TWI299262B - - Google Patents

Description

1299262 IX. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD The present invention relates to a sampling device, and more particularly to a quantitative sampling device capable of quantitatively capturing a sample and a method of using the same. [Prior Art] With the development of the economy, the awareness of people touching themselves (4) is also rising. Many hospitals or laboratories now provide various biochemical tests to provide people with

Basic physical function tests, such as blood glucose tests, liver and kidney function tests, cholesterol tests, etc. ° 曰 _ _ bed medical test Bu Pu ·, the basic process is to ask the patient to go to the blood collection station to draw blood or collect body fluid tissue samples, after obtaining the sample, 'send the sample to the towel central inspection record inspection, and finally The report of the fruit is transferred to the person in charge of the county for inspection. Through t, the inspectors are not quite === her, or _ county impressed people need to use these reports. In recent years, the name has been established on the side of force, surgery and restoration to the vicinity (or inside); Because people have been interested in the Wei report _ ^ ((Wang T--Tlme (ΤΑΤ) is the importance of the speed of the body transport system. Go to the details from the top of the 卞 西 西 衣 衣 衣 叹 ; ; ; ; ; ; ; When the operation is good, the inspection speed inspection procedure becomes more _. The domain is honest and integrated, and the progress of the whole technology has affected every level of society. Through various studies, the amazing change of a temple is also the same. Step by step, 荖 夂 夂 铋 铋 铋 铋 检验 检验 检验 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 铋 二 二 二 二 二 二P〇int Care

Testing; P0CT). POCT is a small, portable instrument that can be used to measure test results in a short period of time and instantly know that this fast and convenient test form has a significant effect, but its responsibility for quality, quality control, instrument calibration, and inspection results. The attribution impacts the traditional laboratory.

P0CT is not tested in a traditional laboratory, but is tested at the patient's side, such as a physician's office, emergency room, clinic, ward, battalion, or even home inspection. Common tests include blood glucose = test ', ', urine test, occult blood test, cholesterol test, HDL test, blood coagulation test, etc. These P0CT tests may be performed by non-inspection personnel who may be trained professionals (eg, physicians, nurses, physicians, etc.) or may be individuals who have only had simple basic training (eg, patients, themselves) Etc.), therefore one of the potential shortcomings of P0CT, namely: ,, the instability of the executive caused by sampling or the uncertainty of the instrument used

Take the second = job as an example 'When the patient wants to carry out the blood test, in the completion of the step, the money sample (4) to carry out the plasma cell separation. These separation and inspection of the pollution 4 = rate r added to the separation solvent and other human operations, improved The blood is subject to a non-specialized iterative, and many blood samples that need to be quantified to perform the test will also increase the error rate when the fruit seeker performs it. However, although 3=^_ is an exciting simplified test mode, the low-level fine medical industry has developed a test instrument and its peripheral components that are easy to operate and can effectively reduce the errors caused by the company. , has become one of the current important goals of ^9262. f SUMMARY OF THE INVENTION j Quantitative sampling device, for the two-body = provide - the 'recommended to provide - quantitative sampling package' to reduce human error and pollution, another major object of the invention, to inter-sample processing procedures The chance. The present invention discloses a method of seeding a liquid sample. The peak U and its use and output. Among them, the sampling department of the factory department, the 衫 侧 侧 — - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - :: When advancing the sampling section, 'diluted solution 吏 = membrane: check == product. The output is concise to the _, _ generation, in summary, by the difficult health management _ reading is increasing, this type of 』, type can be assigned to match the blood collection device of this judgment, will be very suitable for home use Care-related (home-care), care point monitoring (P 〇f Care) and transportation distance (telehealth) and other related fields, should find a quantitative display device, can effectively improve the efficiency of sample processing, and reduce artificial Improper operation on the _ result. 299 !299262 [Embodiment] The present invention discloses a quantitative sampling device for a liquid sample and a method of using the same. It is desirable to utilize the quantitative sampling device of the present invention to simplify the processing steps prior to the sample sample and to reduce the error rate of human manipulation by integrated pre-processing. In order to make the description of the present invention more complete and complete, the preferred embodiments of the present invention are illustrated. Please refer to the following description and match the following diagram.

A schematic diagram of a preferred embodiment of a quantitative sampling device as claimed by the hook umbrella. As shown in the figure, the quantitative sampling device 1 in FIG. 1A includes a sampling portion 11, a set portion 12, and an output portion=: wherein the sampling portion 11 has a sampling ring ill of a predetermined size for determining, Taking (staining) a liquid sample, the liquid sample may be a blood sample or a corpus callosum sample (for example, cerebrospinal fluid; cerebrospinal fluid; (10). ',,: and 'the technical features of the present invention In this case, in other words, other liquid samples formed on the ring-like film should also be regarded as the protection of the present invention. In addition, the size of the sampling ring (1), the shape of the disk size

Id=ensiQn) can also be designed according to the actual needs of the process according to the liquid sample request 1 , for example, the ring of metal or other materials of Li Tai Cong; familiar with the line:: Description It is not intended to limit the central entity of the present invention, but only: the actual immersion is: the pre- _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ The pre-sense is that the volume and concentration of the liquid sample after dilution are almost maintained at 9 1299262. That is, the present invention has a quantitative function. sample. The output of the sample to the outer upper part of the sleeve is combined with the over-axis 14 =, the dilution surface is forced to pass, and the transfer-n = the outlet 13 is lightly coupled to the filter membrane 14 for use in the inspection. The sampling unit u described above is a propeller 1 and a propulsion handle (1). The push handle U2 can be more sleeved: = = elastic and slightly abrasive material provides the sampling portion and fits into the sleeve portion 12. 〆 山 山 山 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , The seal groove 121 is broken by the pressure at the time of the joint portion 12, so that the buffer solution filled in the inside thereof is mixed with the liquid sample. Pre-fill (4) the buffer solution of the fitting part 12, not - seal in one (four) shot 'Please take the phase - B. The buffer solution 121a can also be filled in the sleeve portion 12 and maintained at a distance from the sampling ring lu. The portion of the portion further includes a venting opening 122. When the sampling portion is immersed in the entanglement portion 12 At this time, the pressure of the gas formed during the advancing process is discharged from the vent hole 122 to prevent the buffer solution from being discharged from the rim portion 13 due to the pressure. So far, the quantitative sampling and dilution of the liquid sample is completed, and the quantitative sampling of the present invention is compared with the conventional method of first making the age of the liquid body»the body, and the step of dividing the liquid to the pipet to take the quantitative dilution. The device integrates the above two steps into the fitting, so that the sample detection 10 1299262 can not only be determined. Further, the technique sampling device of the present invention is entirely mixed and mixed with the quantitative buffer solution, and is lowered in the open fitting portion, so as to effectively contaminate the artificial operation which may be caused by the clothes. The seed sampling device can lie on the blood or each of them (for example, cerebrospinal fluid, CSF). Some blood tests only need to be in the right-handed device, ie, _^ liquid first mixed with sputum, first need to pass through the whole blood and buffer solution-ball before the fruit, the dilution further passes through the aponeurium to get rid of 5 It can be used to perform plasma separation of blood cells. It is screened by the particle size of the material to make the smear sample __ different types of health: "When the membrane field advances the sampling section ii, the dilution solution is forced to pass through the filtration, and the generation of the sample is isolated. The output portion 13 is surfaced to the filter membrane, 4' is used to output the sample to the external quantitative sampling device ι. The plasma passing through the membrane 14 can be different by the output portion 13 (combined with the type of analytical instrument) The shape 'such as a needle' is pushed and injected. This blood accumulation can be directly dropped into a small-scale measuring device such as blood glucose, kidney function, liver function, blood lipids, cardiovascular disease and other biochemical analysis devices, or hormones, cancer indicators, allergens, Pathogenic bacteria and other size-only immunoassay devices. ... At this point, self-collecting bleeding> night or body fluid, and then into the analytical instrument to enter the quantitative sampling, mixing solution, filtration, etc., each procedure is in The quantitative sampling device of the present invention is carried out in such a manner that not only the pre-processing steps are simplified, but also the errors caused by the human operation are reduced. 1299262 It means a method of quantitative sampling of a liquid processing, comprising the following steps: Step "2G1: firstly - the sampling unit - the amount of sample taken slaves (= stick) - New liquid body. The remaining sample may be a money sample or a body fluid sample of various types. Sampled paste surface tension with a predetermined area. Liquid sample.

Step 202: Then insert the sampling part into a set of joints. Extend m3: Repeat the shaking quantitative sampling device (shake the quantitative sampling itself or repeatedly pull the sampling part), mix the liquid sample with a buffer solution, and turn the wire. The surface may be pre-filled in the fitting portion (the above embodiment) or filled in the sampling portion (please refer to the "Example"), regardless of where it is sealed in advance, in the liquid sample It is released into the ferrule to be mixed with the liquid sample.

Step 204: Finally, the sampling portion is advanced to force the diluted solution obtained by the above-mentioned mixing to pass through the sample which is separated from the output of the H output portion. The filter membrane here is selected by the particle size of the material. The filter film of different particle size and size can be selected by the user for different samples to be analyzed. The buffering > gluten liquid is pre-filled and sealed in one of the sealing grooves of the fitting portion. The sealing groove can be broken by the pressure when the sampling portion is fitted into the fitting portion, so that the buffer solution and the liquid filling filled inside are broken. Body mixing. However, the quantitative sampling device disclosed in the present invention does not limit the position at which the buffer solution is placed, as long as it can be mixed for the liquid sample to be fed into the nest. 12

1299262 Schematic. Another embodiment of the invention in FIG. 2 is a structural joint portion 22, and an output device 2 includes a sampling portion 21, and the sleeve portion 21 also has a first preferred embodiment of H + described, and a buffer solution is used. - The predetermined volume is taken (dip) into a liquid sample, the liquid test is the test body (parent material), and the sampling ring is inserted into the set of people 22: the amount of the night sample is changed. When the sampling unit 211 i is liquid. The above-mentioned fitting portion is coupled with a ruthenium film 24, and when the field is separated: 7:21, the diluted solution is forced to be separated through the filter membrane - the sample is sampled. The output portion 33 is difficult to be joined to the filter membrane 24 for taking the test sample out to the outside. ^, = The sampling portion 21 of the embodiment is a squeeze tube, one end is a sampling ring, and the other end is a sealing groove 212 filled with a buffer solution. The buffer solution having a predetermined volume is pre-filled and sealed in the sealing groove 212. The 観 观 敎 敎 杂 杂 杂 杂 杂 杂 杂 。 。 。 。 。 。 。 。 1 is the position (4) filled in the buffer solution of Figure 1 (including Figure A A, Figure 1 b) and Figure 2 in the above two embodiments, but this combination affects the main ship of the hair of Zhu After checking the body and quickly mixing it with the liquid, I passed the test of the 捡 理 理 理 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特 特The blood collection device of the invention is very suitable for use in home care (hQme_cafe), care point monitoring 13 1299262 (point-of-care), and remote home care (telehealth) and other related fields, the quantitative mining of (4) «Set, can effectively improve the efficiency of sample processing" and reduce the impact of improper silk on the silk. The present invention has been described above by way of a preferred example, and the present invention is not limited to the above-described embodiments. Therefore, modifications that do not depart from the spirit of the invention and that of Gusaki should be included in the scope of the following patent application. BRIEF DESCRIPTION OF THE DRAWINGS The above and other advantages of the invention will be readily apparent from the following description of the appended claims. A schematic structural view of an embodiment. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing the structure of another preferred embodiment of the quantitative sampling device of the present invention. [Description of main component symbols] 1Quantitative sampling device 11 Sampling section 111 Sampling ring 112 Propeller 113 Piston 12 Nesting part 121 Sealing part 14 1299262 121a Buffer solution 122 Exhaust hole 13 Output part 14 Filter membrane 2 Quantitative sampling device 21 Sampling section 211 sampling ring 212 sealing groove 22 sleeve portion 23 output portion 24 filter membrane

15

Claims (1)

1299262 Patent application scope: 1. A quantitative sampling device for a liquid sample, comprising: a quantitative take-sampling portion, a ## ring having a predetermined size, the liquid sample; and a set of joints, fitted with a shape _ _ solution, nested into the kit, Wei Shang's face seams are mixed with each other to obtain a diluted solution. X, bite Le Luo liquid 2. As described in the scope of the patent application, the quantitative collection of the kit and the combination of - filter membrane, t push the sampling section mad, the solution will be forced to pass the _, transferred to - Substitute sample: Dilution 3. Quantitative sampling as described in item 2 of the patent application area = eve: output part, _ _, used to transfer the sample of the test sample. 5. As described in item 3 of the patent application scope Quantitative sampling device, the buffer is dissolved in the basin and pre-filled and sealed in the sealing portion - the sealing slot is as described in claim 4 of the patent application scope, and the == slot system may be due to the sampling portion The buffer solution filled in the interior is mixed with the sample while the pressure is applied to the sleeve. 7. A quantitative sampling device for a liquid sample, comprising: ························································· Such as the scope of application for patents! The quantitative sampling described in the item and the sampling portion is a propeller, including the sampling ring and the - propulsion, the hand, and the hand. 16 1299262 sets; ^ fits with the sampling part, when the sampling part is nested in the solution, it will be ' ' 嗜 嗜 嗜 嗜 嗜 9 9 9 9 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如 如The filter membrane was discharged to the outside with a second generation. In the case of the sample of the sample, the quantitative sampling device of the sample is described, and the one is the squeezing device, and one end is the sealing groove for the buffer solution. The other end is the back of the towel: / She is surrounded by the quantitative extraction of the eighth item, and the reading solution is pre-filled and sealed in the (four) tank. Its i2. The sealing groove of the eighth aspect of the scope of the patent application can be broken by extrusion to be filled therein, and the liquid is mixed with the sample. The method for buffering and dissolving, the first package includes a pre-treatment of the liquid sample by using a certain amount of sampling device, and the sampling portion is taken into a set of parts by taking a liquid test. The body is buffered and shaken, and the quantitative sampling device is shaken repeatedly to make the liquid sample sufficiently mixed to obtain a diluted solution; and 17 to force the diluted solution to pass through a filter membrane, and the membrane system utilizes Γ^(4), wherein The size of the filter stomach is screened. The method of claim 13, wherein the buffering The 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸 糸Body mixing. The method of claim 13, wherein the buffer solution is pre-filled and sealed in a sealing groove of the sampling portion, and the sealing groove can be broken by extrusion so that the buffer solution filled in the interior is The liquid sample is mixed. 18