TWI433691B - 苯并咪唑之非水性組合物 - Google Patents
苯并咪唑之非水性組合物 Download PDFInfo
- Publication number
- TWI433691B TWI433691B TW095145431A TW95145431A TWI433691B TW I433691 B TWI433691 B TW I433691B TW 095145431 A TW095145431 A TW 095145431A TW 95145431 A TW95145431 A TW 95145431A TW I433691 B TWI433691 B TW I433691B
- Authority
- TW
- Taiwan
- Prior art keywords
- composition
- triclabendazole
- moxidectin
- group
- benzimidazole
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 52
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title description 18
- 238000000034 method Methods 0.000 claims description 18
- NQPDXQQQCQDHHW-UHFFFAOYSA-N 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole Chemical compound ClC=1C=C2NC(SC)=NC2=CC=1OC1=CC=CC(Cl)=C1Cl NQPDXQQQCQDHHW-UHFFFAOYSA-N 0.000 claims description 14
- 241001465754 Metazoa Species 0.000 claims description 14
- 229960000323 triclabendazole Drugs 0.000 claims description 13
- YZBLFMPOMVTDJY-CBYMMZEQSA-N moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-CBYMMZEQSA-N 0.000 claims description 12
- 229960004816 moxidectin Drugs 0.000 claims description 12
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- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- BWCRYQGQPDBOAU-UHFFFAOYSA-N Milbemycin D Natural products C1CC(C)C(C(C)C)OC21OC(CC=C(C)CC(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 BWCRYQGQPDBOAU-UHFFFAOYSA-N 0.000 description 1
- YRWLZFXJFBZBEY-UHFFFAOYSA-N N-(6-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCCC1=CC=C2N=C(NC(=O)OC)NC2=C1 YRWLZFXJFBZBEY-UHFFFAOYSA-N 0.000 description 1
- RAOCRURYZCVHMG-UHFFFAOYSA-N N-(6-propoxy-1H-benzimidazol-2-yl)carbamic acid methyl ester Chemical compound CCCOC1=CC=C2N=C(NC(=O)OC)NC2=C1 RAOCRURYZCVHMG-UHFFFAOYSA-N 0.000 description 1
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- VXTGHWHFYNYFFV-UHFFFAOYSA-N albendazole S-oxide Chemical compound CCCS(=O)C1=CC=C2NC(NC(=O)OC)=NC2=C1 VXTGHWHFYNYFFV-UHFFFAOYSA-N 0.000 description 1
- 229950010075 albendazole sulfoxide Drugs 0.000 description 1
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- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
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- DJIGQKWBFJTLNH-UHFFFAOYSA-H bis(1,5-dioxo-2,4,3-benzodioxabismepin-3-yl) benzene-1,2-dicarboxylate Chemical compound [Bi+3].[Bi+3].[O-]C(=O)c1ccccc1C([O-])=O.[O-]C(=O)c1ccccc1C([O-])=O.[O-]C(=O)c1ccccc1C([O-])=O DJIGQKWBFJTLNH-UHFFFAOYSA-H 0.000 description 1
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- QZWHWHNCPFEXLL-UHFFFAOYSA-N propan-2-yl n-[2-(1,3-thiazol-4-yl)-3h-benzimidazol-5-yl]carbamate Chemical compound N1C2=CC(NC(=O)OC(C)C)=CC=C2N=C1C1=CSC=N1 QZWHWHNCPFEXLL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74272405P | 2005-12-06 | 2005-12-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200800293A TW200800293A (en) | 2008-01-01 |
| TWI433691B true TWI433691B (zh) | 2014-04-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095145431A TWI433691B (zh) | 2005-12-06 | 2006-12-06 | 苯并咪唑之非水性組合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7687471B2 (https=) |
| EP (1) | EP1957040B1 (https=) |
| JP (1) | JP5342239B2 (https=) |
| KR (1) | KR20080073700A (https=) |
| AR (1) | AR057219A1 (https=) |
| AU (1) | AU2006322120B2 (https=) |
| BR (1) | BRPI0619620B1 (https=) |
| CA (1) | CA2630458C (https=) |
| DK (1) | DK1957040T3 (https=) |
| ES (1) | ES2527120T3 (https=) |
| NZ (1) | NZ567991A (https=) |
| PT (1) | PT1957040E (https=) |
| TW (1) | TWI433691B (https=) |
| WO (1) | WO2007067470A2 (https=) |
| ZA (1) | ZA200804915B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007144362A1 (en) | 2006-06-14 | 2007-12-21 | Intervet International B.V. | A suspension comprising benzimidazole carbamate and a polysorbate |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| ES2617672T3 (es) * | 2008-10-08 | 2017-06-19 | Zoetis Services Llc | Composiciones antihelmínticas de bencimidazol |
| WO2010126857A1 (en) * | 2009-04-28 | 2010-11-04 | Wyeth Llc | Parasiticidal combinations of macrocyclic lactones and polyether antibiotics |
| US9808529B2 (en) | 2012-05-18 | 2017-11-07 | Luoda Pharma Pty Ltd | Liquid formulation |
| BR102013031277B1 (pt) * | 2013-12-05 | 2018-10-02 | Ouro Fino Participacoes E Empreendimentos S A | processo para preparar uma suspensão anti-helmíntica e suspensão anti-helmíntica injetável |
| CN112006981B (zh) * | 2020-07-30 | 2023-01-10 | 瑞普（天津）生物药业有限公司 | 一种长效复方驱虫药物液体制剂及其制备方法与应用 |
| CN116744917A (zh) | 2020-09-04 | 2023-09-12 | 礼蓝美国公司 | 适口调配物 |
| BR102020021181A2 (pt) * | 2020-10-16 | 2022-04-26 | Ipanema Industria De Produtos Veterinarios Ltda | Microssuspensão contra parasitas e método para sua obtenção |
| CN114304161B (zh) * | 2021-11-25 | 2024-08-09 | 兰州大学 | 三氯苯达唑在防治农业病原菌中的用途 |
| WO2025221973A1 (en) * | 2024-04-18 | 2025-10-23 | Jjr&D, Llc | Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027598A1 (en) | 1993-05-26 | 1994-12-08 | Commonwealth Scientific And Industrial Research Organisation | Antiparasitic compositions |
| FR2755824B1 (fr) * | 1996-11-19 | 1999-01-08 | Virbac Sa | Formulation galenique des benzimidazoles a usage topique, son procede de preparation et ses utilisations |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
| AR035550A1 (es) * | 1999-06-04 | 2004-06-16 | Nufarm Ltd | Composiciones estables biocidas |
| NZ515772A (en) * | 1999-06-04 | 2002-12-20 | Nufarm Ltd | Pesticidal emulsion composition containing levamisole in the aqueous phase and an anthelmintic in the organic phase |
| CN1435176A (zh) | 2002-01-29 | 2003-08-13 | 王玉万 | 以表面活性剂为基础的含三氯苯哒唑的新制剂 |
| AU2002952597A0 (en) | 2002-11-11 | 2002-11-28 | Schering-Plough Pty. Limited | Topical parasiticide formulations and methods of treatment |
| WO2005074914A1 (en) * | 2004-02-03 | 2005-08-18 | Wyeth | Anthelmintic composition |
-
2006
- 2006-12-04 AR ARP060105354A patent/AR057219A1/es not_active Application Discontinuation
- 2006-12-04 EP EP06838906.3A patent/EP1957040B1/en active Active
- 2006-12-04 JP JP2008544409A patent/JP5342239B2/ja not_active Expired - Fee Related
- 2006-12-04 KR KR1020087009605A patent/KR20080073700A/ko not_active Ceased
- 2006-12-04 NZ NZ567991A patent/NZ567991A/en unknown
- 2006-12-04 DK DK06838906.3T patent/DK1957040T3/en active
- 2006-12-04 BR BRPI0619620-9A patent/BRPI0619620B1/pt active IP Right Grant
- 2006-12-04 PT PT68389063T patent/PT1957040E/pt unknown
- 2006-12-04 ES ES06838906.3T patent/ES2527120T3/es active Active
- 2006-12-04 CA CA2630458A patent/CA2630458C/en not_active Expired - Fee Related
- 2006-12-04 WO PCT/US2006/046197 patent/WO2007067470A2/en not_active Ceased
- 2006-12-04 AU AU2006322120A patent/AU2006322120B2/en active Active
- 2006-12-05 US US11/634,027 patent/US7687471B2/en not_active Expired - Fee Related
- 2006-12-06 TW TW095145431A patent/TWI433691B/zh not_active IP Right Cessation
-
2008
- 2008-06-05 ZA ZA200804915A patent/ZA200804915B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2527120T3 (es) | 2015-01-20 |
| JP2009518400A (ja) | 2009-05-07 |
| NZ567991A (en) | 2010-07-30 |
| AU2006322120B2 (en) | 2012-07-26 |
| US20070128239A1 (en) | 2007-06-07 |
| JP5342239B2 (ja) | 2013-11-13 |
| AR057219A1 (es) | 2007-11-21 |
| US7687471B2 (en) | 2010-03-30 |
| CA2630458C (en) | 2014-10-28 |
| BRPI0619620B1 (pt) | 2020-11-10 |
| PT1957040E (pt) | 2015-01-14 |
| DK1957040T3 (en) | 2014-12-08 |
| EP1957040A2 (en) | 2008-08-20 |
| WO2007067470A2 (en) | 2007-06-14 |
| TW200800293A (en) | 2008-01-01 |
| BRPI0619620A2 (pt) | 2011-10-04 |
| EP1957040B1 (en) | 2014-11-19 |
| AU2006322120A1 (en) | 2007-06-14 |
| CA2630458A1 (en) | 2007-06-14 |
| KR20080073700A (ko) | 2008-08-11 |
| ZA200804915B (en) | 2010-08-25 |
| WO2007067470A3 (en) | 2007-10-18 |
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| Date | Code | Title | Description |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |