ZA200709395B - Synthesis of bis(thio-hydrazide amide) salts - Google Patents

Synthesis of bis(thio-hydrazide amide) salts

Info

Publication number
ZA200709395B
ZA200709395B ZA200709395A ZA200709395A ZA200709395B ZA 200709395 B ZA200709395 B ZA 200709395B ZA 200709395 A ZA200709395 A ZA 200709395A ZA 200709395 A ZA200709395 A ZA 200709395A ZA 200709395 B ZA200709395 B ZA 200709395B
Authority
ZA
South Africa
Prior art keywords
thio
bis
synthesis
salts
hydrazide amide
Prior art date
Application number
ZA200709395A
Other languages
English (en)
Inventor
Chen Shoujun
Xia Zhi-Qiang
Original Assignee
Synta Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of ZA200709395B publication Critical patent/ZA200709395B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200709395A 2005-05-16 2007-10-31 Synthesis of bis(thio-hydrazide amide) salts ZA200709395B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68126305P 2005-05-16 2005-05-16

Publications (1)

Publication Number Publication Date
ZA200709395B true ZA200709395B (en) 2008-10-29

Family

ID=37057197

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709395A ZA200709395B (en) 2005-05-16 2007-10-31 Synthesis of bis(thio-hydrazide amide) salts

Country Status (16)

Country Link
US (1) US7709683B2 (enExample)
EP (1) EP1888520A2 (enExample)
JP (1) JP2008540658A (enExample)
KR (1) KR20080008399A (enExample)
CN (1) CN101223133B (enExample)
AU (1) AU2006247470B2 (enExample)
BR (1) BRPI0611262A2 (enExample)
CA (1) CA2607890A1 (enExample)
IL (1) IL187056A (enExample)
MX (1) MX2007014314A (enExample)
NO (1) NO20075707L (enExample)
NZ (1) NZ563124A (enExample)
RU (1) RU2407734C2 (enExample)
TW (1) TWI387579B (enExample)
WO (1) WO2006124736A2 (enExample)
ZA (1) ZA200709395B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI297335B (en) 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI332943B (en) 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2006009940A1 (en) 2004-06-23 2006-01-26 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
JP5204489B2 (ja) * 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
NZ562572A (en) * 2005-04-15 2011-01-28 Synta Pharmaceuticals Corp Combination cancer therapy with BIS (thiohydrazide) amide compounds
WO2006113572A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
KR20080035642A (ko) 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제
US20100068174A1 (en) * 2006-08-21 2010-03-18 Synta Pharmaceuticals Corp. Combination with bis (thiohydrazide amides) for treating cancer
WO2008024301A2 (en) * 2006-08-21 2008-02-28 Synta Pharmaceuticals Corp. Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma
US20080226588A1 (en) * 2006-08-21 2008-09-18 Mcleod Matthew Treating melanoma with bis(thiohydrazide amides)
RU2475478C2 (ru) 2006-08-21 2013-02-20 Синта Фармасьютиклз Корп. Соединения для лечения пролиферативных расстройств
JP2010502616A (ja) * 2006-08-31 2010-01-28 シンタ ファーマシューティカルズ コーポレーション 癌を治療するためのビス（チオヒドラジドアミド）の組み合わせ
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
WO2008033494A2 (en) 2006-09-15 2008-03-20 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009105257A1 (en) 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
AU2009308511B2 (en) 2008-10-22 2013-03-07 Synta Pharmaceutical Corp. Transition metal complexes of a bis[thiohydrazide amide] compound
CA2741189A1 (en) 2008-10-22 2010-04-29 Synta Pharmaceuticals Corp. Transition metal complexes of bis[thiohydrazide amide] compounds
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
AU2009322603B2 (en) 2008-12-01 2013-08-29 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
WO2011133673A1 (en) 2010-04-20 2011-10-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2097737A5 (en) 1970-07-14 1972-03-03 Berlin Chemie Veb Virustatic 4-substd 1-acylthiosemicarbazides -from carboxylic acid - hydrazide and isothiocyanates or from carboxylic acid chloride and 4-
DE2037257A1 (en) 1970-07-28 1972-02-03 Farbwerke Hoechst AG, vorm. Meister Lucius & Brüning, 6000 Frankfurt Poly-(5-amino-1,3,4-thiadiazol-2-yl) derivs prepn - intermediates for drug and polymer prodn
US4012360A (en) 1973-12-03 1977-03-15 Ciba-Geigy Corporation Bis-salicyloyl-dicarboxylic acid dihydrazides as stabilizers for polyolefines
JPS5091056A (enExample) 1973-12-17 1975-07-21
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
FR2697752B1 (fr) 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
ATE184613T1 (de) 1995-09-22 1999-10-15 Novo Nordisk As Varianten des grünen fluoreszenzproteins, gfp
US6235787B1 (en) 1997-06-30 2001-05-22 Hoffmann-La Roche Inc. Hydrazine derivatives
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
TW479053B (en) 1998-10-19 2002-03-11 Agro Kanesho Co Ltd Hydrazineoxoacetamide derivatives and pesticides
ES2161594B1 (es) 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
US6322303B1 (en) 2000-05-12 2001-11-27 David M. John Dunnage bag and method of making same
EP1164126A1 (de) 2000-06-16 2001-12-19 Basf Aktiengesellschaft Salicylsäurehydrazid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung zur Bekämpfung von Schadpilzen
US6365745B1 (en) 2000-07-14 2002-04-02 Sumika Fine Chemicals Co., Ltd. Method for producing hydrazine derivative
WO2002059080A2 (en) 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US6602907B1 (en) 2001-06-08 2003-08-05 University Of Central Florida Treatment of breast cancer
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI297335B (en) * 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2006009940A1 (en) * 2004-06-23 2006-01-26 Synta Pharmaceuticals Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
WO2006033913A2 (en) 2004-09-16 2006-03-30 Synta Pharmaceuticals Corp. Bis (thio-hydrazide amides) for treament of hyperplasia
JP5204489B2 (ja) * 2004-11-19 2013-06-05 シンタ ファーマスーティカルズ コーポレイション Ｈｓｐ７０発現を増加するためのビス（チオ‐ヒドラジドアミド）
WO2006113572A1 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of increasing natural killer cell activity for therapy
NZ562572A (en) 2005-04-15 2011-01-28 Synta Pharmaceuticals Corp Combination cancer therapy with BIS (thiohydrazide) amide compounds
WO2006113493A2 (en) 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Methods of determining cancer prognosis via natural killer cell activity
KR20080035642A (ko) * 2005-08-16 2008-04-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 제제

Also Published As

Publication number Publication date
TW200722411A (en) 2007-06-16
NO20075707L (no) 2007-12-11
EP1888520A2 (en) 2008-02-20
JP2008540658A (ja) 2008-11-20
CA2607890A1 (en) 2006-11-23
BRPI0611262A2 (pt) 2010-08-24
WO2006124736A3 (en) 2007-03-29
IL187056A0 (en) 2008-02-09
MX2007014314A (es) 2008-02-11
CN101223133B (zh) 2012-02-29
US20060270873A1 (en) 2006-11-30
TWI387579B (zh) 2013-03-01
AU2006247470A1 (en) 2006-11-23
RU2007144216A (ru) 2009-06-27
AU2006247470B2 (en) 2010-04-01
IL187056A (en) 2013-10-31
WO2006124736A2 (en) 2006-11-23
NZ563124A (en) 2010-12-24
KR20080008399A (ko) 2008-01-23
US7709683B2 (en) 2010-05-04
RU2407734C2 (ru) 2010-12-27
CN101223133A (zh) 2008-07-16

Similar Documents

Publication Publication Date Title
IL187056A0 (en) Synthesis of bis (thio-hydrazide amide) salts
IL189156A0 (en) Bis(thio-hydrazide amide)formulation
IL179632A0 (en) Bis (thio-hydrazide amide) salts for treatment of cancers
PT1778618E (pt) Síntese de trietilenotetraminas
IL191035A0 (en) Pharmaceutical use of substituted amides
IL191034A0 (en) Pharmaceutical use of substituted amides
ZA200710877B (en) Preparation of syngas
ZA200708947B (en) Production of Synthesis Gas
ZA200705792B (en) Synthesis of himbacine analogs
EP1953151A4 (en) SALTS FROM A CYNNAMIDE COMPOUND OR SOLVATE THEREOF
ZA201206140B (en) An exo-selective synthesis of himbacine analogs
PL2468724T3 (pl) Synteza związków pirolidynowych
EP1841424A4 (en) SYNTHESIS OF ARYL PYRROLIDONES
GB0521244D0 (en) Benzamide compounds
EP1711484A4 (en) SYNTHESIS OF CYANOIMINO-BENZOIMIDAZOLES
IL189547A0 (en) Synthesis of 1??-fluoro-25-hydroxy
IL187856A0 (en) ??-lactam synthesis
IL184354A0 (en) New one-step synthesis of useful disubstituted amines
GB0501146D0 (en) Novel benzamide derivatives
HK1112892A (en) Synthesis of bis(thio-hydrazide amide) salts
PL377747A1 (pl) Synteza amidu kwasu 3-(4-hydroksyfenylo) propanowego
ZA200710408B (en) Synthesis of hydroquinone derivatives
GB0618703D0 (en) Synthesis of leikotriene compounds
IL178184A0 (en) Synthesis of pyrrole-2-carbonitriles
ZA200610440B (en) Bis(thio-hydrazide amide) salts for treatment of cancers