TWI239807B - Covered type controlled release of agrochemical granular agent - Google Patents

Abstract

The invention provides a mixed agrochemical granular agent capable of performing a controlled release of two or more different kinds of agrochemical active ingredients having especially different solubility in water from each other and suitable for the treating method of a seedling box of rice at an individual eluting rate, and a method for producing the same. This controlled releasing mixed agrochemical granular agent is obtained by preparing a granulated material consisting of more than one kind of agrochemical active ingredient having a high water solubility, an inorganic diluting carrier and a first thermoplastic material hardly soluble in water, setting the granulated material as an inner core and covering the surface of the core with a mixture of more than one kind of agrochemical active ingredient different from the agrochemical active ingredients contained in the inner core and having a low water solubility, an inorganic diluting carrier and a second thermoplastic material hardly soluble in water to make an outer surface.

Description

1239807 A7 B7 V. Description of the invention (I) TECHNICAL FIELD The present invention relates to a slow-release pesticide granule containing two or more different kinds of pesticide active ingredients, and used to dissolve each of the pesticide active ingredients into an aqueous medium, and to use them The manufacturing method, more specifically, relates to, for example, a slow-release pesticide granule that is suitable for agrochemical granules for rice seedling boxes and a method for manufacturing the same. As a slow-release seedling box pesticide granule, it is applied to the seedling box used for rice seedlings. When the seedlings are subsequently transplanted, the seedlings are transplanted into the paddy field with the inserted seedlings for a period of time. The multiple pesticides in this granule are active and released slowly and continuously at their respective dissolution rates. Background Art In recent years, large-scale production and mechanization of paddy fields have been rapidly promoted with a view to achieving low cost by growing rice. Correspondingly, technological innovations in pesticide application methods have been continuously developed, and various convenient and efficient preparations and application methods have been developed. As an example, significant progress has been made in the development of a seedling box treatment method in which a pesticide composition is applied to a rice seedling box before transplanting. The biggest advantage of this rice cultivation nursery box treatment method is that pesticides can be applied to the seedlings at the same time as transplanting. In addition, after the pesticide is transplanted into the paddy field with the seedlings, due to the slow release of the pesticide active ingredients contained in the pesticide formulation used, the purpose of controlling pests and diseases can be achieved for a long time after transplanting the seedlings. Because of this advantage, the nursery box treatment method is an ideal convenient and efficient application method for pesticides that must be applied during transplanting. On the other hand, in recent years, compared with preparations containing only one pesticide active ingredient, by combining two or more pesticide active ingredients, such as pesticides and fungicides, pesticide preparations that can simultaneously control pests and diseases for one treatment are people. Pursued. In short, two or more pesticide active ingredients showing slow action are slowly released. 3 (Please read the precautions on the back before filling this page) Table

Order ----; ----- line 丨 I Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs This paper is printed in accordance with China National Standard (CNS) A4 (210 X 297 mm) 1239807 A7 B7 Intellectual Property of the Ministry of Economic Affairs Printed by the Bureau ’s Consumer Cooperatives V. Invention Description (; ►) Mixed preparations, specifically, during the rice cultivation period, between 30 days and 60 days that must be controlled by pests or diseases, or longer than 60 days depending on the situation In China, a mixed preparation capable of continuously releasing active ingredients of pesticides is sought after. As an example of such slow release of two or more pesticide active ingredients, Japanese Patent Application Laid-Open No. 2000-44404 discloses a mixed preparation having a structure in which core particles containing the pesticide active ingredient necessary for slow release are made After coating particles on the surface of the resin-coated particles are formed, an outer layer portion containing another pesticide active ingredient is further provided on the outside of the resin-coated particles. The important characteristics of the structure of the mixed preparation described here are: 1. Its structure must be coated with the surface of the core particles by resin; 2. The outer layer portion does not need to be made into a slow release type; 3. The core particles and the outer layer portion are each separate The difference in water solubility of the two main pesticide active ingredients is not a special consideration. Referring to Japanese Patent Application Laid-Open No. 2000-44404 for more details, regarding the effect of coating the core particles with a resin, Table 4 showing the results of Test Example 1 (dissolution test) is the same as that of Examples 2-4 and Comparative Example 2 When comparing the results of -4, it can be clearly seen that, in Example 2-4 in which the core particles were coated with resin, compared with Comparative Example 2-4 in which the core particles were not coated, the compounds contained in the core particles were suppressed. The dissolution of the resin film has a significant contribution to the slow release of the pesticide active ingredient contained in the core particles (controlling the dissolution). However, after preparing the core particles, a step of coating the surface with a resin is additionally provided. Of course, the number of steps for manufacturing the granules is increased, and the operation cost is also increased. In addition, regarding the point that it is not necessary to slowly release the outer layer portion, in Test Example 1 (dissolution test), Examples 1 to 3 whose dissolution characteristics were verified were formed by using an unstructured solid carrier to form the outer layer portion, especially due to the facts shown Is it slow-releasing? 4 This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm). F Please read the note on the back first? Matters refill this page > >

Man · I n —ϋ 1 i · — l n Γ, · i n n mmaMm n ϋ Bmmmmm I · Speech 1 1239807 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. There is room for μ in the tomb construction. However, Table 4 shows the results of the slow dissolution of encore of the pesticide active ingredient contained in the outer layer portion in water. This slow dissolution, the water solubility of Encore at 20 ° C is 80ppm. Since Encore is a relatively difficult water-soluble compound, it can be understood that this reflects that its dissolution rate is also very high in the standing state. low. In addition, the test time is shorter than that of the same day. It can be inferred that within this period of time, only the inorganic solid carrier forming layer constituting the outer layer portion is broken, and it is possible to suppress the same without the need for slow release treatment. Contact with aqueous media. Regarding the two kinds of pesticide active ingredients contained in the inner particle and the outer layer part, in Japanese Patent Application Laid-Open No. 2000-44404, there is no special consideration for the water solubility of the pesticide active ingredient used. As for the difference in water solubility between the two, Not considered at all. By the way, for the mixed preparations shown in these examples, the water solubility of Encore contained in the outer layer portion was 80 ppm as described above, and the thiabendazole contained in the core particles was at 20 ° C. Water solubility is 150ppm, the difference is only 70ppm, there is no big difference. In addition, as shown in Japanese Patent Application Laid-Open No. 2000-26206, waxes for slow release of agriculturally active ingredients having high water solubility have been known to the public. However, using a slow-release method using a hydrophobic substance such as wax, for two or more pesticide active ingredients, especially two pesticide active ingredients that have a great difference in water solubility, when the same wax is used for sustained release During chemical conversion, if the wax with the best release rate for one pesticide active ingredient is selected, the release rate for the other pesticide active ingredient is extremely fast, or the opposite is extremely slow. The speed of release is difficult. That is, it is limited to the present inventor's knowledge, and as a method of including two or more pesticide active ingredients having greatly different water solubility in one grain of 5 ′ paper, the Chinese National Standard (CNS) A4 specification (210 X 297 mm) is applicable. J1 * —il · I -------------- ^^ ------ ^ (Please read the precautions on the back before filling out this page) Employees ’Cooperatives, Intellectual Property Bureau, Ministry of Economic Affairs Printing 1239807 A7 -__ B7 V. Description of the Invention (Policy) In the granule formulation, the pesticide formulation which releases more than two kinds of pesticide active ingredients at the same time is still unknown. In addition, no examples of sustained release of two or more waxes for each of the agricultural active ingredients have been reported. As mentioned above, for a technical solution that contains at least two pesticide active ingredients and at least one of the pesticide active ingredients slows down the release of a pesticide formulation, in a pesticide formulation containing at least two pesticide active ingredients with greatly different water solubility If both can be slow-released at the same time so that they can be released at different dissolution rates to make, for example, pesticide granules suitable for use in rice seedling box treatment methods, so far no one that meets this requirement has been seen. New dosage form program. SUMMARY OF THE INVENTION The object of the present invention is to solve the above problems, and to provide a new type of slow-release pesticide granules used in a rice seedling box treatment method desired by people, and an efficient manufacturing method thereof. In the case of containing two or more different pesticide active ingredients having greatly different water solubility, each of the pesticide active ingredients having such a large difference in water solubility is released at a respective desired dissolution rate and At the same time, slow release is achieved. The inventors of the present invention conducted in-depth research on the problems to be solved, and thought that when two or more kinds of pesticide active ingredients with great differences in water solubility were sustained-released, they could be prepared by the following methods: Granules with a double-layer structure, that is, a pesticide active ingredient with high water solubility is dispersed in a wax binder to be formed into a granule and used as a core. On the other hand, a pesticide active ingredient with low water solubility is kerneled year-on-year. Another wax with a lower melting point is mixed with another wax and then coated on the surface of the inner core to form an outer layer portion. By adopting this structure, the inventor of the present invention can see that the paper size of the inner grains 6 is in accordance with the Chinese National Standard (CNS) A4 specification (210 > < 297 mm) — hit U ----- --------- ^ --- Ϊ ------ ^ 0 (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 A7 _ B7 5 (Invention) Both the pesticide active ingredient in the solubility board and the pesticide active ingredient with low water solubility in the outer layer have been slow-released. The pesticide granules of the present invention are more specifically produced as described below. First, at least one or more water-soluble pesticide active ingredients, an inorganic dilution carrier, and a first water-insoluble thermoplastic material used as a rhenium component are heated, mixed, and granulated to produce a uniformly dispersed component. Kernel pellets. Then, at least one or more pesticide active ingredients having a low water solubility, an inorganic dilution carrier, and a second thermoplastic material that has a lower melting point than the first thermoplastic material and is difficult to dissolve in the water are lowered below the melting point of the first thermoplastic material. The mixture is heated under heating and mixed to obtain a uniformly dispersed mixture of the components. The mixture is coated on the surface of the granulated material as the core, and the granule having the two-layer structure of the present invention is prepared after cooling. The research by the inventors of the present invention has confirmed that in the granules of the present invention, by adopting the double-layer structure prepared as above, the pesticide active ingredient contained in the core, regardless of its high water solubility, is due to the effect of the first thermoplastic material It achieves a sufficient sustained release, and the additional pesticide active ingredient contained in the outer layer part, coupled with the pesticide active ingredient itself, is hardly soluble in water. Due to the action of the second thermoplastic material, it fully realizes sustained release. As a result, in Two or more kinds of pesticide active ingredients with different water solubility in one granule can realize sustained release respectively. Through these studies, the inventor of the present invention explored the knowledge obtained by himself and completed the present invention. That is, the slow-release pesticide granules of the present invention are sustained-release pesticide granules used to continuously dissolve the active ingredients of pesticides and supply them to an aqueous medium. The granules have an inner layer and an outer layer covering the inner surface of the inner core. Of the coated granules (please read the precautions on the back before filling this page)

This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1239807 A7 B7 V. Description of the invention (k) structure, the core is made of at least 20⑻ppm and less than 10% water solubility at 20 ° C A pesticide active ingredient, an inorganic-based diluent carrier, a granulated product composed of a first thermoplastic material that is hardly soluble in water, and the outer layer part is at least one pesticide active ingredient having a water solubility of 20 ° C from 0.01 to 500 ppm. A coating layer composed of a diluent carrier and a second thermoplastic material that is lower in melting point than the first thermoplastic material contained in the core and is a different material and hardly soluble in water. Both the pesticide active ingredient contained in the inner core and the pesticide active ingredient contained in the outer layer portion can be slowly released in a controlled manner. In the sustained-release pesticide granule of the present invention, the outer layer portion may further contain a surfactant. In addition, for example, it is also possible to make the following structure: g 卩: The first water-insoluble first thermoplastic material contained in the inner core is a nonacosanoic acid wax and / or a nonacosanoic acid ester wax. On the other hand, it is preferable to have a structure in which the above-mentioned second water-insoluble thermoplastic material contained in the outer layer portion is paraffin. In the case of the sustained-release pesticide granules of the present invention, for example, the pesticide active ingredient contained in the inner core may be (RS) --1-methyl-2-nitro-3- (tetrahydro- 3-- Furylmethyl) guanidine, the active ingredient of the pesticide contained in the outer layer can be selected from thiabendazole. The method for producing a sustained-release pesticide granule of the present invention is a method for producing a sustained-release pesticide granule having the above-mentioned structure. For the granulated material as the inner core, when the coating layer as the outer layer portion is formed on the surface of the inner core, the second thermoplastic material constituting the coated layer is heated and melted, in order to achieve coating on the surface of the granulated material. The heating temperature should be lower than the melting point of the first thermoplastic material contained in the core. In addition, in the double-layer structure of the sustained-release pesticide granules of the present invention, the inner core 8 (please read the precautions on the back before filling this page) Order —— * ------ Line · Ministry of Economic Affairs Printed on the paper by the Intellectual Property Bureau employee consumer cooperatives. The paper size applies to the Chinese National Standard (CNS) A4 (210 X 297 mm). Printed by the Intellectual Property Bureau Employee Consumer Cooperatives of the Ministry of Economic Affairs. 1239807 A7 __ B7 V. Description of the invention (ί) The part used as the pesticide core for the inner center of the granule, and the term "outer part" is used to refer to the surface of the granule, covering the outer periphery of the inner core. BEST MODE FOR CARRYING OUT THE INVENTION The slow-release pesticide granules of the present invention will be described in more detail below. For the slow-release pesticide granules of the present invention, for example, in the granules for a nursery box used in the treatment of rice nursery boxes, a mixed preparation containing at least two pesticide active ingredients in one granule is prepared. Is a dosage form that works well. In other words, after being applied as a granule for a nursery box, it slowly dissolves at different times and maintains the desired concentration. When these two or more kinds are required, their effects are different from each other. In the case of ingredients, by using the sustained-release pesticide granules of the present invention having a double-layered structure, a pesticide active ingredient can be continuously released from the outer layer part in a certain period of time, and another core part can be continuously released for a longer period of time. Pesticide active ingredients. Therefore, the so-called dissolution control achieved by the slow-release pesticide granules of the present invention means that different kinds of pesticide active ingredients contained in the outer layer portion and the inner core are simultaneously and slowly dissolved. In the slow-release pesticide granules of the present invention, a double-layer structure composed of a core and an outer layer portion is used, so that two or more kinds of pesticide active ingredients having greatly different water solubility are contained in the double-layer structure. The inner core contains a highly water-soluble pesticide active ingredient, and the outer layer contains a low water-solubility pesticide active ingredient. The water-solubility of the pesticide active ingredient is reduced to distinguish its position in the entire granule. Specifically, the pesticide active ingredient contained in the inner core is selected to have a water solubility of 20 ° C above 10 ppm and 10% or less. Conversely, the pesticide active ingredient contained in the outer layer is limited to a water solubility limit of 20 ° C. For 9 paper sizes, the Chinese National Standard (CNS) A4 specification (210 X 297 mm) is applied — »ΙΜ ·-« J —u IIIII-— — I! — — — 1 — — — — — — — (Please (Read the precautions on the back before filling this page) 1239807 V. Description of the invention (exhaustive) 〇 · 01-500ppm, a combination with a significant difference in water solubility between the two is made. At this time, in order to control the rate of dissolution and release of the pesticide active ingredient with a very high water solubility contained in the inner core, and to make it have sufficient sustained release properties, it is made into a form dispersed in a concrete adhesive, as the Wax for adhesives, | use the first thermoplastic material that is hardly soluble in water. As a result of making this first water-insoluble thermoplastic material into a binder, contact between the pesticide active ingredient and the aqueous medium is suppressed. In addition, its outer layer is also made of another second thermoplastic material that is hardly soluble in water, as a coating layer using the mole-like compound as a bonding agent. As a result, the pesticide activity contained in the inner core is further increased. Slow release of ingredients. On the other hand, the low-water-soluble pesticide active ingredient contained in the outer layer is dispersed in the wax adhesive using the second water-insoluble second thermoplastic material and combined with its low water-solubility, which can be controlled. Its dissolution release rate achieves the required sustained release. In this way, in the sustained-release pesticide granules of the present invention, regarding the contained multiple kinds of pesticide active ingredients, the positions of them in the double-layer structure composed of the inner core and the outer layer portion are selected according to the difference in water solubility, plus The role of its water solubility, the type of wax used is selected differently so that the optimal wax binder can achieve the required sustained release. At this time, the release rate is due to the particle diameter (surface area

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The ratio of system and volume) is closely related. The required particle diameter of the inner core and the diameter of the entire particle covering the outer layer portion are brought to a certain value. The inorganic dilution carriers added to the respective active ingredients of pesticides make The pesticide active ingredient and the inorganic-based diluted carrier are dispersed in a wax binder made of a thermoplastic material in a uniformly mixed manner, and the content of the pesticide active ingredient per unit volume is adjusted to an appropriate range. 10 This paper size applies Chinese National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 A7 B7 V. Description of the invention (minutes) As mentioned above, the slow-release properties of the present invention Pesticide granules have a double-layer structure composed of a core and an outer layer. As a manufacturing method suitable for this structure, different thermoplastic materials are used as wax binders, and the shapes are clearly divided into core and outer layers. In order to easily produce such a structure, a first thermoplastic material is used as the core, and after heating and mixing, it is formulated into a granulate having a desired particle diameter, and the coating composition as an outer layer portion is coated on the granule. The surface of the object is coated with the granulated object after the second thermoplastic material is melted into a liquid state when heated. Specifically, in the step of covering the outer layer portion, when the first layer is placed in a heating environment, in order to avoid remelting the first thermoplastic material that maintains the shape of the pellets as the inner core, the second used in the outer layer portion The melting point of the thermoplastic material should be selected to be lower than the melting point of the first thermoplastic material. Therefore, the heating conditions of the step of forming the outer layer portion should be selected at a temperature not exceeding the melting point of the first thermoplastic material so as to be above the melting point of the second thermoplastic material without causing the above-mentioned first thermoplastic material to melt. In this way, in the sustained-release pesticide granules of the present invention, as a result of the sustained-release treatment using different thermoplastic materials in the inner core and the outer layer portion, for example, when it is necessary to control mutually different diseases and insect pests, When two or more kinds of pesticide active ingredients which have a controlling effect on diseases and pests can be ensured to be continuously released respectively, the functional effects of these two or more kinds of pesticide active ingredients. Hereinafter, the method for producing the sustained-release pesticide granules of the present invention will be described more specifically. First, in order to slow the release of a pesticide active ingredient with a water solubility of 20 ° C from 1 (X) Oppm to 10%, the pesticide active ingredient, an inorganic dilution carrier, and a first thermoplastic which is hardly soluble in water are used. The material is heated to a temperature above the melting point of the first thermoplastic material, and the above uniformly mixed composition is formed into 11 papers. The size of the paper is applicable to China National Standard (CNS) A4 (210 X 297 mm) I U4 LI n 1 ϋ I n ϋ n —.1 -------- Order --- ^ ------ line (Please read the notes on the back before filling this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 A7 B7 Fifth, the invention course (v) required; the shape of ^, the diameter of the particles, after cooling to obtain the pellets for the core. Subsequently, the pesticide active ingredient having a water solubility of 0.01-500 ppm at 20 ° C, an inorganic-based diluted carrier, and a second thermoplastic material which is hardly soluble in water are uniformly mixed together, and the composition obtained by using the mixture is heated to the The second thermoplastic material is coated on the surface of the pellets for the inner core at a temperature higher than the melting point of the second thermoplastic material, so that granules having a double-layer structure composed of the inner core and an outer layer portion provided on the surface can be obtained. At this time, the melting point of the second thermoplastic material should be lower than the melting point of the first thermoplastic material. By selecting these materials in advance, the heating temperature during the coating of the outer layer portion can be a temperature that does not reach the melting point of the first thermoplastic material. . In addition, the so-called dissolution of the active ingredient of the inner core to a sustained release means that the first thermoplastic material that is hardly soluble in water is heated and melted to form a binder, so that the release of the active ingredient of the pesticide into water can be controlled. Pesticide formulation. In short, the sustained-release pesticide granules of the present invention can be specifically produced by the following steps. Step 1. First, a 20 ° C water-soluble pesticide active ingredient having a high water solubility in the range of 1000 ppm to 10% is used, an inorganic dilution carrier, and a first thermoplastic material are equipped with a heating device. Heating mixer (such as a floating mixer). At this time, the heating temperature should be above the melting point of the first thermoplastic material, and its temperature does not reach the melting point of the pesticide active ingredient contained therein. Step 2. After heating and mixing, the obtained homogeneous mixture is granulated with a granulation mechanism equipped with a heating device. The type of the granulator can be appropriately selected in consideration of the shape and particle diameter of the granulated product as the target product. Specifically, when a cylindrical shaped article is to be obtained, an extrusion type molding machine equipped with a screen matching the required particle size may be selected. When a spherical shaped article is to be obtained, a rotary granulator may be selected. Wait. Granulation temperature is up to 12 This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) (Please read the precautions on the back before filling this page) Order——: ------ Line- 1239807 A7 B7 5. Description of the invention (A) It is preferable that the melting point temperature of the first thermoplastic material used is higher than the melting point temperature of the contained pesticide active ingredient. In Step 3, the obtained granules often adhere to each other, and they must be crushed and sieved as required to obtain the slow-release granules (cores) of the required shape and particle diameter. Step 4, the same as the pesticide active ingredient with high water solubility contained in the core, the pesticide active ingredient with low water solubility in the range of 0.01-500ppm at 20 ° C, the inorganic dilution carrier, and The second thermoplastic material, which is different from the first thermoplastic material contained in the core and has a lower melting point than the first thermoplastic material, is difficult to dissolve in the second thermoplastic material, and if necessary, also has a surfactant and an auxiliary agent, such as a floating mixer Machine), etc., to obtain raw material powder for the outer layer portion. Step 5, adding the core prepared in Step 3 to a mixer equipped with a heating device (for example, a floating mixer, a rotary granulator, a Kura (々-5-) mixer, a drum mixer, Marumai Laza 5〗 (i) and so on), mix while heating, and quantitatively add the outer layer raw materials prepared in step 4 to cover the surface of the inner core to produce particles with the required particle size distribution. At this time, the heating temperature of the coated outer layer is set to the melting temperature of the contained second thermoplastic material, and the molten second thermoplastic material becomes a binder, so that the pesticide active ingredients with low water solubility and the inorganic dilution carrier are uniformly formed. The dispersed coating layer is used to prepare the coated sustained-release pesticide granules of the present invention. In addition, in this heating and coating step, in order to prevent the adhesion and adhesion between the cores due to the softening and melting of the first thermoplastic material in the core, and to prevent the cores from adhering to the inner wall of the mixing tank, crimping, etc. The heating temperature should be higher than the melting temperature of the second thermoplastic material used in the outer layer and the melting temperature of the first thermoplastic material used in the core. 13 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) ) (Please read the precautions on the back before filling out this page) Order —— ^ ------ Printed by the Consumers' Cooperatives of the Intellectual Property Bureau of the Ministry of Economics Printed by the Consumers ’Cooperatives of the Intellectual Property Bureau of the Ministry of Agriculture and Economy 1239807 A7 — B7 5. Description of the invention (\ >) The following. In the coated sustained-release pesticide granules of the present invention having the above-mentioned structural characteristics, the composition ratio of each composition constituting the outer layer portion and the inner core thereof is not particularly limited, and it may be considered that the active ingredients of each pesticide should be maintained according to the following circumstances The concentration range, for example, the effective concentration range to achieve the preventive effect, and the duration of the concentration should be maintained appropriately. G 卩. · The components of one or more pesticide active ingredients contained in the surface layer portion and the inner core, respectively. Dissolution rate, speed of energy dissipation and absorption in the corresponding plant body, and transplantation of plant seedlings to the field. At this time, in general, for each granule, the mass of at least one or more pesticide active ingredients contained in the outer layer portion and the inner core of each granule is separately calculated, and the calculated mass ratio can be controlled in the inner core: outer layer portion = 1 : 15-15: 1 range. In addition, the coated sustained-release pesticide granules of the present invention or a solid agent composed of an outer layer portion and a core are not limited in shape and dosage form, and may be, for example, ordinary granules, pills, or tablets. Wait for any shape. In addition, when selecting the above dosage form, its size can be appropriately selected according to the use form. For example, the diameter of a cylindrical or spherical shape can be in the range of 0.1 to 3 legs, which is not particularly limited. Specifically, in the coated sustained-release pesticide granules of the present invention, the particle size can be appropriately selected according to the application form. For example, when using granules for rice nursery boxes, it is best to adjust the particle size. Control the particle size and shape of the mesh of the sieve, select within the range of 0.3-3mm. In addition, the length of the cylinder is preferably selected within a range that is not too long according to its diameter. For example, when the diameter of the cylinder is within the range of 0.1 to 3 strokes, the length is preferably selected to be between 0.1 and 10. Within range. In addition, in the coated sustained-release pesticide granules of the present invention, for example, when the spherical shape is selected, the diameter ratio of the inner core and the outer layer portion is not particularly limited. Generally, 14 paper sizes are applicable to the Chinese National Standard (CNS ) A4 size (210 x 297 mm) — Ίν — 1—x -------------- ^ --- :: -------- (Please read the precautions on the back first Refill this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ^^ 1239807 A7 B7 V. Description of the invention (θ) can be selected within the range of 1: 3. In general, the dissolution of the contained pesticide active ingredients, the smaller the particle size of the granules, the larger the granule surface per unit content of the pesticide active ingredients, and the dissolution is accelerated accordingly. However, in the coating type of the present invention, In the release pesticide granules, the inner core and the outer layer are each made of different hardly water-soluble thermoplastic materials. Through independent control of slow release, the particle size and the diameter ratio of the inner core and the outer layer are limited to the above ranges. Can achieve the required dissolution characteristics. Specifically, both the inner core and the outer layer are each added with a pesticide active ingredient. By adopting a structure containing an inorganic dilution carrier, since the amount of the pesticide active ingredient per unit volume can be adjusted within a wide range, the The granule surface area per unit content of the pesticide active ingredient is controlled within a certain range. At this time, since the pesticide active ingredients are uniformly diluted with an inorganic-based dilution carrier in each of the inner core and outer layer portions, it is preferable to adopt a method in which each of the pesticide active ingredients and the inorganic-based dilution carrier are powdered together and uniformly mixed with each other. In the coated sustained-release pesticide granules of the present invention, among the different types of pesticide active ingredients contained in the inner core portion and the outer layer portion of the granular sustained-release pesticide granules, usually, the pesticide active ingredient that can be used for a plant body as an object, for example, rice At least one or more pesticide active ingredients with high water solubility in the range of 1000 ° C to 10% in water at 20 ° C and pesticide activity with low water solubility in the range of 0 · Olppm to 500ppm at 20 ° C At least one kind of ingredients, and it is preferable to use any kind of biocidal compound for agricultural and horticultural purposes. For example, among the above compounds having biocidal activity, it is best to select a combination of insecticide and fungicide, but the following combinations are not excluded from the optimal combination. Combination of insecticides or fungicides 15 (Please read the precautions on the back before filling out this page) · nnn ϋ nn ϋ 5rJ * I nnn ϋ 1 n I, this paper size applies Chinese National Standard (CNS ) A4 size (210 X 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 Λ7 B7 V. Invention description (\ Ao, etc., can also choose a combination of drugs that have differences during their effective control period. 01 质量 ％ —50 质量 ％ 范围 ， The content of these pesticide active ingredients in the coated sustained-release pesticide granules is not different according to whether the contained part is the core or the outer part. In each part, it is usually selected in the range of 0.01% by mass to 50% by mass. It is preferably within the range of 0.5 to 30% by mass, and is not particularly limited. That is, for each granule, the content of each pesticide active ingredient contained, according to the nature of the active ingredient, applicable field According to the decision, the application form is, for example, according to the application form as a granule for a nursery box, the amount to be applied per 1,000 square meters can be selected so that its content meets the necessary treatment amount per 1,000 square meters. In the coated sustained-release pesticide mixed granules of the present invention, in order to obtain mixed granules in which two or more pesticide active ingredients with particularly different water solubility are sustained-released, 20 ° of the pesticide active ingredients contained in the kernel The water solubility of C must be significantly higher than the water solubility of the pesticide active ingredient contained in the outer layer. In short, the water solubility of the pesticide active ingredient contained in the core at 20 ° C is at least 1,000 ppm to 10%. (Preferably 5000 ppm to 10%, particularly preferably lCK) 00 ppm to 10%, and on the other hand, the water solubility of the pesticide active ingredient contained in the outer layer at 20 ° C is selected to be at least 〇 · 〇 1-500ppm, preferably in the range of 1-300ppm, particularly preferably 0.5-200ppm, it is best to use this selection to make a very disparity in water solubility between the two. In addition, when the melting point of the pesticide active ingredient contained in the inner core is the same as or lower than the melting point of the first thermoplastic material used in the inner core, in the step of manufacturing the sustained-release pesticide granules of the present invention, the manufacturing system for the inner core is manufactured. In the case of particulate matter, when heated to melt the first thermoplastic material, the pesticide active ingredients mixed therein are also completely melted. 16 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) —, J ii 1- L -------------- ^ --- ^ ------ line (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 A7 B7 V. Description of the invention). In this case, there is a possibility that they cannot be uniformly mixed with each other in a liquid state, and even if they are uniformly mixed, there is a possibility that the pesticide active ingredient segregates and cannot be uniformly dispersed when it is solidified thereafter. In this case, in the inner core, the active ingredients of the pesticide cannot form a form uniformly dispersed in the wax binder of the first thermoplastic material together with the added inorganic-based diluent carrier, so that the desired sustained release cannot be achieved Such a major issue. In order to solve this problem, the flame content of the pesticide active ingredient contained in the core is higher than the melting point of the first thermoplastic material used, and it is best to use a melting point of 100 ° C. If selected in this way, the pesticide active ingredient contained in the inner core does not melt. In this way, it is heated to a temperature at which the first thermoplastic material softens and melts. For example, it is best to form a powdery pesticide active ingredient and an inorganic dilution carrier to form a uniform mixture. , Dispersed in the first thermoplastic material. Similarly, when the melting point of the pesticide active ingredient contained in the outer layer portion is the same as or lower than the melting point of the second thermoplastic material used in the outer layer portion, in the step of coating the outer layer portion on the surface of the inner core in order to melt the second When the thermoplastic material is heated, the pesticide active ingredient mixed therein is also completely melted. At this time, there is a problem that the same abnormality occurs. In order to prevent these problems in advance, the melting point of the pesticide active ingredient contained in the outer layer should be at least higher than the melting point of the second thermoplastic material used. If possible, it is desirable that the first thermoplastic material has a higher melting point. The melting point is also high, it is best to use one with a melting point above 100 ° C. As the pesticide active ingredient that satisfies the above conditions, the following can be specifically exemplified. As the pesticide active ingredient contained in the core, for example, in the case of pesticides, the following can be exemplified. Melting point and water solubility at 20 ° C Have values in parentheses, respectively, insecticidal ring> evening 7 A) (125-128Γ, about 80%), Acetamipril (7 Seven Women S Bu,) (101-10-1 3 · 3 ° C · 42.0 ppm), Kiamato clone 17 — Jhlt ----------- ^ ------ ^ (Please read the precautions on the back before filling this page) The standard is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm). Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 1239807 A7 __B7 V. Description of the invention) / Bu Jin 廿 Λ) (139 · rC, 4100ppm), or The compound (KS) shown in Japanese Patent Application Laid-Open No. 7-178448 (1-methyl-2-nitro-3- (tetrahydro-3-pyranylmethyl) guanidine (about 105 ° C, 54 (X ) 0ppm). Examples of fungicides include pilocon (112 ° C, 4000ppm, blastin S (235 ° C, 3%), etc.) On the other hand, as the active ingredient of the pesticide stream contained in the outer layer, for example, Kill insects Examples include the following, melting point and solubility in water at 20 ° C with the value .NAC (142 ° C, about lOOppm) shown in brackets, and with Karup > Xi, < Less talented ^), (124 · 6-128 · 7 ° C, 40ppm); Kuloch Anijin (Xikou ^ 7 Erxue >), (176-178 ° C, 270ppm), leather Metoprolin (dagger. J bu α >), (234.4 ° C, 270 ppm) Fipronil (7 4 7. Mouth and mouth) (approximately 200 ° C, 1.9 ppm), Bupron Philippine (7, 7, 7. Port 7 y, y, >) (approximately i0 ° C, 0.9 ppm), Tebuferroquito (at 乂 >) (191 ° C, 0.83 ppm) In addition, as the bactericide, Fumeishuang (155 ° C, 30ppm), isocarbazone (136 ° C, 13ppm), Wang Jiaduo (102 ° C, 9.6ppm), Chifuzamido , $ K) (approximately 178 ° C, 1.59 ppm), Caruplopamide (Likou ~ Sb,) (147-149 ° C, 3.6 ppm), azostoropine oxide ( r, / now i 7 π π, >) (approximately 118 ° C, 10 ppm), Probezina Zulu (Wenkou ~ Yu, / a; 0 (approximately 138 ° C, 150 ppm), Kikulo Hemetor σ y) (approximately 150. (:, 5 mouth? 111), naphthalene tetraketonic acid (now today: ^ "di 7 acetic acid) (310. 0, 3.2 mouth 111), Tekulov Talam (7 Mouth and 3 A) (198 ° C, 14 ppm), Philly Zong a, / >) (175 ° C, 162 ppm), Kikulomakin (^ 々π J) (250-253 · 5 ° C, 0.74 ppm), Clotridone (178 ° C, (3 · 3 ppm), in which the pesticide (RS) — 1 —methyl — 2 —nitro — 3 — (tetrahydro — 3 —furylmethyl) guanidine is used as a core, and the fungicide is used The combination of Thicarbin for the outer layer is made from the sustained-release pesticide granules of the present invention to produce 18 paper sizes. The paper size applies the Chinese National Standard (CNS) A4 (210 X 297 mm) — „J h I, ----------- ^ ----- 1 (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economy 1239807 A7 __ B7 V. Description of the invention. 〇) One of the best combinations when used in seed box granules. Among the first thermoplastic materials for the core used in the slow-release pesticide powder of the present invention, it is best to use water with a solubility of less than 0.5% at 20 ° C. Organic matter that is insoluble or hardly soluble in water at room temperature and has a melting point of 70 ° C-110 ° C, preferably 72 ° C-W0 ° C, particularly preferably 74 ° C-98 ° C Within the range. For example, candelilla wax, the main plus original (i Erli, ^ &);) wax, Russ (57) wax, other plant-based waxes, nonacosanoic acid wax, ceresin wax, white ground hunting and other mineral waxes microcrystalline wax wax esters to get a feeling of petroleum-based wax, Fuchsal- Tropsch wax and other synthetic hydrocarbons, derivatives of icosanoic acid waxes, paraffin derivatives, microcrystalline wax derivatives, modified waxes, hardened sesame oil, hardened sesame oil derivatives, hydrogenated waxes, 12 -Hydroxystearic acid, amine stearate, imine phthalic anhydride, and fatty acids having chlorinated hydrocarbon groups, amidines, esters, ketones, and the like. Among them, the acid value determined by titration with an alkali according to the test method specified in the ASTM D1386 standard is preferably 10 mgkoH / g or more. For example, the main addition of the original p Erli, wax (melting point: 75 Ό, acid value: about 21mgkOH / g) or docosanoic acid wax (manufactured by BASF, trade name Luwax S, melting point: 75-85 °) C, acid value: 135-160mgkoH / g) icosanoic acid ester (made by BASF company, trade name LuwaxE, melting point: 75-85 ° C, acid value ·· 10-25mgkoH / g), etc. can be paid Sustained release, and can make the pesticide solvent components contained in the kernel release nearly 100%, especially suitable. These waxes may be used alone or as a mixture of two or more of them as a thermoplastic material. The total amount of the first thermoplastic material used is relative to the total amount of the composition constituting the inner core of the slow-release pesticide granules of the present invention. The mass is usually selected from 5 mass% or more and preferably 10 mass% or more. The amount of the pesticide active ingredient to be added, the nature of the inorganic diluent carrier and the amount thereof may be appropriately determined. It is best to look at it from an economic point of view. The 19 degree of the first thermoplastic material is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm ^ — .JV ^ I 1-L ---------- --- ^ ---: ------ ^ (Please read the notes on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 A7 _____ B7 V. Description of Invention (\?) The upper limit of the amount of addition can be selected to be 20% by mass. The inorganic-based diluent carrier for the core used in the sustained-release pesticide granules of the present invention is at least limited to show little water solubility and is not particularly limited. For example, examples include Clay, quartz, diatomaceous earth, calcium carbonate, pumice, bentonite, vermiculite, perlite, green palygorskite and non-aqueous hydrous silicic acid, commonly known as white carbon black, etc., usually one or more of them are used in pesticide powder or The so-called bulking agents or carriers used in the granules are used in combination. In addition, in the sustained-release pesticide granules of the present invention, in addition to the above-mentioned inorganic diluent carrier in the core, the objects and effects of the present invention are not impaired. Within the range, it can also be made into powders and added with antioxidant UV absorption Various additives such as antistatic interference agents. For example, as the antioxidant, syndado (t > Xi'K) phenol-based antioxidant, sulfur-based antioxidant, phosphorus-based antioxidant, ammonia-based antioxidant, internal Ester-based antioxidants, vitamin E-based antioxidants, etc. Examples of the ultraviolet absorber include inorganic compound-based ultraviolet absorbers such as cobalt dioxide, benzotriazole or benzophenone, triazine benzoate, and water-based Organic compounds such as acid esters are UV absorbers, etc. At this time, these antioxidants or UV absorbers can be selected based on the physicochemical properties of the active ingredient of the pesticide contained in the core, or an amount can be added to confirm the effect. Examples of the antistatic interference agent include cobalt oxide, zinc oxide, manganese oxide, etc., inorganic compounds, calcium phosphate-based compounds, etc. In addition, phosphate-based surfactants such as polyoxyethylene alkyl ether phosphate can also be used as antistatic interference. In addition, the antistatic interference agent can be used as needed, and the amount used is within a range that does not impair the object and effect of the present invention. An amount capable of confirming the antistatic effect may be used. On the other hand, in the sustained-release pesticide granules of the present invention, it is difficult to be used as the outer layer. This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297). ） Ni 丨 -------------- Order --- ^ ------ line (please read the precautions on the back before filling this page) A7 1239807 V. Description of the invention ( A) The d-th thermoplastic material that is soluble in water is substantially the same as the thermoplastic material used in the core. It can also be used in combination of two or more. Its melting point is compared with the first thermoplastic material contained in the core. Must be lower, the melting point of the specific second thermoplastic material is best selected within the following range, usually 40 C-70 C, preferably 50 ° C-69 ° C, especially 60 ° C-68 ° C. There is a second thermoplastic material. In the coating step, since it is melted to form an adhesive, if the melt viscosity is low, there is less adhesion between particles during coating, which is suitable. As suitable specific examples of the second thermoplastic material satisfying the above-mentioned various conditions, botanical waxes such as candelilla wax and Japanese wax, beeswax, laurel, whale wax, animal waxes such as tallow, petroleum oils such as paraffin, petrolatum, and the like are listed. Fully hydrocarbon-forming waxes such as system waxes, Fuchscher-Tropsch waxes, and modified waxes such as paraffin derivatives. Among them, paraffin wax (made by Nippon Seiki Wax Co., Ltd., trade name: paraffin 140, melting point: 61 ° C, or trade name · SP-0145, melting point: 63 ° C, stone snail 150, melting point 66 ° C) and more it is good. The amount used is determined by the amount of the pesticide active ingredient contained in the outer layer portion and the nature of the inorganic diluent carrier. However, in the sustained-release pesticide granules of the present invention, the total mass of the composition of the outer layer portion can be in the following range Internal selection, that is, usually 1% to 20% by mass, preferably 1% to 15% by mass, and the content of the second thermoplastic material needs to be set below the total oil absorption of the outer layer composition. The inorganic diluent carrier for the outer layer portion used in the sustained-release pesticide granule of the present invention is at least limited to show no water solubility and is not particularly limited. The use of substantially the same material as the aforementioned inorganic diluent carrier for the inner core can sufficiently achieve the purpose. Therefore, for example, clay, quartz, talc, bentonite, calcium carbonate, pumice, diatomaceous earth, vermiculite, perlite, green palygorskite and non-quality hydrous silicic acid, commonly known as silica, etc. Or one or more of the same as 21 to re-size / f CNS A4 specifications (210x 297 public) " ": — .J. V Ί- -------- ^ --- \ ------ ^ (Please read the notes on the back before filling this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs A7 1239807 V. Description of the invention (> °) in pesticide powder or granules The so-called bulking agents or carriers are used in combination. Further, in the sustained-release pesticide granules of the present invention, in addition to the inorganic-based diluent carrier, the surface layer may further contain a surfactant and a supplementary agent within a range that does not impair the object and effect of the present invention. Among the sustained-release pesticide granules of the present invention, examples of the surface active agent that can be added to the outer layer include nonionic surface active agents, anionic surface active agents, and cationic surface active agents commonly used in pesticide formulations. And amphoteric surfactants, such as alkyl ethers, polyoxyethylene alkylaryl ethers, polyoxyethylene phenadienyl phenyl ethers, polyoxyethylene alkyl esters, polyoxyethylene sorbitan aryl alkyl Compounds, polyoxyethylene phenyl ether polymers, polyoxydiene alkylene phenyl aryl ethers, polyoxyethylene alkylene glycols, polyoxyethylene polyoxypropylene block copolymers and other nonionic interface activities Agent, lignosulfonate, alkylarylsulfonate, dialkylsulfosuccinate, polyoxyethylene alkylaryl ether sulfate, naphthalene alkylsulfonate, polyoxyethylene styrylphenyl sulfate Anionic surfactants such as salts, cationic surfactants such as alkylamine salts, quaternary ammonium salts, alkylbetaines, and amine oxides, and amphoteric surfactants. When these surfactants are added, one kind may be used, or the same kind or different kinds may be used in combination. In addition to the surfactant, examples of the auxiliary agent that can be added to the outer layer include solid organic acids such as aromatic aromatic acids, polycarboxylic acids, sugar derivative carboxylic acids, and water-soluble polymers. Specific examples of the organic acid include dibasic acids such as oxalic acid, malonic acid, succinic acid, maleic acid, and fumaric acid, or sugar-derived types such as malic acid, tartaric acid, and other hydroxyl-substituted dibasic acids, ascorbic acid, and citric acid. carboxylic acid. Examples of water-soluble polymers include polyvinyl alcohol, carboxymethyl cellulose, dextrin hydroxyethyl cellulose, methyl cellulose, alginate, gelatin, pectin, and pullulan paper. China National Standard (CNS) A4 Specification (210 X 297 mm) — • " 7 * ------------------- Order --- · ----- -Line (Please read the precautions on the back before filling out this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs Printed by the Consumer Cooperatives of the Ministry of Economic Affairs and Intellectual Property Bureau printed 1239807 A7 ________________ B7 V. Description of the Invention (> \) Polyethylene Pyrrolidone, polypropionate, polyethylene oxide, etc. The total amount of the surface active agent and these supplements relative to the total mass of the outer layer composition is preferably kept in the following range, which is generally 0.01 mass% to 20 mass%, and preferably 0.01 mass to 10 mass%. . The slow-release pesticide adhesive of the present invention having the structure described above can realize slow-release, so that two or more different pesticide active ingredients that can greatly differ in water solubility have their respective dissolution rates. Release, can be used as pesticide granules especially suitable for rice seedling box granules. By using the slow-release pesticide granules of the present invention, granules for rice nursery boxes can be obtained. Among the 30-60 days that must be prevented from pests and diseases during the rice cultivation period from rice transplanting, depending on the situation, it is also longer than 60 days. The pesticide active ingredient is continuously released over time and can be released substantially completely. In addition, the slow-release pesticide granules of the present invention can reduce the manufacturing cost because the drying process necessary for the method described in JP-A-2000-44404 can be omitted. For example, when the slow-release pesticide granules of the present invention are used as granules for a rice seedling nursery, they can be put into the rice seedling nursery before transplanting. In addition, when used as a granule for a nursery box, its application amount is approximately 10g-100g per rice nursery box (approximately 30cmX60cm), generally 50 or so, which is not particularly limited. The content of pesticide active ingredients in the preparation is necessary. The period of preventing pests and diseases can be determined according to the number of nursery boxes used in every 10 ares. In addition, when the pesticide granules of the present invention are applied to a rice nursery box, for example, when the granules are evenly spread throughout the nursery box and then the seedlings are transplanted to the paddy field, the number of pesticide granules around each seedling is the largest. Don't make a big difference. For this purpose, the particle size of the granules, specifically the size of the sieve used to determine the particle size distribution, etc. should not be too large, so prevent the use of pesticide granules corresponding to a certain amount of use. Standard (CNS) A4 (210 X 297 mm) Μ ΜΙ »b— I Ji -ΊΙ n I n ϋ I ϋ · ϋ nn II n ϋ 一 ^ J« n I ml nn ϋ \ I \ (Please read first Note on the back, please fill out this page again) ^ ___ Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 Invention Description (> >) The number should not be too small. That is, as a user of rice seedling box granules, the number of agricultural granules per lg is 300 or more, preferably 400 or more, and the sieve mesh size is selected accordingly. However, due to differences in the content of the inorganic diluent carrier and its loose specific gravity, the particle size of the granules must not be too small, and it must be prevented from floating in water due to too small a particle size. Adding a surface active agent to the outer layer to increase the affinity to the surface of the water can prevent some of the above-mentioned abnormal conditions. In this way, the number of pesticide granules per lg is expected to remain within the range of no more than 2000. DETAILED DESCRIPTION i The present invention will be described in further detail through the following examples. In particular, the slow-release pesticide granules of the present invention are used as specific examples of rice seedling box granules. However, the present invention is not limited by the method for producing such a seedling box granules and the obtained formulation. For example, (KS) -1-methyl-2-nitro-3- (tetrahydro-3-furanylmethyl) guanidine used as a core pesticide active ingredient is used as a pesticide active ingredient in the outer layer The thiabendazole can be replaced by the above-mentioned various pesticide active ingredients, or each of the thermoplastic materials used in the inner and outer parts shown in the examples, and the inorganic dilution carrier can also be replaced by other materials mentioned above. The slow-release pesticide granules of the invention can be used to prepare granules for rice nursery boxes. It should be noted that the composition ratios shown in the following specific examples are all yield% ratios except for those specified. In Reference Example 1-6, the cores of Reference Example 1-6 were obtained at the composition ratios shown in Table 1 by the production method described below. 24 IJ >-Ίν -------------- Order --- ^ ------ line (Please read the precautions on the back before filling this page) This paper size is applicable China National Standard (CNS) A4 specification (210 X 297 mm) A7 1239807 B7 V. Description of the invention (y >) [Table 1] Composition of the granulated substance (core) (quality 邰) Manufacturing conditions Luwax Luwax white Carbon talc heating mesh 1 SE J > Calcium temperature dimension reference example 1 3 · 0 18.0 5.0 10.0 64.0 90 ° C 0.8 mm reference example 2 3.0 18.0 3.8 10.0 65. 3 83 ° C 0.8 mm reference example 3 3.0 3.6 14.4 5.0 10.0 64 · 〇83 ° C 0.8 mm Reference Example 4 5.0 18.0 5.0 10.0 62. 0 90 ° C 0.7 mm Reference Example 5 5.0 18.0 3.8 10.0 63 · 3 83 ° C 0.7 mm Reference Example 6 5.0 3.6 14.4 5.0 10.0 62. 0 83 ° C 0.7 mm J—ί double ------- — order --- ^ ------ line (please read the precautions on the back before filling this page) Bureau of Intellectual Property, Ministry of Economic Affairs Printed by an employee consumer cooperative as a pesticide active ingredient contained in the kernel. (KS) -l-methyl-2-nitro-3- (synthesized according to the method described in Japanese Patent Application Laid-Open No. 7-178448 Hydrogenated 3-furanylmethyl) guanidine (hereinafter abbreviated as: Compound 1). As the inorganic diluent carrier, white carbon black, talc, and calcium carbonate were used. As the first thermoplastic material, nonacosanoic acid wax (manufactured by BASF Corporation) was used. , Trade name Luwax S, melting point: 75-85 ° C, acid value: 135-160 mgkoH / g) and / or icosanoic acid ester wax (manufactured by BASF, trade name LuwaxE, melting point 75-85 ° C, acid value: 10-25mgkoH / g), the paper size of the above materials shall be in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm). Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. 1239807 A7 _____ B7 V. Description of the invention (Put together into a floating mixer equipped with a heating device, heat to 83 ° C-90 ° C and mix and use the mixture. Horizontal extrusion granulator (mesh size) maintained by the heating device at 90 ° C. (0.7 mm or 0.8 mm sieve)), extruded and granulated, the composition shown in Table 丨 and the granules obtained under the manufacturing conditions are pulverized and sieved according to the preparation of Reference Example 1-6. Particulate matter (nucleus) Experimental example 1: Dissolution experiment of kernel. The following method was used to measure the dissolution rate of the pesticide active ingredient (chemical 1) released from the kernel prepared in Reference Examples 1-6 ^ That is, the kernel obtained in Reference Examples 1-6 was placed in a 25 degree approved 3 degree container In a test tube with a sealing plug with a melting capacity of 50 ml of hard water, when all the pesticide active ingredients are fully dissolved, the amount that can be released corresponds to the amount that makes the concentration of pesticide active ingredients (compounds) reach 920 ppm, which is insoluble. The material was precipitated in water. In this state, after a certain amount of static time at 25 ° C, the whole amount was filtered, and the amount of the pesticide active ingredient (compound 1) dissolved in the filtrate was measured by HPCC. According to the measured value. The dissolution rate was calculated by the following formula, and the results are summarized in Table 2. Dissolution rate = (amount of pesticide active ingredient in the filtrate / pesticide active ingredient in the granules) X 100. As shown in Table 2, in the sustained-release pesticide granules of the present invention, the granules (cores) of Reference Examples 1-6 equivalent to the cores may be in the range of one week to two months at any time. Both release the contained pesticide active ingredient (Compound 1) slowly, and at the same time can be released substantially completely. 26 This paper size applies to China National Standard (CNS) A4 (210 X 297 public love) nn —1 1— ϋ nn I n ϋ · -Ϊ n 1.1 .1 II «III ϋ I n ϋ ϋ n II (please first Read the notes on the back and fill in this page again) 1239807 A7 V. Description of the invention (/) [Table 2] Dissolution rate of compound 1 released from the granules (inner core) Dissolution rate (%) of compound 1 7 days later, 14 days later ------- 30 days and 60 days later Reference Example 1 59.2 77. 7 98. 5 ιαι · 1 Reference Example 2 17.6 26.8 40. 1 53.2 72.6 97.7 Reference Example 3 31.8 44. 7 59. 2 75.6 95.4 100.2 Reference Example 4 51.6 75.0 97.6 100.2 Reference Example 5 20.6 32. 3 44 · 5 58.4 75.8 94.8 Reference Example 6 35.5 50.0 65.0 82 · 2 98.4 100.0 n -i ^ in J— «nn I n! I— 1— · Mu nn · 1 n (Please read the precautions on the back before filling in this page) Ordering Examples 1 -12 With the composition ratio shown in Table 3, on the pellets of Reference Example 1-6 as the core, The outer layer was coated by the method described below to prepare the granules for rice seedling boxes of Examples 1-12. [Table 3] Production line for rice seedling box granules of King Mgl 1-12 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Kernel (Quality Department) 67.5 (Reference Example 1) Primitive powder Crushed stone

24. sorp〇l-5〇5〇

This paper size applies to China National Standard (CNS) A4 (21 × 297 mm)

1239807 A7 B7 Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy V. S __ Example 2 67. 5 (Reference Example 2) 24.0 4. 5 4. 0 Example 3 67.5 (Reference Example 2) 24.0 4. 5 1. 0 3.0 Example 4 67. 5 (Reference Example 3) 24 · 0 4.5 4.0 Example 5 67.5 (Reference Example 3) 24.0 4.5 • 1.0 3.0 Example 6 40.0 (Reference Example 4) 24.0 7.0 29.0 Example 7 40.0 (Reference Example 5) 24.0 7.0 29.0 Example 8 40.0 (Reference Example 5) 24. 0 7.0 6.0 23.0 Example 9 40.0 (Reference Example 5) 24.0 7.0 1.0 23.0 Example 10 40.0 (Reference Example 6) 24.0 7.0 29.0 Example 11 40.0 (Reference Example 6) 24.0 7.0 6.0 23.0 Example 12 40.0 (Reference Example 6) 24.0 7.0 1.0 23.0 First, as a raw material powder for the outer layer portion, (7 ° Mouth: / 于 '/ A; u) the original body, as the clay of the inorganic dilution carrier, as the clay 28 (please read the precautions on the back before filling this page) This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1239807 Λ7 B7 V. Description of the invention (V?) Shizuo (Japanese refined wax) for thermoplastic materials Company name, trade name: paraffin 150 melting point 66 ° C, and dialkyl sulfosuccinate as surfactant (manufactured by Dongbang Chemical Industry Co., Ltd., S_RP0L-5050) as needed, or citric acid as a supplement Put them together in a floating or mixer to mix them. Next, put any of the granules (cores) prepared in Reference Examples 1-6 into a floating mixer equipped with a heating device and heat to 70 ° C. 0mm 的 的 粒 的 量 和 粒 ， 被 实施 例。 Preparation, mixing, quantitative addition of the previously prepared outer layer of raw material powder. Finally, coating, so as to obtain only the required particle size distribution, equivalent to a mesh size of 1.0-2. 0mm particle size and particles, to obtain an example Granules for rice seedling boxes of 1-12. In addition, the number of granules per lg of any of the granules available here is approximately 400. Comparative Example 1-2 Two pesticide active ingredients: compounds (kill Insecticide) and mouth X Yu, / a; (fungicide) are included in the preparation together, and in order to obtain the granules without a coating layer, a composition of 100 is shown in Table 4, and the same reference example 1- 6 (Kernel) Prepare the granules by the same method of granulation. The obtained granulated product is pulverized. After sieving, granules of Comparative Examples 1 and 2 were prepared. n -H ϋ J— i— nn--I n ·--I in 1-nf a t 1 II il I ϋ I (Please read the precautions on the back before filling out this page) Intellectual Property Bureau Staff Consumer Cooperatives Printed [Table 4] Composition of granules and manufacturing conditions of Comparative Examples 1 and 2 Granule composition (mass fraction) of Comparative Examples 1 and 2 Production conditions Compound 1 Thiabendia pulverized powder Luwax S Luwax E white carbon talc Calcium carbonate heating temperature mesh size 29 This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 1239807 A7 B7 tdk Comparative Example 1 2.0 24.0 18.0 3.8 10.0 42. 3 83 ° C 0. 8mm t Comparative Example 2 2.0 24.0 3.6 14.4 5.0 10.0 41.0 83 ° C 0. 8mm Comparative Example 3-5 'As shown in Table 5, two pesticide active ingredients: Compound 1 (insecticide Agent) and π 夂 '/ a> (fungicide) were mixed together, and granulated material (inner core) was obtained by the same granulation method as in Reference Examples 1-6. Thereafter, in the same procedure as in Example 1-12, the raw material powder of the outer layer portion containing no pesticide active ingredient was completely coated to obtain granules of Comparative Example 3-5. IM -h I π Ί .-------------- Order ---- 1 ------ line (Please read the precautions on the back before filling this page) [Table 5 ] Comparative Example 3-5 Granule composition Core composition (mass part) Production conditions Compound 1 Thiabendia pulverized powder Luwax S Luwax E white carbon talc calcium carbonate temperature temperature mesh size b dagger comparative example 3 2.0 24.0 12. 2 3.4 6.8 19. 1 90 ° C 0. 8mm 30 This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) A7

6.8 20. 83 ° C ---- ~ 90 ° C 〇 · Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economy π 1239807 Comparative example 4 2.0; -1—24.0 12.2 2.5 [: comparative example 2.0 24.0 7.2 2.0 Example 5 4. Composition of the raw material powder in the outer layer (mass fraction ^^ Paraffin clay ^ ---. Sorpoll, 5 050 Comparative example 3 4.5 27.0 1 · 0 Comparative example 4 4. 5 27.0 --- 1.0 Comparative example 5 7.0 52.0 1.0 Comparative Examples 6-8 As shown in Table 6, 7 π X in / /; U (fungicide) was added to the core material and granulated by the same granulation method as in Reference Examples 1-6. (Inner core) Subsequently, compound 1 (insecticide) is added, and the outer raw material powder obtained by mixing is coated in the same order as in Example 1-12. The surface of the granulated product (inner core) is coated to obtain a comparative example. Granules 6-8. 31 f Please read the > i sound on the back? Matters before filling out this page)

This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1239807 V. Description of the invention (V9) A7 Table 6 Composition of the granules of Comparative Examples 6-8 Composition of the core (mass fraction) Manufacturing conditions Bacteria Luw- Luw- White carbon slip carbonic acid heating mesh Lingyuan ax S ax E Lithium calcium temperature dimensional body crushing powder * Comparative Example 24.0 12.2 3. 4 '6.8 21. 1 90 V 〇 · 8 6 mm Comparative Example 24.0 12.2 2 · 5 6.8 22.0 83 V 0.8 7 mm Comparative Example 8 24.0 7.2 2.0 4.0 2.8 90 ° C 0.7 mm (Please read the precautions on the back before filling out this page) Employees of the Intellectual Property Bureau of the Ministry of Economic Affairs Consumer Cooperatives Printed materials for the outer layer Powder composition (mass fraction) Compound 1 Paraffin Clay Comparative Example 6 2.0 4. 5 26 · 〇 Comparative Example 7 2.0 4.5 26.0 Comparative Example 8 2.0 7.0 51.0 Comparative Example 9 The composition shown in Table 7 will be given first. (Insecticide) The dissolved methanol solution is blown onto a spherical solid carrier (manufactured by Tokai Industries Co., Ltd., trade name: Izu paper size applicable to Chinese National Standard (CNS) A4 (210 X 297 mm) Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy 1239807 a? B7 V. Description of the invention (M) Surface of quartz sand (particle size: 0.3-lmm), and then left in a desiccator at 50 ° C for 3 hours to remove Methanol produced a core that could not be slow-released. Subsequently, (bactericide) having the composition shown in Table 7 was added, and the raw material powder of the outer layer portion obtained by mixing was coated on the surface of the inner core in the same manner as in Example 1-2 to obtain a granule of Comparative Example 9. Table 7 Composition core (mass fraction) of the granules of Comparative Example 9 Composition (mass fraction) of raw material powder of the external part Compound 1 Spherical solid support (Izu quartz sand) Thiazethrin paraffin clay comparative example 9 2.0 38.0 24.0 12.0 24.0 Test Example 2, Granule Dissolution Test for Rice Nursery Box For granules obtained in the above Examples 1-12 and Comparative Examples 1-9, the dissolution rate of the pesticide active ingredient released from each granule was measured. ① Dissolution rate of compound 1 (insecticide). Among the two pesticide active ingredients contained in the granules prepared in Examples 1-12 and Comparative Examples 1-9, the compound 1 (insecticide) released from each granule was measured by the method described below. ) Dissolution rate. That is, each of the granules prepared in the examples and comparative examples was placed in a test tube with a stopper capacity of 50 ml containing 25 ml of standard 3 degree hard water in an amount equivalent to that of compound 1 (insecticide). When the concentration reached 920 ppm, when all the contained Compound 1 (insecticide) were dissolved out, insoluble matter was precipitated in water. In this case (please read the precautions on the back before filling this page). ¾ This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) A7 1239807 V. Description of invention (β state, 25 ° C Let it stand for a certain period of time, filter the whole amount, and measure the amount of Compound 1 (insecticide) dissolved in the filtrate by HPLC method. Based on the measured value, calculate the dissolution rate according to the following formula, and summarize the results in Table 8. Dissolution rate = (filtrate Insecticide dose / Insecticide dose in granules) X 100 I Ί ^ Ί. -------- Order ----: ------ line (Please read the precautions on the back first Refill this page) Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economy Table 8 Compound 1 released from each granule (dissolution rate of pesticide λ (%) Dissolution rate of compound 1 day 3 days 7 days 14 days later Example 30 after 60 days and 90 days after Example 1 3.3 9.7 22. 1 44 · 9 100. 1 Example 2 0. 7 2. 7 6.6 15.7 33. 3 77.8 97.8 Example 3 10.2 22.7 41.9 59.6 81.2 99. 1 Example 4 5. 5 11. 2 21.9 41.6 87.2 101.0 Example 5 27.8 42. 7 59. 1 77.0 94.4 100. 5 Example 6 2. 7 8.8 19.8 4 0.9 92.6 Example 7 0.4 2. 1 5. 7 12.8 30. 1 66. 6 94.6 34 This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 1239807 B7 A7 Intellectual Property Bureau, Ministry of Economic Affairs, employee consumption Cooperative printed five, name tn spokesperson public mouth, ______ " mm 8 9. 8 18. 7 33.6 52.8 78. 1 100.4 Example 9 8. 5 23. 1 39. 7 56.6 78. 3 97.8 Example 10 5 7 11 · 1 22.2 41.3 85.3 99. 9 Example 11 28. 1 44.0 64. 1 81.4 98.9 Example 12 31.3 44.2 60.0 77. 1 96.2 Comparative Example 1 82.6 96.8 100 · 1 Comparative Example 2 95. 7 99.4 99.3 Comparative Example 6 97.3 100.8 101.0 Comparative Example 7 94. 1 99.2 99.8 Comparative Example 8 95. 5 97.6 99.3 Comparative Example 9 79. 3 92.8 98.8 As shown in Table 8, the granules of the examples In other words, the insecticidal active ingredients contained in the inner grains can be continuously released for about 1 month to 3 months (please read the precautions on the back before filling this page) This paper size applies to China Standard (CNS) A4 specification (210 X 297 mm) 1239807 A7 B7 V. Description of invention (today ), And almost all of the insecticidal active ingredients contained can be completely released. In contrast, for Comparative Examples 1, 2 without a cladding layer, and Comparative Examples 6 to 8 containing compound 1 in the outer layer portion without a core; or for compounds containing Compound 1 in a core without using an interpretation technique In Comparative Example 9, neither release was sustained, and the dissolution rate reached almost 100% in approximately 1-3 days. ② Dissolution rate of d-port f and / a> (sterilization ij). The dissolution rate of the d-portion {于 / 一; l (bactericide)) released from each of the two pesticide active ingredients contained in the granules obtained in Examples 1-2 and Comparative Examples 1-9 The measurement was performed by the method mentioned below. That is, each of the granules prepared in the examples and comparative examples was placed in a sealed Erlenmeyer flask containing 1000 ml of ion-exchanged water with a capacity of 1,000 ml, and the amount added was equivalent to d α {于 ' (一); (fungicide) concentration reaches 30ρρπι, when the contained d '' / a; u (fungicide) all dissolves, insoluble matter precipitates in water, and left to stand at 25 ° C in this state, Then, at a certain time interval, a sample of 1 ml was taken from a water depth of 5 cm to determine the concentration of the bactericidal active ingredient in the sample by HPLC. The experimental condition was that the entire amount of the bactericidal agent in the granules to be tested was in 1.0 ml of water in a conical flask. The concentration at the time of dissolution was 30 ppm, and the concentration value of the measured bactericide was removed at 30 ppm to obtain the dissolution rate. The results are summarized in Table 9. IM -h U ---------------- Order --- ^ ------ line (Please read the notes on the back before filling this page) Intellectual Property Bureau of the Ministry of Economic Affairs Printed by Employee Consumer Cooperatives π 36 This paper size is in accordance with Chinese National Standard (CNS) A4 (210 X 297 mm) 1239807 λ7 B7 V. Description of the invention (^) [Table 9] ^ 一 released by each granule >) Dissolution rate of fungicides Printed clothing of employees' cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs (7. Mouth ^: Yu y a; Dissolution rate of fungicides (0 / 〇) 1 after 3 days 7 days after 14 days 30 days after 60 days 60 After the 90th day, Example 1 0 · 7 5. 1 9.2 18.4 40.0 82.1 1101. 0 Example 2 1. 1 2.9 7.3 15.9 35.6 77. 7 96.2 Example 3 2.0 5. 7 12.4 22 · 6 52 · 1 97 · 2 98.0 Example 4 0.2 3.1 7.9 17.7 39.3 84.8 93.5 Example 5 2.9 6.2 14.5 28.9 55.6 100.0 Example 6 0.4 6. 1 10.0 22.2 44. 2 84.6 102.0 Example 7 3.0 6.9 15. 1 27 · 1 46.2 88. 1 97.7 Example 8 3. 3 7 · 1 13.2 25.9 54.4 100.6 Example 9 2. 7 5. 5 13. 1 24.9 55.6 98. 9 Example 10 3.6 6 · 13. 3 28.0 47.0 84. 0 96.8 paper ruler Applicable to China National Standard (CNS) A4 specification (210 X 297 mm) (Please read the precautions on the back before filling this page) 1239807 B7}-5.8 Example 11 2.2 13. 7 26.8 58.8 99.0 Example 12 3.0 5.7 17.2 31.6 57.3 100. 7 Comparative Example 3 0.2 1. 1 3.2 6 · 6 14.9 28.8 38.1 Comparative Example 4 ND ND 0.8 2.4 7.5, 18.2 26.9 Comparative Example 5 0.2 0.8 2.4 5 · 1 12.0 24.7 33. 3 Comparative Example 6 ND 0.4 1.7 3.7 7.4 13.6 22.8 Comparative Example 7 ND 0 · 1 0.4 2 · 1 5.0 11 · 1 22. 7 Comparative Example 8 ND ND 0.4 1. 1 3.6 9.9 16.3 As the results shown in Table 9 show, each of the examples The granules can gradually release the fungicide in about 3 months, and almost all the fungicides required in the outer layer can be completely released. On the contrary, as for Comparative Example 3 of all fungicides in the inner core, 3- For the granules of 8, even after about 2 months, only a part of the content was dissolved out, and the dissolution rate was extremely low. In the coated sustained-release pesticide granules of the present invention, when two or more pesticide active ingredients having greatly different water solubility are contained, generally one of them may have a water solubility of 1,000 ppm or more. Concentration activity of 38 This paper size is applicable to China National Standard (CNS) A4 (210 x 297 mm) (Please read the precautions on the back before filling this page) Printed by the Consumer Property Cooperative of the Intellectual Property Bureau 1239807 A7 B7 V. Description of the Invention (7 texts) The sustained release can be realized separately. For example, pesticide mixed granules suitable for rice seedling box granules can be prepared. The coated sustained-release pesticide granules of the present invention can release substantially all of the contained contents of two or more pesticide active ingredients, and can be slowly dispersed in the field in a required period. The pesticide active ingredients in the solution are continuously dissolved, and there is no need to worry about a part remaining in the granules. Furthermore, the coated sustained-release pesticide granules of the present invention do not need to cover the surface of the inner core with a resin during manufacture. In the production of coated particles, the drying process after the resin coating can be omitted, and redundant processes are saved. In this way, its superior viscosity is achieved by using a double-layered dosage form and reducing its manufacturing cost. (Please read the precautions on the back before filling out this page) • Canned clothing set i — T ----- line-Printed agricultural paper size for employees' cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs applies Chinese National Standard (CNS) A4 specifications (210 X 297 mm)

1239807 Application date category (

Revision A A4 C4 Supplement: Name Group "" Type Patent Specification Chinese Covered Slow Release Pesticide Granules English Name First Name Nationality • Kishi Daisuke • Nagashima Koichi .Yunbei Takahashi • Receiving Shinji • Ueno Shibuki Japan

Daisuke KISHI Koichi NAGASHIMA Takashi WATANABE Shinji SAKURAI Shigeru UENO Pretends to live and live in 1 · Toyo 1144, Togo, Mobara, Chiba Prefecture, Japan (inside Mitsui Chemicals Co., Ltd.) H44, Togo, Mobara, Chiba Prefecture, Japan (Mitsui Chemical Co., Ltd. Rabbit?) 4. Lingzi i 3, No. 760, Shioka-cho, Kohoku-ku, Obama-shi, Naikawa Prefecture (Meiji Corporation Limited, No. 760, Shioka-cho, Kita-ku, Japan Meiji Chemical Industry Co., Ltd. (Inside the Company's Pharmaceutical Research Institute) ___ Name (name). Mitsui Chemicals Co., Ltd. MITSUI CHEMICALS, INC. 2. Meiji Chemical Industry Co., Ltd. MEIJISEIKAKAISHA., LTD. Ministry of Economy Xihui 57 / |. ^ $ 工; /] ^ Printed by a cooperative 3. The applicant's nationality resides and resides in the office) Name of representative 1. Japanese version 2. Japanese version 1. Japanese version 2. Kasumigaru 3, Chiyoda-ku, Tokyo, Japan 2-5, No. 2 · Said in the home country, Tokyo, Chuo-ku, Tokyo 2nd, No. 16 No. 16 I. Nakasushi Hiroshi 2 North Kitaichi immediate line paper size applicable to China National Standards (CNS) Α4 grid (210 × 297 mm)

Claims (1)

1239807 this £ 0 | more, rv A month / PAj 8 88 8 ABCD Ministry of Economic Affairs Central Bureau of Standards and Technology Bureau of Work and Consumption Coordinator Wang Zhongzhuang applied for 1-release pesticide granules to continuously dissolve and supply pesticide active ingredients The sustained-release pesticide granules used in an aqueous medium are characterized in that: the granules have a structure of a coated granule composed of a core and an outer layer portion coated on the surface of the core; the core has a water solubility of 20 ° C; Granules composed of at least one pesticide active ingredient above 1000 ppm and below 10%, an inorganic dilution carrier and a first thermoplastic material which is hardly soluble in water; the outer layer portion is made of water with a solubility of 20 ° C at 0 · Olppm— 500 ppm of at least one pesticide active ingredient, an inorganic dilution carrier, and a coating layer composed of a second thermoplastic material that is of a different material and hardly soluble in water compared to the first thermoplastic material contained in the core described above Because of the structure of such coated granules, the pesticide active ingredient contained in the inner core and the pesticide active ingredient contained in the outer layer part can be controlled to make it slowly dissolve separately. 2. The sustained-release pesticide granule according to item 1 of the scope of the patent application, characterized in that the outer layer part further contains a surfactant. 3. The slow-release pesticide granules described in item 1 or 2 of the scope of the patent application, which are characterized in that the first hardly water-soluble first thermoplastic material contained in the inner core is a nonacosanoic acid wax, And / or icosanoate wax. 4. The sustained-release pesticide granules described in item Γ or 2 of the scope of the patent application, which are characterized in that the second heat-resistant material which is hardly soluble in water and contained in the outer layer portion is stone mortar. 5. The slow-release pesticide granules described in item 1 or 2 of the scope of the patent application, characterized in that the pesticide active ingredient contained in the kernel is (RS) —1 — 2A 1:-ig --- < Please read the notes on the back before filling in this page} i Awn ^ ------ -Order ----- Line ---- Γ: --- This paper size is free to use Chinese national broadcast standards (CNS) A4 specification (210 × 297 mm) 1239807 6. Scope of patent application S ~ 3 ~ · Nitro-3 ~ (tetrahydro-3 ~ furylmethyl) guanidine, the active ingredient of pesticide contained in the outer part is thiabendazim. 6. A method for manufacturing a sustained-release pesticide granule according to item 丨 of the patent application scope, characterized by comprising the following steps (1)-(3): (1) A step of obtaining a granulated product, 2 (TC has at least one pesticide active ingredient with a water solubility of 10,000 ppm or more and 10% or less, an inorganic dilution carrier, and a first thermoplastic material that is hardly soluble in water, mixed and granulated to form a granulated substance as a core; (2 ) — A step of obtaining a coating composition, the coating composition as an outer layer part is composed of at least one of a water solubility of 20 ° C. and i-500 ppm, a pesticide active ingredient, an inorganic dilution carrier, and The first thermoplastic material contained in the inner core is composed of a second thermoplastic material having a low melting point, which is a different material and is hardly soluble in water; (3)-a coating step, that is, the core obtained in step (1) is used as the inner core; On the surface of the granulated product, the coating composition obtained in step (2) is above the melting point of the second thermoplastic material and does not reach the melting point of the first thermoplastic material contained in the core on the surface thereof. The temperature of The second thermoplastic material is dissolved by heating to cover the granulated material. (Please read the precautions on the back before filling this page) Ψ · Hah— — > ni —.Hi nn .τ L · Line Central Government Bureau of the Ministry of Economic Affairs, Λ Industrial Consumption Cooperation, Du Yin U 41 This paper ruler is used in China's National Kneading Rate (CNS) A4 Washing (210X297)