CN101091816B - Device and method for raising permeability of preparation on skin of living body - Google Patents

Device and method for raising permeability of preparation on skin of living body Download PDF

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Publication number
CN101091816B
CN101091816B CN 200610082898 CN200610082898A CN101091816B CN 101091816 B CN101091816 B CN 101091816B CN 200610082898 CN200610082898 CN 200610082898 CN 200610082898 A CN200610082898 A CN 200610082898A CN 101091816 B CN101091816 B CN 101091816B
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soft material
ic chip
film
skin
electrophoresis
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CN 200610082898
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Chinese (zh)
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CN101091816A (en )
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刘珮珮
叶仰山
许英昌
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刘珮珮;叶仰山;许英昌
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Abstract

The present invention relates to a method capable of utilizing wireless radio-frequency control chip to raise permeability of preparation to vital skin. Said method is characterized by that one or several IC chips capable of receiving wireless radio-frequency can be inlaid in a soft material film, and can be used for receiving wireless radio-frequency signal and energy sent out by one or several wireless controller so as to control said one or several chips and make them produce at least one kind of electric current, electrophoresis, heat source and ultrasonic wave so as to make the componentscontained in said preparation be permeated into vital skin interior. Said invention also relates to a soft material film for above-mentioned method.

Description

提高制剂对活体皮肤渗透性的装置及方法 Improved apparatus and method for the preparation of a living body skin permeability

技术领域 FIELD

[0001 ] 本发明涉及利用无线射频控制IC芯片以提高制剂对活体皮肤渗透性的装置及方法。 [0001] The present invention relates to radio frequency IC chip to improve the control apparatus and method of preparation on the skin permeability of a living body.

背景技术 Background technique

[0002] 已知业界有兴趣研究非侵入性、无痛的新技术,将有效成分或制剂通过皮肤吸收,达到美容保健或医疗效果,并可减少口服及注射药物的困扰和产生剂量不足或过多的问题,多种技术已被讨论。 [0002] Known industry interested in studying non-invasive, painless new technology, the active ingredient or formulation absorbed through the skin, to beauty care or health outcomes, and reduce the shortage plagued oral and injectable drugs and produced a dose or too more problems, various techniques have been discussed. 利用电泳法可改变皮肤的渗透性,使制剂易于渗入正常或受损活体皮肤上的汗腺、皮脂腺及细胞间脂质,已知电泳法能增强局部皮肤对离子成分或制剂的吸收(Glass, JM et al. , Int. J. Dermatol. 19, 519 (1980) ;Russo J. , Am. J. Hosp. Pharm. 37,843(1980) ;Gangarosa, LP etal. , J. Pharmacol. Exp. Ther. 212, 377 (1980); Kwon, BSet al. , J. Infect. Dis. 140,1014(1979) ;Hill, JM et al. , Ann. NY Acad. Sci. 284, 604 (1977)及Tanneba咖,M. Phys. Ther. 60, 792 (1980)) 。 Using electrophoresis can alter the permeability of the skin, the formulation is easy to penetrate or damage the normal sweat glands on the skin of a living body, between the sebaceous gland and cell lipid, electrophoresis is known to enhance the skin absorption of topical formulation or ion components (Glass, JM et al, Int J. Dermatol 19, 519 (1980);... Russo J., Am J. Hosp Pharm 37,843 (1980);... Gangarosa, LP etal, J. Pharmacol Exp Ther 212,.... 377 (1980); Kwon, BSet al, J. Infect Dis 140,1014 (1979);....... Hill, JM et al, Ann NY Acad Sci 284, 604 (1977) and Tanneba coffee, M. phys. Ther. 60, 792 (1980)). 1984年美国专利第4, 474, 570号已公开一种皮肤电泳仪器。 1984 US Patent Nos. 4, 474, 570 disclosed a skin electrophoresis instrument. 利用直流电剌激培养皿中的细胞,已证明能抑制金黄色葡萄球菌生长,并认为电流剌激能抑制伤口上细菌的生长(Merriman,H丄.,et al., JRRD Vol 41, p. 139-146,2004)。 DC stimulation dish using a cell, has been shown to inhibit the growth of Staphylococcus aureus, and currents that stimulate a wound inhibits the growth of bacteria (Merriman, H Shang., Et al., JRRD Vol 41, p. 139 -146,2004). 另一方面,超声波已知能增加皮肤表皮吸收及剌激角质(Homy Layer)细胞分散。 On the other hand, the ultrasonic known to stimulate and increase the absorption of the epidermis keratinocytes (Homy Layer) cells were dispersed. 研究人员利用低频超声波配合药物已应用于治疗斑型脱发、黑色素斑(Melasma)及曰晒斑(Solar Lentigo) (Santoia皿i,P. , et al. , Dermatology Online Journal 10(2)24,2004)。 Researchers have a low frequency ultrasonic wave applied to the treatment with drug spot pattern baldness, melanin spots (Melasma) and said sunburn (Solar Lentigo) (Santoia dish i, P., Et al., Dermatology Online Journal 10 (2) 24,2004 ). 并利用低频超声波经皮渗透装置,达到美白、除皱、除脂及治疗香港脚的效果(中国台湾第1220386号专利)。 And the use of low-frequency ultrasonic percutaneous penetration device, whitening, wrinkle removal, degreasing and athlete's foot treatment effect (China Taiwan patent No. 1,220,386). 在动物实验上,也证明低频超声波能增强局部药物吸收(Singer, AJ , Church, AL , McClain, SA Academic EmergencyMedicine, Vol 5,35-40, 1998 (Society for Academic Emergency Medicine出版))。 In animal experiments, the low-frequency ultrasonic energy also demonstrated enhanced topical drug absorption (Singer, AJ, Church, AL, McClain, SA Academic EmergencyMedicine, Vol 5,35-40, 1998 (Society for Academic Emergency Medicine Publishing)). 石开究人员发现,提升热量也能增加皮肤对药物的吸收、药物的溶解度、体内液体循环及血管壁的通透性(Hull, W. ,The Journal ofApplied Research,2002)。 The researchers found that stone open, heat can be increased to enhance the skin absorption of the drug, solubility of the drug, body fluid circulation and blood vessel wall permeability (Hull, W., The Journal ofApplied Research, 2002).

[0003] 已知现在使用电流及电泳通常是通过将连续直流产生器或脉冲直流产生器的输出端连接至第一电极或主动电极,并连接至第二电极或次要电极,其中该第一电极或主动电极由金属板或导电物质组成,其覆盖有经浸渍制剂水溶液的具孔隙材料的潮湿膜。 [0003] Known current and electrophoretic now typically connected to the first electrode or the output end of the active electrode by continuous or pulsed direct current generator is a DC generator, and is connected to the secondary electrode or the second electrode, wherein the first active electrode or an electrode or a conductive substance composed of a metal plate, which is covered with a wet film of an aqueous formulation having pores impregnated material. 因此, 已知该方法在使用上十分不方便,因而限制了使用该方法局部施用药剂的普及与发展,而只在医院或专业处所才能使用。 Therefore, this method is known very inconvenient in use, thus limiting the use of this method topical application development and popularity of the drug, but only to use in a hospital or professional premises.

[0004] 上述用于对皮肤产生电流、电泳、热源及超声波中的已知装置都是有交流电电源供应线的有线装置,并在载体中设置有电源或电池,对有交流电电源供应线的有线装置的使用者而言,有移动性差的缺点,且部分系统操作需要他人辅助才能完成。 [0004] The skin is used to generate electricity, electrophoresis, heat and ultrasonic waves are known devices wired AC power supply line of the apparatus, and is provided with a battery power source or in a carrier, there are wired to the AC power supply line user of the device, it has the disadvantage of poor mobility, and the others parts of the system require auxiliary operations to complete. 另外,美国专利第4, 474, 570号及美国专利申请公开第2003/0023187号公开了一种利用交流电电源供应线控制的已知装置,其不方便施用于活体皮肤各部位。 Further, U.S. Patent No. 4, 474, 570 and U.S. Patent Application Publication No. 2003/0023187 discloses a known device using the AC power supply line of the control, which is inconvenient and applied to each part of the living body skin.

发明内容 SUMMARY

[0005] 本发明的目的是利用无线射频控制IC芯片以克服上述已知装置在使用上不便之处,通过在软质材料膜中嵌入一个或多个具有接收该无线射频的IC芯片,以接收一个或多个无线控制器所发出的无线射频信号及能量而控制该IC芯片产生电流、电泳、热源及超声波中的至少一种。 [0005] The object of the present invention is the use of a control radio frequency IC chip to overcome the above inconvenience in the known devices used, by embedding one or more films having a soft material for receiving the radio frequency IC chip to receive radio frequency signal and one or more of the energy emitted from the wireless controller controlling IC chip generates at least one current, electrophoresis, heat and ultrasonic wave is. 使用者可于日常活动的状态,即通过简易操作该无线控制器而控制置于活体皮肤上的软质材料膜内的ic芯片产生电流、电泳、热源及超声波中的至少一种。 In daily activities of the user can state that the soft material and the control film placed on the skin of a living body by a simple operation of the chip ic radio controller generates at least one current, electrophoresis, heat and ultrasonic wave is.

附图说明 BRIEF DESCRIPTION

[0006] 图1为本发明软质材料膜中的IC芯片经无线控制器所发出的无线射频信号及能量控制的示意图。 [0006] Figure 1 is a schematic view of a soft material film IC chip via radio frequency signals emitted by the radio controller and energy control of the present invention.

[0007] 图2为本发明软质材料膜嵌入IC芯片的示意图。 [0007] Fig 2 a schematic view of a soft material of the IC chip embedded in the membrane of the present invention.

[0008] 图3为显示IC芯片接收无线控制器所传送的信号及能量的示意图。 [0008] FIG. 3 is a received radio signal and the power controller transmitted a schematic diagram of the IC chip.

具体实施方式 detailed description

[0009] 本发明提供一种利用无线射频控制IC芯片以提升制剂对皮肤渗透性的方法,该方法包括在软质材料膜中嵌入一个或多个具有接收该无线射频的IC芯片,以接收一个或多个无线控制器所发出的无线射频信号及能量而控制该IC芯片产生电流、电泳、热源及超声波中的至少一种,从而将该制剂所含成分渗透至皮肤内。 [0009] The present invention provides an IC chip using radio frequency control method to enhance the permeability of the skin preparation, which comprises one or more embedded in flexible material film having received the radio frequency IC chip to receive a or radio frequency energy, and a plurality of radio signals emitted from the controller and generates a current control IC chip, at least one of electrophoresis, heat and ultrasonic waves, thereby the penetration of the components contained in the formulation to the skin.

[0010] 另外,本发明涉及一种利用无线射频控制IC芯片的软质材料膜,该软质材料膜主 [0010] Further, the present invention relates to a soft film material is controlled using a wireless RF IC chip, the main soft material film

要由含有制剂的软质材料构成,其包含一个或多个具有接收该无线射频的ic芯片嵌入于 Be made of a soft material containing formulations comprising one or more of the RF receiver having a chip embedded in the ic

该软质材料膜中,以接收一个或多个无线控制器所发出的无线射频信号及能量而控制该软 The flexible material film, and a radio frequency signal energy to receive one or more wireless controllers and controlling the emitted soft

质材料膜中的ic芯片使其产生电流、电泳、热源及超声波中的至少一种,从而将该制剂所 Material in the film to produce a current ic chip, at least one of electrophoresis, heat and ultrasonic waves, thereby the formulation

含成分渗透至活体皮肤内。 Containing ingredients penetrate into the skin of a living body.

[0011] 该软质材料膜可为面膜、皮肤敷膜、经皮吸收贴片或创可贴等,其是经浸渍制剂于 [0011] The soft material may be a mask film, coated film skin, transdermal absorption patch or band-aid, which is impregnated in the formulation

其中的潮湿膜,该制剂为流体制剂,其包含至少一种化学物质或自然物质的成分。 Wherein the wet film, the formulation is a fluid formulation, which composition comprises at least one chemical or natural substances. 该软质材 The soft material

料膜中的ic芯片接收无线射频信号及能量后,通过该IC芯片仿真而产生电流、电泳、热源 After the material in the film chip ic and receiving radio frequency energy signal, and generates a current, electrophoresis, by which heat the IC chip simulation

及超声波中的至少一种,从而使该制剂渗透至活体皮肤内,也可用于控制施药剂量。 And at least one of the ultrasonic wave, so that the preparation penetrated into the skin of a living body, may also be used to control dosage administration.

[0012] 该软质材料膜中的IC芯片可通过无线控制器控制,该无线控制器为具有电源及 [0012] The soft material film IC chip by radio controller, the radio controller and a power supply

IC芯片的电子装置,可控制软质材料膜上的IC芯片产生电流、电泳、热源及超声波中的至 IC chip of the electronic device can be controlled soft material film generates a current IC chip, electrophoresis, heat and ultrasonic waves to

少一种,该电子装置可包含手机、个人计算机、PDA及定制的电子控制装置等。 At least one, the electronic device may comprise a mobile phone, personal computer, PDA and customized electronic control device or the like.

[0013] 如图1所示,该软质材料膜4是经制剂浸渍处理的薄膜,该制剂为流体制剂,其包 [0013] As shown, the flexible film 4 is a film by dipping a formulation, the formulation is a fluid formulation which packet

含至少一种化学物质或自然物质的成分。 Composition comprising at least one chemical or natural substances. 该软质材料膜4中具有多个IC芯片1以接收该 The soft material film 4 having a plurality of IC chips to receive the

无线射频信号2及能量,并进一步产生电流、电泳、热源及超声波中的至少一种,从而加强 2 and the RF power signal, and further generates a current, electrophoresis, at least one of heat and ultrasonic waves, thereby enhancing

了该制剂渗透至活体皮肤内。 Formulation has penetrated into the skin of a living body.

[0014] 该软质材料膜4中的IC芯片1在接收无线控制器3所发出的无线射频信号及能量后,即进一步产生电流、电泳、热源及超声波中的至少一种。 [0014] The soft material film 4 after the IC chip 1 receives the radio frequency signal emitted from the wireless controller 3 and energy, i.e., current is generated further, at least one of electrophoresis, the heat and ultrasonic. 本发明的IC芯片1可通过无线控制器3控制,该无线控制器3为具有电源及IC芯片的电子装置,可控制该软质材料膜上的IC芯片l产生电流、电泳、热源及超声波中的至少一种,该电子装置可包含手机、个人计算机及PDA等,也可为定制的电子控制装置。 The IC chip 3 of the present invention can be controlled by a radio controller, the radio controller 3 is an electronic device having a power supply and the IC chip, the soft material can be controlled film generates a current IC chip l, electrophoresis, heat and ultrasonic waves at least one electronic device may comprise a mobile phone, personal computer, PDA and the like, as may be customized electronic control means.

[0015] 图2的示意图显示本发明的软质材料膜4中嵌入具有接收无线射频的IC芯片1, 其中没有电源供应电线连接至该膜之上,其可为主动组件或被动组件。 Schematic [0015] Figure 2 shows the flexible film 4 of the present invention embedded in a reception radio frequency IC chip 1, which is not connected to the power supply lines on the film, which may be active components or passive components. [0016] 图3的示意图显示本发明由无线控制器3与软质材料膜中IC芯片1所组成。 Schematic [0016] FIG. 3 shows the invention, the wireless controller 3 by a soft material with a film composed of an IC chip. IC 芯片1也就是所谓的应答器(Transponder),其由两个部分所组成。 IC chip 1 is a so-called transponder (Transponder), which is composed of two parts. 其操作原理为,由无线控制器3发射一特定频率的无线射频信号及能量2给膜端应答器,感应方式为电感耦合(Inductive Coupling)或反向散射耦合(Backscatter Coupling),其用于驱动膜端IC芯片1内的电路,而将内部指令送出执行,此时IC芯片l应用电流系统依次接收解读此指令, 产生电流、电泳、热源及超声波中的至少一种。 Its operating principle, transmit a specific frequency controller 3 by a radio signal and a radio frequency energy to the film end transponder 2, induction of the inductive coupling (Inductive Coupling) or backscattered coupling (Backscatter Coupling), for driving 1 film end circuitry within the IC chip, and sends the internal instruction execution, when the IC chip system sequentially receives the current application l interpret this instruction generates at least one current, electrophoresis, heat and ultrasonic wave is. 此被动式IC芯片l将接收自无线控制器3 所传送的信号及能量,转换成IC芯片1内部电路操作所需的电能,不需外加电池;该无线控制器3经天线发射信号及能量。 This passive IC chip and l signal received from the wireless energy transmission controller 3, converted into an internal circuit. 1 IC chip energy required for the operation, without external battery; controller 3 via the radio antenna transmitting signals and power.

[0017] 通过上述说明,可知本发明如以下所述各方面均优于现有技术的装置: [0018] [0017] By the above description, the present invention can be seen as the following aspects of the apparatus are superior to the prior art: [0018]

<table>table see original document page 5</column></row> <table>[0019] 本发明可在不离开本发明的精神及基本特征下作成各种特定的例子。 <Table> table see original document page 5 </ column> </ row> <table> [0019] The present invention may be made in various specific examples without departing from the spirit and basic features of the present invention. 本发明的范围由随附的权利要求范围所限定,而并非由上述说明所限制,所有与权利要求范围意义相等的变化均应包含于本发明中。 The scope of the invention be defined by the scope of the appended claims is defined, and is not limited by the foregoing description, the scope of the claims and all equivalent variations should be included in the meaning of the present invention.

Claims (4)

  1. 一种利用无线射频控制IC芯片的软质材料膜,该软质材料膜主要由含有制剂的软质材料构成,其包含一个或多个具有接收该无线射频的IC芯片嵌入于该软质材料膜中,以接收一个或多个无线控制器所发出的无线射频信号及能量而控制该软质材料膜中的IC芯片使其产生电流、电泳、热源及超声波中的至少一种,从而将该制剂所含成分渗透至皮肤内。 Utilizing a soft material film RF control IC chip, the soft material film mainly made of a soft material containing formulations comprising one or more of the soft material having a film receiving the radio frequency IC chip embedded in the , the radio frequency signal to receive one or more wireless controllers and emitted energy control film of the soft material of the IC chip to produce at least one current, electrophoresis, heat and ultrasonic waves, thereby the formulation component contained penetrate into the skin.
  2. 2. 如权利要求1所述的软质材料膜,其中,该制剂为流体制剂,其包含至少一种化学物质或自然物质的成分。 2. The film of soft material according to claim 1, wherein the formulation is a fluid formulation, which composition comprises at least one chemical or natural substances.
  3. 3. 如权利要求1所述的软质材料膜,其中,该无线控制器为具有电源及IC芯片的电子装置,可控制该软质材料膜中的IC芯片产生电流、电泳、热源及超声波中的至少一种。 3. The soft material film according to claim 1, wherein the controller is a wireless electronic device having a power supply and the IC chip may be controlled in the soft membrane material generates a current IC chip, electrophoresis, heat and ultrasonic waves at least one.
  4. 4. 如权利要求l所述的软质材料膜,其中,该IC芯片需要电池或不需要电池。 L soft material film, wherein the IC chip requires no batteries or battery as claimed in claim.
CN 200610082898 2006-06-19 2006-06-19 Device and method for raising permeability of preparation on skin of living body CN101091816B (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474570A (en) 1981-07-10 1984-10-02 Kabushikikaisya Advance Kaihatsu Kenkyujo Iontophoresis device
CN1284005A (en) 1997-12-30 2001-02-14 久光制药株式会社 Iontophoresis device and method of assembling same
CN1606461A (en) 2001-10-24 2005-04-13 纸型电池有限公司 Device and method for controlled delivery of active substance into the skin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474570A (en) 1981-07-10 1984-10-02 Kabushikikaisya Advance Kaihatsu Kenkyujo Iontophoresis device
CN1284005A (en) 1997-12-30 2001-02-14 久光制药株式会社 Iontophoresis device and method of assembling same
CN1606461A (en) 2001-10-24 2005-04-13 纸型电池有限公司 Device and method for controlled delivery of active substance into the skin

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