TWI232756B - Nail lacquer composition for drug delivery - Google Patents
Nail lacquer composition for drug delivery Download PDFInfo
- Publication number
- TWI232756B TWI232756B TW090103582A TW90103582A TWI232756B TW I232756 B TWI232756 B TW I232756B TW 090103582 A TW090103582 A TW 090103582A TW 90103582 A TW90103582 A TW 90103582A TW I232756 B TWI232756 B TW I232756B
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- Prior art keywords
- nail
- composition
- scope
- enhancer
- film
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- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 239000004922 lacquer Substances 0.000 title claims abstract description 11
- 238000012377 drug delivery Methods 0.000 title description 5
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 44
- 239000002904 solvent Substances 0.000 claims abstract description 40
- 229940121375 antifungal agent Drugs 0.000 claims abstract description 38
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 36
- 239000003429 antifungal agent Substances 0.000 claims abstract description 35
- 239000003623 enhancer Substances 0.000 claims abstract description 31
- 230000035515 penetration Effects 0.000 claims abstract description 11
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 3
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- 210000000282 nail Anatomy 0.000 claims description 55
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- 241000233866 Fungi Species 0.000 claims description 15
- -1 tripropionate Chemical compound 0.000 claims description 15
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- 239000003814 drug Substances 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| TW (1) | TWI232756B (OSRAM) |
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| US6585963B1 (en) * | 2001-02-15 | 2003-07-01 | Watson Pharmaceuticals, Inc. | Nail compositions and methods of administering same |
| GB0203276D0 (en) * | 2002-02-12 | 2002-03-27 | Novartis Ag | Organic compounds |
| JP2005538156A (ja) | 2002-09-05 | 2005-12-15 | ガルデルマ・ソシエテ・アノニム | 爪塗布用溶液 |
| EP1635770B1 (en) * | 2003-03-21 | 2009-05-27 | Nexmed Holdings, Inc. | Antifungal nail coat and method of use |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| US8741332B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| JP5010125B2 (ja) * | 2005-09-02 | 2012-08-29 | 有限会社日本健康科学研究センター | 水虫治療用フィルム製剤 |
| WO2007056068A2 (en) * | 2005-11-02 | 2007-05-18 | Bentley Pharmaceuticals, Inc. | Macrocyclic formulations for transmembrane drug delivery |
| CA2633489C (en) * | 2005-12-14 | 2013-09-24 | Zars Pharma, Inc. | Compositions and methods for treating dermatological conditions |
| JP5290582B2 (ja) * | 2005-12-28 | 2013-09-18 | 帝國製薬株式会社 | 爪用医薬組成物 |
| EP2112923A1 (en) | 2007-01-22 | 2009-11-04 | Targacept Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
| ES2468540T3 (es) * | 2009-02-13 | 2014-06-16 | Topica Pharmaceuticals, Inc | Formulación antif�ngica |
| EP2408299B1 (en) * | 2009-03-20 | 2013-10-23 | Stiefel Laboratories, Inc. | Fatty acid monoglyceride compositions |
| GB201021386D0 (en) * | 2010-12-16 | 2011-01-26 | Burke Michael H | A process for the manufacture of an antifungal nail lacquer |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US8697753B1 (en) | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| KR101580077B1 (ko) | 2015-03-28 | 2015-12-24 | 한국콜마주식회사 | 시크로피록스 함유 네일락카 조성물 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4299826A (en) * | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
| US5023252A (en) * | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5731303A (en) * | 1985-12-04 | 1998-03-24 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery compositions |
| DE3720147A1 (de) | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
| EP0503312B1 (fr) * | 1991-03-13 | 1997-01-08 | Firmenich Sa | Procédé de préparation de la 15-pentadécanolide ou de mélanges riches en cette macrolide |
| WO1996012467A1 (en) * | 1994-10-20 | 1996-05-02 | The Procter & Gamble Company | Personal treatment compositions and/or cosmetic compositions containing enduring perfume |
| US5693828A (en) * | 1996-05-09 | 1997-12-02 | International Flavors & Fragrances Inc. | Process for preparing lactones and intermediates therefor |
| US6224887B1 (en) * | 1998-02-09 | 2001-05-01 | Macrochem Corporation | Antifungal nail lacquer and method using same |
| US6231875B1 (en) * | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
| US6495124B1 (en) * | 2000-02-14 | 2002-12-17 | Macrochem Corporation | Antifungal nail lacquer and method using same |
-
2001
- 2001-02-16 NZ NZ520749A patent/NZ520749A/en unknown
- 2001-02-16 BR BR0108438-0A patent/BR0108438A/pt not_active IP Right Cessation
- 2001-02-16 AU AU2001243189A patent/AU2001243189B2/en not_active Ceased
- 2001-02-16 AU AU4318901A patent/AU4318901A/xx active Pending
- 2001-02-16 CN CN01807713A patent/CN1422142A/zh active Pending
- 2001-02-16 HU HU0204555A patent/HUP0204555A3/hu unknown
- 2001-02-16 AT AT01916128T patent/ATE526917T1/de not_active IP Right Cessation
- 2001-02-16 MX MXPA02008072A patent/MXPA02008072A/es not_active Application Discontinuation
- 2001-02-16 KR KR1020087011722A patent/KR20080049148A/ko not_active Withdrawn
- 2001-02-16 TW TW090103582A patent/TWI232756B/zh not_active IP Right Cessation
- 2001-02-16 CA CA002400178A patent/CA2400178A1/en not_active Abandoned
- 2001-02-16 KR KR1020027010571A patent/KR20030016227A/ko not_active Ceased
- 2001-02-16 JP JP2001559423A patent/JP2005503318A/ja active Pending
- 2001-02-16 PL PL01357111A patent/PL357111A1/xx not_active Application Discontinuation
- 2001-02-16 WO PCT/US2001/005302 patent/WO2001060325A1/en not_active Ceased
- 2001-02-16 EP EP01916128A patent/EP1257248B1/en not_active Expired - Lifetime
-
2002
- 2002-08-15 NO NO20023866A patent/NO20023866L/no not_active Application Discontinuation
- 2002-08-15 ZA ZA200206553A patent/ZA200206553B/en unknown
- 2002-09-11 MA MA26811A patent/MA26883A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001243189B2 (en) | 2005-06-09 |
| AU4318901A (en) | 2001-08-27 |
| BR0108438A (pt) | 2003-04-01 |
| EP1257248A1 (en) | 2002-11-20 |
| EP1257248A4 (en) | 2007-10-03 |
| EP1257248B1 (en) | 2011-10-05 |
| CA2400178A1 (en) | 2001-08-23 |
| HUP0204555A3 (en) | 2004-06-28 |
| JP2005503318A (ja) | 2005-02-03 |
| ZA200206553B (en) | 2003-11-17 |
| ATE526917T1 (de) | 2011-10-15 |
| NO20023866D0 (no) | 2002-08-15 |
| MXPA02008072A (es) | 2004-04-05 |
| HUP0204555A2 (en) | 2003-05-28 |
| WO2001060325A1 (en) | 2001-08-23 |
| NO20023866L (no) | 2002-10-01 |
| KR20030016227A (ko) | 2003-02-26 |
| MA26883A1 (fr) | 2004-12-20 |
| KR20080049148A (ko) | 2008-06-03 |
| PL357111A1 (en) | 2004-07-12 |
| NZ520749A (en) | 2004-06-25 |
| CN1422142A (zh) | 2003-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |