TWI433686B - Far-infrared substrate for whitening skin - Google Patents

Far-infrared substrate for whitening skin Download PDF

Info

Publication number
TWI433686B
TWI433686B TW96121948A TW96121948A TWI433686B TW I433686 B TWI433686 B TW I433686B TW 96121948 A TW96121948 A TW 96121948A TW 96121948 A TW96121948 A TW 96121948A TW I433686 B TWI433686 B TW I433686B
Authority
TW
Taiwan
Prior art keywords
far
composition
infrared
cream
infrared emitting
Prior art date
Application number
TW96121948A
Other languages
Chinese (zh)
Other versions
TW200848084A (en
Inventor
Yung Sheng Lin
ming yu Lin
Tsung Tao Huang
Ting Kai Leung
Chuen Ming Shih
Original Assignee
Nat Applied Res Laboratories
Univ Taipei Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Applied Res Laboratories, Univ Taipei Medical filed Critical Nat Applied Res Laboratories
Priority to TW96121948A priority Critical patent/TWI433686B/en
Priority to US11/857,158 priority patent/US20080311059A1/en
Priority to DE102007046799A priority patent/DE102007046799B4/en
Priority to JP2007332171A priority patent/JP2008308482A/en
Publication of TW200848084A publication Critical patent/TW200848084A/en
Application granted granted Critical
Publication of TWI433686B publication Critical patent/TWI433686B/en

Links

Description

用於美白的遠紅外線基材Far infrared ray substrate for whitening

本案係指一種遠紅外線基材,特別是指一種用於美白的遠紅外線基材。This case refers to a far-infrared substrate, and in particular to a far-infrared substrate for whitening.

人體的黑色素係由皮膚中黑色素細胞(melanocytes)內之酪胺酸受酪胺酸酶催化而氧化形成,故皮膚白的人就是酪胺酸酶的功能被壓抑,而顯得白皙,而皮膚黑的人就是酪胺酸酶作用旺盛之後的結果。一般市售的美白產品多利用化學的方法來減少黑色素的形成,例如使用植物萃取的熊果素等,但是使用化學方法來美白常存在有效成分吸收不良的問題,更甚者易出現皮膚過敏不適等負面作用,而導致美白的效果大打折扣。The melanin of the human body is formed by the oxidation of tyrosine in the melanocytes of the skin by tyrosinase, so the white-skinned person is the function of tyrosinase, which is suppressed and appears white and black. People are the result of the strong tyrosinase action. Generally, commercially available whitening products use chemical methods to reduce the formation of melanin, for example, using plant-derived arbutin, but the use of chemical methods to whiten often has problems of poor absorption of active ingredients, and even more susceptible to skin irritation and discomfort. The effect, and the effect of whitening is greatly reduced.

遠紅外線是波長3-1000微米之一種電磁波,其中波長介於3-14微米之遠紅外線,因其對於動植物的生長都有促進的效用,故科學家稱之為生命光線。遠紅外線不但不會刺激人體,反而可以使人體能量增幅,其特性是能深入人體內部的組織,促進人體內細胞的水分子產生共振,賦予細胞生命力,加速血液循環,活化新陳代謝,增進組織再生的能力,活化免疫系統等,目前在醫學上已證實遠紅外線對於多種人體疾病都有治療的功效。Far-infrared rays are electromagnetic waves with a wavelength of 3-1000 micrometers. The far-infrared rays with wavelengths between 3 and 14 micrometers have a promoting effect on the growth of animals and plants, so scientists call them life rays. Far-infrared rays not only do not stimulate the human body, but can increase the energy of the human body. Its characteristics are that it can penetrate into the internal tissues of the human body, promote the resonance of water molecules in the cells of the human body, impart vitality to the cells, accelerate blood circulation, activate metabolism, and promote tissue regeneration. The ability to activate the immune system, etc., has been medically proven to have therapeutic effects on a variety of human diseases.

職是之故,發明人鑑於習知技術之缺失,乃經悉心試驗與研究並一本鍥而不捨之精神,終發明出一種利用遠紅外線功能來達到美白目的之組合物與基材,以下為本發明之簡要說明。As a result of the job, the inventor, in view of the lack of the prior art, has carefully tested and researched the spirit of perseverance, and finally invented a composition and substrate that utilizes the far-infrared function to achieve whitening purposes. A brief description.

本發明提供一種物理美白方式,用以解決習知技藝中利用化學方法來美白所存在之吸收不良及過敏等缺失。The present invention provides a physical whitening method for solving the malabsorption and allergic defects such as the use of chemical methods to whiten in the prior art.

本案之目的為提供一種遠紅外線乳霜,其包含一遠紅外線釋放物質,該遠紅外線釋放物質的主要成分為一氧化礦物,其中該氧化礦物包含60-95%之氧化鋁。The purpose of the present invention is to provide a far-infrared ray cream comprising a far-infrared emitting substance, the main component of which is an oxidized mineral, wherein the oxidized mineral comprises 60-95% of alumina.

根據上述構想,該遠紅外線乳霜更包含其他活性物質、佐劑及添加劑。According to the above concept, the far-infrared cream further contains other active substances, adjuvants and additives.

根據上述構想,其中該遠紅外線乳霜係一化妝品製品。According to the above concept, the far-infrared cream is a cosmetic product.

根據上述構想,其中該化妝品製品更包含至少一種選自於油、脂肪、蠟、烴、脂肪酸、固醇、荷爾蒙、維他命、脂肪酸酯、濕潤劑、界面活性劑、顏料、黏度改善劑、成膜劑、紫外線吸收劑、抗真菌劑、消炎劑、抗汗劑、防腐劑及芳香劑之化妝品原料。According to the above concept, wherein the cosmetic preparation further comprises at least one selected from the group consisting of oils, fats, waxes, hydrocarbons, fatty acids, sterols, hormones, vitamins, fatty acid esters, humectants, surfactants, pigments, viscosity improvers, and Cosmetic raw materials for films, UV absorbers, antifungals, anti-inflammatory agents, antiperspirants, preservatives and fragrances.

根據上述構想,其中該遠紅外線乳霜係一醫藥製品。According to the above concept, the far-infrared cream is a medical product.

根據上述構想,其中該遠紅外線乳霜係一工業製品。According to the above concept, the far infrared ray cream is an industrial product.

根據上述構想,其中該工業製品係選自包含油漆、塗料、潤滑劑、薄膜、凝膠、紙上膠劑、乳膠、營造或築路材料、油墨、染料、蠟及亮光劑。According to the above concept, the industrial product is selected from the group consisting of paints, coatings, lubricants, films, gels, paper sizing agents, latexes, building or building materials, inks, dyes, waxes and glazing agents.

根據上述構想,其中該遠紅外線釋放物質所釋放之遠紅外線在4~16 μm波長的放射係數在0.9以上。According to the above concept, the far-infrared rays released by the far-infrared emitting material have an emissivity of 0.9 or more at a wavelength of 4 to 16 μm.

根據上述構想,其中該氧化礦物更包含1-20%之氧化鐵。According to the above concept, the oxidized mineral further contains 1-20% of iron oxide.

根據上述構想,其中該氧化礦物更包含1-10%之氧化鎂。According to the above concept, the oxidized mineral further contains 1-10% of magnesium oxide.

根據上述構想,其中該氧化礦物更包含1-30%之碳酸鈣。According to the above concept, the oxidized mineral further comprises 1-30% of calcium carbonate.

本案之另一目的為提供一種遠紅外線基材,其包含一基材以及一遠紅外線釋放物質,該遠紅外線釋放物質混合於該基材中且其成分包含60-95%之氧化鋁。Another object of the present invention is to provide a far infrared ray substrate comprising a substrate and a far infrared ray releasing substance mixed in the substrate and having a composition comprising 60 to 95% of alumina.

根據上述構想,其中該基材係選自金屬、玻璃、陶瓷及高分子材質至少其中之一。According to the above concept, the substrate is selected from at least one of a metal, a glass, a ceramic, and a polymer material.

根據上述構想,其中該遠紅外線釋放物質的成分更包含1-20%之氧化鐵。According to the above concept, the component of the far-infrared emitting substance further contains 1-20% of iron oxide.

根據上述構想,其中該遠紅外線釋放物質的成分更包含1-10%之氧化鎂。According to the above concept, the component of the far-infrared emitting substance further contains 1-10% of magnesium oxide.

根據上述構想,其中該遠紅外線釋放物質的成分更包含1-30%之碳酸鈣。According to the above concept, the component of the far-infrared emitting substance further contains 1 to 30% of calcium carbonate.

根據上述構想,其中該遠紅外線釋放物質所釋放之遠紅外線在4-16 μm波長的放射係數在0.9以上。According to the above concept, the far-infrared rays released by the far-infrared emitting substance have an emissivity of 0.9 or more at a wavelength of 4 to 16 μm.

根據上述構想,其中該遠紅外線釋放物質的成分包含氧化鋁、二氧化鈦、硼化鈦、氧化鎂、氧化矽、氧化鐵、氫氧化鋅、氧化鋅及碳化物至少其中之一。According to the above concept, the component of the far-infrared emitting substance contains at least one of alumina, titania, titanium boride, magnesium oxide, cerium oxide, iron oxide, zinc hydroxide, zinc oxide, and carbide.

根據上述構想,其中該遠紅外線釋放物質在結構上係選自為塊狀、顆粒狀、粉末狀及薄膜至少其中之一。According to the above concept, the far-infrared emitting substance is structurally selected from at least one of a block, a granule, a powder, and a film.

本案之另一目的為提供一種用於美白的組成物,其包含一遠紅外線釋放物質,該遠紅外線釋放物質的主要成分為一氧化礦物,該組成物透過該遠紅外線釋放物質釋放之遠紅外線達到美白的目的。Another object of the present invention is to provide a composition for whitening, which comprises a far-infrared emitting substance, the main component of which is an oxidized mineral, and the composition reaches the far-infrared rays released by the far-infrared emitting substance. The purpose of whitening.

根據上述構想,更包含其他活性物質、佐劑及添加劑。According to the above concept, other active substances, adjuvants and additives are further included.

根據上述構想,其中該組成物係為乳液、乳霜、凝膠、溶液、膠體分散液、懸浮液、軟膏、洗劑、乳霜、泡沫、泡沫乳膠及凝膠至少其中之一。According to the above concept, the composition is at least one of an emulsion, a cream, a gel, a solution, a colloidal dispersion, a suspension, an ointment, a lotion, a cream, a foam, a foamed latex, and a gel.

根據上述構想,其中該組成物係一化妝品組成物。According to the above concept, the composition is a cosmetic composition.

根據上述構想,其中該化妝品組成物更包含至少一種選自於油、脂肪、蠟、烴、脂肪酸、固醇、荷爾蒙、維他命、脂肪酸酯、濕潤劑、界面活性劑、顏料、黏度改善劑、成膜劑、紫外線吸收劑、抗真菌劑、消炎劑、抗汗劑、防腐劑及芳香劑之化妝品原料。According to the above concept, wherein the cosmetic composition further comprises at least one selected from the group consisting of oils, fats, waxes, hydrocarbons, fatty acids, sterols, hormones, vitamins, fatty acid esters, humectants, surfactants, pigments, viscosity improvers, Cosmetic raw materials for film formers, UV absorbers, antifungals, anti-inflammatory agents, antiperspirants, preservatives and fragrances.

根據上述構想,其中該組成物係一醫藥組成物。According to the above concept, wherein the composition is a pharmaceutical composition.

根據上述構想,其中該醫藥組成物更包含醫藥上可接受的載劑。According to the above concept, wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.

根據上述構想,其中該遠紅外線釋放物質所釋放之遠紅外線在4~16 μm波長的放射係數在0.9以上。According to the above concept, the far-infrared rays released by the far-infrared emitting material have an emissivity of 0.9 or more at a wavelength of 4 to 16 μm.

根據上述構想,其中該氧化礦物包含氧化鋁。According to the above concept, wherein the oxidized mineral comprises alumina.

根據上述構想,其中該氧化礦物包含60-95%之氧化鋁。According to the above concept, wherein the oxidized mineral comprises 60-95% alumina.

根據上述構想,其中該氧化礦物包含1-20%之氧化鐵。According to the above concept, wherein the oxidized mineral contains 1-20% of iron oxide.

根據上述構想,其中該氧化礦物包含1-10%之氧化鎂。According to the above concept, wherein the oxidized mineral contains 1-10% of magnesium oxide.

根據上述構想,其中該氧化礦物包含1-30%之碳酸鈣。According to the above concept, wherein the oxidized mineral comprises 1-30% of calcium carbonate.

本案得藉由下列詳細說明,俾得更深入之了解:The case can be further explained by the following detailed explanation:

本發明將藉由下述之較佳實施例及其配合之圖示,做進一步之詳細說明。The invention will be further described in detail by the following preferred embodiments and the accompanying drawings.

第一實施例First embodiment

本發明提供一種遠紅外線乳霜,其係將一遠紅外線釋放物質依不同比例混入一化妝品乳霜中,較佳的比例是化妝品乳霜中包含1~20%之遠紅外線釋放物質。該化妝品乳霜中包含油、脂肪、蠟、烴、脂肪酸、固醇、荷爾蒙、維他命、脂肪酸酯、濕潤劑、界面活性劑、顏料、黏度改善劑、成膜劑、紫外線吸收劑、抗真菌劑、消炎劑、抗汗劑、防腐劑或芳香劑等化妝品原料。為使該化妝品乳霜同時具有更多功效,其亦可包含其他活性物質、佐劑及添加劑。本實施例之遠紅外線乳霜經標準規範實驗證實不會引起皮膚過敏反應,故以此遠紅外線乳霜作為皮膚外用美白用途理應有廣大之商機。The present invention provides a far-infrared ray cream which incorporates a far-infrared ray releasing substance into a cosmetic cream in different proportions. A preferred ratio is that the cosmetic cream contains 1 to 20% of a far-infrared ray releasing substance. The cosmetic cream comprises oil, fat, wax, hydrocarbon, fatty acid, sterol, hormone, vitamin, fatty acid ester, wetting agent, surfactant, pigment, viscosity improver, film former, ultraviolet absorber, antifungal Cosmetic ingredients such as anti-inflammatory agents, antiperspirants, preservatives or fragrances. In order to make the cosmetic cream more effective at the same time, it may also contain other active substances, adjuvants and additives. The far-infrared cream of this embodiment is confirmed by standard normative experiments to not cause skin allergic reaction, so the far-infrared cream should be used as a skin for external whitening.

本實施例中之遠紅外線釋放物質之原料乃採用儀器科技研究中心與台北醫學大學共同開發之高效能遠紅外線陶瓷粉末,其生物效應已經過多項實驗證實具有相當程度之效果。其成分由數種天然礦物成分組成,其中可包含60-95%之氧化鋁、1-20%之氧化鐵、1-10%之氧化鎂及1-30%之碳酸鈣。其他成分尚可包含二氧化鈦、硼化鈦或更多天然礦物成分,例如氧化矽、氫氧化鋅、氧化鋅和碳化物等。以黑體當作基準,利用遠紅外線光譜儀量測,該遠紅外線釋放物質於生命光線波長範圍在6~14微米區間具有平均0.98以上釋放率。且依據美國AATCC100標準方法測試滅菌率,該釋放之遠紅外線對於金黃色葡萄球菌及大腸桿菌都有99.9%以上的抑菌效果。The raw material of the far-infrared emitting material in the present embodiment is a high-efficiency far-infrared ceramic powder jointly developed by the Instrument Technology Research Center and the Taipei Medical University, and its biological effects have been confirmed by a number of experiments to have a considerable degree of effect. The composition consists of several natural mineral components, which may comprise 60-95% alumina, 1-20% iron oxide, 1-10% magnesium oxide and 1-30% calcium carbonate. Other ingredients may still contain titanium dioxide, titanium boride or more natural mineral components such as cerium oxide, zinc hydroxide, zinc oxide and carbides. The black body is used as a reference and measured by a far-infrared spectrometer. The far-infrared emitting material has an average release rate of 0.98 or more in the range of 6 to 14 micrometers in the wavelength range of the living light. And the sterilization rate is tested according to the American AATCC100 standard method, and the released far infrared rays have an antibacterial effect of 99.9% or more for both Staphylococcus aureus and Escherichia coli.

本實施例中之遠紅外線乳霜係一化妝品製品,其提供皮膚外用之塗覆以達美白、加強血液循環、促進新陳代謝、改善個人體質、進而達到保健醫療的目的。但是其型式並不以此為限,其亦可為一醫藥製品或一工業製品。The far-infrared cream in the present embodiment is a cosmetic product, which provides a coating for external application of the skin to whiten the skin, enhance blood circulation, promote metabolism, improve personal physique, and thereby achieve health care. However, the type thereof is not limited thereto, and it may also be a medical product or an industrial product.

若本發明所提供之遠紅外線乳霜係為一工業製品,其可作為油漆、塗料、潤滑劑、薄膜、凝膠、紙上膠劑、乳膠、營造或築路材料、油墨、染料、蠟及亮光劑等。只要處於有該些工業製品的環境中,就可以得到遠紅外線帶給人體正面的影響,該遠紅外線乳霜可應用及影響之層面之廣由此可見一班。If the far infrared ray cream provided by the invention is an industrial product, it can be used as paint, paint, lubricant, film, gel, paper sizing agent, latex, building or road building material, ink, dye, wax and light Agents, etc. As long as it is in the environment of these industrial products, the influence of the far-infrared rays on the front side of the human body can be obtained, and the wide range of applications and influences of the far-infrared cream can be seen.

第二實施例Second embodiment

請參閱第一圖,其為本發明所提遠紅外線基材的第二較佳實施例之示意圖。如圖示,本發明之遠紅外線基材包含一基材20以及混合於該基材中的一遠紅外線釋放物質10。其中該基材20係選自金屬、玻璃、陶瓷及高分子材質至少其中之一。該遠紅外線釋放物質10在結構上係選自為塊狀、顆粒狀、粉末狀及薄膜至少其中之一。該遠紅外線釋放物質10的其他性質如成分及功效等皆同於第一實施例,故此不再複述。Please refer to the first drawing, which is a schematic view of a second preferred embodiment of the far infrared ray substrate of the present invention. As illustrated, the far infrared ray substrate of the present invention comprises a substrate 20 and a far infrared ray releasing substance 10 mixed in the substrate. The substrate 20 is selected from at least one of metal, glass, ceramic, and polymer materials. The far-infrared emitting substance 10 is structurally selected from at least one of a block, a granule, a powder, and a film. Other properties such as composition and efficacy of the far-infrared emitting substance 10 are the same as those in the first embodiment, and thus will not be described again.

該遠紅外線基材可應用的範圍十分廣泛,尤其為了美白之用途,該遠紅外線基材可做成日常生活中的各種器具、醫療用品、建材、交通工具或紡織品,以達到隨時隨地都可美白的便利性。The far-infrared substrate can be applied in a wide range of applications, especially for the purpose of whitening, the far-infrared substrate can be made into various instruments, medical supplies, building materials, vehicles or textiles in daily life, so as to be whitened anytime and anywhere. Convenience.

第三實施例Third embodiment

本發明的第三實施例為一種用於美白的組成物,其包含一遠紅外線釋放物質,該遠紅外線釋放物質的其他性質如成分及功效等皆同於第一實施例,故此不再複述。該組成物透過該遠紅外線釋放物質釋放之遠紅外線達到美白的目的。本實施例中之美白組成物可包含其他活性物質、佐劑及添加劑以達到更多之功效。本實施例之美白組成物可以各種形式呈現,例如乳液、乳霜、凝膠、溶液、膠體分散液、懸浮液、軟膏、洗劑、乳霜、泡沫、泡沫乳膠或凝膠等。若該組合物添加於化妝品當中,則該化妝品可包含油、脂肪、蠟、烴、脂肪酸、固醇、荷爾蒙、維他命、脂肪酸酯、濕潤劑、界面活性劑、顏料、黏度改善劑、成膜劑、紫外線吸收劑、抗真菌劑、消炎劑、抗汗劑、防腐劑及芳香劑等化妝品原料。若該組合物用於醫藥上,則該醫藥用的組合物可包含醫藥上可接受的載劑、賦形劑或稀釋劑,使其經各種途徑用於美白用途。A third embodiment of the present invention is a composition for whitening, which comprises a far-infrared emitting substance, and other properties such as composition and efficacy of the far-infrared emitting substance are the same as those in the first embodiment, and thus will not be described again. The composition achieves the purpose of whitening through the far infrared rays released by the far-infrared emitting substance. The whitening composition of this embodiment may contain other active substances, adjuvants and additives to achieve more efficacy. The whitening composition of this embodiment can be presented in various forms such as emulsions, creams, gels, solutions, colloidal dispersions, suspensions, ointments, lotions, creams, foams, foamed latex or gels and the like. If the composition is added to a cosmetic, the cosmetic may comprise oil, fat, wax, hydrocarbon, fatty acid, sterol, hormone, vitamin, fatty acid ester, humectant, surfactant, pigment, viscosity improver, film formation. Cosmetics such as agents, UV absorbers, antifungals, anti-inflammatory agents, antiperspirants, preservatives and fragrances. If the composition is for pharmaceutical use, the pharmaceutical composition may comprise a pharmaceutically acceptable carrier, excipient or diluent which is used in various ways for whitening purposes.

請參閱第二圖(a)(b),其揭露本發明所提供之遠紅外線釋放物質對B16F10細胞中黑色素含量影響之柱狀圖。本試驗是以B16F10黑色素瘤細胞做為試驗材料,取每盤含104 個B16F10黑色素瘤細胞的細胞培養盤於37℃培養24小時。之後分別將細胞培養盤置於100公克的遠紅外線釋放物質(實驗組)及100公克的奶粉(對照組)上,使細胞與遠紅外線釋放物質無直接接觸,置放24及48小時之後收集細胞,將細胞裂解後以分光光度計測定波長475 nm之吸光值以做為細胞中黑色素含量的代表。如圖中所示,以本發明所提供之遠紅外線釋放物質處理B16F10細胞24小時後可有效降低B16F10細胞中黑色素含量達10%;在處理48小時後黑色素含量則可降低15%。由本試驗可知本發明所提供之遠紅外線釋放物質確實可降低細胞中黑色素的含量。Please refer to the second figure (a)(b), which discloses a histogram of the effect of the far infrared ray releasing substance provided by the present invention on the melanin content in B16F10 cells. In this test, B16F10 melanoma cells were used as test materials, and a cell culture plate containing 10 4 B16F10 melanoma cells per plate was cultured at 37 ° C for 24 hours. Then, the cell culture plates were placed on a 100 gram far-infrared emitting material (experimental group) and 100 gram of milk powder (control group), so that the cells were not in direct contact with the far-infrared emitting material, and the cells were collected after 24 and 48 hours. After lysing the cells, the absorbance at a wavelength of 475 nm was measured by a spectrophotometer as a representative of the melanin content in the cells. As shown in the figure, treatment of B16F10 cells with the far-infrared emitting material provided by the present invention can effectively reduce the melanin content in B16F10 cells by 10% after 24 hours; the melanin content can be reduced by 15% after 48 hours of treatment. It is known from the test that the far-infrared emitting substance provided by the present invention can actually reduce the content of melanin in the cells.

請參閱第三圖(a)(b),其揭露本發明所提供之遠紅外線釋放物質對B16F10細胞體外生長的影響之柱狀圖。本試驗同樣是以B16F10黑色素瘤細胞做為試驗材料,取每盤含104 個B16F10黑色素瘤細胞的細胞培養盤培養16小時。之後分別將細胞培養盤置於100公克的遠紅外線釋放物質(實驗組)及100公克的奶粉(對照組)上處理24及48小時。處理後的B16F10黑色素瘤細胞以MTT(3,[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide)測定法檢測細胞於體外增殖的情形。如圖中所示,以本發明所提供之遠紅外線釋放物質處理B16F10細胞24小時和48小時,都有抑制B16F10細胞增殖的效果。Please refer to the third figure (a)(b), which discloses a histogram of the effect of the far infrared ray releasing substance provided by the present invention on the growth of B16F10 cells in vitro. This test also used B16F10 melanoma cells as test materials, and cultured in a cell culture tray containing 10 4 B16F10 melanoma cells for 16 hours. The cell culture plates were then placed on a 100 gram far infrared ray release material (experimental group) and 100 gram of milk powder (control group) for 24 and 48 hours, respectively. The treated B16F10 melanoma cells were tested for proliferation in vitro by MTT (3,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay. As shown in the figure, treatment of B16F10 cells with the far-infrared emitting material provided by the present invention for 24 hours and 48 hours all had an effect of inhibiting the proliferation of B16F10 cells.

請參閱第四圖(a)(b),其揭露本發明所提供之遠紅外線釋放物質對B16F10細胞酪胺酸酶活性的影響之柱狀圖。本試驗同樣是以B16F10黑色素瘤細胞做為試驗材料,取每個孔洞包含104 個B16F10黑色素瘤細胞的6孔細胞培養盤培養16小時。之後分別將細胞培養盤置於100公克的遠紅外線釋放物質(實驗組)及100公克的奶粉(對照組)上處理24小時。以胰蛋白酶使處理後的B16F10黑色素瘤細胞自細胞培養盤中脫落並收集該些處理後的細胞,之後以酵素連結免疫吸附測定(enzyme-linked immunosorbent assay,ELISA)之測定法檢測細胞中酪胺酸酶的活性。如圖中所示,酪胺酸酶的活性以波長650 nm及370nm之吸光值做為代表,以本發明所提供之遠紅外線釋放物質處理B16F10細胞24小時,確實有抑制B16F10細胞中酪胺酸酶活性的效果。因酪胺酸酶是合成黑色素前趨物的重要酵素,故若該酵素受到抑制,將使黑色素的形成受到顯著的抑制。Please refer to the fourth diagram (a)(b), which discloses a histogram of the effect of the far infrared ray releasing substance provided by the present invention on B16F10 cell tyrosinase activity. In this test, B16F10 melanoma cells were also used as test materials, and 6-well cell culture plates containing 10 4 B16F10 melanoma cells per well were cultured for 16 hours. The cell culture plates were then placed on a 100 gram far infrared ray release material (experimental group) and 100 gram of milk powder (control group) for 24 hours. The treated B16F10 melanoma cells were detached from the cell culture dish by trypsin and the treated cells were collected, and then the tyramine in the cells was detected by an enzyme-linked immunosorbent assay (ELISA) assay. Acidase activity. As shown in the figure, the activity of tyrosinase is represented by the absorbance at wavelengths of 650 nm and 370 nm. Treatment of B16F10 cells with the far-infrared emitting material provided by the present invention for 24 hours does inhibit the inhibition of tyrosine in B16F10 cells. The effect of enzyme activity. Because tyrosinase is an important enzyme for the synthesis of melanin precursors, if the enzyme is inhibited, the formation of melanin will be significantly inhibited.

本發明所採用的遠紅外線釋放物質成分來源為天然礦物成分,經儀器檢測不但有壓電位性負離子發放,且檢測不出游離輻射。目前游離輻射仍普遍被認為具有造成人體基因突變並致癌的危險性,而很多坊間遠紅外線產品為提高產品中遠紅外線的放射係數,添加過量之稀有元素,以致使用者暴露在過量游離輻射中而不自知。本發明不但具有很高的遠紅外線放射係數,且亦沒有游離輻射的疑慮。所以本發明的應用產品,尤其是與人體接觸或是與人體攝取食品水分相關之產品,皆十分健康安全。The source of the far-infrared emitting substance used in the invention is a natural mineral component, and not only the piezoelectric negative ions are emitted by the instrument, but also the free radiation is not detected. At present, free radiation is still generally considered to have the risk of causing mutations in the human body and causing cancer. Many far-infrared products in order to increase the emission coefficient of far-infrared rays in the product, adding excessive rare elements, so that the user is exposed to excessive free radiation without Know yourself. The present invention not only has a high far-infrared radiation coefficient, but also has no doubt about free radiation. Therefore, the application products of the present invention, especially those related to the human body or related to the moisture intake of the human body, are very healthy and safe.

惟以上所述僅為本發明之較佳實施例,非據此即拘限本發明之專利範圍,故舉凡運用本發明說明書及圖示內容所為之等效結構變化者,均同理包含於本發明之範圍內,合予陳明。However, the above description is only the preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, and the equivalent structural changes of the present specification and the illustrated contents are all included in the same. Within the scope of the invention, it is given to Chen Ming.

10...遠紅外線釋放物質10. . . Far infrared ray releasing substance

20...基材20. . . Substrate

第一圖:本發明之遠紅外線基材的較佳實施例之示意圖;第二圖(a)(b):本發明之遠紅外線釋放物質對B16F10細胞中黑色素含量影響之柱狀圖;第三圖(a)(b):本發明之遠紅外線釋放物質對B16F10細胞體外生長的影響之柱狀圖;及第四圖(a)(b):本發明之遠紅外線釋放物質對B16F10細胞酪胺酸酶活性的影響之柱狀圖。1 is a schematic view of a preferred embodiment of the far-infrared substrate of the present invention; and second diagram (a) (b): a histogram of the influence of the far-infrared emitting substance of the present invention on the melanin content in B16F10 cells; Figure (a) (b): a histogram of the effect of the far-infrared emitting substance of the present invention on the growth of B16F10 cells in vitro; and the fourth figure (a) (b): the far-infrared emitting substance of the present invention against B16F10 cell tyramine A histogram of the effects of acidase activity.

Claims (16)

一種包含60-95%之氧化鋁且其所釋放之遠紅外線在4~16μm波長的放射係數在0.9以上的遠紅外線釋放物質用於美白的用途。 A far-infrared emitting material comprising 60-95% of alumina and having a far-infrared light emitted at a wavelength of 4 to 16 μm having a radioactivity of 0.9 or more is used for whitening. 一種美白方法,包括將一遠紅外線釋放物質添加於一乳霜中,該遠紅外線釋放物質包含60-95%之氧化鋁且該遠紅外線釋放物質所釋放之遠紅外線在4~16μm波長的放射係數在0.9以上。 A whitening method comprising adding a far-infrared emitting substance to a cream, the far-infrared emitting substance comprising 60-95% of alumina and the far-infrared rays released by the far-infrared emitting substance having a radiation coefficient at a wavelength of 4 to 16 μm Above 0.9. 如申請專利範圍第2項所述之方法,其中該乳霜更包含其他活性物質、佐劑及添加劑。 The method of claim 2, wherein the cream further comprises other active substances, adjuvants and additives. 如申請專利範圍第2項所述之方法,其中該乳霜係一化妝品製品。 The method of claim 2, wherein the cream is a cosmetic product. 如申請專利範圍第4項所述之方法,其中該化妝品製品更包含至少一種選自於油、脂肪、蠟、烴、脂肪酸、固醇、荷爾蒙、維他命、脂肪酸酯、濕潤劑、界面活性劑、顏料、黏度改善劑、成膜劑、紫外線吸收劑、抗真菌劑、消炎劑、抗汗劑、防腐劑及芳香劑之化妝品原料。 The method of claim 4, wherein the cosmetic preparation further comprises at least one selected from the group consisting of oils, fats, waxes, hydrocarbons, fatty acids, sterols, hormones, vitamins, fatty acid esters, humectants, surfactants. Cosmetic raw materials for pigments, viscosity improvers, film formers, ultraviolet absorbers, antifungals, anti-inflammatory agents, antiperspirants, preservatives and fragrances. 如申請專利範圍第2項所述之方法,其中該乳霜係一工業製品,該工業製品係選自油漆、塗料、潤滑劑、薄膜、凝膠、紙上膠劑、乳膠、營造或築路材料、油墨、染料、蠟及亮光劑的其中之一。 The method of claim 2, wherein the cream is an industrial product selected from the group consisting of paints, coatings, lubricants, films, gels, paper sizing agents, latex, building or road building materials. One of inks, dyes, waxes and polishes. 如申請專利範圍第2項所述之方法,其中該遠紅外線釋放物質更包含1-20%之氧化鐵。 The method of claim 2, wherein the far-infrared emitting material further comprises 1-20% of iron oxide. 如申請專利範圍第2項所述之方法,其中該遠紅外線 釋放物質更包含1-10%之氧化鎂。 The method of claim 2, wherein the far infrared ray The release material further contains 1-10% magnesium oxide. 如申請專利範圍第2項所述之方法,其中該遠紅外線釋放物質更包含1-30%之碳酸鈣。 The method of claim 2, wherein the far-infrared emitting material further comprises 1-30% of calcium carbonate. 一種用於美白的組成物,其包含:一遠紅外線釋放物質,其主要成分為一氧化礦物且其所釋放之遠紅外線在4~16μm波長的放射係數在0.9以上,該組成物透過該遠紅外線釋放物質釋放之遠紅外線達到美白的目的,其中,該氧化礦物包含60-95%之氧化鋁、1-20%之氧化鐵、1-10%之氧化鎂及1-30%之碳酸鈣。 A composition for whitening, comprising: a far-infrared emitting substance whose main component is an oxidized mineral and the far-infrared rays emitted therefrom have an emission coefficient of 0.9 or more at a wavelength of 4 to 16 μm, and the composition transmits the far infrared rays. The far-infrared rays released by the released material achieve the purpose of whitening, wherein the oxidized mineral comprises 60-95% of alumina, 1-20% of iron oxide, 1-10% of magnesium oxide and 1-30% of calcium carbonate. 如申請專利範圍第10項所述之組成物,更包含其他活性物質、佐劑及添加劑。 The composition described in claim 10 further contains other active substances, adjuvants and additives. 如申請專利範圍第10項所述之組成物,其中該組成物係為乳液、乳霜、凝膠、溶液、膠體分散液、懸浮液、軟膏、洗劑、乳霜、泡沫、泡沫乳膠及凝膠至少其中之一。 The composition of claim 10, wherein the composition is an emulsion, a cream, a gel, a solution, a colloidal dispersion, a suspension, an ointment, a lotion, a cream, a foam, a foamed latex, and a coagulum. At least one of the glues. 如申請專利範圍第10項所述之組成物,其中該組成物係一化妝品組成物。 The composition of claim 10, wherein the composition is a cosmetic composition. 如申請專利範圍第13項所述之組成物,其中該化妝品組成物更包含至少一種選自於油、脂肪、蠟、烴、脂肪酸、固醇、荷爾蒙、維他命、脂肪酸酯、濕潤劑、界面活性劑、顏料、黏度改善劑、成膜劑、紫外線吸收劑、抗真菌劑、消炎劑、抗汗劑、防腐劑及芳香劑之化妝品原料。 The composition of claim 13, wherein the cosmetic composition further comprises at least one selected from the group consisting of oils, fats, waxes, hydrocarbons, fatty acids, sterols, hormones, vitamins, fatty acid esters, humectants, interfaces. Cosmetic raw materials for active agents, pigments, viscosity improvers, film formers, ultraviolet absorbers, antifungals, anti-inflammatory agents, antiperspirants, preservatives and fragrances. 如申請專利範圍第10項所述之組成物,其中該組成物 係一醫藥組成物。 The composition of claim 10, wherein the composition A pharmaceutical composition. 如申請專利範圍第15項所述之組成物,其中該醫藥組成物更包含醫藥上可接受的載劑。 The composition of claim 15 wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.
TW96121948A 2007-06-15 2007-06-15 Far-infrared substrate for whitening skin TWI433686B (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
TW96121948A TWI433686B (en) 2007-06-15 2007-06-15 Far-infrared substrate for whitening skin
US11/857,158 US20080311059A1 (en) 2007-06-15 2007-09-18 Composition for skin care and method for the same
DE102007046799A DE102007046799B4 (en) 2007-06-15 2007-09-29 Use of a skin whitening composition
JP2007332171A JP2008308482A (en) 2007-06-15 2007-12-25 Composition and method for whitening skin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW96121948A TWI433686B (en) 2007-06-15 2007-06-15 Far-infrared substrate for whitening skin

Publications (2)

Publication Number Publication Date
TW200848084A TW200848084A (en) 2008-12-16
TWI433686B true TWI433686B (en) 2014-04-11

Family

ID=44823703

Family Applications (1)

Application Number Title Priority Date Filing Date
TW96121948A TWI433686B (en) 2007-06-15 2007-06-15 Far-infrared substrate for whitening skin

Country Status (1)

Country Link
TW (1) TWI433686B (en)

Also Published As

Publication number Publication date
TW200848084A (en) 2008-12-16

Similar Documents

Publication Publication Date Title
CN103415294A (en) Hydrogen-emitting composition
CN101267799B (en) Composition based on mineral concentrates derived for precious stones
JP2022513171A (en) Polypeptides and methods for improving skin symptoms
JP2022502396A (en) Compositions and methods to be applied to the skin
KR20070057380A (en) Powder type cosmetic composition
JP6963549B2 (en) Cellulose-containing articles for the skin
CN104983607A (en) Massage essential oil, preparation method thereof and application thereof
CN101163462B (en) Cosmetic composition for skin and wrinkle improver
CN109248135A (en) A kind of sheen highlights, the external-use skin care of concealing moisturizing combination and preparation method thereof
KR20150008609A (en) Cosmetic composition comprising natural minerals
CN102333546A (en) Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin
WO2003022206A2 (en) Cosmetic kit and method
TWI433686B (en) Far-infrared substrate for whitening skin
CN108478498A (en) A kind of composition and its preparation method and application improving skin complexion
KR20080043781A (en) Preparation containing barium sulfate
JP2002265348A (en) Composition for external use
KR100471359B1 (en) Skin Care Compositions containing crystalline inorganic minerals
WO2018012157A1 (en) Melanin production inhibitor, skin-lightening agent, fibroblast cell activator, collagen and/or elastin production promotor, and wrinkle-improving agent
JP2008308482A (en) Composition and method for whitening skin
CN108578297A (en) A kind of compounding moisturizing sun cream and preparation method thereof
KR20060081174A (en) Skin massage kit containing crystalline minerals and skin care massage method using crystalline minerals
KR102053646B1 (en) Powder composite for protecting Blue-light and IR ray and cosmetics composition using the same
US20110307036A1 (en) Compositions and methods for enhancing collagen growth
CN102579272A (en) Application of GX50 to cosmetic composition and GX50-containing cosmetic composition
TWI572366B (en) Use of mandelic acid for manufacturing cosmetic composition for whitening and anti-wrinkle

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees