TWI389715B - 適用於藥物傳送裝置的驅動機構及含有該驅動機構的藥物傳送裝置、及藥物傳送方法 - Google Patents
適用於藥物傳送裝置的驅動機構及含有該驅動機構的藥物傳送裝置、及藥物傳送方法 Download PDFInfo
- Publication number
- TWI389715B TWI389715B TW093105522A TW93105522A TWI389715B TW I389715 B TWI389715 B TW I389715B TW 093105522 A TW093105522 A TW 093105522A TW 93105522 A TW93105522 A TW 93105522A TW I389715 B TWI389715 B TW I389715B
- Authority
- TW
- Taiwan
- Prior art keywords
- drug delivery
- piston rod
- dose
- lead
- delivery device
- Prior art date
Links
- 238000012377 drug delivery Methods 0.000 title claims description 37
- 230000007246 mechanism Effects 0.000 title claims description 27
- 239000003814 drug Substances 0.000 title claims description 16
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
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- 102000018997 Growth Hormone Human genes 0.000 claims description 3
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- 102000004877 Insulin Human genes 0.000 claims description 3
- 108090001061 Insulin Proteins 0.000 claims description 3
- 239000000122 growth hormone Substances 0.000 claims description 3
- 229940125396 insulin Drugs 0.000 claims description 3
- 230000002440 hepatic effect Effects 0.000 claims description 2
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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- 210000004185 liver Anatomy 0.000 description 1
- 229940090048 pen injector Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0304824.6A GB0304824D0 (en) | 2003-03-03 | 2003-03-03 | Improvements in and relating to a pen-type injector |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200510027A TW200510027A (en) | 2005-03-16 |
| TWI389715B true TWI389715B (zh) | 2013-03-21 |
Family
ID=9954012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093105522A TWI389715B (zh) | 2003-03-03 | 2004-03-03 | 適用於藥物傳送裝置的驅動機構及含有該驅動機構的藥物傳送裝置、及藥物傳送方法 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7094221B2 (https=) |
| EP (1) | EP1601396B2 (https=) |
| JP (1) | JP4847857B2 (https=) |
| KR (1) | KR101113001B1 (https=) |
| CN (1) | CN100457209C (https=) |
| AR (1) | AR043460A1 (https=) |
| AT (1) | ATE540714T1 (https=) |
| AU (1) | AU2004216829B2 (https=) |
| BR (1) | BRPI0408021B8 (https=) |
| CA (1) | CA2518011C (https=) |
| CY (1) | CY1112685T1 (https=) |
| DK (1) | DK1601396T4 (https=) |
| EA (1) | EA007402B1 (https=) |
| ES (1) | ES2379950T5 (https=) |
| GB (1) | GB0304824D0 (https=) |
| HR (1) | HRP20050768A2 (https=) |
| IL (1) | IL170620A (https=) |
| MX (1) | MXPA05009284A (https=) |
| PL (1) | PL1601396T5 (https=) |
| PT (1) | PT1601396E (https=) |
| SI (1) | SI1601396T2 (https=) |
| TW (1) | TWI389715B (https=) |
| WO (1) | WO2004078226A2 (https=) |
| ZA (1) | ZA200506941B (https=) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69900026T2 (de) | 1998-01-30 | 2001-05-10 | Novo Nordisk As | Eine injektionsspritze |
| TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| EP2210634A1 (en) | 2009-01-22 | 2010-07-28 | Sanofi-Aventis Deutschland GmbH | Drug delivery device dose setting mechanism |
| GB0308267D0 (en) | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
| AU2004266131C1 (en) * | 2003-08-12 | 2010-12-16 | Eli Lilly And Company | Medication dispensing apparatus with triple screw threads for mechanical advantage |
| CN100569307C (zh) | 2004-02-18 | 2009-12-16 | 阿瑞斯贸易股份公司 | 用于注射液态药物的手持式电控注射装置 |
| NZ554384A (en) * | 2004-10-04 | 2010-04-30 | Sanofi Aventis Deutschland | Drive mechanism for drug delivery device |
| US7686786B2 (en) | 2004-10-21 | 2010-03-30 | Novo Nordiks A/S | Dial-down mechanism for wind-up pen |
| US8083711B2 (en) | 2004-10-21 | 2011-12-27 | Novo Nordisk A/S | Injection device with internal dose indicator |
| JP4903160B2 (ja) * | 2005-01-18 | 2012-03-28 | ウォックハート アメリカズ インコーポレイテッド | ペン型薬物注入デバイス |
| EP1855744A1 (en) * | 2005-02-28 | 2007-11-21 | Novo Nordisk A/S | A dose setting mechanism for an injection device |
| CN101163514B (zh) | 2005-04-24 | 2012-01-25 | 诺和诺德公司 | 注射装置 |
| WO2006114395A1 (en) * | 2005-04-24 | 2006-11-02 | Novo Nordisk A/S | An injection device with a gearbox |
| DE102005023824A1 (de) * | 2005-05-24 | 2006-12-07 | Tecpharma Licensing Ag | Dosiervorrichtung für eine Injektionsvorrichtung |
| DE102005023823B4 (de) * | 2005-05-24 | 2022-11-17 | Tecpharma Licensing Ag | Dosiervorrichtung für eine Injektionsvorrichtung und Injektionsvorrichtung mit einer solchen Dosiervorrichtung |
| WO2007104697A2 (en) | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device having a gearing arrangement |
| WO2007104636A1 (en) | 2006-03-10 | 2007-09-20 | Novo Nordisk A/S | An injection device and a method of changing a cartridge in the device |
| ATE458517T1 (de) | 2006-05-16 | 2010-03-15 | Novo Nordisk As | Getriebemechanismus für ein injektionsgerät |
| PL2023982T3 (pl) | 2006-05-18 | 2012-11-30 | Novo Nordisk As | Urządzenie wstrzykujące ze środkami blokującymi |
| HUE060243T2 (hu) | 2006-09-15 | 2023-02-28 | Ypsomed Ag | Injekciós eszköz továbbfejlesztett továbbítóelemmel |
| WO2008083875A1 (en) * | 2007-01-09 | 2008-07-17 | Shl Medical Ab | Information device |
| DE602008002896D1 (de) | 2007-02-05 | 2010-11-18 | Novo Nordisk As | Injektionsknopf |
| CA2681023C (en) | 2007-03-23 | 2015-11-03 | Novo Nordisk A/S | An injection device comprising a locking nut |
| WO2009044401A2 (en) | 2007-10-02 | 2009-04-09 | Yossi Gross | External drug pump |
| US8672896B2 (en) | 2009-06-01 | 2014-03-18 | Sanofi-Aventis Deutschland Gmbh | Inner housing for a drug delivery device |
| US9125994B2 (en) * | 2009-06-01 | 2015-09-08 | Sanofi—Aventis Deutschland GmbH | Drug delivery device with dose dial sleeve rotational stop |
| US8257319B2 (en) * | 2009-06-01 | 2012-09-04 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device inner housing having helical spline |
| AR076722A1 (es) * | 2009-06-02 | 2011-06-29 | Sanofi Aventis Deutschland | Conjunto para un dispositivo para l a entrega de farmacos y dispositivo para la entrega de farmacos |
| EP2292286A1 (en) * | 2009-09-07 | 2011-03-09 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a medication delivery device and medication delivery device |
| DK2475411T3 (en) * | 2009-09-07 | 2015-04-07 | Sanofi Aventis Deutschland | A drive mechanism for device for drug delivery |
| WO2011039202A1 (en) * | 2009-09-30 | 2011-04-07 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device and reset member for a drive mechanism |
| CN102548600B (zh) * | 2009-09-30 | 2014-06-25 | 赛诺菲-安万特德国有限公司 | 给药装置和用于给药装置的驱动构件 |
| DK2482889T3 (en) * | 2009-09-30 | 2016-05-17 | Sanofi Aventis Deutschland | ACCOMMODATION drug delivery device |
| AR078457A1 (es) * | 2009-09-30 | 2011-11-09 | Sanofi Aventis Deutschland | Mecanismo accionador para un dispositivo de descarga de farmacos |
| WO2011060785A1 (en) | 2009-11-20 | 2011-05-26 | Moeller Claus Schmidt | Injection device without a gearing |
| ES2814256T3 (es) * | 2009-12-01 | 2021-03-26 | Becton Dickinson Co | Pluma de inyección con retroceso automático y control de última dosis |
| EP2618872B1 (en) | 2010-09-24 | 2020-04-15 | CPU Innovation ApS | A gearing mechanism for a dose delivery device |
| CN103180000B (zh) * | 2010-10-25 | 2015-09-09 | 赛诺菲-安万特德国有限公司 | 药物递送装置和用于组装药物递送装置的方法 |
| JP6199748B2 (ja) * | 2011-03-01 | 2017-09-20 | ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツングBoehringer Ingelheim microParts GmbH | カープルの作動器具及び方法 |
| US12350474B2 (en) | 2011-03-16 | 2025-07-08 | Becton, Dickinson And Company | Multiple use disposable injection pen |
| US11577029B2 (en) | 2012-03-15 | 2023-02-14 | Becton, Dickinson And Company | Multiple use disposable injection pen |
| PL3542843T5 (pl) | 2011-03-16 | 2026-03-16 | Becton, Dickinson And Company | Pen jednorazowy do wielu zastosowań |
| JP6057991B2 (ja) * | 2011-06-17 | 2017-01-11 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイス用カートリッジ・ホルダ・アセンブリ |
| US8333716B1 (en) | 2011-06-21 | 2012-12-18 | Yofimeter, Llc | Methods for using an analyte testing device |
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2003
- 2003-03-03 GB GBGB0304824.6A patent/GB0304824D0/en not_active Ceased
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2004
- 2004-03-02 US US10/790,026 patent/US7094221B2/en not_active Expired - Lifetime
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- 2004-03-03 AT AT04716589T patent/ATE540714T1/de active
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- 2004-03-03 CN CNB2004800117768A patent/CN100457209C/zh not_active Expired - Lifetime
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- 2004-03-03 TW TW093105522A patent/TWI389715B/zh not_active IP Right Cessation
- 2004-03-03 HR HR20050768A patent/HRP20050768A2/xx not_active Application Discontinuation
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- 2004-03-03 PL PL04716589T patent/PL1601396T5/pl unknown
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- 2004-03-03 WO PCT/EP2004/002118 patent/WO2004078226A2/en not_active Ceased
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