TWI329738B - - Google Patents
Download PDFInfo
- Publication number
- TWI329738B TWI329738B TW092106502A TW92106502A TWI329738B TW I329738 B TWI329738 B TW I329738B TW 092106502 A TW092106502 A TW 092106502A TW 92106502 A TW92106502 A TW 92106502A TW I329738 B TWI329738 B TW I329738B
- Authority
- TW
- Taiwan
- Prior art keywords
- film layer
- reaction film
- electrode
- reaction
- layer formulation
- Prior art date
Links
- 238000012360 testing method Methods 0.000 claims description 68
- 238000006243 chemical reaction Methods 0.000 claims description 66
- 239000008280 blood Substances 0.000 claims description 44
- 210000004369 blood Anatomy 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 42
- 238000009472 formulation Methods 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 23
- 229940116269 uric acid Drugs 0.000 claims description 18
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 17
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 17
- 230000002255 enzymatic effect Effects 0.000 claims description 17
- 229920003169 water-soluble polymer Polymers 0.000 claims description 16
- 239000000758 substrate Substances 0.000 claims description 15
- 239000003960 organic solvent Substances 0.000 claims description 14
- 238000003487 electrochemical reaction Methods 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 6
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 6
- 230000001681 protective effect Effects 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 1
- YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 claims 1
- 102000001554 Hemoglobins Human genes 0.000 description 16
- 108010054147 Hemoglobins Proteins 0.000 description 16
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000009792 diffusion process Methods 0.000 description 6
- 239000003292 glue Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- 238000009534 blood test Methods 0.000 description 5
- 150000003278 haem Chemical class 0.000 description 5
- 238000007650 screen-printing Methods 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
- 235000017491 Bambusa tulda Nutrition 0.000 description 2
- 241001330002 Bambuseae Species 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000007430 reference method Methods 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 229920001342 Bakelite® Polymers 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- RRKGBEPNZRCDAP-UHFFFAOYSA-N [C].[Ag] Chemical compound [C].[Ag] RRKGBEPNZRCDAP-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000004637 bakelite Substances 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW092106502A TW200304544A (en) | 2002-03-29 | 2003-03-24 | Method to prepare whole-blood examining electrode test strip reaction membrane preparing object, and the related product |
| US10/401,035 US7384659B2 (en) | 2002-03-29 | 2003-03-28 | Method of producing whole blood detecting electrode strip and reaction film formulation and the related products |
| US12/035,231 US8512532B2 (en) | 2002-03-29 | 2008-02-21 | Method of producing whole blood detecting electrode strip and reaction film formulation and the related products |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW91106310 | 2002-03-29 | ||
| TW092106502A TW200304544A (en) | 2002-03-29 | 2003-03-24 | Method to prepare whole-blood examining electrode test strip reaction membrane preparing object, and the related product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200304544A TW200304544A (en) | 2003-10-01 |
| TWI329738B true TWI329738B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2010-09-01 |
Family
ID=32109603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092106502A TW200304544A (en) | 2002-03-29 | 2003-03-24 | Method to prepare whole-blood examining electrode test strip reaction membrane preparing object, and the related product |
Country Status (2)
| Country | Link |
|---|---|
| US (2) | US7384659B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
| TW (1) | TW200304544A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7807043B2 (en) * | 2004-02-23 | 2010-10-05 | Oakville Hong Kong Company Limited | Microfluidic test device |
| TWI495874B (zh) * | 2008-10-17 | 2015-08-11 | Apex Biotechnology Corp | 非酵素型電化學檢測系統之品管控制液及其使用方法 |
| GB0820817D0 (en) * | 2008-11-13 | 2008-12-24 | Wireless Biodevices Ltd | Electrode, electrochemical sensor and apparatus, and methods for operating the same |
| WO2013019102A2 (en) * | 2011-08-01 | 2013-02-07 | Mimos Berhad | A non-enzymatic sensor |
| US8603309B2 (en) * | 2011-09-12 | 2013-12-10 | Nova Biomedical Corporation | Disposable sensor for electrochemical detection of hemoglobin |
| CN108982617A (zh) * | 2018-08-01 | 2018-12-11 | 湖南海源医疗科技股份有限公司 | 一种尿酸电化学试条及其制作方法 |
| CN109387620B (zh) * | 2018-12-20 | 2025-01-07 | 广州南雪医疗器械有限公司 | 一种血液测量装置 |
| CN109541196A (zh) * | 2018-12-20 | 2019-03-29 | 广州南雪医疗器械有限公司 | 一种血液检测试纸 |
| CN111624246A (zh) * | 2020-06-18 | 2020-09-04 | 桂林乐尔医疗器械有限公司 | 一种尿酸生物传感器的检测配方 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4264560A (en) * | 1979-12-26 | 1981-04-28 | Samuel Natelson | Clinical analytical system |
| GB8619627D0 (en) * | 1986-08-12 | 1986-09-24 | Genetics Int Inc | Electrochemical assay |
| US5385846A (en) * | 1993-06-03 | 1995-01-31 | Boehringer Mannheim Corporation | Biosensor and method for hematocrit determination |
| US5437999A (en) * | 1994-02-22 | 1995-08-01 | Boehringer Mannheim Corporation | Electrochemical sensor |
| TW369411B (en) * | 1998-11-09 | 1999-09-11 | Apex Biotechnology Co Ltd | Disposal electrode test block for current-type non-enzymatic uric acid test, its process and application |
| TW466344B (en) * | 2000-09-01 | 2001-12-01 | Apex Biotechnology Corp | Disposable electrode for whole blood hemoglobin (HGB) and hematocrit (HCT) measurement, and preparation and application thereof |
| EP1225449B1 (en) * | 2001-01-19 | 2008-10-22 | Apex Biotechnology Corporation | Non-enzymatic disposable electrode strip comprising a surfactant for detecting uric acid or hemoglobin; method for producing the same and its use |
| CN1367382A (zh) * | 2001-01-23 | 2002-09-04 | 五鼎生物技术股份有限公司 | 非酶一次性检测电极条,其生产方法及其应用 |
-
2003
- 2003-03-24 TW TW092106502A patent/TW200304544A/zh not_active IP Right Cessation
- 2003-03-28 US US10/401,035 patent/US7384659B2/en not_active Expired - Lifetime
-
2008
- 2008-02-21 US US12/035,231 patent/US8512532B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7384659B2 (en) | 2008-06-10 |
| US20080142362A1 (en) | 2008-06-19 |
| US8512532B2 (en) | 2013-08-20 |
| US20040081752A1 (en) | 2004-04-29 |
| TW200304544A (en) | 2003-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW548095B (en) | Electrochemical electrode test piece and method for producing the same | |
| CN2372689Y (zh) | 电流型生物传感器 | |
| US6491803B1 (en) | Test strip and biosensor incorporating with nanometer metal particles | |
| de França et al. | Development of novel paper-based electrochemical device modified with CdSe/CdS magic-sized quantum dots and application for the sensing of dopamine | |
| CN104280431B (zh) | 用于生物传感器的试剂组合物及包含所述试剂组合物的生物传感器 | |
| CN101074963B (zh) | 电化学胆固醇检测电极测试条和其制造方法 | |
| JP2003042995A (ja) | 熱伝導性センサー | |
| EP1680673A1 (en) | Biosensor | |
| CN1463361A (zh) | 生物传感器 | |
| US8512532B2 (en) | Method of producing whole blood detecting electrode strip and reaction film formulation and the related products | |
| CN104330448A (zh) | 一种高灵敏度电极式尿酸试纸及其制作方法 | |
| CN115266865B (zh) | 一种提高电化学传感器稳定性的方法 | |
| US6746708B2 (en) | Disposable plate electrode with biologicalactive film and manufacture method thereof | |
| CN1710418A (zh) | 一种快速检测血红蛋白的生物传感器及其测试方法 | |
| CN1349096A (zh) | 电化学电极试片及其制造方法 | |
| CN101614746A (zh) | 血红蛋白检测电极试片和包含其的装置 | |
| JPH07311175A (ja) | 電流検出型イオン選択性電極 | |
| JP2004264247A (ja) | バイオセンサ | |
| CN1367382A (zh) | 非酶一次性检测电极条,其生产方法及其应用 | |
| EP1225449B1 (en) | Non-enzymatic disposable electrode strip comprising a surfactant for detecting uric acid or hemoglobin; method for producing the same and its use | |
| CN108802157A (zh) | 一种总胆汁酸检测试剂、试纸及检测方法与应用 | |
| JP2002221508A (ja) | バイオセンサ | |
| CN2195757Y (zh) | 一次性生物传感器 | |
| Iwamoto et al. | Activity enhancement of a screen-printed carbon electrode by modification with gold nanoparticles for glucose determination | |
| TWI276799B (en) | Electrode trip and biosensor comprising the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Expiration of patent term of an invention patent |