1374957 、發明說明： 【發明所屬之技術領域】 本發明關於一種抗氧化性之抗菌纖維，其包含幾丁聚 醣纖維及黃芩（Scutellaria radix )萃取物，且該抗菌纖維 具有耐水洗之優點。本發明亦關於抗菌纖維之製法及其用 途。特別地’此抗菌纖維及其所製得之紡織品，可用於食 品業之食材包裝保鮮基材、化妝品業之面膜基材及紡織業 之保健衣物。 10 15 【先前技術】 一 一近在來―’虫於健康導向二希望衣物對於肌膚的刺激性 越低越好。對於虛弱的幼兒或者過敏體質的人而言，特別 ，此^有強烈的需求。除此之外，強烈的太陽紫外光、空 煙害以及環境周遭的電磁歸等因素，會導致皮 二的=來2:及病變等問題，故對於機能性纖維纺 要包的抗自由基物質係為抗氧化維生素系統，主 系統，例如=維生素”及胡蘿葡素等；抗氧化酵素 以及多:魅^ 麵過氧化酶及超氧歧化酶等； 苯及第三丁Γ，例如：丁基經基甲氧苯、丁基經基曱 此，若將等有天然多盼類和綠茶多驗等。因 右將此荨物質與纖維製品結合， 果的纖維製品。 ⑴叱產生具抗氧化效 纖維$ 目前先前技術已提l些抗氧化及抗8功效之 20 品。=’特開平1G-331G7揭示-種抗氧化性纖維材料之 解材料係藉由在胤1至之蛋白質 摻合|旦蛋白貝與抗氧化植物組織之粉碎物或萃取物之 產品^比和各組成濃度為G.5至2G重量％，來處理織維 除马了増加穩定性及耐水性而使用交聯劑，但交聯劑 生相關毒性問題’亦增加製造的成本。 造方^開+ 1M82G揭示—種改質纖維素再[纖維及其製 的粉碎物特徵在於含有具抗氧化能力之植物組織 纖維素微小粒狀再生幾丁聚醣，分散於含有 之植^ 纖維中’而其製造法為將含有具抗氧化能力 添.、、且織的粉碎物和萃座物之微小粗狀再生幾丁聚醣， 因=纖Ϊ素勒膠溶液中混合’並將該溶液纺絲。然而， 能^) I聚醣的添加量有其限制且與纖維素之間並無存在 :的用力，故此先前技術並無進一步揭示相 笊冼性5式驗，且亦無提及在一般使用上會遭遇的水 問題之解決方式。 利用纟寺開2008-156787揭示一種抗氧化抗菌性纖維，其係 丁产表余多酚附著於60%去醯化度之幾丁聚醣纖維，該幾 、=醣纖維具有高反應性的胺基，能跟多紛的氫氧基穩固 故除了具有優越的抗菌性和抗氧化性外，還具有耐 性。然而，此先前技術僅使用後處理加工方式來製造 Hi·生纖維，故有許多仍需改進的地方。 中 口此，由上述可知，在製造具氧化及抗菌功效之纖維 若使用交聯劑，則會有產生毒性或成本增加的問題； 13749571374957, EMBODIMENT OF THE INVENTION: FIELD OF THE INVENTION The present invention relates to an antibacterial antibacterial fiber comprising chitin fiber and Scutellaria radix extract, and the antibacterial fiber has the advantage of being water-resistant. The invention also relates to the preparation of antimicrobial fibers and their use. In particular, the antibacterial fiber and the textile produced therefrom can be used for food packaging fresh-keeping substrates in the food industry, mask substrates for the cosmetics industry, and health-care garments for the textile industry. 10 15 [Prior Art] One is near--the insect is in the health direction. The hope that the clothing is less irritating to the skin is as good as possible. For frail young children or people with allergies, in particular, there is a strong demand for this. In addition, the strong solar ultraviolet light, air smoke and electromagnetic reversion factors around the environment will lead to the problem of skin 2 = 2 and lesions, so the anti-free radicals for functional fiber spinning For the antioxidant vitamin system, the main system, such as = vitamins and carotenoids; antioxidant enzymes and more: enchanting surface peroxidase and superoxide dismutase; benzene and third butyl, such as: butyl According to this, if the methoxybenzene and butyl groups are used, if there are natural vitamins and green tea, etc., the fiber product is combined with the fiber product by the right. (1) Antimony production Fiber $ At present, the prior art has proposed some anti-oxidation and anti-8 efficacy products. = 'Special Kaiping 1G-331G7 reveals that the anti-oxidative fiber material is solved by the protein blending in 胤1~ The ratio of the product of the protein shell and the anti-oxidized plant tissue to the pulverized product or the extract is G. 5 to 2 G% by weight, and the cross-linking agent is used to treat the stability and water resistance of the woven worm. Cross-linking problems associated with toxicity' also increase the cost of manufacturing造方开+1M82G reveals a kind of modified cellulose. [The fiber and its pulverized product are characterized by the micro-granular regenerated chitosan of the plant tissue containing antioxidant capacity, dispersed in the planting fiber. Medium' and its manufacturing method is to regenerate chitosan from the tiny coarse form containing the anti-oxidation ability and the pulverized material and the liquefied material, and the mixture is mixed with the fiber. Solution spinning. However, there is a limitation in the amount of addition of the glycan, and there is no force between the cellulose and the cellulose. Therefore, the prior art does not further disclose the correlation test, and there is no mention. And the solution to the water problem that will be encountered in general use. The use of 纟寺开 2008-156787 reveals an anti-oxidative antibacterial fiber, which is derived from the polyphenols that are attached to 60% deuterated degree of chitosan. Fiber, the sugar fiber has a highly reactive amine group, which is stable with a large number of hydroxyl groups, and has resistance in addition to superior antibacterial and antioxidant properties. However, this prior art is only used after Processing the processing method to manufacture Hi·sheng fiber, so there is Many areas that still need improvement. From the above, it can be seen that in the manufacture of fibers with oxidizing and antibacterial properties, the use of cross-linking agents may cause toxicity or increase in cost; 1374957
20 若具有功效之植物萃取物無法與纖維穩固地結合，則具有 該功效之纖維的使用壽命會下降。 【發明内容】 有鑑於此，本發明旨在提供具有抗氧化及抗菌功效之 ，維’該纖維含有幾丁輯纖維及黃答（Seutelladaradix) 萃取物，其中黃芩（Scutellada mdix)萃取物所含的普芩 (BaiCalin)(如下列式所示）除了具有抗氧化及抗菌功效外， 其所具有的絲’能與幾丁㈣帶有的胺基形成穩固的鍵 結，20 If the potent plant extract does not bind firmly to the fiber, the life of the fiber with this effect will decrease. SUMMARY OF THE INVENTION In view of the above, the present invention aims to provide an antioxidant and antibacterial effect, which contains a few butyl fibers and a Seutelladaradix extract, which is contained in the extract of Scutellada mdix. In addition to its antioxidant and antibacterial properties, BaiCalin (as shown in the following formula) has a silk' capable of forming a firm bond with the amine group carried by the chitin (4).
六本發明的另一目的係為提供製造具有抗氧化及抗菌功 、之、截、、隹的方法，其使用黃芩（Scute丨丨aria )萃取物與 歲丁艰醣纖維並分別以後處理加工方式或濕式紡絲方式製 成。 口此外，本發明之抗氧化性抗菌纖維及其所製得之紡織 :’可用於食品業之食材包裝保鮮基材、化妝品業之面膜 基材及紡織業之保健衣物。 本發明之特點可參閱本案圖式及以下較佳實施方式之 5 詳細說明而獲得清楚地瞭解β 【實施方式】 本發明之具有抗氧化之抗菌功效纖維，其係包含幾丁 聚醣纖維及黃芩（Scutellaria radix)萃取物，其中普芩 (SCUtellaria —Χ)萃取物所含的黃芩(Baicalin)除了具有 優越的抗氧化及抗菌功效外，其所具有㈣基，能與幾丁 聚醣帶有的胺基形成穩固的鍵結，而增加幾n纖維的 耐水洗性，故浦於先前技術，解決了產生毒性、增加製 造成本以及时水洗性等問題。此外，本發明所使用之纖維 -中幾丁聚酿含量可為10重量I至100重量％，相較於先前 技術’本㈣對於幾丁聚_含量範圍更加地擴大。 上述之幾丁聚酶纖維’除了包含幾丁聚醣外，亦可視 情況至少加人-種或-種以上之額外組分，其包括螺營、 棉、蠶絲、聚酯纖維及尼龍纖維等。 皇造具抗氧化性之抗菌鏃难之方法 ^本發明之製造方法（如第】圖所示）主要分為（A)黃 今（Scutellaria radix)萃取物的製備和（B)具抗氧化性之 抗菌纖維的製備兩部分進行，其中（B)部分再細分為（B〇 後處理加工方式及（B2)濕式紡絲方式兩部分，所有步驟 詳述如下： (A)黃芩萃取物係可藉由下例步驟製得： (a)黃芩（Scutellariaradix)粉末與水以 i:i〇 至 1 : 1 之 重里比’較佳1 .5至1 . 1之重量比，更佳i . 2牵 1 : 1之重量比，混合； (b) 在約l〇〇°C下進行萃取〇·5至3小時，較佳〇75 小時，更佳1至1.5小時；及 (c) 過濾去除雜質， 其中以黃料取物之總H積為基準，該黃料取物 後固體含量為5%至20% (重量/體積）。 m 較佳，步驟（c)係以抽氣過濾方式去除雜質。 (B)具抗氧化性之抗菌纖維的製備可由下列兩種方法之一穿 備： (B1)以後處理加工方式製備該纖維： (a) 將步驟（A)黃芩萃取物與等重量之水混合； (b) 以壓吸方式使黃芩萃取物附著於幾丁聚醣纖維上； 以及 (c) 將步驟⑺所得之纖維烘乾。 步驟(b)可重複一至五次，以三次較隹。 本發明之一具體例中，步驟（b)中壓吸係在室溫下進行。 本發明之另一具體例中，步驟(c)中烘乾可在7〇至13(rc 之溫度下進行，較佳80至12〇。(：。 (B2)以濕式紡絲方式製備該纖維： (a)取步驟（A)黃芩萃取物與幾丁聚醣及酸混合以形 成幾丁聚醣之紡絲原液；其中該黃芩萃取物乾燥後 固體含量為0.5至6% (重量/體積），以黃芩萃取物 之總體積為基準；且幾丁聚醣濃度為3至5% (重量 /體積）及酸濃度為1至5% (重量/體積），以紡絲原 液之總體積為基準； (b) 進行濕式紡絲；以及 (c) 將步驟(b)所得之纖維進行水洗乾燥。 步驟(a)中，酸為有機酸。較佳，該酸係選自 丙酸或醋酸。以醋酸為最佳。 文乳酉夂、 步驟⑼中使用3至6% (重量/體積）之含 水溶液作為纖維成型液，較佳步驟(b)中該醇為;^ 7 醇且醇含量為20至5〇% (重量/體積）。步驟(b)係在^ 40°C之紡絲溫度下及60 m/min至95 m/min之紡絲速度下 進行。 又 -步驟（c)-中’該水洗乾燥係以發明所屬技術領域中具有 通常知識者習知之一般水洗乾燥步驟進行。 、此外，上述製造步驟所使用之幾丁聚醣為以上之 脫乙酸化度’且分子量為50000-500000。 測試方法 本發明纖維之抗氧化測試、抗菌測試和耐水洗性測試之方法 如下所述： 拉Ai匕測試（清除α,α-二苯基-β-苦基肼自由$^ppH . u n 檢測對於2,2-二苯基-1-苦基肼(DPPH)的清除能力以評估纖 維的抗氧化活性。將DPPH(6毫克)溶於由去離子水(1〇〇毫升)及 乙醇(100毫升)所組成之混合溶液。將纖維樣品（〇 〇5克）浸在 DPPH (6毫升）中。該反應混合物在黑暗中持續震盈，直到量測 到該溶液的吸光度。所產生之溶液的吸光度係以缺少DPPH之空 用UV/可見光光譜儀分析。 白樣品為背景’在波長517奈米下利 抑制百分比由下列方程式計算： 抑制率(％)A further object of the present invention is to provide a method for producing an antioxidant and an antibacterial work, a cut, and a sputum, which uses a scavenger extract and a succulent fiber, and processes the processing method separately. Or made by wet spinning. Further, the antioxidant antibacterial fiber of the present invention and the obtained textile thereof are: 'a food packaging fresh-keeping substrate for the food industry, a mask substrate for the cosmetics industry, and a health care garment for the textile industry. The characteristics of the present invention can be clearly understood by referring to the detailed description of the present invention and the following detailed description of the fifth embodiment. [Embodiment] The antibacterial antibacterial fiber of the present invention comprises chitosan fiber and jaundice. (Scutellaria radix) extract, in which Baicalin contained in the extract of SCUtellaria-Χ has a superior anti-oxidation and antibacterial effect, and it has a (meth) group which can be carried with chitosan. The amine group forms a stable bond and increases the water wash resistance of a few n fibers, so that the prior art solves problems such as toxicity, increased manufacturing cost, and water washability. Further, the fiber used in the present invention may have a content of 10 parts by weight to 100% by weight, which is more expanded than the prior art '(4)). The above-mentioned chitin polymer fiber 'in addition to chitosan, it is also possible to add at least one or more kinds of additional components, including snails, cotton, silk, polyester fibers and nylon fibers. The method for producing antibacterial antibacterial remedies of the invention is as follows: (A) preparation of extracts of Scutellaria radix and (B) oxidation resistance The preparation of the antibacterial fiber is carried out in two parts, wherein part (B) is subdivided into two parts: (B〇 post-treatment processing method and (B2) wet spinning method, all the steps are detailed as follows: (A) Astragalus extract system can be By the following steps: (a) Scutellaria radix powder and water with i: i 〇 to a weight ratio of 1:1, preferably a weight ratio of 1.5 to 1.1, better i. 2 lead (1) extraction at about 1 ° C for 5 to 3 hours, preferably 〇 75 hours, more preferably 1 to 1.5 hours; and (c) filtration to remove impurities, Wherein the solid content of the yellow material is 5% to 20% (weight/volume) based on the total H product of the yellow material. m is preferably, step (c) is to remove impurities by suction filtration. (B) Preparation of antibacterial antibacterial fiber can be prepared by one of the following two methods: (B1) The fiber is prepared by a later processing method: (a) the step ( A) the Astragalus extract is mixed with an equal weight of water; (b) the Astragalus extract is attached to the chitosan fiber by pressure suction; and (c) the fiber obtained in the step (7) is dried. Step (b) Repeating one to five times, three times more. In one embodiment of the invention, the pressure sucking system in step (b) is carried out at room temperature. In another specific embodiment of the invention, the drying in step (c) may be 7 to 13 (at a temperature of rc, preferably 80 to 12 Torr. (: (B2) The fiber is prepared by wet spinning: (a) Step (A) Astragalus extract and chitosan And a mixture of acids to form a spinning dope of chitosan; wherein the extract of the astragalus extract has a solid content of 0.5 to 6% (weight/volume) based on the total volume of the extract of astragalus; and the concentration of chitosan 3 to 5% (w/v) and an acid concentration of 1 to 5% (w/v) based on the total volume of the spinning dope; (b) wet spinning; and (c) steps ( b) The obtained fiber is washed with water. In the step (a), the acid is an organic acid. Preferably, the acid is selected from propionic acid or acetic acid, and acetic acid is preferred. In the step (9), an aqueous solution of 3 to 6% (weight/volume) is used as the fiber forming liquid, and preferably the alcohol in the step (b) is an alcohol having an alcohol content of 20 to 5 % (weight/volume). Step (b) is carried out at a spinning temperature of 40 ° C and a spinning speed of 60 m / min to 95 m / min. Further - step (c) - in the 'washing and drying system" In the field, there is a general washing and drying step which is conventionally known to those skilled in the art. Further, the chitosan used in the above production step has the above degree of deacetation and has a molecular weight of 50,000 to 500,000. Test Methods The methods of the antioxidant test, the antibacterial test and the water wash resistance test of the fibers of the present invention are as follows: Pull Ai匕 test (clearing α,α-diphenyl-β-picrylamine free $^ppH. undetected for The scavenging ability of 2,2-diphenyl-1-picrylhydrazyl (DPPH) was evaluated to evaluate the antioxidant activity of the fiber. DPPH (6 mg) was dissolved in deionized water (1 ml) and ethanol (100 ml). a mixed solution consisting of the fiber sample (5 g) was immersed in DPPH (6 ml). The reaction mixture continued to vibrate in the dark until the absorbance of the solution was measured. The absorbance of the resulting solution It is analyzed by UV/visible spectrometer in the absence of DPPH. The white sample is the background. The percentage of inhibition at the wavelength of 517 nm is calculated by the following equation: Inhibition rate (%)
X 100 ’热纖維樣品之空白樣品的 本發明係在浸潰於DppH後 其中’ Ab和As分別為在預定時間下 吸光度以及具有纖維樣品的吸光度。 約30分鐘測其吸光度。 抗菌測試方法 .取纖雜品進行抗缝色葡_菌（肌c 6538p 以檢測纖狀抗_功效哪贼方法係根據照日本纖 ς 能評價協齡避τ之㈣標準⑽L19QM = 步驟如下所述： 订坪細 吋±30分 (1)以培養液，在攝氏37±1度之環境下 鐘。（目標菌數為每毫升1〇7個） ⑺採用吸光度法(波長_nm)，將前述之菌液以稀 之培養液將菌濃度調製成每毫升l±0.3xl〇5個。 β (3)將每毫升含菌量祕㈣5個之菌液(Μ毫升)接種於〇 4 公克之測離品上（每個不含萃取物之_樣品各3 個含萃取物之纖維樣品各3個檢體）。 豆. (4) 以攝氏3±1度之環境下培養18±1小時。 (5) 使用20毫升含〇.〇5%Tween80之生理食鹽水，以 (震幅30公分’ 30次）後，再用攪拌器«拌，而將菌洗出t ^ (6)將上述洗出之菌液稀釋，分別取出各稀釋倍率之菌液i 毫升’於固態培養基中，以攝氏37土1度、24至48小時之條 培養後’將於培養基上培養後之數，細下式計算出生 數. M=ZxRx20 ，R•為稀 其_ Μ為生菌數，z為菌叢數（兩個培養皿的平均值） 釋倍率；2G為用於將菌洗出之生理食鹽水的量。 (7)活性値以下式計算： 抑菌活性値S=Mb —Me ; -殺菌活性値L=Ma—Μ_ς ; " ' —-'—· — ____ 增殖活性値F=Mb—Ma ; 一 Τι f取物之纖維樣品於接種後立刻測出之生菌卖 (3個樣品的平均）對數倍； 隱：不含萃取物之纖維樣品於培養 (3個樣品的平均）對數植； 诫之生_ 於培養18小時後之生菌數（3The present invention of the blank sample of the X 100 'hot fiber sample is after the impregnation of DppH where 'Ab and As are the absorbance at a predetermined time and the absorbance of the fiber sample, respectively. The absorbance was measured in about 30 minutes. Antibacterial test method. Take the scum of the fiber to prevent the smear _ _ bacteria (muscle c 6538p to detect the fibrosis resistance _ efficacy of the thief method according to the Japanese fiber can evaluate the association of the age of avoiding τ (four) standard (10) L19QM = the steps are as follows: Set the fine 吋 吋 ± 30 points (1) with the culture solution, in the environment of 37 ± 1 ° C. (The target number of bacteria is 1 〇 7 per ml) (7) using the absorbance method (wavelength _nm), the above The bacterial solution is adjusted to a concentration of l±0.3xl/ml per ml in a dilute culture solution. β (3) Inoculate a bacterial solution (5 ml) per ml of bacteria (4 ml) in a solution of 4 g of 〇 On the product (each sample containing 3 extracts of each sample containing no extract). Bean. (4) Incubate for 18 ± 1 hour in an environment of 3 ± 1 ° C. (5) ) using 20 ml of physiological saline containing 〇.〇5% Tween80, (sense 30 cm '30 times), and then using a stirrer «mix, and wash the bacteria out of t ^ (6) to wash out the above Dilute the bacterial solution, and take out the microbial solution of each dilution ratio of i ml in a solid medium, culture at 37 ° C for 1 degree, 24 to 48 hours, and then culture on the medium. The number of births is calculated by the following formula. M=ZxRx20, R• is dilute _ Μ is the number of bacteria, z is the number of flora (average of two culture dishes) release rate; 2G is the physiology used to wash the bacteria out (7) Activity 値 Calculation of the following formula: Antibacterial activity 値S=Mb — Me ; - bactericidal activity 値L=Ma—Μ_ς ; " ' —-' —· — ____ Proliferation activity 値F=Mb —Ma ; a fiber sample taken from a Τ f f sample immediately after inoculation, the number of times the number of times the number of logs of the fiber sample (the average of 3 samples) is not counted;植; 诫生生_ The number of bacteria after 18 hours of culture (3
Me :含萃取物之纖維樣品 個樣品的平均）對數値， 效果’殺菌值>〇表示測 其中當抑紐>2.2表示峨樣品有抑菌 试樣品有殺菌效果。 耐水洗測試方法 驗方法，將不同的纖維樣 及抗氧化性，其中AATCC： 依據AATCC 135之水洗評價之试 ασ水洗10及20次後’分別消彳試其抗菌 135之操作步驟如下所述： (1) 試樣準備後’取一定量測試樣品； 磅）； (2) 秤樣品試樣與附布總重量達1.8±0丨公斤（4〇〇±〇25 (3) 在1.8±1加侖之水量下，調整所需水溫至27±3它； (4) 杻動機器之選擇器至一般水洗條件，並加入1993 MTCC洗劑66±1克； ;以 (5) 機益開始自動操作，水洗、洗清、脫水自動完成 (6)將水洗過後之試樣⑽乾方式魏，其巾烘乾機設定 -二燥條择為66坑之乾燥溫度.、乾燥1〇分鐘，隨之將試樣與 附布同時放入，進行乾燥。 1本七明貝她例之抗氧化性抗菌纖係根據上述纖維之製 =方法進饤’其中黃答（Scutdlaria radix)係構自於勝昌製藥 =股份有限公司，而比較例之綠茶係購自於天仁茗茶。此外，本 I明之較佳實施例如下所述： (A)歲丁聚/黃答纖維（經後處理加工）之製造例： (a) 汽今（Scutellaria radix)粉末與水以1:1〇之重量比 混合； (b) 在約i〇〇°c下進行萃取1小時； (c) 以抽氣過濾方式去除雜質； (d) 將步驟黃答萃取物與等重量之水混合； (e) 在室溫下’以錢3次之壓吸方式使黃料取物附 1374957Me: average of the fiber sample containing the extract) logarithm 値, effect 'bactericidal value> 〇 indicates that when the sputum > 2.2 indicates that the sputum sample has a bacteriostatic test sample has a bactericidal effect. The method of washing resistance test method, different fiber samples and oxidation resistance, wherein AATCC: according to the AATCC 135 water washing evaluation test ασ water washing 10 and 20 times, respectively, the operation steps of the antibacterial 135 are respectively tested as follows: (1) After the sample is prepared, 'take a certain amount of test sample; pounds'; (2) The total weight of the sample and the attached sample is 1.8 ± 0 丨 kg (4 〇〇 ± 〇 25 (3) at 1.8 ± 1 gallon Under the amount of water, adjust the required water temperature to 27 ± 3; (4) shake the machine selector to the general water washing conditions, and add 1993 MTCC lotion 66 ± 1 gram; ; (5) machine benefits start automatic operation , washing, washing, dehydration is completed automatically (6) after washing the sample (10) dry method Wei, its towel dryer set - two drying strips selected for the drying temperature of 66 pits, drying for 1 minute, followed by The sample and the attached cloth are placed at the same time for drying. 1 The anti-oxidation antibacterial fiber of the sample of the seven Mingbei is based on the above-mentioned method of fiber=the method of 'Scutdlaria radix' is constructed from Shengchang Pharmaceutical = Co., Ltd., and the green tea of the comparative example was purchased from Tianren Tea. In addition, the preferred embodiment of the present invention For example, the following is a description of the following: (A) Production examples of aged polystyrene/yellow fiber (post-treated): (a) Scutellaria radix powder and water are mixed at a weight ratio of 1:1; (b) Extracting at about i〇〇°c for 1 hour; (c) removing impurities by suction filtration; (d) mixing the step yellow extract with an equal weight of water; (e) at room temperature 3 times of the suction method to make the yellow material take 1374957
10 1510 15
20 著於幾丁聚醣纖維上；以及 (f)將上述步驟所得之纖維以70及13(TC烘乾。 (B)幾丁聚餹/黃芩纖維（經濕式紡絲）之製造例： (a) 黃芩（Scutellaria radix)粉末與水以1:1〇之重量比 屍合； (b) 在約1〇〇。〇下進行萃取1小時； (c) 以抽氣過濾方式去除雜質； (d) 分別將以黃芩萃取物之總體積為基準之乾燥後固體 含量為0.68重量/體積％之黃芩萃取物，與以紡絲原 ——液之總體積為基準之5%幾丁聚醣（重量/體積）及 L67%醋酸（重量/體積）混合以形成幾丁聚醣之紡 絲原液； (e) 使用5% (重量/體積）之含甲醇的氫氧化納水溶液 作為纖維成型液，其中甲醇含量為4〇% (重量/體 積)’並且在30C紡絲溫度下及95m/min紡絲速度下 進行濕式紡絲；以及 (f) 將上述步驟所得之纖維以—㈣知之方式進行水洗 乾燥。 實施例 黃粉末、黃答萃取液、綠茶粉以及幾丁聚膽/ 果行抗氧化測試，其結果如第2圖所示。結 為80 4=。/今77末的自由基清除能力為8〇.79%，黃答萃取液 為〇.〜，幾丁聚膽/黃答之抗氧化纖維為8〇1、5%。由此 12 25 可知由黃芩粉末萃取成黃芩萃取液以及再由黃芩萃取液製 成幾丁聚醣/黃芩纖維，兩者處理前後之的自由基消除率 (%)差異不大，這表示萃取程序以及製造抗菌纖維程序 對於具有功效之抗氧化因子（黃芩），並未造成纖維抗氧化 能力明顯的改變。此外，亦可從第2圖中得知黃芩粉末的 自由基清除率相較綠茶粉來的高。 實施例2 將嫘縈、嫘縈（經黃芩萃取液後處理加工）、幾丁聚醣 /嫘縈纖維（經黃芩萃取液後處理加工）、幾丁聚醣纖維和幾 -丁聚醣-纖-維C與黃芩-萃取液-濕妨)一四個-樣品-分別進抒抗菌 性測試、抗氧化測試以及耐水洗測試，其結果數據如表一 至三所示。其中，幾丁聚醣佔幾丁聚醣/嫘縈纖維10重量％。 表一中，嫘縈（經黃芩萃取液後處理加工）、幾丁聚醣 /嫘縈纖維（經黃芩萃取液後處理加工）以及幾丁聚醣纖維 (與黃芩萃取液濕紡）3個樣品，在清除自由基能力（抗氧 化能力）方面，遠高於未經黃芩萃取液處理過之纖維，這 代表黃芩萃取液本身的抗氧化能力，已附加於經其處理之 纖維上。 此外，耐水洗測試方面，與黃芩萃取液混紡製得之幾 丁聚醣纖維在水洗前的自由基清除能力（抗氧化能力）為 80.15% ;在經過水洗10次時，其抗氧化能力為80.09% ; 在經過水洗20次時，其抗氧化能力為53.09%。由此可知此 抗氧化纖維在經水洗的過程後，仍保有相當程度的抗氧化 1374957 能力，尤其在水洗20次後的抗氧化纖維其抗氧化能力依然 保有50%以上的抗氧化能力。這代表本發明之含黃芩萃取 物之幾丁聚醣纖維除了具有優越的抗氧化能力外，還具有 優越的对水洗性。 •5 表一 清除自由基能力 (%) 水洗10次 後之清除自 由基能力 (%) 水洗20次後之 清除自由基能 力（％) 嫘縈---------------------------- 0.589 --------- —— ------------_ - 嫘縈_(經黃芩萃取液後 處理加工） 79.97 0.707 0.699 幾丁聚醣/嫘縈纖維（經 黃芩萃取液後處理加 工） 80.09 16.88 9.495 幾丁聚醣纖維 21 20.44 19.857 幾丁聚醣纖維（與黃芩 萃取液濕紡） 80.15 80.09 53.094 表二中，嫘縈（經黃芩萃取液後處理加工）、幾丁聚醣 10 /嫘縈纖維（經黃芩萃取液後處理加工）以及幾丁聚醣纖維 (與黃芩萃取液濕紡）3個樣品，其殺菌值皆大於0，且高 於未經黃芩萃取液處理過之纖維，根據JIS L1902之說明， 這3個樣品皆具有殺菌能力，以及證明黃芩萃取液本身的 14 U/4957 殺菌能力，可有效地附加於經其處理之纖維上。 此外，耐水洗測試方面，與黃芩萃取液混紡製得之幾 丁 ♦酷纖維在水洗前的殺菌值為2 2以及在經過水洗1〇次 恰為1.9。由此可知此抗氧化纖維在經水洗過程後，仍保有 相當程度的殺g能力。這代表本發明之幾丁㈣/黃答纖維 除了具有優越的殺菌能力外，還具有優越的耐水洗性。 • · - _ 抗菌性（殺菌 值）. 水洗10次後之抗菌性 (殺藤值)— 嫘縈 <0 <0 嫘縈（經黃荅萃取液後處理加工） 2.1 0.71 幾丁聚醣/嫘縈纖維（經黃芩萃取 液後處理加工） 2.3 0.93 幾丁聚醣纖維 1.2 0.9 幾丁聚醣纖維（與黃答萃取液濕 紡） ·’、、 2.2 1.9 表三中，嫘縈（經黃芩萃取液後處理加工）、幾丁聚醣 /嫘縈纖維（經黃芩萃取液後處理加工）以及幾丁聚醣纖維 (與黃芩萃取液濕紡）3個樣品，其抑菌值皆大於2 2，且 冋於未經黃芩萃取液處理過之纖維，根據JIS [19〇2之說 明，廷3個樣品皆具有抑菌能力，以及證明黃芩萃取液本 15 1374957 身的抑菌能力，可有效地附加於經其處理之纖維上。 此外，耐水洗測試方面，幾丁聚醣/嫘縈纖維f — 萃取液後處理加工）在水洗前的抑菌值為3.8，在緩過^先 10次時為3.4以及在經過水洗20次時為3.1 ;以及幾丁聚 醣/黃芩纖維在水洗前的抑菌值為4.7，在經過水洗1〇次時 為4.3以及在經過水洗20次時為4.2。由這兩種抗氣化纖維 可知在經水洗過程後，仍保有相當程度的抑菌能力。這代 表本發明之幾丁聚醣/嫘縈纖維（經黃芩萃取液後處理加工） 和幾丁聚醣/黃芩纖維除了具有優越的抑菌能力外，還具有 優越的耐水洗性。 表三 抗菌性（抑 菌值） 水洗10次後 之抗菌性（抑 菌值） 水洗20次後之 抗菌性（抑菌 值） 嫘縈 <0 <0 <0 嫘縈（經黃芩萃取液後處 理加工） 2.6 2.1 2.0 幾丁聚醣/嫘縈纖維（經 黃答萃取液後處理加工） 3.8 3.4 3.1 幾丁聚醣纖維 2.3 2.1 2.1 幾丁聚醣纖維（與黃芩萃 取液濕紡） 4.7 4.3 4.2 15 貫施例3 1374957 將克綠茶及50克黃答（Scutellaria radix )以相同方式 萃取（即粉末與水之固液比為1:10且在100〇C萃取1小時） 後’再將此兩種萃取液分別以相同方式（即後處理加工和 濕式紡絲）進行纖維處理，隨後將經萃取液後處理加工之嫘 營及幾丁聚醣/螺縈纖維和與萃取液濕紡之幾丁聚醣纖維進行抗 氧化測試，其結果如表四所示。其中幾丁聚醣佔幾丁聚醣/ 嫘縈纖維10重量％。此外，由表四可明顯得知利用黃芩萃取 液處理相較於綠茶萃取液，不論在嫘縈（經萃取液後處理 加工）、幾丁聚醣/嫘縈纖維（經萃取液後處理加工）或是幾 丁聚膽纖維（與萃取液濕紡），皆具有較高的抗氧化能力。 表· 四 ... — 經綠茶萃取液處理後清 除自由基能力（％) 經黃芩萃取液處理後 清除自由基能力（％) 嫘縈(經萃取液後處理 加土） 70.216 79.97 幾丁聚醣/嫘縈纖維 (經萃取液後處理加 工） 71.51 80.09 幾丁聚醣纖維（與萃取 液濕紡） 68.345 80.15 實施例4 分別以70°C及130°C之溫度條件，烘乾經壓吸處理之 幾丁聚醣纖維（黃芩後加工處理）以及幾丁聚醣纖維（綠 茶後加工處理）’隨後進行耐水洗測試’並量測每次清洗前 1374957 後之清除自由基能力和抗菌性，其結果數據如表五及六所 示。從表五及表六可知，在這兩個烘乾溫度條件下處理壓 吸過後含黃芩萃取物之幾丁聚醣纖維，其在該纖維之抗氧 - 化能力以及抗菌性上無明顯差異。此外，本實施例亦再次 5 證明經黃芩後加工處理之幾丁聚醣纖維相較於經綠茶後加工處 理之幾丁聚醣纖維，不論在清除自由基能力上或抗菌性上皆有更 優越的性能；且在水洗10次、20次後，仍能保有其清除自由基 之能力與抗菌性。 10 表五 清除自由基 能力（％) 水洗10次後 之清除自由 基能力（％) 水洗20次後之 清除自由基能 力（％) 幾丁聚醣纖維(黃 芩後加工處理，處 理溫度70°C) 80.13 49.29 40.21 幾丁聚醣纖維(黃 芩後加工處理，處 理溫度130°C) 80.24 50.01 41.84 幾丁聚醣纖維(綠 茶後加工處理，處 理溫度70°C) 75.98 33.57 31.14 幾丁聚醣纖維(綠 茶後加工處理，處 理溫度130°C) 79.65 41.85 38.46 表 六 18 1374957 抗菌性（抑菌 值） 水洗10次後 之抗菌性（抑 菌值） 水洗20次後 之抗菌性（抑 菌值） 幾丁聚醣纖維（黃 芩後加工處理，處 理溫度70°C) 4.5 3.7 3.5 幾丁聚醣纖維（黃 芩後加工處理，處 理溫度130°C) 4.6 4.0 3.9 幾丁聚醣纖維(綠 茶後加工處理，處 理溫度70°C) 4.0 3.2 2.8 幾丁聚醣纖維（綠 茶後加工處理，處 理溫度130°C) 4.1 ~ 3.5 3.1 實施例5 以尼龍與經黃答萃取液後處理加工之尼龍和幾丁聚醣/ 5 尼龍纖維，在抗氧化性、抗菌性及耐水洗部分做比較，其 ^ 結果如表七及表八所示，其中幾丁聚醣/尼龍纖維中，幾丁 聚醣的含量為10重量％。結果顯示，在抗氧化及抗菌測試 方面，不論是尼龍或者幾丁聚醣/尼龍纖維，在經黃芩萃取液後 處理加工後皆具有較佳的清除自由基能力及抗菌性；而在財水洗 10 方面，幾丁聚醣/尼龍纖維在經黃芩萃取液後處理加工後，不論是 水洗10次或20次，仍具有相當之抗菌及抗氧化能力。 表七 19 1374957 清除自由基能 力（％) 水洗10次後之 清除自由基能 力（％) 水洗20次後之 清除自由基能 力（％) 尼龍 0.463 尼龍（經黃芩萃取液 後處理加工） 80.21 1.02 0.99 幾丁聚醣/尼龍纖維 (經黃芩萃取液後 處理加工） 81.13 18.93 17.03 表八 抗菌性（抑菌 值） 水洗10次後之 抗菌性（抑菌 值） 水洗20次後之 抗菌性（抑菌 值） 尼龍 <0 <0 <0 尼龍（經黃芩萃取液 後處理加工） 2.7 2.1 2.0 幾丁聚醣/尼龍纖維 (經黃芩萃取液後 處理加工） 4.1 3.5 3.1 本發明亦可以其他的特定形式來實施，而不脫離本發 明之精神和重要特性。因此上文所列之實施例在各方面都 應認為是例示性而非限制性，所有之改變只要合乎申請專 利範圍之意義和範圍或其等效者，均應包含在本發明所欲 20 1374957 主張的範疇内。 【圖式簡單說明】 第1圖為本發明機能性纖維之製造流程圖。 第2圖為黃芩粉末、黃答萃取液、綠茶粉以及幾丁聚 醣/黃芩纖維分別進行抗氧化測試之條狀圖。 【主要元件符號說明】 益 〇»、20 on the chitosan fiber; and (f) the fiber obtained in the above step is dried at 70 and 13 (TC). (B) Production example of chitosan/xanthine fiber (wet spinning): (a) Scutellaria radix powder and water in a weight ratio of 1:1 ;; (b) extraction at about 1 Torr for 1 hour; (c) removal of impurities by suction filtration; d) The extract of Astragalus membranaceus with a dry solid content of 0.68 wt/vol% based on the total volume of the Astragalus membranaceus extract, and 5% chitosan based on the total volume of the spinning original-liquid ( (weight/volume) and L67% acetic acid (weight/volume) mixed to form a spinning dope of chitosan; (e) using 5% (w/v) aqueous solution of methanol containing sodium hydroxide as the fiber forming solution, wherein a methanol content of 4% by weight (w/v) and wet-spinning at a spinning temperature of 30 C and a spinning speed of 95 m/min; and (f) washing the fibers obtained in the above step in a manner known as - (IV) Drying. Example yellow powder, yellow extract, green tea powder and chitosan/fruit anti-oxidation test, The results are shown in Fig. 2. The knot is 80 4 =. / The free radical scavenging ability at the end of 77 is 8〇.79%, the yellow extract is 〇.~, the chitosan/yellow antioxidant fiber is 8 〇1, 5%. From this, it can be seen that the extract of Astragalus membranaceus is extracted into Astragalus membranaceus extract and the extract of Astragalus membranaceus is made of chitosan/xanthine fiber. The difference of free radical elimination rate (%) before and after treatment is not the same. Large, this means that the extraction procedure and the manufacturing of the antibacterial fiber program do not cause significant changes in the antioxidant capacity of the fiber for the effective antioxidant factor (xanthine). In addition, the free radical scavenging of the xanthine powder can also be seen from Fig. 2. The rate is higher than that of green tea powder. Example 2 嫘萦, 嫘萦 (post-treatment of Astragalus membranaceus extract), chitosan/嫘萦 fiber (post-treatment by Astragalus membranaceus extract), chitosan Fibers and several-butanose-fiber-dimensional C and jaundice-extract-wet- ing-four-sample-injection test, anti-oxidation test and water-resistant test, the results are shown in Tables 1 to 3. Show. Among them, chitosan accounts for 10% by weight of chitosan/germanium fibers. In Table 1, three samples of 嫘萦 (after treatment with Astragalus membranaceus extract), chitosan/嫘萦 fiber (post-treatment with Astragalus extract) and chitosan fiber (wet spinning with Astragalus extract) In terms of scavenging free radicals (antioxidant ability), it is much higher than the fiber which has not been treated with the astragalus extract, which represents the antioxidant capacity of the extract of Astragalus membranaceus itself, which has been attached to the fiber treated therewith. In addition, in the water-resistant test, the free radical scavenging ability (antioxidant ability) of the chitosan fiber obtained by blending with the astragalus extract was 80.15% before washing, and the antioxidant capacity was 80.09 after washing 10 times. %; When washed 20 times, its antioxidant capacity is 53.09%. It can be seen that the antioxidant fiber retains a considerable degree of resistance to oxidation 1374957 after the water washing process, and the antioxidant fiber of the antioxidant fiber after 20 times of washing still retains more than 50% of the antioxidant capacity. This represents that the chitosan fiber containing the xanthine extract of the present invention has superior water washability in addition to superior antioxidant ability. •5 Table 1 Clearing free radical ability (%) Scavenging free radical ability after washing 10 times (%) Scavenging free radical ability after washing 20 times (%) 嫘萦------------- --------------- 0.589 --------- —— ------------ _ 嫘萦 _ (after jaundice extract Treatment processing) 79.97 0.707 0.699 Chitosan/嫘萦 fiber (post-treatment with Astragalus extract) 80.09 16.88 9.495 Chitosan fiber 21 20.44 19.857 Chitosan fiber (wet spinning with Astragalus extract) 80.15 80.09 53.094 In Table 2, 嫘萦 (after treatment with Astragalus membranaceus extract), chitosan 10 / 嫘萦 fiber (post-treatment with Astragalus extract) and chitosan fiber (wet spinning with Astragalus extract) 3 The bactericidal value of the sample is greater than 0 and higher than that of the fiber not treated with the scutellaria extract. According to JIS L1902, all three samples have bactericidal ability and 14 U/4957 bactericidal ability to prove the scutellaria extract itself. It can be effectively attached to the fiber treated therewith. In addition, in the wash-resistant test, the bactericidal value of the short-fiber blended with the astragalus extract was 2 2 before washing and 1 1.9 after washing. It can be seen that the antioxidant fiber retains a considerable degree of g killing ability after the water washing process. This means that the chitin (tetra)/yellow fiber of the present invention has superior water repellency in addition to superior bactericidal ability. • · - _ Antibacterial (bactericidal value). Antibacterial property after killing 10 times (killing vine value) - 嫘萦 <0 <0 嫘萦 (post-treatment with Astragalus membranaceus extract) 2.1 0.71 Chitosan /嫘萦 fiber (after treatment with Astragalus extract) 2.3 0.93 chitosan fiber 1.2 0.9 chitosan fiber (wet spinning with yellow extract) ·',, 2.2 1.9 Table 3, 嫘萦 (jing After treatment with Astragalus membranaceus extract, chitosan/嫘萦 fiber (post-treatment with Astragalus membranaceus extract) and chitosan fiber (wet spinning with Astragalus extract), the bacteriostatic value is greater than 2 2, and in the fiber without the treatment of Astragalus extract, according to JIS [19〇2 description, the three samples have antibacterial ability, and prove the antibacterial ability of Astragalus extract 15 1374957 body, can be effective Attached to the fibers treated therewith. In addition, in the water wash resistance test, the chitosan/嫘萦 fiber f-extracted post-treatment treatment has a bacteriostatic value of 3.8 before water washing, 3.4 when it is delayed 10 times, and 20 times after washing with water. 3.1 and the chitosan/xanthine fiber had a bacteriostatic value of 4.7 before water washing, 4.3 when washed 1 time, and 4.2 when washed 20 times. From these two anti-gasification fibers, it is known that after the water washing process, a considerable degree of bacteriostatic ability is maintained. This represents the chitosan/anthraquinone fiber of the present invention (post-treatment of the astragalus extract) and the chitosan/xanthine fiber, in addition to having superior antibacterial ability, and excellent water washing resistance. Table 3 Antibacterial (Antibacterial value) Antibacterial property (inhibitory value) after washing 10 times Antibacterial (antibacterial value) after washing 20 times 嫘萦<0 <0 <0 嫘萦 (extracted by astragalus Liquid post-treatment processing) 2.6 2.1 2.0 Chitosan/嫘萦 fiber (post-treatment with yellow extract) 3.8 3.4 3.1 Chitosan fiber 2.3 2.1 2.1 Chitosan fiber (wet spinning with Astragalus extract) 4.7 4.3 4.2 15 Example 3 1374957 The green tea and 50 g of Scutellaria radix are extracted in the same manner (ie, the solid-liquid ratio of powder to water is 1:10 and extracted at 100 ° C for 1 hour). The two extracts are subjected to fiber treatment in the same manner (ie, post-treatment processing and wet spinning), followed by post-treatment of the extract and the chitosan/snail fiber and the extract The spun chitosan fibers were subjected to an antioxidant test, and the results are shown in Table 4. Among them, chitosan accounts for 10% by weight of chitosan/anthraquinone fiber. In addition, it can be clearly seen from Table 4 that the treatment with Astragalus membranaceus extract is compared to the green tea extract, whether in 嫘萦 (after processing with extract), chitosan/ 嫘萦 fiber (after processing with extract) Or a few butyl fiber (wet spinning with the extract), have a high antioxidant capacity. Table · Four... — Ability to scavenge free radicals after treatment with green tea extract (%) Ability to scavenge free radicals after treatment with Astragalus extract (%) 嫘萦 (post-treated with extract) 70.216 79.97 Chitosan /嫘萦 fiber (after processing with extract) 71.51 80.09 Chitosan fiber (wet spinning with extract) 68.345 80.15 Example 4 drying at 70 ° C and 130 ° C, respectively, by pressure suction treatment Chitosan fiber (after treatment of jaundice) and chitosan fiber (green tea post-treatment) 'subsequent to water wash test' and measure the ability to scavenge free radicals and antibacterial after 1374957 before each wash, The results are shown in Tables 5 and 6. It can be seen from Tables 5 and 6 that the chitosan fibers containing the xanthine extract after the pressure treatment are treated under these two drying temperature conditions, and there is no significant difference in the anti-oxidation ability and the antibacterial property of the fibers. In addition, this example also demonstrates that the chitosan fiber processed by the astragalus is superior to the chitosan fiber processed by the green tea, regardless of the ability to scavenge free radicals or the antibacterial property. The performance; and after washing 10 times, 20 times, still retain its ability to scavenge free radicals and antibacterial. 10 Table 5 Scavenging free radical ability (%) Scavenging free radical ability after washing 10 times (%) Scavenging free radical ability after washing 20 times (%) Chitosan fiber (after processing of jaundice, processing temperature 70 ° C 80.13 49.29 40.21 Chitosan fiber (processing of jaundice, treatment temperature 130 °C) 80.24 50.01 41.84 Chitosan fiber (green tea processing, processing temperature 70 ° C) 75.98 33.57 31.14 chitosan fiber ( Green tea post-processing, treatment temperature 130 ° C) 79.65 41.85 38.46 Table 6 18 1374957 Antibacterial (antibacterial value) Antibacterial (antibacterial value) after washing 10 times Antibacterial (bacteriostatic value) after washing 20 times Butan fiber (after treatment of astragalus, treatment temperature 70 ° C) 4.5 3.7 3.5 chitosan fiber (processing after jaundice, treatment temperature 130 ° C) 4.6 4.0 3.9 chitosan fiber (green tea post-processing, Processing temperature 70 ° C) 4.0 3.2 2.8 Chitosan fiber (green tea post-processing, treatment temperature 130 ° C) 4.1 ~ 3.5 3.1 Example 5 Nylon and Jinghuang extract after processing nylon and chitosan / 5 Nylon fiber, in the oxidation resistance, antibacterial and washable parts of the comparison, the results are shown in Table 7 and Table 8, in the chitosan / nylon fiber, the content of chitosan is 10 weight %. The results showed that in the anti-oxidation and anti-bacterial tests, whether it is nylon or chitosan/nylon fiber, it has better free radical scavenging ability and antibacterial property after the post-treatment of Astragalus membranaceus extract; In the aspect, the chitosan/nylon fiber has considerable antibacterial and anti-oxidation ability after being treated by the astragalus extract, whether it is washed 10 times or 20 times. Table 7 19 1374957 Free radical scavenging ability (%) Free radical scavenging ability after washing 10 times (%) Free radical scavenging ability after washing 20 times (%) Nylon 0.463 Nylon (post-treatment with Astragalus extract) 80.21 1.02 0.99 Chitosan/nylon fiber (post-treatment with Astragalus membranaceus extract) 81.13 18.93 17.03 Table 8 Antibacterial (antibacterial value) Antibacterial property after 10 washes (inhibitory value) Antibacterial property after 20 washes (Antibacterial) Value) Nylon <0 <0 <0 Nylon (after treatment with Astragalus extract) 2.7 2.1 2.0 Chitosan/nylon fiber (post-treatment with Astragalus extract) 4.1 3.5 3.1 The present invention may also be used in other The specific forms are implemented without departing from the spirit and essential characteristics of the invention. The above-listed embodiments are to be considered in all respects as illustrative and not restrictive. Within the scope of the claim. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a flow chart showing the manufacture of functional fibers of the present invention. Fig. 2 is a bar graph of anti-oxidation test of astragalus powder, yellow extract, green tea powder and chitosan/xanthine fiber, respectively. [Main component symbol description] Benefits 〇»,