TW492874B - Solid preparation for oral hygiene - Google Patents

Abstract

The present invention relates to a solid preparation for oral hygiene, which comprises (a) 15 to 90 wt.% of a bubbling component and (b) 0.001 to 10 wt.% of an orally-usable medicinal component at an (a):(b) ratio ranging from 10:1 to 1000:1. Use of the preparation brings about a drastic improvement in the drug efficacy and moreover, breath is freshened by bubbling.

Description

B7 V. Description of the invention (i) Technical transformation The present invention relates to a solid preparation for oral hygiene by foaming in the oral cavity, washing the inside of the oral cavity, and at the same time improving the effectiveness of the oral effective ingredients. Technical background " Previously, in the oral cavity of pharmaceutical products (low-dose non-regulated medicines) and pharmaceutical products in a dissolved form inside the oral cavity, attempts have been made to combine oral effective ingredients such as halitosis prevention components. However, the efficacy of this preparation in preventing bad breath is not very satisfactory. On the one hand, it is known that foaming lozenges are described in W093 / 00 886 for formulations containing a foaming ingredient and a medicinal ingredient, and Japanese Patent Application Laid-Open No. 丨 _275 μ 1 (USSN 1 6 7,5 04) describes Mouthwash. However, in the former, the medicinal ingredient used is a compound that is absorbed from the digestive tract such as the intestine and exerts medicinal effects. When taking tincture, the preparation must be dissolved in water and the aqueous solution obtained after drinking. And mix with foaming ingredients. In the latter case, the mouthwash in the latter is a liquid mouthwash preparation in which the tablet is dissolved in water in advance, and the dissolved ingredients are directly used. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, as mentioned above, in the past, the oral medicinal ingredients and foaming ingredients were combined to foam and dissolve in the oral cavity, and the cooling effect and washing effect were obtained by foaming. In addition, preparations which exert the effect of releasing the effective ingredients for oral use in the oral cavity are not known. Disclosure of the Invention — Therefore, the present inventors have matched the foaming component with the medicinal ingredient acting in the oral cavity 'and conducted various reviews on the solid oral preparations used for foaming and dissolving in the oral cavity. High-concentration foaming properties _____ ~ 4 -__ This paper size applies to China National Standard (CNS) A4 (210X297 mm) " '492874 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (For a specific blending ratio with the effective ingredients for oral use, the mouth can be washed by foaming in the mouth (especially the tongue fur on the back of the tongue can be effectively removed, and the filamentous nipples on the tongue can appear), and The effect of such an oral medicinal ingredient 'enhances the medicinal effects of the ingredients. Moreover, if the preparation is designed to foam before the dissolution of the medicinal ingredient, the medicinal ingredient is on the back of the tongue. The attachment efficiency of the upper filiform nipples will be rapidly improved, and the medicinal effect will be sustained. The present invention is now completed. That is, the present invention is to provide an oral hygiene method, which is characterized in that It has the following ingredients (a), (b) and (c): (a) Foaming ingredients 15 to 90% by weight (b) Oral medicinal ingredients 0.001 to 10% by weight (c) Excipients 8 4.9 9 9% by weight or less (a): (b) = 10: 1 to 100: 1: a solid preparation (hereinafter referred to as "the solid preparation of the present invention") is foamed and dissolved by contact with moisture in the mouth, And the solution obtained after drinking the solid preparation is dissolved, or it is spit out from the mouth. Secondly, the present invention provides an oral hygiene method, which is characterized in that by controlling the components of the solid preparation (a ): The composition ratio of (b) is such that during the initial dissolution in the oral cavity, the component (a) is foamed and after the foaming is completed, the component (b) is dissolved to perform the foaming and dissolving process. In addition, the present invention provides Use of the solid preparation of the present invention in oral hygiene.-Furthermore, the present invention provides a solid preparation of the present invention which is used by dissolving in a q cavity, and the relative concentration of (a) component and \ b) component in the preparation is There is a difference in the part. The part that dissolves first in the oral cavity is high in (a) and the part that dissolves later. (B) in a high component. __- 5-This paper size is in accordance with Chinese National Standard (CNS) A4 (210X297 mm) (Please read the notes on the back before filling out this page) Order 492874 A7 B7 Five Invention Instructions Brief description of the printed diagram __ Figure 1 shows the relative concentration of the component (a) in the outer portion and the relative concentration of the (b) component in the inner portion. Sectional view. The small circle shown in Figure 1 is the component (b). Figure 2 shows a preparation with an inner layer and an outer layer. The relative concentration of the (a) component in the outer layer is high, and the relative concentration of the (b) component in the inner layer is high. A cross-sectional view of a tablet. The oblique line shows the high concentration of component (b). Figure 3 shows a layered preparation with three layers. The relative concentration of component (b) in the middle layer is high, while the upper layer and A cross-sectional view of a lozenge with a high relative concentration of the component (a) in the lower layer. The oblique line shows the portion with a high concentration of the component (b). The best state for carrying out the present invention is in the solid preparation of the present invention so as to have a high concentration. The foaming component (a) and oral effective component (b) It is characterized by a specific mixing ratio. Due to this structure, as shown above, the removal of tongue coating is very successful, and because of the action of the medicinal ingredients, a multiplying high pharmacological effect is obtained. Among them, the ingredients that are foaming ingredients (A) It is preferable to include a carbonate and an organic acid that can generate carbon dioxide gas. Organic acids such as citric acid, wine = acid, ascorbic acid, rhizolic acid, fumaric acid, succinic acid, and Malonic acid, etc. Carbonate is, for example, sodium carbonate, sodium bicarbonate, calcium carbonate, bicarbonate, Junli, sesquicarbonate, etc. Among them, sodium carbonate, sodium ammonium carbonate, calcium carbonate, etc. are particularly preferred. In order to obtain a good foaming property so that the tongue can be fully removed, it is preferably 15 to 90% by weight of the preparation, but 25 to 50% by weight is the second best. Oral medicinal ingredients Such as bad breath prevention ingredients, antibacterial agents (please read the precautions on the back before filling this page)

This paper scale applies to the national standard 492874 A7 B7 printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (, anti-inflammatory agent, blood promoter, fluorine compounds and enzymes, etc. Among the self-preventing components such as chlorophyllic acid Sodium, Sodium Iron Chlorophyll, Memcol, Methenol = Alcohol, Licorice, Cinnamon, Clove, Agastache, Yellow_, Fungus = Substance, Perilla Extract, Oolong Tea Extract, Sky Tea Extract, etc. Among them, sodium copper chlorophyll and / or sodium iron chlorophyll are more preferred. Secondly, the antibacterial agents are, for example, cetylpyridine chloride, ammonium chloride, ammonium ethoxylate, chloride Decalin, Chlorhexidine and trichlorohydroxy diphenyl ether, etc. Anti-inflammatory agents, such as chamomile ring, chamomile ring sulfonate, glycyrrhetic acid, chlorinated lysozyme, cork extract, angelica tincture Extracts, ε-aminocaproic acid, etc. Hematology promoters are, for example, tocopherols, etc. Fluorine compounds are, for example, sodium fluorophosphate, calcium monofluorophosphate, sodium fluoride, etc. In addition, the enzyme is, for example, glucosidase , Mutant enzyme, lysozyme, enzyme powder enzyme, protease Lysozyme, etc. These ingredients can be combined with one or two or more. The combination of bad breath prevention ingredients is the tongue that causes the bad breath, which is continuously removed by foaming, and the special silky nipple on the back of the tongue has bad breath prevention. After a large amount of ingredients are attached, the bad breath prevention effect can be multiplied, and the effect can be sustained, and it has a particularly good effect on the prevention of bad breath. Although the amount of the oral effective ingredient varies, the amount of the effective ingredient varies, but From a medicinal point of view, it is 0. 0 0 1 to 10% by weight in the preparation, and more specifically / i. When sodium copper chlorophyll is used, it is 0.001 to 5% by weight, and iron leaf green is used. In the case of sodium, 0.001 to 5% by weight is preferred. In order to obtain a multiplied effect, the mixing ratio of component (a) and component (b) is 10: 1 to 1000: 1, and 100: 1 to 500: 1. In addition, the component (c) may be a solid preparation for oral use, for example, 7-This paper size is applicable to Chinese National Standard (CNS) 8 4 ^ grid (210X297 mm) (please read the back first) (Notes for filling in this page)

492874 5-A7 B7 printed by the Consumer Cooperatives of the Central Bureau of Standards of the Five Ministry of Economic Affairs, invention description (lactose, starch, dextrin, cellulose, polyethylene glycol, magnesium stearate, and maltitol. Etc.) Ingredients (c The blending amount of) is 84.999% by weight or less, and preferably 74 999% by weight or less. In the solid preparation of the present invention, in order to maintain the effect of the medicinal active ingredient for oral cavity, the component (a) is designed to have a component (b) It is better to dissolve first (that is, to foam first). In other words, in the process of foaming and dissolving, it is better to control the composition ratio of each part (a) :( b) in the solid preparation of the present invention to In the initial dissolution in the oral cavity, the component (a) is foamed, and the component (b) is dissolved after the foaming is completed. With this foaming and dissolution process, the (a) component and (b) in the solid preparation The relative concentration of the ingredients varies depending on the part they are in, and it is better to design it to have a higher component (a) in the Shao Fen which is first resolved in the oral cavity, and a higher component (b) in the later dissolved part. Specific examples are as follows: (丨) In the solid preparation, (a) The method of high relative concentration of ingredients and high relative concentration of (b) component in the inner part (refer to Figure 1). (2) Preparations with inner layer and outer layer. The relative concentration of (a) component in the outer layer is high and the inner layer is high. Method for high relative concentration of ingredients (refer to Figure 2) ° (3) Laminated preparation with 3 layers, the relative concentration of component (b) in the middle layer is south, and the relative concentration of (a) component in the upper and lower layers is high Method (refer to FIG. 3). Here, the relative concentration of ingredients here includes the case where one of the k degrees is 0. The solid preparation of the present invention can be blended with menthol for the purpose of imparting a cooling sensation. It can be used in an overall and uniform manner, or it can be applied to the national standard of the paper (CNSTT ^ (2i〇x 297 cm) (please read the precautions on the back before filling this page)

Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 492874 A7 B7 V. Description of the Invention (6) ^ ^ (a) The difference between the concentration of the component (a) and the component (b), and one of them is mixed in a large amount. If a large amount of the component (a) is blended with a high concentration of menthol, on the one hand, the bitterness from menthol can be reduced, and on the other hand, the amount of menthol can be increased. The amount of menthol in the formulation is preferably from 5 to 5% by weight. In addition, menthol is preferably blended in a portion having a high relative concentration of the component (a) in a range of 0.05 to 1 weight / 0 ', and is preferably blended in a portion having a high relative concentration of the component (b) in an amount of 0.1 to 5% by weight. The solid preparation of the present invention has the purpose of imparting fragrance and preventing bad breath, and can be selected with suitable spices, especially one or two or more selected from thyme, celery, cinnamon, sage, pepper, parsley, holland, Those with nutmeg, scented ether, gerbera, peppermint oil, marjoram, rale, and rosemary can significantly improve the prevention of bad breath. Regarding the blending amount of the fragrance, 0.001 to 5% by weight is preferred, and (^^ wt. /) Is particularly preferred. In addition to the above components, the solid preparation of the present invention can also be added with sucrose fatty acid esters and particles commonly used in general preparations. Lubricants such as silicon dioxide, vitamins, caffeine, and other ingredients formulated for the purpose, and sweeteners such as sodium saccharin, sucrose, sorbitol, aspartame, and erythritol, etc ... The form of the solid preparation of the present invention is not particularly limited. Lozenges, pills, and granules can be used, but lozenges are preferred. The solid preparation of the present invention can be manufactured by ordinary methods. Layer formation of foam ingredients-after it is formed, a layer containing medicinal ingredients for oral cavity is formed on the upper part, and a layer containing hair: ingredients < is also formed on the upper part. Furthermore, it has an inner layer and an outer layer of tablets, Can be formed after the inner layer containing the effective ingredients for oral use is formed, and then wrapped in its surrounding garden ------ 9 ~ (CNs ") AmM (210X297 ^ 1 ~~~-(Please read the back (Please fill in this page again)

A7. Description of the invention It is produced by a layer of a foaming component. The solid preparation of the present invention is used for oral # 7k ^ ^ ^ L ^ hygienic treatment, without having to use this preparation in the under / intoxicated, and drink directly into the system-T hunt in the mouth and contact with moisture to foam > 谷 _ 'After the preparation is dissolved, the dissolving liquid is good. If you want to get the job done, or spit it out of your mouth, the following examples will be used to explain the present invention in detail. However, the present invention is not limited to these examples. Examples 1 to 2 and Comparative Examples 1 to 2 are shown in the table! The various bonding agents (lg, diameter 15 is called) are prepared by using hydraulic multi-layer ingot punching machine made by M-a Co., Ltd. The person's exhalation is pre-packed with an exhalation bag and evaluated by: (Domain 6) was evaluated. After the two evaluations, 40 so-called "halitosis patients" were selected and divided into 4 groups, and the samples in Table 丨 were those who had taken them. After taking them, the breath bag was taken out for evaluation again. In order to investigate the effect of lozenges, the evaluation criteria are: halitosis improved +, Shao points improved +, no improvement (still bad breath). The results are shown in Table 1. Obviously, the formulation of the present invention does not contain foaming ingredients. The condition (Comparative Example 1) and the foaming component is less than 15 weights. The case (Comparative Example 2) has a relatively obvious effect of preventing bad breath. Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs -10- ----- This paper size applies the Chinese National Standard (CMS) A4 specification (21〇X 297 mm) 492874

7 B V. Description of the invention (8) Table 1 Ingredients (% by weight) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Corn starch 50.32 18.32 68.32 56.32 Hydrogen carbonate 9 23 0 6 Ascorbic acid 3 9 0 2 Citric acid 3 9 0 2 Tartrate 3 9 0 2 Maltitol 30 30 30 30 Saccharin sodium 0.5 0.5 0.5 0.5 Fatty acid fatty acid ester 1 1 1 1 Sodium copper chlorophyll 0.18 0.18 0.18 0.18 + + 5 8 0 1 Reviewer A + 5 2 3 6 — 0 0 7 3 + + 4 8 0 0 Evaluator B + 6 2 2 7 — 0 0 8 3 Examples 3 to 9 In accordance with the same method as in Example 1, various types of ingredients with the composition shown in Table 2 combined with bad breath prevention ingredients were prepared. Key agent. (Please read the notes on the back before filling this page)

11T ΙΛ. The paper size printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs applies to the Chinese National Standard (CNS) A4 (210X297 mm). 5. Description of the invention (A7 B7 Table 2 Weight 0 / 〇) Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 '~~ —— Example 9 Corn starch 50.4 50.4 50.4 50.4 50.4 ~ 5〇4 ^-^^ 50.4 Sodium hydrogen gallate 9 9 9 9 9 9 9 k Ascorbic acid 3 3 3 3 3 3 3 citric acid 3 3 3 3 3 3 3 tartaric acid 3 3 3 3 3 3 3 maltitol 30 30 30 30 30 30 30 saccharin sodium 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Benzyl ethoxylammonium chloride 0.1 0 0 0 0 0 0 isopropyl methylphenol 0 0.1 0 0 0 0 0 genolol 0 0 0.1 0 0 0 0 clove powder 0 0 0 0.1 0 0 0 cinnamon powder 0 0 0 0 0.1 0 0 Licorice powder 0 0 0 0 0 0.1 0 Brass 0 0 0 0 0 0 0.1 ί Please read the notes on the back before filling in this page j 、-= & Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Example 10 In the same manner as in Example 1, various bonding agents having a composition shown below were prepared. This lozenge has an excellent halitosis prevention effect and a refreshing feeling. (Ingredients) Sodium ascorbyl corn starch ascorbic acid (% by weight) 48: 6 9 12-The paper scale is applicable to Chinese National Standard (CNS) A4 specification (21〇 > < 297gongchu) 11---8 2 9 4 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A7 B7 Description of the invention (10) Citric acid 3 Tartaric acid 3 Maltitol 30 Saccharin steel 1.5 Sucrose fatty acid ester 1 Menthol 0.8 Flavonoid 0.1 Example 1 1 Follow the same procedure as in Example 1 The method is to prepare a lozenge. This lozenge has excellent halitosis prevention effect. (Ingredient) (weight%) corn starch 49.52 bicarbonate steel 9 citric acid 3 yunolic acid 3 ascorbic acid 3 maltitol 30 saccharin sodium 0.5 sucrose fatty acid ester 1 sodium copper chlorophyll 0.12 Iron leaf green acid steel 0.Ώ6 menthol '0.8 (Please read the precautions on the back before filling out this page) -13-This paper size applies to China National Standard (CNS) A4 (210X297 mm) 7 厶 〇 / fiber • Five, description of the invention (

Example 1 2 According to the same method as in Example 1, I, ', Ben < Wanfa, a variety of bonding agents having the composition shown below were prepared. This keying agent has a long-term bad breath prevention effect and a cool feeling. (Ingredients) Corn Palace Powder (% by weight) 43.02 12 4 4 4 30 0.5 1 0.12 0.06 0.8 0.5 Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs ¾ Bicarbonate steel citrate malate ascorbyl maltitol saccharin sodium sucrose fatty acid ester copper leaf Natto green phytate Natitol chlorophyllol spice (thyme) Example 1 3 Has various three-layer bonds not composed as shown in Table 3 One ... ^ One king to king ratio · Outer layer / Inner layer / Outer layer = 丨 / 丨 / j) It is prepared by hydraulic multi-layer ingot beater manufactured by Machi Sen Co., Ltd. The names of those with tongue coating were collected, and their breath was collected by exhalation bags. These people were divided into 2 groups of 7 people each. After taking the two three-layer tablets of Table 3 for 3 hours, they were collected again in an exhalation bag. Exhale. The presence or absence of halitosis after using the three-layer ingot was evaluated by 2 reviewers. The evaluation criteria were: halitosis disappeared ◎, some halitosis disappeared 〇, no change. The results are shown in Table 4 g, 15 mm diameter, weight ( Please read the precautions on the back before filling out this page) •• I Binding 14-This paper size is suitable for financial and family care standards (CNS) A4 specifications (21 () > < 297 Queen 492874

Patent Application No. 86118226 Chinese Revised Page of the Specification (March 91) ^ V. Description of the Invention (12). table 3

It can be clearly seen from Tables 4 and 5 that the relative concentration of eighteen in the first dissolved portion in the oral cavity is high and the relative concentration of the component (b) in the later dissolved portion is high. Very good. Table 4 Evaluator A Evaluator B Evaluation Example 1 3 Comparative Example 3 Evaluation Example 1 3 Comparative Example 3 ◎ 5 〇〇2 1 X 〇6 ◎ 6 0 〇1 2 x 0 5 -15- This paper size applies Chinese national standards (CNS) A4 size (210 X 297 mm) 492874 A7 B7 • V. Description of the invention (13 Example 1 4 A nuclear rotary key press manufactured by Orange Water Manufacturing Co., Ltd. was used to modulate a diameter of 15 mm and a thickness of 5 mm. Yes. (Also, you must first use hydraulic pressure to make money to prepare a spinner with a diameter of 1Q mm and a thickness of 3 coffee.) After the preparation, use the outer layer of Example 13 as the cored ingot. The inner layer of Example 13 was taken as the core part of the cored ingot. Furthermore, as in Example 3, 7 persons with tongue coating were collected, and their breath was collected in an exhalation bag. After 3 hours, the core tablets were again exhaled in an exhalation bag, and the presence or absence of bad breath before and after the tablet was used was evaluated by two reviewers. The evaluation criteria were: bad breath disappeared ◎, some bromine disappeared 0, no change 乂. The results are shown in Table 5. —_______ Table 5 Evaluation

Reviewer A

Reviewer B

◎ 〇X 5 2 0 4 3 0 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1 5 Table 6 shows various three-layered bonds (丨 g, melon diameter, weight ratio: outer layer) with good medicinal ingredients. / Inner layer / outer layer = 1/1/1), which is modulated in the same way as in Example 13 $. These ingot layers are excellent in both the bad breath prevention effect and the durability. _ 16 _ Zhang Zhang scale Shicai Guanjia County (CNS) A4 specification (21 () χ 297 male sauce (Please read the precautions on the back before filling in this page)

492874 A7 B7 i. Description of the invention (14 corn starch carbon rat steel ascorbic acid citrate tartrate maltitol saccharin sodium sucrose fatty acid ester 50.5 9 3 3 3 30 0.5 1 gasification ethoxyammonium isopropyl phenol called linalool clove powder Cinnamon powder and licorice powder 0 0 0 0 30 30 30 30 30 30 0.5 0.5 0.5 0.5 0.5 0.5 1 1 1 1 1 1 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 (Please read the notes on the back before filling this page)

, 1T Example of the printing of consumer cooperatives by the Central Government Bureau of the Ministry of Economic Affairs of the People's Republic of China 16 Table 7 shows a blue-layered ingot with menthol (fg, 15 mm diameter, weight ratio: outer layer / inner layer / outer layer = 1/1/1 ) Was prepared in the same manner as in Example 13. · Used to evaluate the degree of coolness in the mouth. After using this lozenge, both the refreshment 'and the persistence of refreshment are very valuable. -17-'The paper size applies the Chinese National Standard (CNS) A4 specification (210X297 public envy) 492874 A7 B7 V. Description of the invention (15) Table 7 Example 16 Outer inner corn starch 48.4 67.89 Sodium bicarbonate 10 0 Citric acid 5 0 Apple Acid 5 0 Maltitol 30 30 Saccharin sodium 0.5 0.5 Sucrose fatty acid ester 1 1 Copper chlorophyllic acid steel 0 0.2 1 Menthol 0.1 0.4 (Please read the precautions on the back before filling this page) Staff Consumer Cooperatives, Central Bureau of Standards, Ministry of Economic Affairs Printing example 17 Table 8 shows a three-layer bond (1 g, 15 mm diameter, weight ratio: outer layer / inner layer / outer layer) with copper chlorophyllic acid steel and iron chlorophyllic acid steel as a medicinal ingredient. = 1/1/1), which is modulated in the same way as in Example 13. These tablets are very different from each other in terms of their bad breath prevention effect or their persistence. This paper size applies to Chinese National Standard (CNS) A4 (210X29 * 7mm) 492874 A7 V. Description of the invention (16

48.4 10 5 5 30 0.5 1 0 0 0 67.89 0 0 3 0 Printed by the Economic and Social Organization of the Central People's Republic of China Employees' Cooperative to produce corn starch, sodium bicarbonate, citrate, malate, maltitol, saccharin, sucrose fatty acid ester, sodium copper chlorophyll Sodium iron chlorophyll menthol tjH 1 8 Table 9 shows a three-layer ingot Ug, 15_ straight warp and braided with copper chlorophyll acid, which is used as a medicated layered tincture. It is the same as Example 13 Ratio: Outside A, only 1 sample of modulation. These lozenges are excellent in both the bad breath prevention effect and the persistence. 0.5 1 0.11 0.1 0.4 (Please read the precautions on the back before filling out this page) r Pack · ， 11 19-This paper size applies to China National Standard (CNS) A4 (210X; 297 mm) 7 ^ 8 2 9 4 A7 B7 5. Description of the invention (17 Table 9 Example 18 Outer inner corn starch 48.1 67.39 Sodium nitrate 10 0 Citric acid 5 0 Malic acid 5 0 Maltitol 30 30 Saccharin sodium 0.5 0.5 Sucrose fatty acid ester 1 1 Copper leaf Sodium chlorate 0 0.11 Sodium iron chlorophyll 0 0. 1 menthol 0.1. 1 0.4 Spices (Dutch Mint) 0.3 0.5 Please read the note on the back and fill in this page again. Test example 1 printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs The three-layered tablet obtained according to Example 13 and the following tablets were produced, and the presence or absence of bad breath was evaluated. As a result, the tablets of Example 13 were optimal in terms of the effect of preventing bad breath and its persistence. -20 paper Zhang scale is applicable to China National Standard (CNS) A4 specification (210X297 mm) 492874 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs ^ A7 B7 V. Description of the invention (18) Table 10 Non-foaming single-layer key Foaming single-layer key corn Starch 68.4 3 56.43 hydrogen carbonate steel 0 6 ascorbic acid 0 2 citric acid 0 2 tartaric acid 0 2 maltitol 30 30 saccharin sodium 0.5 0.5 sugar fatty acid ester 1 1 sodium copper chlorophyll 0.07 0.07 (please read the precautions on the back before filling in this (Page) This paper size applies to Chinese National Standard (CNS) A4 (210X 297 mm)

Claims (1)

492874 No. 86118226 Patent Application g Final V: Chinese Patent Application Scope Amendment (March 91) C8 VI. Application Scope 1. A solid preparation for oral hygiene, which contains the following ingredients (a), (7) And (〇): 〇) Foaming ingredients 15 to 90% by weight / 〇 (b) Oral medicinal ingredients 0.001 to 10% by weight (c) Excipients 8 4.9 9 9%. /. The following and (a): (b) = 1 0: 1 to 1 000: 1 is a solid preparation used for dissolution in the oral cavity. The relative concentration of (a) component and (b) component of the preparation depends on Some of them are different, and the concentration of (a) component is high in the pre-dissolved shaw in the oral cavity, and the concentration of (b) component is high in the later dissolved portion. 2. The solid preparation for oral hygiene according to item 1 of the scope of patent application, having more than two layers (a): (b) having a different composition ratio. 3. The solid preparation for oral hygiene according to item 2 of the scope of patent application, which has a laminated structure of three or more layers, or an inner layer and an outer layer of two or more layers. 4. The oral solid preparation according to any one of claims 1 to 3, wherein the component (a) is a carbonate and an organic acid. ~ 5. The solid preparation for oral hygiene according to any one of claims 1 to 3, wherein the component (b) is selected from the group consisting of a halitosis preventive component, an antibacterial agent, an anti-inflammatory agent, a bloodstream promoter, a fluorine compound, and an enzyme. One or more of them. 6. The solid preparation for oral hygiene according to any one of claims 1 to 3, wherein the component (b) is sodium copper chlorophyll and / or sodium iron chlorophyll. 7. According to any of the items in the scope of the applied patent, any one of the solid preparations for oral hygiene, which are still formulated with menthol. This paper size applies to China National Standard (CNS) A4 specifications (210X297 mm) — ------ — 492874 A8 B8 C8 D8, patent application scope 8. According to any one of the scope of patent applications 1 to 3 A solid preparation for oral hygiene, wherein the (a) component blending layer and (b) component blending layer are blended with menthol, and the blending concentration of the menthol is higher than (a) ) Concentration of component blending layer. 9. The solid preparation for oral hygiene according to any one of claims 1 to 3, wherein one or two or more kinds are selected from the group consisting of thyme, sprouts, cinnamon, sage, pepper, parsley, and mint , Nutmeg, fennel ether, gerbera, marjoram, peppermint oil, ralle and rosemary. Packing-2 paper ruler for Chinese paper standard (CNS) A4 (210 X 297 mm)