KR20110031530A - Ultrasound and RF high frequency integrated fusion system for drug absorption promotion - Google Patents

Abstract

PURPOSE: An ultrasonic wave and RF high frequency integrated hybrid system for accelerating absorption of medicine is provided to maximize the effect of pain removing treatment. CONSTITUTION: An ultrasonic wave and RF high frequency integrated hybrid system for accelerating absorption of medicine comprises: a power module(100) generating power; an ultrasonic wave generation module(200) generating ultrasonic wave; an RF high frequency generation module(300) generating RF high frequency; a skin contact module(400) facilitating the absorption of the medicine applied on the human body skin; and a control module(500) controlling the overall operation of the system.

Description

Ultrasound and RF high frequency integrated fusion system for promoting absorption of drugs

The present invention relates to a system for promoting drug absorption, and more particularly, to an ultrasonic and RF high frequency integrated fusion system for promoting the absorption of drugs.

Diseases such as skeletal diseases have the disadvantage of accompanied by many gastrointestinal disorders and digestive disorders due to the need for continuous administration of oral administration drugs. In order to solve this problem, a method of directly treating the skin in the form of a drug delivery system (Drug Delivery System; DDS) is now widely used. The drug delivery system is a formulation and technology designed to efficiently deliver the required amount of drug to the required area by minimizing the side effects of the existing medicine and maximizing the efficacy and effect.As technology innovation progresses, it is a key element of medicine development. It is emerging and is one of the best topics in the pharmaceutical industry. Types of drug delivery systems include oral, transdermal, inhalable, injectable, mucosal, and gene therapy.

Among the DDS, transdermal drug delivery (TDS) systems include patches, plasters, pastae, cataplasma, gels, ointments, and lotions ( A technology that delivers drugs into the blood quickly through the skin using lotions, creams, or electrical devices, which can avoid metabolism by the liver or stomach, resulting in immediate action and adhesion of the drugs to the skin. Because it is possible to continuously administer the drug, it is not necessary to take it every day, and when adhered to the skin, since the therapeutic agent is continuously released for about one week, there is an advantage over the oral type. However, in the case of sonic wave electrophoresis, electrophoresis, and iontophoresis, which are the field of TDS medical device technology integration among DDS, drug absorption is absorbed to the displacement of frequency, intensity, power, wavelength, etc. of medical devices that have been developed only by the pharmaceutical perspective. Effect research and analysis are the main.

On the other hand, high frequency treatment is applied to apply high frequency to living tissue to convert it into thermal energy in the human body, and to increase the temperature inside the human body by the thermal energy to achieve a therapeutic or cosmetic effect. Here, the high frequency means a radio transmission frequency (300 ~ 1,200 kHz) in a dictionary meaning, but in the RF for the treatment means a high frequency current. In general commercial alternating current, the frequency of alternating between + and-is 60 times per second (60 Hz), but AC current of 0.3 MHz to several tens of MHz is required for therapeutic use. In other words, when high-frequency electricity is applied to biological tissues, ions in cells move back and forth from the cathode to the anode, and generate tremendous frictional heat on their own to obtain a therapeutic or cosmetic effect. By using high-frequency heat energy as a continuous and repetitive massage of the average heat of 39 ~ 45 ℃ to the core, the blood vessels are dilatated, and all metabolic functions are smoothed. In addition, sterilization function due to high temperature and dermal layer induces collagen production, and also plays a role in releasing the aggregated muscle tissue due to heat. In addition, it is widely known that there is an excellent effect on pain relief, wrinkle removal, obesity treatment, pore reduction, and the like.

The present invention has been proposed to overcome the problems of the proposed methods and to combine the advantages of the present invention, and the RF radiofrequency of the transdermal drug delivery system (TDS), which has been proven to be stable and effective in treating pain, is applied to the pathological site. By allowing simultaneous irradiation, drug absorption promotion and deep fever treatment may be simultaneously performed, and an object thereof is to provide an ultrasound and RF high frequency integrated fusion system capable of maximizing the efficacy of pain treatment.

According to a feature of the present invention for achieving the above object, the ultrasonic and RF high frequency integrated fusion system for promoting the absorption of the drug,

(1) a power supply module for generating power;

(2) an ultrasonic wave generating module generating ultrasonic waves by receiving power from the power module;

(3) an RF high frequency generation module receiving power from the power module to generate an RF high frequency;

(4) a skin contact module which contacts the skin of the human body and promotes the absorption of the drug applied to the human skin in contact with the ultrasonic wave generated by the ultrasonic wave generating module and the RF high frequency wave generated by the RF high frequency wave generating module; And

(5) It is characterized by including the power supply module, the said ultrasonic wave generation module, the said RF high frequency generation module, and the control module which controls the said skin contact module.

Preferably, the power module,

A pulse width modulation (PWM) output controlled by the control module may be supplied to the ultrasonic wave generation module and the RF high frequency generation module.

Preferably, the ultrasonic wave generation module,

An ultrasonic wave generator for generating ultrasonic waves having a frequency controlled by the control module;

A frequency stabilizer for correcting and stabilizing the frequency of the ultrasonic waves generated by the ultrasonic generator;

An amplifier for amplifying the ultrasound having a frequency stabilized by the frequency stabilizer;

An output unit which outputs the ultrasonic wave amplified by the amplifier to the outside through a skin contact module; And

It may include an ultrasonic wave generation period control unit for controlling the generation cycle of the ultrasonic wave output from the output unit by the control of the control module.

More preferably, the ultrasonic wave generation module,

The apparatus may further include an ultrasonic focusing unit configured to focus the ultrasonic waves amplified by the amplification unit or the ultrasonic waves output from the output unit to generate focused ultrasonic waves.

Even more preferably, the ultrasonic focusing unit,

A piezoelectric element unit configured to convert electrical energy of ultrasonic waves amplified by the amplifier or ultrasonic energy output from the output unit and mechanical energy of ultrasonic pulses;

A matching layer unit positioned at a lower end of the piezoelectric element unit and formed of a single layer or multiple layers and transferring ultrasonic energy generated by the piezoelectric element unit; And

It may include an ultrasonic focusing lens unit for amplifying the ultrasonic energy transmitted from the matching layer unit to deliver to the contact human skin.

Even more preferably, the ultrasonic focusing unit,

It may be integrated with the skin contact module.

Preferably, the RF high frequency generation module,

A high frequency generator for generating an RF high frequency having a frequency controlled by the control module;

A frequency stabilizer for correcting and stabilizing a frequency of the RF high frequency generated by the high frequency generator;

An amplifier for amplifying an RF high frequency having a frequency stabilized by the frequency stabilizer;

An output unit which outputs the RF high frequency amplified by the amplifier to the outside through a skin contact module; And

It may include an RF high frequency generation period control unit for controlling the generation period of the RF high frequency output from the output unit by the control of the control module.

Preferably, the skin contact module,

Ultrasonic delivery lens unit for delivering the ultrasonic wave generated in the ultrasonic generation module to the contacted skin, And

The RF high frequency generation module may include an RF electrode unit for transmitting the RF high frequency generated in contact with the skin.

Preferably, the apparatus may further include a user interface module configured to set the frequency, the generation period, and the intensity of the generated ultrasonic wave and the RF high frequency wave.

More preferably, the frequency of the ultrasonic waves may be set within the range of 0.01 to 4.0 MHz, and the frequency of the RF high frequency may be set within the range of 0.3 to 1.0 MHz.

Preferably, the method may further include a gel pad which is contacted between the skin contact module and the human skin, and transmits ultrasonic waves and RF radio waves generated by the skin contact module to the human skin without energy attenuation.

More preferably, the gel pad is detachable to the skin contact module.

Preferably, the control module,

Simultaneously operating the ultrasonic wave generating module and the RF high frequency generating module, or controlling only one of the ultrasonic wave generating module and the RF high frequency generating module to operate,

When operating at the same time, it is possible to control so that the ultrasonic wave generated in the ultrasonic wave generating module and the duty of the RF high frequency in the RF high frequency generating module are correlated with each other.

Preferably, the control module,

It may be controlled to find and set the maximum tuning frequency through the tuning frequency of the ultrasonic wave generated by the ultrasonic wave generation module.

Preferably,

Further comprising a temperature sensor module for sensing the temperature of the skin contact module,

The control module may control the temperature of the skin contact module to a predetermined range through output control of the ultrasonic wave generation module and the RF high frequency generation module based on the temperature of the skin contact module sensed by the temperature sensor module. Can be.

According to the present invention, the ultrasound and RF high frequency integrated fusion system for promoting the absorption of drugs, RF has been proven to be stable and pain treatment efficacy in transdermal drug delivery system (TDS) using ultrasound By providing an ultrasound and RF high frequency integrated fusion system to simultaneously irradiate the high frequency to the diseased area, the drug absorption promotion and deep fever treatment can be performed at the same time, thereby maximizing the efficacy of pain treatment. In particular, the present invention has the advantage that it is easy to carry by configuring the ultrasonic and RF high frequency integrated fusion system so that its size can be minimized.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a view showing the configuration of the ultrasound and RF high frequency integrated fusion system for absorption absorption of a drug according to an embodiment of the present invention. As shown in FIG. 1, the ultrasound and RF high frequency integrated fusion system for absorption absorption of a drug according to an embodiment of the present invention receives power from a power module 100 and a power module 100 that generate power. Ultrasonic wave generation module 200 for generating an ultrasonic wave, RF high frequency wave generation module 300 for generating RF high frequency by receiving power from the power supply module 100, in contact with the skin of the human body, generated in the ultrasonic wave generation module 200 Skin contact module 400 for promoting the absorption of the drug applied to the skin of the human body by using the RF high frequency generated by the ultrasonic wave and the RF high frequency generation module 300, and the power supply module 100, the ultrasonic wave generation module 200 ), An RF high frequency generation module 300, and a control module 500 for controlling the skin contact module 400. In addition, as shown in Figure 1, the ultrasound and RF high frequency integrated fusion system for absorption absorption of the drug according to an embodiment of the present invention, it is possible to set the frequency, the generation period, and the intensity of the generated ultrasound and RF high frequency A gel pad 700 which is contacted between the user interface module 600, the skin contact module 400, and the human skin so as to transmit ultrasonic waves and RF radio waves generated by the skin contact module 400 to the human skin without energy attenuation, and The apparatus may further include a temperature sensor module 800 that senses a temperature of the skin contact module 400.

The power supply module 100 serves to generate power. The power supply module 100 may generate a pulse width modulation (PWM) output under the control of the control module 500, and supply the generated PWM output to the ultrasonic wave generation module 200 and the RF high frequency generation module 300. . That is, when the control signal is generated by the control module 500 and input to the power supply module 100 by the pre-stored setting contents or by the user's input input from the user interface module 600, According to the output energy intensity is set according to the PWM output is supplied to the ultrasonic wave generation module 200 and the RF high frequency generation module 300.

The ultrasonic wave generation module 200 receives power from the power supply module 100 to generate ultrasonic waves. 2 is a view showing a detailed configuration of the ultrasonic wave generation module 200 in the ultrasound and RF high frequency integrated fusion system for absorption promotion of the drug according to an embodiment of the present invention. As illustrated in FIG. 2, the ultrasonic wave generating module 200 may include an ultrasonic wave generator 210 that generates ultrasonic waves having a frequency controlled by the control module 500, and an ultrasonic wave generated by the ultrasonic wave generator 210. A frequency contacting unit 220 for correcting and stabilizing a frequency, an amplifying unit 230 for amplifying an ultrasonic wave having a frequency stabilized by the frequency stabilizing unit 220, and an ultrasonic wave amplified by the amplifying unit 230 may be a skin contact module ( And an ultrasonic generation cycle controller 250 for controlling the generation cycle of the ultrasonic waves output from the output unit 240 under the control of the control module 500 and an output unit 240 outputting to the outside through the 400. Can be. The ultrasonic wave generation period control unit 250 is controlled by the control module 500. The control module 500 uses the ultrasonic wave generation period control unit 250 to store previously set contents or through the user interface module 600. The duty cycle of the ultrasonic waves output by using the setting contents input from the user is controlled. Here, the generation period of the ultrasonic wave affects the depth of penetration of the drug into the human body. Therefore, the signal cycle of the ultrasound, for example, 1: 1 to 1:20 can be set in various ways according to the treatment purpose to be used.

Also, as illustrated in FIG. 2, the ultrasonic wave generating module 200 may focus on ultrasonic waves amplified by the amplifier 230 or ultrasonic waves output from the output unit 240 to generate focused ultrasonic waves ( 260 may be further included. The ultrasound focusing unit 260 may be configured integrally with the skin contact module 400. Preferably, the ultrasound energy and the electric energy of the ultrasound amplified by the amplifier 230 or the ultrasound output from the output unit 240 are provided. The piezoelectric element portion 262 and the piezoelectric element portion 262 configured to convert the mechanical energy of the pulse to each other are formed at the bottom of the piezoelectric element portion 262 consists of a single layer or multiple layers, the ultrasonic energy generated by the piezoelectric element portion 262 Matching layer unit 264 for transmitting a, and the ultrasound focusing lens unit 266 to amplify the ultrasound energy transmitted from the matching layer unit 264 to deliver to the human skin contacted. In particular, the ultrasonic focusing lens unit 266 may further include a lens height adjusting unit capable of adjusting the height of the focusing lens. The user may adjust the height of the focusing lens using the lens height adjusting unit according to the area of the treatment affected part. In addition, the ultrasonic focusing lens unit 266 may use an acoustic lens or an acoustic lens array as the ultrasonic focusing lens. Of course, the ultrasonic focusing lens that can be used in the ultrasonic focusing lens unit 266 is not limited to the acoustic lens or the acoustic lens array, and various focusing means for effectively focusing the ultrasonic wave may be used.

The RF high frequency generation module 300 receives power from the power supply module 100 to generate RF high frequency. 3 is a view showing a detailed configuration of the RF high frequency generation module 300 in the ultrasound and RF high frequency integrated fusion system for absorption promotion of drugs according to an embodiment of the present invention. As shown in FIG. 3, the RF high frequency generation module 300 is generated by the high frequency generator 310 and the high frequency generator 310 for generating an RF high frequency having a frequency controlled by the control module 500. A frequency stabilizer 320 for correcting and stabilizing a frequency of an RF high frequency, an amplifying unit 330 for amplifying an RF high frequency having a frequency stabilized by the frequency stabilizing unit 320, an RF high frequency amplified by the amplifying unit 330 RF high frequency generation period control unit for controlling the generation period of the RF high frequency output from the output unit 340, and the output unit 330 under the control of the control module 400, the output to the outside through the skin contact module 400 It may be configured to include (350).

The skin contact module 400 is in contact with the skin of the human body, using the ultrasonic waves generated by the ultrasonic wave generation module 200 and the RF high frequency generated by the RF high frequency generation module 300, the drug applied to the human skin contacted It serves to promote the absorption of. The skin contact module 400 may include an ultrasound delivery lens unit 410 for delivering the ultrasound generated by the ultrasound generation module 200 to the contacted skin, and an RF radio frequency generated by the RF radio frequency generating module 300. It may be composed of an RF electrode unit 420 to deliver to the skin. The detailed configuration of such a skin contact module 400 is also shown in Figure 4 showing the configuration of the probe for the ultrasound and RF high frequency integrated fusion system for absorption absorption of the drug according to an embodiment of the present invention. As shown in FIG. 4, the ultrasonic delivery lens unit 410 may be disposed inward, and the RF electrode unit 420 may be disposed outward. In particular, the shape of the skin contacting part may be flat as well as the ultrasonic wave. The transfer lens unit 410 may be concave, and the RF electrode unit 420 disposed outside may be convex. Of course, the detailed configuration of the skin contact module 400 is not limited to the configuration shown in FIG.

The control module 500 controls the power supply module 100, the ultrasonic wave generation module 200, the RF high frequency generation module 300, and the skin contact module 400. The control module may operate the ultrasonic wave generation module 200 and the RF high frequency generation module 300 simultaneously or control only one of the ultrasonic wave generation module 200 and the RF high frequency generation module 300 to operate. In this case, the ultrasonic wave generated by the ultrasonic wave generation module 200 and the RF high frequency wave generation module 300 may be controlled to correlate the duty of the RF high frequency. The following Table 1 is a table showing an example of the duty control of the RF high frequency in the ultrasonic wave generated by the control module 500 and the RF high frequency generation module 300 by the ultrasonic generation module 200.

ultrasonic wave continuity 9 8 7 6 5 4 3 2 One 0 High frequency 0 One 2 3 4 5 6 7 8 9 continuity

In addition, the control module 500 may control to find and set the maximum tuning frequency by varying the tuning frequency of the ultrasonic wave generated by the ultrasonic wave generating module 200. For the specific control method of the control module 500, the description of each component controlled by the control module 500 will be referred to.

The user interface module 600 serves to allow a user to set the frequency, generation period, and intensity of the generated ultrasonic wave and the RF high frequency wave. The frequency of the ultrasound may be set within the range of 0.01 to 4.0 MHz depending on the therapeutic purpose to be used. In other words, if the drug is administered deep in the skin of the human body to set a high frequency, if the drug is administered in a relatively shallow setting a low frequency. In addition, the frequency of the RF high frequency can be set within the range of 0.3 ~ 1.0MHz. The intensity of the ultrasound and RF radiofrequency used may also be adjusted according to the therapeutic purpose to be used.

The ultrasound and RF high frequency integrated fusion system for promoting absorption of the drug proposed in the present invention may be used in direct contact with the skin, but may also transmit ultrasound and RF radio frequency to the skin through a medium in the form of a gel. The gel pad 700 is in contact between the skin contact module 400 and the human skin, and serves to deliver ultrasonic waves and RF radio waves generated by the skin contact module 400 to the human skin without energy attenuation. It is important that the gel pad 700 is free of energy attenuation, particularly during the delivery of ultrasound and RF high frequencies. Until now, the aquatic environment is best known for the ultrasonic energy transfer, therefore, the gel pad 700 used in the present invention may also be composed of water as its main component. In particular, the gel pad 700 may be configured to be detachable with the skin contact module 400, which enables the gel pad 700 as a disposable consumable component, preventing the infection of fungi, It is possible to prevent the risk of secondary reaction of the gel and the drug and a decrease in the drug penetration efficiency, which may occur when the ultrasonic gel and the drug for transdermal drug absorption are used simultaneously.

The temperature sensor module 800 serves to sense the temperature of the skin contact module 400. The ultrasound and RF high frequency integrated fusion system for promoting absorption of a drug proposed in the present invention may further include a temperature sensor module 800 for sensing a temperature of the skin contact module 400. Based on the temperature of the skin contact module 400 sensed by the temperature sensor module 800, the temperature of the skin contact module 400 is previously determined through the output control of the ultrasonic wave generation module 200 and the RF high frequency generation module 300. You can control to a specified range.

Heat is generated in human tissues that absorb ultrasonic and RF high frequency energy from the ultrasonic and RF high frequency integrated fusion system proposed in the present invention, and mechanical energy is converted into heat in the tissue and absorbs drugs by mechanical disturbance and changes in such heat. Acts to promote phonophoretic drug delivery. Depending on the characteristics of the tissue, the thermal effect can also vary, the absorption rate in the tissue increases in proportion to the frequency, and the rise of the temperature of the tissue is proportional to the intensity and application time of the ultrasonic and RF radiofrequency, so considering the frequency Should be set.

In addition, the movement of tissue fluid occurs in one direction by the cavitation of biological tissues by mechanical stimulation of ultrasound and RF radio frequency. As such, the tissue fluid moves in one direction to form acoustic streaming. The flow of the fluid is increased by affecting the tissue in the ultrasonic field and the RF high frequency field according to the flow of the ultrasonic wave and the RF high frequency wave. When RF radio waves are transmitted through the skin, it affects the penetration of the stratum corneum lipid structure, which is a barrier to permeation, further promoting blood and lymph flow, which greatly enhances the therapeutic effect.

5 is a view schematically showing an ultrasound and RF high frequency integrated fusion system and its effect for promoting absorption of drugs according to an embodiment of the present invention. As shown in FIG. 5, the ultrasound and RF high-frequency integrated fusion system for absorption absorption of a drug according to an embodiment of the present invention not only promotes absorption of the drug as indicated by the blue small circle, but also to a large green ellipse. As indicated, deep fever treatment is possible at the same time. In addition, as shown in Figure 5, by configuring the ultrasonic and RF high frequency integrated fusion system so that the size can be minimized, it is also easy to carry.

The present invention described above may be variously modified or applied by those skilled in the art, and the scope of the technical idea according to the present invention should be defined by the following claims.

1 is a view showing the configuration of the ultrasound and RF high frequency integrated fusion system for promoting absorption of drugs according to an embodiment of the present invention.

2 is a view showing the detailed configuration of the ultrasonic wave generation module 200 in the ultrasound and RF high frequency integrated fusion system for absorption absorption of a drug according to an embodiment of the present invention.

3 is a view showing a detailed configuration of the RF high frequency generation module 300 in the ultrasound and RF high frequency integrated fusion system for absorption promotion of drugs according to an embodiment of the present invention.

4 is a view showing the configuration of a probe for the ultrasound and RF high frequency integrated fusion system for absorption absorption of a drug according to an embodiment of the present invention.

5 is a view schematically showing an ultrasound and RF high frequency integrated fusion system and its effects for promoting absorption of drugs according to an embodiment of the present invention.

<Explanation of symbols for main parts of the drawings>

100: power supply module

200: ultrasonic generation module

210: ultrasonic generator

220, 320: frequency stabilizer

230, 330: amplification unit

240, 340: output unit

250: ultrasonic generation cycle control unit

260: ultrasonic focusing unit

300: RF high frequency generation module

310: high frequency generation unit

350: RF high frequency generation period control unit

400: skin contact module

410: ultrasonic transmission lens unit

420: RF electrode portion

500: control module

600: user interface module

700: gel pad

800: temperature sensor module

Claims (15)

An ultrasound and RF high frequency integrated fusion system that promotes absorption of drugs, (1) a power supply module for generating power; (2) an ultrasonic wave generating module generating ultrasonic waves by receiving power from the power module; (3) an RF high frequency generation module receiving power from the power module to generate an RF high frequency; (4) a skin contact module which contacts the skin of the human body and promotes the absorption of the drug applied to the human skin in contact with the ultrasonic wave generated by the ultrasonic wave generating module and the RF high frequency wave generated by the RF high frequency wave generating module; And (5) a control module for controlling the power module, the ultrasonic wave generating module, the RF high frequency wave generating module, and the skin contact module An ultrasound and RF high frequency integrated fusion system for promoting absorption of drugs, comprising a. The method of claim 1, wherein the power module, And a pulse width modulation (PWM) output controlled by the control module to the ultrasonic wave generating module and the RF high frequency generating module. The method of claim 1, wherein the ultrasonic wave generation module, An ultrasonic wave generator for generating ultrasonic waves having a frequency controlled by the control module; A frequency stabilizer for correcting and stabilizing the frequency of the ultrasonic waves generated by the ultrasonic generator; An amplifier for amplifying the ultrasound having a frequency stabilized by the frequency stabilizer; An output unit which outputs the ultrasonic wave amplified by the amplifier to the outside through a skin contact module; And And an ultrasonic wave generation period control unit for controlling the generation cycle of the ultrasonic wave output from the output unit by the control of the control module. The method of claim 3, wherein the ultrasonic wave generation module, And an ultrasonic focusing unit for focusing the ultrasonic waves amplified by the amplifying unit or the ultrasonic waves output from the output unit to generate focused ultrasonic waves. The method of claim 4, wherein the ultrasonic focusing unit, A piezoelectric element unit configured to convert electrical energy of ultrasonic waves amplified by the amplifier or ultrasonic energy output from the output unit and mechanical energy of ultrasonic pulses; A matching layer unit positioned at a lower end of the piezoelectric element unit and formed of a single layer or multiple layers and transferring ultrasonic energy generated by the piezoelectric element unit; And And an ultrasonic focusing lens unit for amplifying the ultrasonic energy transmitted from the matching layer unit and transferring the ultrasonic energy to the contacted human skin. The method of claim 4, wherein the ultrasonic focusing unit, An ultrasound and RF high frequency integrated fusion system for absorption absorption of the drug, characterized in that it is configured integrally with the skin contact module. The method of claim 1, wherein the RF high frequency generation module, A high frequency generator for generating an RF high frequency having a frequency controlled by the control module; A frequency stabilizer for correcting and stabilizing a frequency of the RF high frequency generated by the high frequency generator; An amplifier for amplifying an RF high frequency having a frequency stabilized by the frequency stabilizer; An output unit which outputs the RF high frequency amplified by the amplifier to the outside through a skin contact module; And And an RF high frequency generation period control unit for controlling the generation period of the RF high frequency output from the output unit by the control of the control module. The method of claim 1, wherein the skin contact module, Ultrasonic delivery lens unit for delivering the ultrasonic wave generated in the ultrasonic generation module to the contacted skin, And And an RF electrode unit for delivering the RF high frequency generated by the RF high frequency generation module to the contacted skin. The method of claim 1, The ultrasonic and RF high frequency integrated fusion system, characterized in that it further comprises a user interface module that can set the frequency, frequency, and intensity of the generated ultrasound and RF radio frequency. 10. The method of claim 9, The frequency of the ultrasound is in the range of 0.01 ~ 4.0MHz, the frequency of the RF high frequency is set in the range of 0.3 ~ 1.0MHz, characterized in that the absorption absorption ultrasound and RF high frequency integrated fusion system of the drug. The method of claim 1, And a gel pad in contact between the skin contact module and the human skin, the gel pad configured to deliver ultrasonic waves and RF radio waves generated from the skin contact module to the human skin without energy attenuation. RF high frequency integrated fusion system. The method of claim 11, The gel pad is detachable to the skin contact module, characterized in that the absorption absorption ultrasound and RF high frequency integrated fusion system of the drug. The method of claim 1, wherein the control module, Simultaneously operating the ultrasonic wave generating module and the RF high frequency generating module, or controlling only one of the ultrasonic wave generating module and the RF high frequency generating module to operate, When operating at the same time, the ultrasonic wave generated in the ultrasonic wave generating module and the RF high frequency generating module, characterized in that the control control so as to correlate the duty (duty) of the RF high frequency, ultrasonic absorption and RF high frequency integrated fusion system for drug absorption . The method of claim 1, wherein the control module, Ultrasonic wave and RF high frequency integrated fusion system for controlling absorption, characterized in that the control to find and set the maximum tuning frequency through the tuning frequency of the ultrasonic wave generated in the ultrasonic wave generation module. The method of claim 1, Further comprising a temperature sensor module for sensing the temperature of the skin contact module, The control module is configured to control the temperature of the skin contact module to a predetermined range through output control of the ultrasonic wave generation module and the RF high frequency generation module based on the temperature of the skin contact module sensed by the temperature sensor module. An ultrasound and RF high frequency integrated fusion system for promoting absorption of drugs, characterized in that.

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