TWI323662B - Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy - Google Patents
Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy Download PDFInfo
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- TWI323662B TWI323662B TW092131777A TW92131777A TWI323662B TW I323662 B TWI323662 B TW I323662B TW 092131777 A TW092131777 A TW 092131777A TW 92131777 A TW92131777 A TW 92131777A TW I323662 B TWI323662 B TW I323662B
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- Prior art keywords
- cancer
- tlk286
- alkylating agent
- treatment
- gst
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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Landscapes
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- Chemical & Material Sciences (AREA)
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| TWI323662B true TWI323662B (en) | 2010-04-21 |
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| EP (1) | EP1562564A2 (https=) |
| JP (2) | JP2006508980A (https=) |
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| MX (1) | MXPA05005200A (https=) |
| TW (1) | TWI323662B (https=) |
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| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| TW200538149A (en) * | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| JP5371426B2 (ja) * | 2004-07-09 | 2013-12-18 | プロルックス ファーマシューティカルズ コープ． | ワートマニン類似体及び化学療法薬と組み合わせた同一物を使用する方法 |
| EP1833978B1 (en) * | 2005-01-06 | 2008-10-08 | Telik, Inc. | Tripeptide and tetrapeptide thioethers |
| US8178564B2 (en) | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| US20100310661A1 (en) * | 2007-07-16 | 2010-12-09 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
| HRP20160625T1 (hr) | 2007-09-10 | 2016-08-12 | Boston Biomedical, Inc. | Novi inhibitori stat3 signalnog puta i inhibitori matičnih stanica raka |
| CA2715348A1 (en) * | 2008-02-08 | 2009-08-13 | Poniard Pharmaceuticals, Inc. | Use of picoplatin and bevacizumab to treat colorectal cancer |
| US20110021618A1 (en) * | 2008-03-25 | 2011-01-27 | Paloma Pharmaceuticals, Inc. | Methods of treating fibrotic disorders |
| WO2010086964A1 (ja) * | 2009-01-28 | 2010-08-05 | 株式会社 静岡カフェイン工業所 | がん治療のための併用療法 |
| EP2425830A1 (en) * | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Synergistic drug combination for the treatment of cancer |
| US20140296178A1 (en) * | 2010-12-01 | 2014-10-02 | Niiki Pharma Acquisition Corp. 2 | Combination Therapy with a Gallium Complex |
| US9381187B2 (en) | 2011-02-16 | 2016-07-05 | Paloma Pharmaceuticals, Inc. | Radiation countermeasure agents |
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| AU2017368135A1 (en) * | 2016-11-30 | 2019-06-13 | Tyme, Inc. | Tyrosine derivatives and compositions comprising them |
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| US5599903A (en) * | 1992-04-03 | 1997-02-04 | Terrapin Technologies, Inc. | Glutathione analogs and paralog panels comprising glutathione mimics |
| US5545621A (en) * | 1991-04-29 | 1996-08-13 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5955432A (en) * | 1992-04-03 | 1999-09-21 | Terrapin Technologies, Inc. | Metabolic effects of certain glutathione analogs |
| US5767147A (en) * | 1995-04-21 | 1998-06-16 | The Regents Of The University Of California | Inhibition of glutathione transferase by haloenol lactones |
| DK0831877T3 (da) * | 1995-06-07 | 2005-02-14 | Telik Inc | Metabolske virkninger af visse glutathionanaloge |
| US5880097A (en) * | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
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| US6281223B1 (en) * | 1999-04-13 | 2001-08-28 | Supergen, Inc. | Radioenhanced camptothecin derivative cancer treatments |
| GB9909925D0 (en) * | 1999-04-29 | 1999-06-30 | Pharmacia & Upjohn Spa | Combined preparations comprising anthracycline derivatives |
| JP2003522790A (ja) * | 2000-02-17 | 2003-07-29 | メルク エンド カムパニー インコーポレーテッド | Ｃｏｘ−２選択的阻害薬を用いた前立腺癌の治療または予防 |
| AU2002246827B2 (en) * | 2000-12-22 | 2008-02-21 | Bristol-Myers Squibb Company | Methods for modulating tumor growth and metastasis |
| TW200538149A (en) * | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
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| CN1711076A (zh) | 2005-12-21 |
| CN101590229B (zh) | 2012-12-05 |
| CA2505377A1 (en) | 2004-06-03 |
| JP2006508980A (ja) | 2006-03-16 |
| BR0316364A (pt) | 2005-10-04 |
| US20080159980A1 (en) | 2008-07-03 |
| AR042051A1 (es) | 2005-06-08 |
| KR20050075018A (ko) | 2005-07-19 |
| AU2010200483A1 (en) | 2010-03-04 |
| EP1562564A2 (en) | 2005-08-17 |
| CN100508961C (zh) | 2009-07-08 |
| JP2010265305A (ja) | 2010-11-25 |
| WO2004045593A3 (en) | 2004-08-12 |
| AU2003290805A1 (en) | 2004-06-15 |
| MXPA05005200A (es) | 2005-08-18 |
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