TW I457134B
- Authority
- TW
- Taiwan
- Prior art keywords
- antibody
- amino acid
- acid sequence
- seq
- receptor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009067358 | 2009-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW201034685A TW201034685A (en) | 2010-10-01 |
TWI457134B true TWI457134B (zh) | 2014-10-21 |
Family
ID=42739764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW099108133A TWI457134B (zh) | 2009-03-19 | 2010-03-19 | Rheumatoid arthritis treatment |
Country Status (5)
Country | Link |
---|---|
JP (2) | JP4809930B2 (ro) |
KR (1) | KR101314880B1 (ro) |
RU (1) | RU2524152C2 (ro) |
TW (1) | TWI457134B (ro) |
WO (1) | WO2010107108A1 (ro) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2008000188A1 (es) | 2007-01-23 | 2008-07-18 | Chugai Pharmaceutical Co Ltd | Agente para suprimir la reaccion de rechazo cronica que comprende como ingrediente activo un inhibidor de il-6; y uso del inhibidor de il-6. |
CA2728243C (en) | 2008-06-05 | 2020-03-10 | National Cancer Center | Il-6 inhibitor for suppressing neuroinvasion in pancreatic cancer |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
DK2578231T3 (da) | 2010-05-28 | 2022-12-12 | Chugai Pharmaceutical Co Ltd | Antitumor-t-celle-reaktionsforstærker |
US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
TW202339800A (zh) | 2015-02-27 | 2023-10-16 | 日商中外製藥股份有限公司 | Il-6受體抗體用於製備醫藥組成物的用途 |
ES2888801T3 (es) | 2015-05-19 | 2022-01-07 | Nat Center Neurology & Psychiatry | Método para determinar la aplicación de una terapia nueva en pacientes con esclerosis múltiple (EM) |
JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Il-6及び好中球の関連する疾患の治療効果の予測及び判定方法 |
US11692037B2 (en) | 2017-10-20 | 2023-07-04 | Hyogo College Of Medicine | Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
TWI822728B (zh) | 2018-01-31 | 2023-11-21 | 加藤元一 | 含有il-6抑制劑的哮喘治療劑 |
BR112021017702A2 (pt) | 2019-03-29 | 2021-11-16 | Chugai Pharmaceutical Co Ltd | Inibidor contendo anticorpo anti-receptor de il-6 para inibição de deterioração da função bhe |
TW202110477A (zh) | 2019-04-17 | 2021-03-16 | 國立大學法人廣島大學 | 以組合投予il-6 抑制劑與ccr2 抑制劑為特徵之泌尿器官癌的治療劑 |
AU2022232856A1 (en) | 2021-03-12 | 2023-10-26 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for treatment or prevention of myasthenia gravis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008020079A1 (en) * | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
TW201021829A (en) * | 2008-09-26 | 2010-06-16 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ298325B6 (cs) * | 1994-10-21 | 2007-08-29 | Kishimoto@Tadamitsu | Farmaceutický prípravek pro prevenci nebo lécení plasmocytosy |
DK2476705T3 (en) * | 2004-12-28 | 2015-12-14 | Innate Pharma | Monoclonal antibodies against NKG2A |
WO2009010539A2 (en) * | 2007-07-19 | 2009-01-22 | Ablynx. N.V. | Receptor for interleukin-6 (il-6) from macaca fascicularis |
CA2700498C (en) * | 2007-09-26 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Anti-il-6 receptor antibody |
MY180713A (en) * | 2007-09-26 | 2020-12-07 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
PL2708558T3 (pl) * | 2008-04-11 | 2018-09-28 | Chugai Seiyaku Kabushiki Kaisha | Cząsteczka wiążąca antygen zdolna do wiązania dwóch lub więcej cząsteczek antygenu w sposób powtarzalny |
-
2010
- 2010-03-19 KR KR1020117024354A patent/KR101314880B1/ko active IP Right Grant
- 2010-03-19 WO PCT/JP2010/054763 patent/WO2010107108A1/ja active Application Filing
- 2010-03-19 TW TW099108133A patent/TWI457134B/zh active
- 2010-03-19 RU RU2011142183/10A patent/RU2524152C2/ru active
- 2010-03-19 JP JP2010511837A patent/JP4809930B2/ja active Active
-
2011
- 2011-05-09 JP JP2011104172A patent/JP2011219478A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008020079A1 (en) * | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
TW201021829A (en) * | 2008-09-26 | 2010-06-16 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
Non-Patent Citations (1)
Title |
---|
Nishimoto N. Clinical studies in patients with Castleman's disease, Crohn's disease, and rheumatoid arthritis in Japan. Clin Rev Allergy Immunol. 2005 Jun;28(3):221-30. * |
Also Published As
Publication number | Publication date |
---|---|
RU2524152C2 (ru) | 2014-07-27 |
KR101314880B1 (ko) | 2013-10-04 |
JPWO2010107108A1 (ja) | 2012-09-20 |
JP4809930B2 (ja) | 2011-11-09 |
JP2011219478A (ja) | 2011-11-04 |
RU2011142183A (ru) | 2013-04-27 |
TW201034685A (en) | 2010-10-01 |
KR20110139734A (ko) | 2011-12-29 |
WO2010107108A1 (ja) | 2010-09-23 |
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GD4A | Issue of patent certificate for granted invention patent |