TWI404508B - 用於促進趕上成長進度之營養配方 - Google Patents
用於促進趕上成長進度之營養配方 Download PDFInfo
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- TWI404508B TWI404508B TW095137247A TW95137247A TWI404508B TW I404508 B TWI404508 B TW I404508B TW 095137247 A TW095137247 A TW 095137247A TW 95137247 A TW95137247 A TW 95137247A TW I404508 B TWI404508 B TW I404508B
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Description
本發明係關於用於促進因經受身體或精神緊迫而使成長遲緩之幼年哺乳動物趕上成長進度之配方及該等配方之用途,特言之,本發明係關於含有用於促進趕上成長進度之成分之增效組合的配方。
多年來一直認為,遭受緊迫幼年哺乳動物的成長模式通常會受阻,不論其係因身體之疾病或傷害或心裏創傷所致之緊迫。若幼年哺乳動物可快速恢復且獲得充足營養,則其可趕上在緊迫期間原本應有之成長進度,此突發之成長被稱為"趕上成長進度之成長"。然而,此情況並非總能發生。舉例而言,幼年哺乳動物在疾病或創傷期間及隨即在事後可能產生厭食,因此可食物攝取量可能有限。情況嚴重時,動物可能再也無法達到其若未經受緊迫所可達到之體格。
此現象可見於幼年哺乳動物(包括人類),自幼兒期貫穿其仍然成長之生命期。儘管希望確保能趕上在身體或精神緊迫期間降低之成長,但趕上成長進度亦不應過度乃重要的,因為有跡象顯示,極為快速及/或極為過度趕上成長進度之時期,可能與未來肥胖之風險有關,尤其是幼兒期內發生的話。
因此,本發明之目的在於提供適於促進遭受身體或精神緊迫之幼年哺乳動物之最佳趕上成長進度的配方。
在本發明之研究期間,發明人意外地觀察到施用特定之成分組合可促進遭受緊迫之幼年哺乳動物趕上成長進度。
因此,本發明首先提供一種促進趕上成長進度之營養配方,其包含含有脂肪酸之脂質源、存在組合物中之脂肪酸之至少0.01%之量的n3長鏈多元不飽和脂肪酸(LC-PUFA)、每克配方至少0.001克之量的益生纖維及每克配方103
-101 1
細胞形成單位(cfu)之量的益生細菌菌株。
本發明其次提供n3長鏈多元不飽和脂肪酸(LC-PUFA)、益生纖維及益生細菌菌株用於製造供促進患病及恢復期幼年哺乳動物趕上成長進度之營養配方或藥物的用途。
本發明另外提供一種促進患病或恢復期幼年哺乳動物趕上成長進度之方法,該方法包括將治療量之包含n3 LC-PUFA、益生纖維及益生細菌菌株的配方投予有需要之幼年哺乳動物。
本發明之優點在於其提供不施用合成激素而使用食品級成分之增效組合來促進趕上成長進度的可能性。此外,受迫幼年哺乳動物常會厭食,且不願意或不能消耗大量卡路里;本發明之優點在於提供促進趕上成長進度之機會,而不增加卡路里攝取量,使身體之精肉及脂肪量平衡,而不造成肥胖。
在本說明書中,以下術語具有下文所指定之含義:-"益生細菌菌株"意謂藉由改良宿主動物腸內微生物平衡而對宿主動物產生有益影響之活微生物食物添加劑(具"Probiotics in Man and Animals",J.Appl Bacteriol.66:365-378,1989)。
"益生素"意謂藉由選擇性刺激結腸中一種或有限數目細菌之成長及/或活動而對宿主產生有益影響且因此改良宿主健康之不易消化的食物成分(自"Dietary Modulation of the Human Colonic Microbiota:Introducing the Concept of Prebiotics",J.Nutr.125:1401-1412,1995)。
"幼年哺乳動物"意謂包括自出生至所涉及種類之哺乳動物達到完全體格之年齡的人類及相伴動物之任何哺乳動物。
益生細菌菌株較佳為乳桿菌屬(Lactobacillus)或雙歧桿菌屬(Bifidobacterium)菌株。合適乳桿菌屬菌株包括可自Valio OY(Finland)獲得之鼠李糖乳酸桿菌(Lactobacillus rhamnosus
)ATCC 53103及副乾酪乳桿菌(Lactobacillus paracasei
)CNCM I-2116,其中後者尤其較佳。合適雙歧桿菌屬菌株包括可自Morinaga(Japan)獲得之長雙枝桿菌(Bifidobacterium longum
)BB536、可自Christian Hansen(Denmark)以Bb12商標獲得之比非德氏菌(Bifidobacterium lactis
)及比非德氏菌CNCM I-3446。可使用菌株之組合,其中乳桿菌與雙歧桿菌之組合尤其較佳。配方中可包括藉由冷凍乾燥或噴霧乾燥獲得之粉末形式的所選菌株。或者,營養配方可另外包含諸如牛奶或穀類之可醱酵食物,且益生細菌菌株可用以使食物醱酵。
益生纖維可選自果寡醣、半乳寡醣、涎寡醣、木糖寡醣、菊糖、阿拉伯膠、瓜爾膠、抗性澱粉、牛奶衍生之寡醣及其混合物。較佳益生纖維為果寡醣、菊糖、阿拉伯膠及半乳寡醣,尤其為70至95%半乳寡醣及30至5%果寡醣與40至60%阿拉伯膠、30至40%果寡醣及10至20%菊糖之混合物。合適半乳寡醣為Borculo Domo Ingredients以ViVinal GOS 10商標所售之半乳寡醣。合適果寡醣為Orafti S.A以Raftilose P95商標所售之果寡醣。合適菊糖為Orafti S.A以Raftiline HP商標所售之菊糖。合適阿拉伯膠為CNI以FiberGumP商標所售之阿拉伯膠。益生纖維之存在總量較佳為配方之0.02-0.05 g/g。
配方含有至少一種n-3 LC-PUFA,諸如C20或C22 n-3脂肪酸。C20或C22 n-3 LC-PUFA之存在量較佳為在配方中所有脂肪酸之至少0.1重量%。n-3 LC-PUFA較佳為二十二碳六烯酸(DHA,C22:6,n-3)。
配方較佳亦含有n-6多元不飽和脂肪酸,諸如C20或C22 n-6脂肪酸。合適n-6 LC-PUFA為二十碳四烯酸(AA,C20:4 n-6)。C20或C22 n-6 LC-PUFA之存在量較佳為配方中所有脂肪酸之至少0.1重量%。
n6:n3之比較佳介於1:2與8:1之間,更佳介於4:1與8:1之間。舉例而言,LC-PUFA之來源可為卵磷脂、真菌油、低EPA魚油或海藻油。
配方可呈營養增補劑形式,或其可提供完全營養。根據本發明之營養配方之合適基質的實例為牛奶、酸奶、凝乳、奶酪、醱酵牛奶及牛奶製品、醱酵穀類基製品、牛奶基粉末、用於口服及管飼之嬰兒配方及組合物。
在一較佳實施例中,本發明提供嬰兒配方或兒科營養配方。除上述成分之增效組合之外,其亦可包含蛋白源及/或碳水化合物源。
蛋白源可為任何合適膳食蛋白,例如動物蛋白(諸如牛奶蛋白、肉蛋白、蛋蛋白)、植物蛋白(諸如大豆、小麥、水稻或豌豆蛋白)、游離胺基酸之混合物或其組合。諸如酪蛋白及乳清之牛奶蛋白尤其較佳。在一兒科配方之較佳實施例中,蛋白源提供組合物之7至14%之能量。
對於兒科配方而言,脂質源較佳提供配方之30%至50%之能量。構成脂質源之脂質可為任何合適脂肪或脂肪混合物。植物脂肪尤其合適,例如大豆油、棕櫚油、椰子油、紅花油、向日葵油、玉米油、芥花籽油、卵磷脂及類似脂肪。必要時,亦可添加諸如乳脂之動物脂肪。較佳地,脂肪源包括至少15%中長鏈三甘油酸酯,且脂肪酸構成為20至40%飽和脂肪酸、45至60%單不飽和脂肪酸及10至25%多元不飽和脂肪酸。
若兒科配方包括碳水化合物源,則碳水化合物源較佳提供配方之40%至60%之能量。可使用任何合適之碳水化合物或碳水化合物混合物,例如蔗糖、乳糖、葡萄糖、果糖、玉米漿固形物及麥芽糊精。
合適維生素及礦物質可以通常方式包括於配方中以適於適當準則。必要時,一或多種食品級乳化劑可併入配方中,例如單甘油二酯、卵磷脂及單甘油酯及二甘油酯之二乙醯基-酒石酸酯。可包括相似之合適鹽及穩定劑。
舉例而言,配方較佳呈用於以水復水之粉末形式可經腸投藥。復水配方可口服投藥或藉由鼻胃管投藥。其可以任何合適方式製備,例如藉由以適當比例摻合膳食蛋白源、碳水化合物源及脂肪源。使用時,乳化劑可包括於摻合物中。此時可添加維生素及礦物質,但通常稍後添加以避免熱降解。可將任何親脂性維生素、乳化劑及其類似物在摻合之前溶解於脂肪源中。接著可混入水(較佳為經反滲透之水)以形成液體混合物。水溫便利地為約50℃至約80℃以有助於成分分散。可使用市售液化劑以形成液體混合物。舉例而言,接著分兩階段使液體混合物勻質化。
液體混合物接著可經熱處理以減少細菌負荷。舉例而言,可快速將液體混合物加熱至約80℃至約150℃之範圍內之溫度,歷時約5秒至約5分鐘。此舉可藉由蒸汽注入、高壓滅菌器或藉由熱交換器(例如板式熱交換器)進行。舉例而言,接著可藉由急驟冷卻將液體混合物冷卻至約60℃至約85℃。舉例而言,可分兩階段:第一階段於約7 MPa至約40 Mpa及第二階段於約2 MPa至約14 MPa再次使液體混合物勻質化。接著可進一步冷卻經勻質化之混合物以添加任何熱敏組份,諸如維生素及礦物質。此時便利地使經勻質化之混合物的pH值及固體含量符合標準。
將經勻質化之混合物轉移至諸如噴霧乾燥器或凍乾器之合適乾燥設備中,且轉化成粉末。粉末應具有小於約5重量%之含水量。此時可便利地藉由乾燥混合來添加益生細菌菌株。
若需要製造液體配方時,則較佳在無菌條件下將經勻質化之混合物填充至合適容器中。可藉由預加熱經勻質化之混合物(例如加熱至約75至85℃)接著將蒸汽注入經勻質化之混合物中以將溫度升高至約140至160℃(例如約150℃)來進行容器之無菌填充。舉例而言,接著藉由急驟冷卻將經勻質化之混合物冷卻至約75至85℃之溫度。接著可使經勻質化之混合物勻質化,進一步冷卻至約室溫且填充入容器中。用於進行無菌填充、具有此性質之合適設備為市售。液體配方可呈具有約10至約14重量%之固體含量之即餵食配方形式,或可呈具有約20至約26重量%之固體含量之濃縮物形式。可向液體配方中添加調味劑。在液體配方之情況下,較佳將益生細菌菌株單獨封裝以在液體配方消耗前即刻混合。
幼年哺乳動物所需餵食之配方量將隨諸如患者病況、體重及年齡之因素而變化,不管配方是否為唯一營養源。通常投藥足夠量之配方,以提供患者每天每公斤體重1至4公克補充有上述量之根據本發明之成分的蛋白。若營養配方用作其他食物之添加劑,則可相應地減少每日投藥的營養配方之量。以下非限制性實例進一步說明本發明。
以下給出根據本發明之兒科營養配方之組合物的實例。此組合物僅為說明之用。
該配方具有以下組合物(每100 g粉末):總脂肪18.3 g、總蛋白13.9 g、總碳水化合物59.2 g、AA營養強化油(真菌油)0.2 g、DHA營養強化油(低EPA魚油)0.2 g、阿拉伯膠/FOS/菊糖(51%/34%/15%)12 g、副乾酪乳桿菌CNCM I-2116(Nestl,噴霧乾燥粉末,10E12 cfu/g)0.1 g、長雙枝桿菌BB536(Morinaga,噴霧乾燥粉末,5×10E12 cfu/g)0.1g、鈉222 mg、鉀500 mg、氯化物370 mg、磷278 mg、鈣417 mg、鎂53 mg、錳231 μg、維生素A 680 IU、維生素D 180 IU、維生素E 6.8 IU、維生素C 36 mg、維生素K1 18 μg、維生素B1 0.27 mg、維生素B2 0.36 mg、維生素B6 0.36 mg、煙酸2.7 mg、葉酸91 μg、泛酸1.4 mg、維生素B12 0.68 μg、生物素6.8 μg、膽鹼110 mg、牛磺酸36 mg、肉鹼18 mg、鐵4.5 mg、碘36 μg、銅0.36 mg及鋅4.5 mg。
藉由將221 g粉末與779 ml水混合得到1 L即飲製劑使配方復水。以上所定之組合物可改變以適應關於特定成分量之國家指導。可根據年齡添加足夠量之其他痕量元素(例如硒、鉻、鉬、氟化物)。
以下實驗證明以根據本發明之營養配方、補充有根據本發明之組成之單獨組份之營養配方及未補充之營養配方餵食受迫初生大鼠的效果。
初產懷孕雌性Long-Evans Hooded大鼠購自Janvier(France),於孕期第10及11天到達動物養殖實驗所。將其在恆溫及恆濕下單獨飼養直至分娩,且維持在12:12暗:光循環中。隨意提供食物及水。將飼養條件維持實驗方案之持續時間。分娩後第一天(出生後第2天-PND 2),將母鼠自生育籠移除,且確定幼鼠性別。隨機指定8隻雄性幼鼠作為標準小崽,進行撫養。
將母鼠及其幼鼠分配於兩種飼養條件之一者:1)母鼠分離組,在PND 2至14暴露於每日母鼠分離180 min時期(MS),或2)經處理對照組,暴露於每日處理(稱重及15 min處理)但並不將母鼠分離(NS)。於9 am,自普通籠中移除母鼠,且於等待籠中保持3小時分離期(MS母畜)或15分鐘處理期(NS母畜)。將各MS小崽自窩移除,稱重且作為一組置放於相鄰房間內隔離籠中。將隔離籠保持在32.0±0.5℃下。在隔離期結束時,將幼鼠放回其普通籠中,且在將其與其寄母鼠放在一起前使其在污染草墊上翻滾。相似地處理自NS組之小崽,但其不經歷3小時分離期,而將其溫和處理15 min。有5組MS幼鼠及1組NS幼鼠,各組均由8隻幼鼠組成。
每週一次用清潔草墊替換普通籠中50%之污染草墊。
在PND 15時自寄母鼠完全移除5 MS組中之所有幼鼠,斷奶且餵食對照飲食或補充飲食1至4之一者。將來自該等組之各者的幼鼠一起飼養(5隻動物/籠)。NS組與其母親保留在一起直至PND 21。自PND 15至21,每日監控所有幼鼠之重量。於PND 21,使來自NS組之幼鼠斷奶且餵食對照飲食。自此直至PND 36研究結束,單獨飼養所有幼鼠。自PND 15至PND 36,MS組之幼鼠自斷奶後繼續接受飲食。每天早晨用新鮮食物替換舊食物,且所有幼鼠隨意接受其飲食。
自PND 15至PND 36,以營養適合之半合成飲食(經改質AIN 93 G)飼養MS組中之動物,該等飲食之組合物於下表1中展示。補充飲食含有以下功能性成分之一或多者:副乾酪乳桿菌CNCM I-2116(於0.8 ml廢培養基中4×101 0
cfu/100 g飲食)、0.4 g/100 g飲食菊糖(Raftiline HP,Orafti SA,Belgium)、3.6 g/100 g飲食GOS(VivinalGOS 10,Borculo Domo Ingredients,The Netherlands)、2 g/100 g飲食二十碳四烯酸(ARASCOMartek,USA)及2 g/100 g飲食二十二碳六烯酸(DHASCOMartek,USA)。對照飲食含有新鮮MRS而非廢培養基中之益生細菌菌株、乳糖(Fluka,61340)及增加量之麥芽糊精(Glucidex D12,Roquette Freres,France)而非益生細菌菌株及增加量之可可油及玉米油而非二十二碳六烯酸及二十碳四烯酸。僅含有根據本發明之組合物之一種成分的補充飲食同樣含有適當安慰劑成分。
數據以平均值±SEM表示。檢查各組數據的常態性及同方差性。藉由單因素ANOVA接著藉由費舍爾最小顯著差異法(Fisher Least Significant Difference)(LSD)比較PND 15至PND 21之體重、體重指標及脂墊重量數據,以評估處於各年齡之組之間的差異。藉由重複量測ANOVA及LSD比較自PND 21之體重及攝取量曲線,以評估組間差異。
結果於圖式中展示。如於圖1中可見,NS組的幼鼠在PND 15與21之間持續正常成長,而所有5個MS組的幼鼠體重下降直至PND 17,接著該組因餵食根據本發明之組合物(補充飲食1)而恢復成長,且展示最有效之趕上成長。自PND 21至36,此趨勢因該組接受根據本發明之組合物而加速,且在PND 36時達到與NS組極為相似之體重(圖2)。藉由比較可見,餵食對照飲食(亦及與NS組之相同飲食)之MS組到PND 36時達到顯著較低體重。自圖2亦可見,接受補充飲食4(僅益生素)之MS組亦達到與對照NS組相當之最終重量。其原因可見於圖3,圖3展示此組之食物攝取量在PND 21至36一直高於所有其他組。然而,此較高卡路里攝取量似乎並不直接反映成長進度。藉由比較,接受補充飲食1之MS組比接受補充飲食4之MS組具有較低食物攝取量,且具有與包括對照飲食之其他組相當之食物攝取量。
此外,自圖4及5可見,由接受補充飲食1之MS組所展示之趕上成長進度與體重指標或總身體脂肪質量之增加無關,雖然該等參數與非受迫組之參數相當。吾人總結如下,含有根據本發明之成分之組合的營養配方可有效促進因身體或精神緊迫而成長進度延緩之幼年哺乳動物之趕上成長進度,及因為單獨給與之成分的作用總和小於組合給與之作用,因此該組合為增效。此外,趕上成長進度與不成比例之體重指標增加無關,因此應不增加隨後生活之肥胖風險。
圖1展示自出生後(PND)15-21天接受不同飲食之6組大鼠的體重演變。
圖2展示自PND 21-36天與圖1相同組大鼠的體重演變。
圖3展示自PND 21-36天相同組大鼠的食物攝取量。
圖4展示PND 36天時六組大鼠的體重指標(g/cm2
)。
圖5展示PND 36天時六組大鼠之副睾及腹膜後脂墊之重量(g)。
Claims (18)
- 一種n3長鏈多元不飽和脂肪酸(LC-PUFA)、益生纖維及益生細菌菌株之用途,其係用於製造供促進患病及恢復期幼年哺乳動物趕上成長進度之營養配方或藥物。
- 如請求項1之用途,其中該配方包含一含有脂肪酸之脂質源,且n3 LC-PUFA之量為該脂質源中脂肪酸之至少0.01%。
- 如請求項1或2之用途,其中該營養配方或藥物進一步包含n6 LC-PUFA。
- 如請求項3之用途,其中該n6 LC-PUFA之存在量為脂質源中脂肪酸之至少0.01%。
- 如請求項1或2之用途,其中該益生纖維之量為每克配方0.0001至0.05克。
- 如請求項1或2之用途,其中該益生細菌菌株之量為每克配方之103 -1011 cfu。
- 如請求項1或2之用途,其中該益生細菌菌株為乳酸桿菌屬。
- 如請求項7之用途,其中該乳酸桿菌屬為副乾酪乳酸桿菌(Lactobacillus paracasei )CNCM I-2116。
- 如請求項7之用途,其中該乳酸桿菌屬為鼠李糖乳酸桿菌(Lactobacillus rhamnosus )ATCC 53103。
- 如請求項1或2之用途,其中該益生細菌菌株為比非德氏菌(Bifidobacterium lactis )CNCM I-3446。
- 如請求項1或2之用途,其中該益生纖維之量為每克配方 0.02至0.05克。
- 如請求項1或2之用途,其中該益生纖維為果寡醣、菊糖、半乳寡醣、阿拉伯膠、涎寡醣或其混合物。
- 如請求項12之用途,其中該益生纖維為40至60%阿拉伯膠、10至20%菊糖及30至40%果寡醣之混合物。
- 如請求項1或2之用途,其中n6 LC-PUFA與n3 LC-PUFA之比為1:2至8:1。
- 如請求項1或2之用途,其中n3 LC-PUFA為二十二碳六烯酸。
- 如請求項3之用途,其中n6 LC-PUFA為二十碳四烯酸。
- 如請求項9之用途,其中該益生纖維為涎寡醣。
- 如請求項10之用途,其中該益生纖維為涎寡醣。
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CN (1) | CN101299934B (zh) |
AT (1) | ATE451845T1 (zh) |
AU (1) | AU2006298720C1 (zh) |
BR (1) | BRPI0616899A2 (zh) |
CA (1) | CA2624921C (zh) |
DE (1) | DE602006011195D1 (zh) |
ES (1) | ES2334943T3 (zh) |
MY (1) | MY143654A (zh) |
PL (1) | PL1940248T3 (zh) |
PT (1) | PT1940248E (zh) |
RU (1) | RU2445360C2 (zh) |
TW (1) | TWI404508B (zh) |
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JP2009102292A (ja) * | 2007-04-27 | 2009-05-14 | Chiba Prefecture | ストレス抑制剤 |
EP3263120A1 (en) | 2007-09-17 | 2018-01-03 | N.V. Nutricia | Nutritional formulation with high energy content |
MX2010003090A (es) * | 2007-09-21 | 2010-04-09 | Kerry Group Services Int Ltd | Una composicion de probiotico. |
US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
JP5268916B2 (ja) * | 2008-03-27 | 2013-08-21 | 森永乳業株式会社 | 酸性乳酸菌飲料、酸性乳酸菌飲料の製造方法、およびビフィズス菌の生残性改善方法 |
EP2110028A1 (en) * | 2008-04-15 | 2009-10-21 | Nestec S.A. | Bifidobacterium longum and hippocampal BDNF expression |
US20100074870A1 (en) * | 2008-09-19 | 2010-03-25 | Bristol-Myers Squibb Company | Probiotic infant products |
MX2011010454A (es) | 2009-04-03 | 2012-01-25 | Nestec Sa | Mejoramiento en la promocion de la sana recuperacion del crecimiento. |
MX336030B (es) * | 2009-05-11 | 2016-01-07 | Nestec Sa | Lactobacillus johnsonii la1 mcc533 (cncm i-1225) y padecimientos inmunes. |
WO2010134800A1 (en) * | 2009-05-19 | 2010-11-25 | N.V. Nutricia | Human milk fortifier with high protein and long chain poly unsaturated fatty acids for improving body adipose tissue distribution |
EP2258217A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Children |
EP2258216A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
EP2258218A1 (en) * | 2009-06-02 | 2010-12-08 | Nestec S.A. | Nutritional Composition for Supporting Brain Development and Function of Toddlers |
BR112012002223A2 (pt) * | 2009-07-31 | 2016-06-07 | Nestec Sa | composição nutricional para lactentes ou animais de estimação com probióticos e nutrientes selecionados |
EP2498626B1 (en) * | 2009-11-12 | 2015-06-17 | Nestec S.A. | Nutritional composition for promoting gut microbiota balance and health |
WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
IT1405395B1 (it) * | 2010-08-05 | 2014-01-10 | Proge Farm Srl | Composizioni di probiotici e oli e loro uso. |
WO2012050434A1 (en) * | 2010-10-15 | 2012-04-19 | N.V. Nutricia | Dairy based smoothie for stimulating growth in children |
US9375028B2 (en) | 2010-12-09 | 2016-06-28 | Mead Johnson Nutrition Company | Compositions and methods for nutrient delivery |
US20130095204A1 (en) * | 2011-10-14 | 2013-04-18 | Zeina Jouni | Nutritional phytonutrient compositions |
PT3091973T (pt) | 2013-11-01 | 2018-11-15 | Nutricia Nv | Composição lipídica para melhorar a composição corporal durante o crescimento de recuperação |
CA2942555A1 (en) * | 2014-03-26 | 2015-10-01 | Abbott Laboratories | Nutritional supplement powder |
EP3361885B1 (en) | 2015-10-15 | 2019-05-29 | N.V. Nutricia | Infant formula with special lipid architecture for promoting healthy growth |
US10912323B2 (en) | 2016-02-29 | 2021-02-09 | Abbott Laboratories | Nutritional supplement powder |
CN108882745B (zh) * | 2016-03-10 | 2023-08-18 | 花臣有限公司 | 脂质组合物及其用途 |
EP3550985B1 (en) | 2016-12-09 | 2021-01-06 | N.V. Nutricia | Nutritional composition for improving cell membranes |
CA3169069A1 (en) * | 2020-02-27 | 2021-09-02 | Abbott Laboratories | Methods of improving bone health |
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AU2006298720A1 (en) | 2007-04-12 |
PT1940248E (pt) | 2010-01-26 |
MY143654A (en) | 2011-06-30 |
PL1940248T3 (pl) | 2010-05-31 |
ATE451845T1 (de) | 2010-01-15 |
US20080254012A1 (en) | 2008-10-16 |
EP1940248B1 (en) | 2009-12-16 |
ES2334943T3 (es) | 2010-03-17 |
CN101299934A (zh) | 2008-11-05 |
RU2445360C2 (ru) | 2012-03-20 |
EP1940248A1 (en) | 2008-07-09 |
RU2008117401A (ru) | 2009-11-10 |
ZA200803769B (en) | 2009-07-29 |
CA2624921C (en) | 2012-07-10 |
US9144250B2 (en) | 2015-09-29 |
CA2624921A1 (en) | 2007-04-12 |
BRPI0616899A2 (pt) | 2011-07-05 |
WO2007039596A1 (en) | 2007-04-12 |
AU2006298720C1 (en) | 2013-03-14 |
DE602006011195D1 (de) | 2010-01-28 |
CN101299934B (zh) | 2012-08-08 |
AU2006298720B2 (en) | 2012-07-19 |
TW200803760A (en) | 2008-01-16 |
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