TWI387579B - 雙（硫代醯肼醯胺）鹽之合成 - Google Patents

雙（硫代醯肼醯胺）鹽之合成 Download PDF

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Publication number
TWI387579B
TWI387579B TW095116857A TW95116857A TWI387579B TW I387579 B TWI387579 B TW I387579B TW 095116857 A TW095116857 A TW 095116857A TW 95116857 A TW95116857 A TW 95116857A TW I387579 B TWI387579 B TW I387579B
Authority
TW
Taiwan
Prior art keywords
thioguanamine
bis
group
organic solvent
base
Prior art date
Application number
TW095116857A
Other languages
English (en)
Chinese (zh)
Other versions
TW200722411A (en
Inventor
Shoujun Chen
Zhi-Qiang Xia
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of TW200722411A publication Critical patent/TW200722411A/zh
Application granted granted Critical
Publication of TWI387579B publication Critical patent/TWI387579B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW095116857A 2005-05-16 2006-05-12 雙（硫代醯肼醯胺）鹽之合成 TWI387579B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16

Publications (2)

Publication Number Publication Date
TW200722411A TW200722411A (en) 2007-06-16
TWI387579B true TWI387579B (zh) 2013-03-01

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095116857A TWI387579B (zh) 2005-05-16 2006-05-12 雙（硫代醯肼醯胺）鹽之合成

Country Status (16)

Country Link
US (1) US7709683B2 (enExample)
EP (1) EP1888520A2 (enExample)
JP (1) JP2008540658A (enExample)
KR (1) KR20080008399A (enExample)
CN (1) CN101223133B (enExample)
AU (1) AU2006247470B2 (enExample)
BR (1) BRPI0611262A2 (enExample)
CA (1) CA2607890A1 (enExample)
IL (1) IL187056A (enExample)
MX (1) MX2007014314A (enExample)
NO (1) NO20075707L (enExample)
NZ (1) NZ563124A (enExample)
RU (1) RU2407734C2 (enExample)
TW (1) TWI387579B (enExample)
WO (1) WO2006124736A2 (enExample)
ZA (1) ZA200709395B (enExample)

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* Cited by examiner, † Cited by third party
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TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2006009940A1 (en) 2004-06-23 2006-01-26 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
JP5204489B2 (ja) * 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
NZ562572A (en) * 2005-04-15 2011-01-28 Synta Pharmaceuticals Corp Combination cancer therapy with BIS (thiohydrazide) amide compounds
WO2006113572A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
KR20080035642A (ko) 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
US20080226588A1 (en) * 2006-08-21 2008-09-18 Mcleod Matthew Treating melanoma with bis(thiohydrazide amides)
RU2475478C2 (ru) 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Соединения для лечения пролиферативных расстройств
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
WO2008033494A2 (en) 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
AU2009308511B2 (en) 2008-10-22 2013-03-07 Synta Pharmaceutical Corp. Transition metal complexes of a bis[thiohydrazide amide] compound
CA2741189A1 (en) 2008-10-22 2010-04-29 Synta Pharmaceuticals Corp. Transition metal complexes of bis[thiohydrazide amide] compounds
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
AU2009322603B2 (en) 2008-12-01 2013-08-29 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
WO2011133673A1 (en) 2010-04-20 2011-10-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers

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US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) * 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2006009940A1 (en) * 2004-06-23 2006-01-26 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
JP5204489B2 (ja) * 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
WO2006113572A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
NZ562572A (en) 2005-04-15 2011-01-28 Synta Pharmaceuticals Corp Combination cancer therapy with BIS (thiohydrazide) amide compounds
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
KR20080035642A (ko) * 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제

Also Published As

Publication number Publication date
TW200722411A (en) 2007-06-16
NO20075707L (no) 2007-12-11
EP1888520A2 (en) 2008-02-20
JP2008540658A (ja) 2008-11-20
CA2607890A1 (en) 2006-11-23
BRPI0611262A2 (pt) 2010-08-24
WO2006124736A3 (en) 2007-03-29
IL187056A0 (en) 2008-02-09
MX2007014314A (es) 2008-02-11
CN101223133B (zh) 2012-02-29
US20060270873A1 (en) 2006-11-30
ZA200709395B (en) 2008-10-29
AU2006247470A1 (en) 2006-11-23
RU2007144216A (ru) 2009-06-27
AU2006247470B2 (en) 2010-04-01
IL187056A (en) 2013-10-31
WO2006124736A2 (en) 2006-11-23
NZ563124A (en) 2010-12-24
KR20080008399A (ko) 2008-01-23
US7709683B2 (en) 2010-05-04
RU2407734C2 (ru) 2010-12-27
CN101223133A (zh) 2008-07-16

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