1292329 九、發明說明： 【發明所屬技術領域】 本發明係關於利用含無線射頻控制I c晶片之軟質材料 -膜以提升一製劑滲透至活體皮膚内之裝置及方法。 ， 【先前技術】BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a device and method for enhancing the penetration of a formulation into a living skin using a soft material-membrane containing a radio frequency controlled IC chip. [Prior Art]
習知業界有興趣研究一非侵入性、無痛的新技術，將有 . 效成分或製劑經由皮膚吸收，達到美容保健或醫療效果， •並可減少口服及注射藥物之困擾，及產生劑量不足或過多 的問題，數種技術已被討論。利用電泳法，可改變皮膚之 今透性，使製劑易於滲入正常或受損活體皮膚上的汗腺、 皮脂腺及細胞間脂質，習知電泳法能增強局部皮膚對離子 成分或製劑的吸收（Glass，J.M· ei a/·，Int. J. Dermatol. 1 9, 51 9 (1 980) ； Russo J. , Am. J. Hosp. Pharm 37,843 (1980)； Gangarosa, L. P. etal., J. Pharmacol. Exp. Ther. 212,377 (1 980) ； Kwon, B. S. et al., J • infect· Dis 140, 1 014 (1 979)’· Hill，J· M·…入，Ann· N.Y.Acad.Sci.284,604 (1977)&Tannebaum，M.Phys· Ther· 6〇,792 ( 1 980))。1984 年美國專利第 4,474,57〇 號已揭示一種皮膚電泳儀器。利用直流電刺激培養皿中的 細胞，已證明能抑制金黃色葡萄球菌生長，並認為電流刺 激，能抑制傷口上細菌的生長（Merriman，η. L·，以5人， JRRD Vol 41，ρ·139-146，2004 )。另一方面，超音波已 知月b增加皮膚表皮吸收及刺激角質（fjorny Layer )細胞 分散。研究人員利用低頻超音波配合藥物已應用於治療斑 326\專利說明書(補件)\95-05\TF954512 5 1292329 型脫髮、黑色素斑（Melasma)及日曬斑（Solar Lentigo ) (Santoianni, P. , etal., Dermatology 〇nl ine Journal 10(2) 24，20 04 )。並利用低頻的超音波經皮滲透裝置， 達美白、除敵、除脂，及治療香港腳的效果（中華民國專 利證書第1220386號）。在動物實驗上，也證明低頻超音 波能增強局部藥物吸收（Singer，A.J·，Church，A.L·， McClain, SA Academic Emergency Medicine, Vol 5, 35-40，1 998 (Society for Academic Emergency Medecine 出版））。研究人員發現，提升熱量也能增加皮膚對藥物的 吸收、藥物的溶解度、體内液體循環及血管壁的通透性 (Hull， W·， The Journal 〇f Applied Research， 2002)。 習知現有使用電流及電泳通常係藉由將一連續直流產 生為或脈衝直流產生器之輸出端連接至一策一或主動電 極及連接至一第二或次要電極，其中該第一或主動電極 係由金屬板或導電物質組成，其係覆蓋有一經浸潰製劑水 性溶液之具孔隙材料的潮濕膜。因此，習知該等方法在使 用上係十分不方便，因而限制了使用該等方法局部施用藥 d之曰及與發展，而只在醫院或專業處所才能使用。 壯ί 對皮膚產生電流、電泳、熱源及超音波之習知 :二:為有交流電電源供應線之有線裝置，並具有電源或 :使用又ί於—載體中，對有交流電電源供應線之有線裝置 言，有移動性差之缺點，且部分系統操作係需 宙輔助始能完成。又’美國專利第4, 474, 57G號及美 國專利申請案公開第2003/0023] 87號係揭示—種利財、 通專利說明書(補件)\95-G5\TF954512 6 1292329 交流電電源供應線控制之習知 皮膚各部位。 自知衣置’其不方便施用於活體 【發明内容】 心::：二的係利用無線射頻控制1c晶片以克服上述 白知1置使用上不便之處，夢 或複數個具有接收該無線射;！人貝材料膜中谈入一 數個無線控制器所發出之_^1片，以接收一或複 丨。晶片產生電流、電泳、：、=::及_ 田本^τμ 丄 …、你及赵音波之至少一者。使 二:：於曰㈣之狀態，即經由簡易操作 流、電泳、熱源及超音波1 =内的1C晶片產生電 【實施方式】The industry is interested in researching a non-invasive, painless new technology that will absorb therapeutic ingredients or preparations through the skin to achieve cosmetic health or medical effects. • It can also reduce the risk of oral and injectable drugs, and produce underdosing or Too many problems, several techniques have been discussed. Electrophoresis can change the permeability of the skin, making the preparation easy to penetrate into the sweat glands, sebaceous glands and intercellular lipids on normal or damaged living skin. It is known that electrophoresis can enhance the absorption of ionic components or preparations by local skin (Glass, JM· ei a/·, Int. J. Dermatol. 1 9, 51 9 (1 980) ; Russo J. , Am. J. Hosp. Pharm 37, 843 (1980); Gangarosa, LP et al., J. Pharmacol. Exp Ther. 212,377 (1 980) ; Kwon, BS et al., J • infect· Dis 140, 1 014 (1 979)'· Hill, J·M·..., Ann·NYAcad.Sci.284,604 (1977 ) &Tannebaum, M. Phys· Ther· 6〇, 792 (1 980)). A skin electrophoresis apparatus has been disclosed in U.S. Patent No. 4,474,57, 1984. Stimulation of cells in culture dishes by direct current has been shown to inhibit the growth of S. aureus, and it is believed that current stimulation can inhibit the growth of bacteria on the wound (Merriman, η. L·, to 5 people, JRRD Vol 41, ρ·139 -146, 2004). On the other hand, the ultrasound has been known to increase the skin epidermal absorption and stimulate the horny (fjorny layer) cell dispersion. Researchers have used low-frequency ultrasound with drugs to treat plaque 326\patent specification (supplement)\95-05\TF954512 5 1292329 type hair loss, melasma and solar Lentigo (Santoianni, P. , etal., Dermatology 〇nl ine Journal 10(2) 24,20 04 ). It also uses the low-frequency ultrasonic percutaneous osmosis device to achieve whitening, enemies, fat removal, and the effect of treating Hong Kong feet (Republic of China Patent Certificate No. 1220386). In animal experiments, low-frequency ultrasound has also been shown to enhance local drug absorption (Singer, AJ·, Church, AL, McClain, SA Academic Emergency Medicine, Vol 5, 35-40, 1 998 (Society for Academic Emergency Medecine) ). Researchers have found that boosting heat also increases skin absorption of drugs, solubility of drugs, fluid circulation in the body, and permeability of blood vessel walls (Hull, W., The Journal Appliedf Applied Research, 2002). It is conventional to use current and electrophoresis by connecting a continuous DC generating or pulsed DC generator output to a policy or active electrode and to a second or secondary electrode, wherein the first or active The electrode system consists of a metal plate or a conductive material which is covered with a wet film of a porous material which is impregnated with an aqueous solution of the formulation. Therefore, it is well known that such methods are very inconvenient to use, thus limiting the use and development of the topical application of the drug d, and only in hospitals or professional premises. Zhuangί Known to produce current, electrophoresis, heat source and ultrasonic waves on the skin: 2: For wired devices with AC power supply lines, and with power supply or: use and - in the carrier, the cable with AC power supply line According to the device, there are shortcomings of poor mobility, and some system operation systems need to be assisted. Also, 'US Patent No. 4, 474, 57G and U.S. Patent Application Publication No. 2003/0023, No. 87, No. 87, discloses a kind of profit, patent specification (supplement)\95-G5\TF954512 6 1292329 AC power supply line Control the various parts of the skin. Self-known clothing set 'it is not convenient to apply to the living body】 [Summary of the content] Heart::: The second system uses radio frequency control 1c wafer to overcome the inconvenience of using the above-mentioned Baizhi 1 set, dream or plural have to receive the wireless shot ;! In the human shell material film, a number of _^1 chips issued by the wireless controller are referred to to receive one or more 丨. The chip generates current, electrophoresis, :, =:: and _ Tian Ben ^τμ 丄 ..., you and Zhao Yinbo at least one. In the state of the second:: in the state of (4), the electric power is generated by the simple operation flow, electrophoresis, heat source, and 1C wafer in the ultrasonic 1 = [Embodiment]
本發明係利用無線射頻押制 I 具有接收該無線射頻之1C晶片，以接、:入…或複數個 控制器所發出之益_ a 一或複數個無線 生電产、號及能量而控制該1。晶片產 所含成分滲透至皮膚内。广者’猎以將該製劑 質二料=發明係有關—種利用無線射頻控制1C晶片之’ 、材枓胺，該軟質材料膜主要係由含有一叙 !成，其包含-或複數個具有接收該無線射；之：！7 ::於該軟質材料膜中，以接收一或複數個無線乂 ::The invention utilizes a radio frequency radio frequency I to control a 1C chip that receives the radio frequency, to control, or to input, or a plurality of controllers, or a plurality of wireless generators, numbers and energy. 1. The ingredients contained in the wafer are infiltrated into the skin. Guangzhe 'hunting the preparation of the second material = related to the invention - the use of radio frequency control 1C wafer's, phthalamide, the soft material film mainly consists of a ruin, which contains - or a plurality of Receive the wireless shot; it:! 7 :: In the soft material film to receive one or more wireless 乂 ::
:片：ίΓ,號及能量而控制該軟質材料膜中：1C 326\專利說明書(補件娜卿靡512 曰 /、生電流、電泳、熱源及超音波之至少一— 4 ，籍 1292329 以將該製劑所人 ...„斤3成^刀滲透至活體皮膚内。 5亥軟質材料膜可為一面膜、 二 傷口癒合畔耸甘 、膚敷胰、經皮吸收貼片或 劑係為-流係經浸潰一製劑於其中之潮濕膜，該製 之成分。該含至少—種化學物質或自然物質 能量後，係經晶片接收無線射頻訊號及 熱源及超音波吴擬而產生至少-電流、電泳、 於控制施^量措以使該製劑渗透至活體皮膚内，亦可用 °亥卓人貝材料膜中 曰 無線控制哭# a IC日日片了經由無線控制器控制，該 制軟二及1c晶片之電子裳置，可控 刊丁卞联上之IC晶片產生雷0、+、七^ 波之至少一去兮+ 电爪电冰、熱源及超音: film: Γ, 及, and energy to control the soft material film: 1C 326\ patent specification (repair Na Qing 512 曰 /, current, electrophoresis, heat source and ultrasonic wave at least one - 4, by 1292329 to The preparation of the person... „金三成^刀 penetrates into the living skin. The 5 kel soft material membrane can be a one-sided membrane, two wound healing, succulent, skin-coated pancreas, transdermal absorption patch or agent- The flow system is impregnated with a wet film prepared therein, and the component is prepared. After the energy of at least one chemical substance or natural substance is received, the wafer receives the radio frequency signal and the heat source and the ultrasonic wave to generate at least current. , electrophoresis, in the control of the amount of control so that the preparation penetrates into the living skin, can also be used in the ° Hai Zhuo people shell material film 曰 wireless control cry # a IC day film controlled by the wireless controller, the soft two And the electronic chip of the 1c chip, the IC chip that can be controlled by the Dinglian coupler produces at least one of the 0, +, and 7^ waves of the Thunder + electric claw ice, heat source and super sound
该電子裝置可包含手機、個人電腦、PDA 及客製化之電子控制褒置等。 人“ PDA 如：:所示，該軟質材料膜4係經製 Γ然一流體製劑，其包含至少-種化心或 1以接m時刀騎負材料膜4中具有複數之ic晶片 接=無線射頻訊號2及能量，並進-步產生至少一 體皮膚=了熱源及超音波’藉以使該製劑加強渗透至活 所:!：質材料膜4中之1C晶片1經接收-無線控制器3 所魯出之無線射頻訊號及能量後，即進一步產生至少“ 流、電泳、熱源及超音》皮。本發明之ic晶片！可經由： 線控制器3控制’言亥無線控制器、3係為一具有電源及a 晶片之電子裝置，可控制該軟質材料膜上之“晶'片〗產 326\專利說明書(補件)\95-05\TF954512 1292329 生電流、電泳、熱源及超音波之至 ^ 包含手機、個人電腦及m # j电子叙置可 制裝置。 了為—各製化之電子控 意圖係顯示本案發明之軟 入具有接收無線射頻之IC晶片i2中係Ά 線^該，之上，其可為主動元件或被動元應-料===案:r無線控制器_質材 (Transponder )，其中由兩個 1^1° 由無線控制器3發射—特定^ f、、且成。其操作原理為 c口膜而應…感應方式係為感應偶合（“dive P =或後向散射偶合㈤咖灿心卿， 執晶片1内之電路’而將内部指令送出 令，產生“ -Τ、、/ T電流系、统便依序接收解讀此指 ic晶…1二泳、熱源及超音波。此被動式 換成ΪΓ曰攸…、線控制器3所傳送的訊號及能量，轉 換成IC日日片1内部雷敗p 該無線控制μ心所需的電能，不需外加電池； ^ ' σσ ，、、！天線發射訊號及能量。 經由上述說明，可知 習知技術之裝置：案备明如以下表述各點均係優於 326\專利說明書(補件)\95-05\TF954512 1292329The electronic device can include a mobile phone, a personal computer, a PDA, and a customized electronic control device. The human PDA such as:: the soft material film 4 is made of a fluid preparation, which comprises at least one kind of centrifugation or 1 when the m is attached to the negative material film 4 and has a plurality of ic wafers. Radio frequency signal 2 and energy, and step-by-step production of at least one skin = heat source and ultrasonic 'to make the preparation strengthen penetration into the living room:!: 1C wafer 1 in the material film 4 is received - wireless controller 3 After the wireless RF signal and energy are released, at least the "flow, electrophoresis, heat source and supersonic" skins are generated. The ic wafer of the present invention! The line controller 3 can control the 'Yanhai wireless controller, the 3 series is an electronic device with a power supply and a chip, and can control the "crystal" film on the soft material film to produce 326\patent specification (supplement) \95-05\TF954512 1292329 Current, electrophoresis, heat source and ultrasonic wave ^ Contains mobile phones, personal computers and m #j electronically-arranged devices. The electronic control intention for each system shows the invention of the present invention. The soft-input IC chip in the IC chip i2 that receives the radio frequency is on the top, which can be an active component or a passive component. ==== Case: r wireless controller_Transponder, where two 1^1° is transmitted by the wireless controller 3 - specific ^ f, and is formed. Its operating principle is c-membrane and the sensing method is induction coupling ("dive P = or backscatter coupling (5) coffee can be Qing, the circuit in the chip 1 'and the internal command to send orders, resulting in " - Τ,, / T current system, the system will receive the interpretation of this finger ic crystal ... 1 two swimming, heat source and ultrasonic. This passive change Cheng Hao..., the signal and energy transmitted by the line controller 3 are converted into IC day and day 1 The power of the wireless control μ heart does not need to be added to the battery; ^ ' σσ , , , ! Antenna transmission signal and energy. Through the above description, the device of the prior art is known: the case is as follows Points are better than 326\ patent specification (supplement)\95-05\TF954512 1292329
發明可在不離開本發 種特定之例示。本發 ：二及基本特徵下作成各 限定，而並非由上述說明所限制，請專利範圍所 義相等之變化均應包含於 H請專利範圍意 【圖示簡單說明】 Λ月中。 圖1為本案發明軟質材料膜中之^ 所發出之無線射頻訊號及能量控制之示ζ、，·！無線控制器 圖2為本案發明軟質材料膜歲 二。 圖3係顯示IC晶片接收無 二片之示意圖。 量之示意圖。 °。所傳迗的訊號及能 【主要元件符號說明】 1 1C晶片 2無線射頻訊號及能量 3 無線控制器 4軟質材料膜 10 326\專利說明書(補件)\95-〇5\TF954512The invention may be embodied without particular departure from the invention. This is a limitation of the second and basic features, and is not limited by the above description. The changes in the scope of the patent should be included in the scope of the H patent. [Simplified illustration] In the middle of the month. Figure 1 shows the wireless RF signal and energy control emitted by the soft material film of the present invention. Wireless Controller Figure 2 is the second year of the soft material film of the present invention. Figure 3 is a schematic diagram showing the receipt of two chips from an IC wafer. Schematic diagram of the quantity. °. Signals and energy transmitted [Main component symbol description] 1 1C chip 2 Wireless RF signal and energy 3 Wireless controller 4 Soft material film 10 326\Patent specification (supplement)\95-〇5\TF954512