TW492874B - Solid preparation for oral hygiene - Google Patents

Solid preparation for oral hygiene Download PDF

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Publication number
TW492874B
TW492874B TW86118226A TW86118226A TW492874B TW 492874 B TW492874 B TW 492874B TW 86118226 A TW86118226 A TW 86118226A TW 86118226 A TW86118226 A TW 86118226A TW 492874 B TW492874 B TW 492874B
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Taiwan
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component
solid preparation
oral
oral hygiene
ingredients
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TW86118226A
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Chinese (zh)
Inventor
Shigeto Kayane
Yoshitaka Yano
Shinji Kiji
Keiko Masuki
Eigo Fujinaka
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Kao Corp
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Priority claimed from JP21126696A external-priority patent/JP3706204B2/en
Priority claimed from JP20900897A external-priority patent/JPH10236948A/en
Priority claimed from JP9209009A external-priority patent/JPH10236935A/en
Application filed by Kao Corp filed Critical Kao Corp
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Publication of TW492874B publication Critical patent/TW492874B/en

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Abstract

The present invention relates to a solid preparation for oral hygiene, which comprises (a) 15 to 90 wt.% of a bubbling component and (b) 0.001 to 10 wt.% of an orally-usable medicinal component at an (a):(b) ratio ranging from 10:1 to 1000:1. Use of the preparation brings about a drastic improvement in the drug efficacy and moreover, breath is freshened by bubbling.

Description

B7 五、發明説明(i ) 技術範轉 本發明係關於藉在口腔中發泡,使口腔内部洗淨,同時 使口腔用藥效成分效果提升的口腔衛生用固形製劑。 技術背景 " 以前,在口腔内部呈溶解形態的醫藥部外品(低含藥量而 不受管制之醫藥品)與醫藥品中,即曾嘗試配合口臭防止成 分等口腔用藥效成分。然而,此種製劑防止口臭的藥效, 無法十分令人滿意。 一方面,關於配合發泡成分與藥效成分之製劑,已知在 W093/00 886記載有發泡錠劑,及特開平丨_275 μ 1號公報 (USSN 1 6 7,5 04)記載有漱口藥。然而在前者中,所用的藥 效成分爲從腸等消化管吸收而發揮藥效之化合物,且在服 用岫,需先將製劑溶解在水中及飲用得到的水溶液,並沒 有爲促進藥效成分溶解而配合發泡成分。#者,在後者中 之漱口藥,爲將錠劑預先溶解在水中,直接使用配合成分 已溶解的液體漱口製劑。 經濟部中央標準局員工消費合作社印製 如上所述,以往將口腔用藥效成分與發泡成分相配合, 使其在口腔内發泡及溶解、藉由發泡得到清涼感及洗淨效 果,且發揮口腔用藥效成分在口腔内釋出之效果之製劑, 則尚未爲人所知。 發明之揭示 — 因此,本發明人等將發泡成分與口腔内作用之藥效成分 加以配合’並對所形成之在口腔内發泡及溶解使用的口腔 用固形製劑做種種檢討,結果發現使用高濃度的發泡性成 _____ ~ 4 -__ 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐)" ' 492874 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明( 为與口腔用藥效成分之特定配合比,可藉在口中發泡使口 腔内邵洗淨(特別是使舌背上存在的舌苔有效除去,而使舌 月上的絲狀乳頭出現),且藉由此種口腔用藥效成分的作用 ’使得其成分的藥效相乘地提昇。更且,若該製劑被設計 成發泡比藥效成分之溶解先進行,則該藥效成分在舌背上 絲狀乳頭的附著效率將急速地提昇,而使藥效可持續地存 在’本發明至此於焉完成。 亦即,本發明爲提供一種口腔衛生方法,其特徵爲將含 有下列成分(a)、(b)及(c): (a) 發泡成分 1 5〜9 0重量% (b) 口腔用藥效成分 0.001〜10重量% (c )賦形劑 8 4.9 9 9重量%以下 且(a):(b)=l〇:l〜1〇〇〇:1的固形製劑(以下稱爲「本發明固 形製劑」),在口中與水分接觸而發泡、溶解,以及飲入該 固形製劑溶解後所得之溶解液,或由口中吐出。 其次,本發明提供一種口腔衛生方法,其特徵爲在上述 口腔衛生方法中,藉著控制該固形製劑之各成分中(a):(b) 之組成比,使得在口腔中之溶解初期,由(a)成分進行發泡 ’發泡終了後進行(b)成分之溶解而進行發泡、溶解過程。 又,本發明提供本發明固形製劑在口腔衛生上的使用。-再者,本發明提供一種溶在q_腔中而使用之本發明的固 形製劑,該製劑中(a)成分與\b)成分的相對濃度因所在部分 而有差異,口腔内先行溶解的部分中(a)成分高,而較遲溶 解的部分中(b)成分高。 __- 5 - 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) (請先閱讀背面之注意事項再填寫本頁) 訂 492874 A7 B7 五 發明説明( 經濟部中央標準局員工消費合作社印製 圖示之簡單説明__ 圖1所示爲外側部份中(a)成分的相對濃度高,而内側部 份中(b )成分的相對濃度高之本發明固形製劑(鍵劑)的斷面 圖。圖1所示的小圓爲(b)成分。圖2所示爲具有内層及外層 之製劑,外層中(a )成分的相對濃度高,内層中(b )成分的相 對濃度高之錠劑斷面圖。斜線部分所示爲(b)成分濃度高的 邵分。圖3所示爲具有3層之積層型製劑,中間層中(b)成分 的相對濃度高,而上層及下層中(a)成分的相對濃度高之錠 劑的斷面圖。斜線部分所示爲(b)成分濃度高的部分。 實施本發明之最佳狀態 於本發明固形製劑中,以具有高濃度的發泡成分(a)及口 腔用藥效成分(b)以特定的配合比配合爲特徵,由於此種構 成,如前所示,舌苔的去除十分成功,更由於藥效成分的 作用,得到相乘的高藥理效果。 其中,做爲發泡性成分的成分(a),以含有碳酸鹽及有機 酸而可產生碳酸氣的成分爲較佳。有機酸,例如爲檸檬酸 、酒=酸、抗壞血酸、韻果酸、反丁稀二酸、號站酸及丙 二酸等。碳酸鹽,例如爲碳酸鈉、碳酸氫鈉、碳酸鈣、碳 酸氫药、竣隸、倍半碳酸鋼等。其中以碳酸納、碳酸氨 鈉、碳酸鈣等爲特佳。 發泡成分的配合量,爲得到良好的發泡性以使舌公充分 除去,宜爲製劑中的15〜90重量%,但以25~5〇重量二爲二 佳 再者,口腔用藥效成分者,例如口臭防止成分、抗 菌劑 (請先閱讀背面之注意事項再填寫本頁)B7 V. Description of the invention (i) Technical transformation The present invention relates to a solid preparation for oral hygiene by foaming in the oral cavity, washing the inside of the oral cavity, and at the same time improving the effectiveness of the oral effective ingredients. Technical background " Previously, in the oral cavity of pharmaceutical products (low-dose non-regulated medicines) and pharmaceutical products in a dissolved form inside the oral cavity, attempts have been made to combine oral effective ingredients such as halitosis prevention components. However, the efficacy of this preparation in preventing bad breath is not very satisfactory. On the one hand, it is known that foaming lozenges are described in W093 / 00 886 for formulations containing a foaming ingredient and a medicinal ingredient, and Japanese Patent Application Laid-Open No. 丨 _275 μ 1 (USSN 1 6 7,5 04) describes Mouthwash. However, in the former, the medicinal ingredient used is a compound that is absorbed from the digestive tract such as the intestine and exerts medicinal effects. When taking tincture, the preparation must be dissolved in water and the aqueous solution obtained after drinking. And mix with foaming ingredients. In the latter case, the mouthwash in the latter is a liquid mouthwash preparation in which the tablet is dissolved in water in advance, and the dissolved ingredients are directly used. Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs, as mentioned above, in the past, the oral medicinal ingredients and foaming ingredients were combined to foam and dissolve in the oral cavity, and the cooling effect and washing effect were obtained by foaming. In addition, preparations which exert the effect of releasing the effective ingredients for oral use in the oral cavity are not known. Disclosure of the Invention — Therefore, the present inventors have matched the foaming component with the medicinal ingredient acting in the oral cavity 'and conducted various reviews on the solid oral preparations used for foaming and dissolving in the oral cavity. High-concentration foaming properties _____ ~ 4 -__ This paper size applies to China National Standard (CNS) A4 (210X297 mm) " '492874 A7 B7 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs (For a specific blending ratio with the effective ingredients for oral use, the mouth can be washed by foaming in the mouth (especially the tongue fur on the back of the tongue can be effectively removed, and the filamentous nipples on the tongue can appear), and The effect of such an oral medicinal ingredient 'enhances the medicinal effects of the ingredients. Moreover, if the preparation is designed to foam before the dissolution of the medicinal ingredient, the medicinal ingredient is on the back of the tongue. The attachment efficiency of the upper filiform nipples will be rapidly improved, and the medicinal effect will be sustained. The present invention is now completed. That is, the present invention is to provide an oral hygiene method, which is characterized in that It has the following ingredients (a), (b) and (c): (a) Foaming ingredients 15 to 90% by weight (b) Oral medicinal ingredients 0.001 to 10% by weight (c) Excipients 8 4.9 9 9% by weight or less (a): (b) = 10: 1 to 100: 1: a solid preparation (hereinafter referred to as "the solid preparation of the present invention") is foamed and dissolved by contact with moisture in the mouth, And the solution obtained after drinking the solid preparation is dissolved, or it is spit out from the mouth. Secondly, the present invention provides an oral hygiene method, which is characterized in that by controlling the components of the solid preparation (a ): The composition ratio of (b) is such that during the initial dissolution in the oral cavity, the component (a) is foamed and after the foaming is completed, the component (b) is dissolved to perform the foaming and dissolving process. In addition, the present invention provides Use of the solid preparation of the present invention in oral hygiene.-Furthermore, the present invention provides a solid preparation of the present invention which is used by dissolving in a q cavity, and the relative concentration of (a) component and \ b) component in the preparation is There is a difference in the part. The part that dissolves first in the oral cavity is high in (a) and the part that dissolves later. (B) in a high component. __- 5-This paper size is in accordance with Chinese National Standard (CNS) A4 (210X297 mm) (Please read the notes on the back before filling out this page) Order 492874 A7 B7 Five Invention Instructions Brief description of the printed diagram __ Figure 1 shows the relative concentration of the component (a) in the outer portion and the relative concentration of the (b) component in the inner portion. Sectional view. The small circle shown in Figure 1 is the component (b). Figure 2 shows a preparation with an inner layer and an outer layer. The relative concentration of the (a) component in the outer layer is high, and the relative concentration of the (b) component in the inner layer is high. A cross-sectional view of a tablet. The oblique line shows the high concentration of component (b). Figure 3 shows a layered preparation with three layers. The relative concentration of component (b) in the middle layer is high, while the upper layer and A cross-sectional view of a lozenge with a high relative concentration of the component (a) in the lower layer. The oblique line shows the portion with a high concentration of the component (b). The best state for carrying out the present invention is in the solid preparation of the present invention so as to have a high concentration. The foaming component (a) and oral effective component (b) It is characterized by a specific mixing ratio. Due to this structure, as shown above, the removal of tongue coating is very successful, and because of the action of the medicinal ingredients, a multiplying high pharmacological effect is obtained. Among them, the ingredients that are foaming ingredients (A) It is preferable to include a carbonate and an organic acid that can generate carbon dioxide gas. Organic acids such as citric acid, wine = acid, ascorbic acid, rhizolic acid, fumaric acid, succinic acid, and Malonic acid, etc. Carbonate is, for example, sodium carbonate, sodium bicarbonate, calcium carbonate, bicarbonate, Junli, sesquicarbonate, etc. Among them, sodium carbonate, sodium ammonium carbonate, calcium carbonate, etc. are particularly preferred. In order to obtain a good foaming property so that the tongue can be fully removed, it is preferably 15 to 90% by weight of the preparation, but 25 to 50% by weight is the second best. Oral medicinal ingredients Such as bad breath prevention ingredients, antibacterial agents (please read the precautions on the back before filling this page)

本紙張尺度適用中國國家標 492874 A7 B7 經濟部中央標準局員工消費合作社印製 五、發明説明( 、消炎劑、血行促進劑、氟化合物及酵素等。其中口自 防止成分例如有銅葉綠酸鈉、鐵葉綠酸鈉、異丙甲美酚、 曰扁=醇、甘草、桂皮、丁香、荀香、黃_、蕈菌=物 、紫蘇萃取物、烏龍茶萃取物、天茶萃取物等等,而其中 以銅葉綠酸鈉及/或鐵葉綠酸鈉爲更佳。其次,抗菌劑例 如爲氯化十六烷基吡錠、氯芊烷銨、氯化芊乙氧銨、氯化 萘烷銨、氯化洗必太(Chlorhexidine)類及三氯羥基二苯醚 等等。消炎劑,例如爲甘菊環、甘菊環磺酸鹽、甘草次酸 、氯化溶菌酶、黃柏萃取物、當歸敕萃取物、ε _胺基己酸 等。血行促進劑例如爲生育酚類等。氟 ' 化合物例如爲^ 氟磷酸鈉、單氟磷酸鈣、氟化鈉等。此外,酵素例如爲葡 禾糖酶、突變酶、溶菌酶、殿粉酶、蛋白酶、溶菌酵素等 。這些成分可以一種或兩種以上相配合。 其中口臭防止成分配合的情況,係將造成口臭原因的舌 台,連續以發泡除去,而舌背上特殊絲狀乳頭間有口臭防 止成分大量附著之後,口臭防止效果可相乘地提昇,且效 果能持續,並對口臭的預防有特殊良好的效果。 口腔用藥效成分的配合量,雖因配合的藥效成分而異, 然而以藥效觀點來看,爲製劑中之0 · 0 0 1〜1 〇重量%,更特 /i而吕’使用銅葉綠酸鈉時爲〇 〇 1〜5重量%,而使用鐵葉 綠酸鈉時以0.001〜5重量%較佳i 爲得到相乘的藥效,成分(a)與成分(b)的配合比例爲 10:1 〜1000:1,而以100:1 〜500:1 爲較佳。 再者’成分(c)者,可爲通常用的口腔用固形製劑,例如 7 - 本紙張尺度適用中國國家標準(CNS )八4^格(210X297公釐) (請先閲讀背面之注意事項再填寫本頁)This paper scale applies to the national standard 492874 A7 B7 printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs. 5. Description of the invention (, anti-inflammatory agent, blood promoter, fluorine compounds and enzymes, etc. Among the self-preventing components such as chlorophyllic acid Sodium, Sodium Iron Chlorophyll, Memcol, Methenol = Alcohol, Licorice, Cinnamon, Clove, Agastache, Yellow_, Fungus = Substance, Perilla Extract, Oolong Tea Extract, Sky Tea Extract, etc. Among them, sodium copper chlorophyll and / or sodium iron chlorophyll are more preferred. Secondly, the antibacterial agents are, for example, cetylpyridine chloride, ammonium chloride, ammonium ethoxylate, chloride Decalin, Chlorhexidine and trichlorohydroxy diphenyl ether, etc. Anti-inflammatory agents, such as chamomile ring, chamomile ring sulfonate, glycyrrhetic acid, chlorinated lysozyme, cork extract, angelica tincture Extracts, ε-aminocaproic acid, etc. Hematology promoters are, for example, tocopherols, etc. Fluorine compounds are, for example, sodium fluorophosphate, calcium monofluorophosphate, sodium fluoride, etc. In addition, the enzyme is, for example, glucosidase , Mutant enzyme, lysozyme, enzyme powder enzyme, protease Lysozyme, etc. These ingredients can be combined with one or two or more. The combination of bad breath prevention ingredients is the tongue that causes the bad breath, which is continuously removed by foaming, and the special silky nipple on the back of the tongue has bad breath prevention. After a large amount of ingredients are attached, the bad breath prevention effect can be multiplied, and the effect can be sustained, and it has a particularly good effect on the prevention of bad breath. Although the amount of the oral effective ingredient varies, the amount of the effective ingredient varies, but From a medicinal point of view, it is 0. 0 0 1 to 10% by weight in the preparation, and more specifically / i. When sodium copper chlorophyll is used, it is 0.001 to 5% by weight, and iron leaf green is used. In the case of sodium, 0.001 to 5% by weight is preferred. In order to obtain a multiplied effect, the mixing ratio of component (a) and component (b) is 10: 1 to 1000: 1, and 100: 1 to 500: 1. In addition, the component (c) may be a solid preparation for oral use, for example, 7-This paper size is applicable to Chinese National Standard (CNS) 8 4 ^ grid (210X297 mm) (please read the back first) (Notes for filling in this page)

492874 五 經濟部中央標準局員工消費合作社印製 8 - A7 B7 、發明説明( 乳糖、澱粉、糊精類、纖維素類、聚乙二醇、硬脂酸鎂及 麥芽糖醇.等。 成分(c)的配合量爲84.999重量%以下,而以74 999重量 %以下爲較佳。 本發明固形製劑中,爲使口腔用藥效成分的效果持續, 以設計成(a)成分比(b)成分先溶解(亦即先行發泡)爲較佳。 換句話説,在發泡、溶解的過程中,較佳藉著控制本發明 固形製劑中各部分(a):(b)之組成比,以在口腔中之溶解初 期’由(a)成分進行發泡,發泡終了後再進行(b)成分之溶 解。 有了此種發泡、溶解過程,固形製劑中(a)成分與(b)成分 的相對濃度因所在部分之不同而有差異,較佳設計成在口 腔内先行落解的邵分中(a)成分高,而在較遲溶解的部分中 (b)成分高。 此種製劑的具體例如下··(丨)固形製劑中,外侧部份内之 (a)成分的相對濃度高,内側部份内之(b)成分的相對濃度高 之方法(參考圖1)。(2)具有内層及外層之製劑,外層中(a) 成分的相對濃度高,内層中成分的相對濃度高之方法(參 考圖2) ° (3)具有3層之積層型製劑,中間層中(b)成分的相 對濃度南’而上層及下層中(a)成分的相對濃度高之方法(參 考圖3)。再者,此處成分與成分的相對濃度,包含其 中一方k度爲0之情況。 本發明固形製劑’爲賦予清涼感之目的,可配合薄荷醇 。薄荷醇在製劑中可以整體均一的方式配合方式,也可隨 表纸張尺度適用中國國家標準(CNSTT^ ( 2i〇x 297公藶 (請先閱讀背面之注意事項再填寫本頁)492874 5-A7 B7 printed by the Consumer Cooperatives of the Central Bureau of Standards of the Five Ministry of Economic Affairs, invention description (lactose, starch, dextrin, cellulose, polyethylene glycol, magnesium stearate, and maltitol. Etc.) Ingredients (c The blending amount of) is 84.999% by weight or less, and preferably 74 999% by weight or less. In the solid preparation of the present invention, in order to maintain the effect of the medicinal active ingredient for oral cavity, the component (a) is designed to have a component (b) It is better to dissolve first (that is, to foam first). In other words, in the process of foaming and dissolving, it is better to control the composition ratio of each part (a) :( b) in the solid preparation of the present invention to In the initial dissolution in the oral cavity, the component (a) is foamed, and the component (b) is dissolved after the foaming is completed. With this foaming and dissolution process, the (a) component and (b) in the solid preparation The relative concentration of the ingredients varies depending on the part they are in, and it is better to design it to have a higher component (a) in the Shao Fen which is first resolved in the oral cavity, and a higher component (b) in the later dissolved part. Specific examples are as follows: (丨) In the solid preparation, (a) The method of high relative concentration of ingredients and high relative concentration of (b) component in the inner part (refer to Figure 1). (2) Preparations with inner layer and outer layer. The relative concentration of (a) component in the outer layer is high and the inner layer is high. Method for high relative concentration of ingredients (refer to Figure 2) ° (3) Laminated preparation with 3 layers, the relative concentration of component (b) in the middle layer is south, and the relative concentration of (a) component in the upper and lower layers is high Method (refer to FIG. 3). Here, the relative concentration of ingredients here includes the case where one of the k degrees is 0. The solid preparation of the present invention can be blended with menthol for the purpose of imparting a cooling sensation. It can be used in an overall and uniform manner, or it can be applied to the national standard of the paper (CNSTT ^ (2i〇x 297 cm) (please read the precautions on the back before filling this page)

經濟部中央標準局員工消費合作社印製 492874 A7 B7 五、發明説明(6 ) ^ ^ (a)成分與(b)成分的濃度差,將其中之一配合多量。若在 (a)成分多量配合的部分,配以高濃度的薄荷醇,則一方面 可減輕來自薄荷醇之苦味,另—方面也可使薄荷醇配合的 量較多。薄荷醇在製劑中配合的量以〇 〇 5〜5重量%爲較佳 。再者,薄荷醇在(a)成分相對濃度高的部分較佳配合 0· 05〜1重里/〇’而在(b)成分相對濃度高的部分較佳配合 0.1〜5重量%。 本發明固形製劑,更爲賦予香味及防止口臭之目的,可 選適宜的香料配合,尤以配合一種或二種以上選自百里香 、芹采、肉桂、鼠尾草、胡椒、香菜、荷蘭薄荷、肉莖蔻 、回香醚、丁子香、薄荷油、墨角蘭、羅樂及迷迭香中者 ,能使口臭防止效果顯著提昇者。有關香料的配合量,以 0.001〜5重量%爲較佳,以(^^重量。/。爲特佳。 本發明固形製劑除上述成分以外,也可加入一般製劑常 用l蔗糖脂肪酸酯、微粒二氧化矽等潤滑劑、維生素類及 咖啡因等就目的而碉配之成分、及糖精鈉、蔗糖、山梨糖 醇、阿斯巴甜、赤蘚醇等甘味料等等成分以配合。 。 本發明固形製劑之形態,無特殊限制,錠劑,丸劑、顆 粒劑均可,但以錠劑爲較佳。 本發明固形製劑可由-般方法製造,例如在積層鍵的場 合,可先在含有發泡成分之層形—成後,在其上部形成含有 口腔用藥效成分之層,其次更在其上部再形成含有發:成 分<層而製造。再者具有内層及外層錠劑的情況,可先在 含有口腔用藥效成分之内層形成後,再在其周園包覆含有 —---一 - 9 ~ ( CNs") AmM ( 210X297^1 ~~~ -- (請先閲讀背面之注意事項再填寫本頁)Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs 492874 A7 B7 V. Description of the Invention (6) ^ ^ (a) The difference between the concentration of the component (a) and the component (b), and one of them is mixed in a large amount. If a large amount of the component (a) is blended with a high concentration of menthol, on the one hand, the bitterness from menthol can be reduced, and on the other hand, the amount of menthol can be increased. The amount of menthol in the formulation is preferably from 5 to 5% by weight. In addition, menthol is preferably blended in a portion having a high relative concentration of the component (a) in a range of 0.05 to 1 weight / 0 ', and is preferably blended in a portion having a high relative concentration of the component (b) in an amount of 0.1 to 5% by weight. The solid preparation of the present invention has the purpose of imparting fragrance and preventing bad breath, and can be selected with suitable spices, especially one or two or more selected from thyme, celery, cinnamon, sage, pepper, parsley, holland, Those with nutmeg, scented ether, gerbera, peppermint oil, marjoram, rale, and rosemary can significantly improve the prevention of bad breath. Regarding the blending amount of the fragrance, 0.001 to 5% by weight is preferred, and (^^ wt. /) Is particularly preferred. In addition to the above components, the solid preparation of the present invention can also be added with sucrose fatty acid esters and particles commonly used in general preparations. Lubricants such as silicon dioxide, vitamins, caffeine, and other ingredients formulated for the purpose, and sweeteners such as sodium saccharin, sucrose, sorbitol, aspartame, and erythritol, etc ... The form of the solid preparation of the present invention is not particularly limited. Lozenges, pills, and granules can be used, but lozenges are preferred. The solid preparation of the present invention can be manufactured by ordinary methods. Layer formation of foam ingredients-after it is formed, a layer containing medicinal ingredients for oral cavity is formed on the upper part, and a layer containing hair: ingredients < is also formed on the upper part. Furthermore, it has an inner layer and an outer layer of tablets, Can be formed after the inner layer containing the effective ingredients for oral use is formed, and then wrapped in its surrounding garden ------ 9 ~ (CNs ") AmM (210X297 ^ 1 ~~~-(Please read the back (Please fill in this page again)

A7 、發明説明 發泡成分之層而製造。 本發明固形製劑用於口 # 7k ^ ^ ^ L ^衛生處理,不需將此製劑在 欠中/谷醉,而直接飲入中 制— T猎在口中與水分接觸而發泡 >谷_ ’製劑溶解後,將溶解液 果均佳。 訂’夺解履易下,或由口中吐出,效 以下將舉實例詳細説明本發明 %月不贫明然而本發明並不限於這 些實例。 t例1〜2及比較例1〜2 組成如表!所示的各種鍵劑(lg,直徑15叫,爲使用 M—a股份有限公司所製油壓式多層錠打錠機所調製。 預先以呼氣袋裝取人的呼氣,由:名評價者(域6)加以 評價,兩者評價之後選出所謂「有口臭者」4〇名,將其 分爲4群,而表丨的樣本爲服用過者。服用過後,再度取 出呼氣袋進行評價,以調查錠劑的效果。評價基準爲: 口臭有改善+ +,邵分改善+,沒有改善(仍有口臭)—。 其結果如表1,明顯地,本發明製劑與不含發泡成分之 ^況(比較例1 )及發泡成分未滿1 5重量。之情況(比較例 2 )比較’明顯地有優良的口臭防止效果。 經濟部中央標準局員工消費合作社印製 -10 ------- 本紙張尺度適用中國國家標準(CMS ) A4規格(21〇X 297公釐) 492874A7. Description of the invention It is produced by a layer of a foaming component. The solid preparation of the present invention is used for oral # 7k ^ ^ ^ L ^ hygienic treatment, without having to use this preparation in the under / intoxicated, and drink directly into the system-T hunt in the mouth and contact with moisture to foam > 谷 _ 'After the preparation is dissolved, the dissolving liquid is good. If you want to get the job done, or spit it out of your mouth, the following examples will be used to explain the present invention in detail. However, the present invention is not limited to these examples. Examples 1 to 2 and Comparative Examples 1 to 2 are shown in the table! The various bonding agents (lg, diameter 15 is called) are prepared by using hydraulic multi-layer ingot punching machine made by M-a Co., Ltd. The person's exhalation is pre-packed with an exhalation bag and evaluated by: (Domain 6) was evaluated. After the two evaluations, 40 so-called "halitosis patients" were selected and divided into 4 groups, and the samples in Table 丨 were those who had taken them. After taking them, the breath bag was taken out for evaluation again. In order to investigate the effect of lozenges, the evaluation criteria are: halitosis improved +, Shao points improved +, no improvement (still bad breath). The results are shown in Table 1. Obviously, the formulation of the present invention does not contain foaming ingredients. The condition (Comparative Example 1) and the foaming component is less than 15 weights. The case (Comparative Example 2) has a relatively obvious effect of preventing bad breath. Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs -10- ----- This paper size applies the Chinese National Standard (CMS) A4 specification (21〇X 297 mm) 492874

7 B 五、發明説明(8 ) 表1 成分(重量%) 實例1 實例2 比較例1 比較例2 玉米澱粉 50.32 18.32 68.32 56.32 碳酸氫鋼 9 23 0 6 抗壞血酸 3 9 0 2 檸檬酸 3 9 0 2 酒石酸 3 9 0 2 麥芽糖醇 30 30 30 30 糖精鈉 0.5 0.5 0.5 0.5 蔑糖脂肪酸酯 1 1 1 1 銅葉綠酸納 0.18 0.18 0.18 0.18 + + 5 8 0 1 評價者A + 5 2 3 6 — 0 0 7 3 + + 4 8 0 0 評價者B + 6 2 2 7 — 0 0 8 3 實例3〜9 依照與實例1同樣之方法,調製具有表2所示組成之各種 配合有口臭防止成分之鍵劑。 (請先閱讀背面之注意事項再填寫本頁)7 B V. Description of the invention (8) Table 1 Ingredients (% by weight) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Corn starch 50.32 18.32 68.32 56.32 Hydrogen carbonate 9 23 0 6 Ascorbic acid 3 9 0 2 Citric acid 3 9 0 2 Tartrate 3 9 0 2 Maltitol 30 30 30 30 Saccharin sodium 0.5 0.5 0.5 0.5 Fatty acid fatty acid ester 1 1 1 1 Sodium copper chlorophyll 0.18 0.18 0.18 0.18 + + 5 8 0 1 Reviewer A + 5 2 3 6 — 0 0 7 3 + + 4 8 0 0 Evaluator B + 6 2 2 7 — 0 0 8 3 Examples 3 to 9 In accordance with the same method as in Example 1, various types of ingredients with the composition shown in Table 2 combined with bad breath prevention ingredients were prepared. Key agent. (Please read the notes on the back before filling this page)

11T ΙΛ. 經濟部中央標準局員工消費合作社印製 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) 五、 發明説明( A7 B7 表2 重量 0/〇) 實例3 實例4 實例5 實例6 實例7 實例8 '~~—— 實例9 玉米澱粉 50.4 50.4 50.4 50.4 50.4 ~5〇4^ -—^ 50.4 唉酸氫鈉 9 9 9 9 9 9 9 k壞血酸 3 3 3 3 3 3 3 檸檬酸 3 3 3 3 3 3 3 酒石酸 3 3 3 3 3 3 3 麥芽糖醇 30 30 30 30 30 30 30 糖精納 0.5 0.5 0.5 0.5 0.5 0.5 0.5 蔑糖脂防酸酉旨 1 1 1 1 1 1 1 氯化苄乙氧銨 0.1 0 0 0 0 0 0 異丙甲基酚 0 0.1 0 0 0 0 0 曰扁柏醇 0 0 0.1 0 0 0 0 丁香粉 0 0 0 0.1 0 0 0 桂皮粉 0 0 0 0 0.1 0 0 甘草粉 0 0 0 0 0 0.1 0 類黃銅 0 0 0 0 0 0 0.1 ί請先閱讀背面之注意事項再填寫本頁j 、-=& 經濟部中央標準局員工消費合作社印製 實例1 0 依與實例1同樣之方法,調製具有下文所示組成之各種 鍵劑。該錠劑有優良的口臭防止效果,以及清涼感。(成分) 玉米澱粉 竣酸氫鈉 抗壞血酸 (重量%) 48:6 9 12 - 本纸乐尺度適用中國國家標準(CNS ) A4規格(21〇><297公楚) 11 - -- - 8 2 9 4 經濟部中央標準局員工消費合作社印製 A7 B7 發明説明(10 ) 檸檬酸 3 酒石酸 3 麥芽糖醇 30 糖精鋼 1.5 蔗糖脂肪酸酯 1 薄荷醇 0.8 類黃酮 0.1 實例1 1 依照與實例1同樣之方法, 調製具有 錠劑。該錠劑有優良的口臭防止效果以 (成分) (重量%) 玉米澱粉 49.52 碳酸氫鋼 9 檸檬酸 3 韻果酸 3 抗壞血酸 3 麥芽糖醇 30 糖精鈉 0.5 蔗糖脂肪酸酯 1 銅葉綠酸鈉 0.12 鐵葉綠酸鋼 0.Ώ6 薄荷醇 ’ 0.8 (請先閱讀背面之注意事項再填寫本頁) -13 - 本紙張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) 7厶〇 /纤 •五、發明説明(11T ΙΛ. The paper size printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs applies to the Chinese National Standard (CNS) A4 (210X297 mm). 5. Description of the invention (A7 B7 Table 2 Weight 0 / 〇) Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 '~~ —— Example 9 Corn starch 50.4 50.4 50.4 50.4 50.4 ~ 5〇4 ^-^^ 50.4 Sodium hydrogen gallate 9 9 9 9 9 9 9 k Ascorbic acid 3 3 3 3 3 3 3 citric acid 3 3 3 3 3 3 3 tartaric acid 3 3 3 3 3 3 3 maltitol 30 30 30 30 30 30 30 saccharin sodium 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Benzyl ethoxylammonium chloride 0.1 0 0 0 0 0 0 isopropyl methylphenol 0 0.1 0 0 0 0 0 genolol 0 0 0.1 0 0 0 0 clove powder 0 0 0 0.1 0 0 0 cinnamon powder 0 0 0 0 0.1 0 0 Licorice powder 0 0 0 0 0 0.1 0 Brass 0 0 0 0 0 0 0.1 ί Please read the notes on the back before filling in this page j 、-= & Printed by the Staff Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs Example 10 In the same manner as in Example 1, various bonding agents having a composition shown below were prepared. This lozenge has an excellent halitosis prevention effect and a refreshing feeling. (Ingredients) Sodium ascorbyl corn starch ascorbic acid (% by weight) 48: 6 9 12-The paper scale is applicable to Chinese National Standard (CNS) A4 specification (21〇 > < 297gongchu) 11---8 2 9 4 Printed by the Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A7 B7 Description of the invention (10) Citric acid 3 Tartaric acid 3 Maltitol 30 Saccharin steel 1.5 Sucrose fatty acid ester 1 Menthol 0.8 Flavonoid 0.1 Example 1 1 Follow the same procedure as in Example 1 The method is to prepare a lozenge. This lozenge has excellent halitosis prevention effect. (Ingredient) (weight%) corn starch 49.52 bicarbonate steel 9 citric acid 3 yunolic acid 3 ascorbic acid 3 maltitol 30 saccharin sodium 0.5 sucrose fatty acid ester 1 sodium copper chlorophyll 0.12 Iron leaf green acid steel 0.Ώ6 menthol '0.8 (Please read the precautions on the back before filling out this page) -13-This paper size applies to China National Standard (CNS) A4 (210X297 mm) 7 厶 〇 / fiber • Five, description of the invention (

實例1 2 依照與實例1同於夕士 一、' 、 本 < 万法,碉製具有下文所示組成之各種鍵劑。此鍵劑有俱自沾 久艮的口臭防止效果以及清涼感。(成分)玉米殿粉 (重量%) 43.02 12 4 4 4 30 0.5 1 0.12 0.06 0.8 0.5 經濟部中央標準局員工消費合作社印¾ 碳酸氫鋼 檸檬酸 蘋果酸 抗壞血酸 麥芽糖醇 糖精鈉 蔗糖脂肪酸酯 銅葉綠酸納 鐵葉綠酸納 薄荷醇 香料(百里香) 實例1 3 具有如表3所不組成之各種三層鍵一……^ 一王王 比·外層/内層/外層=丨/丨/ j )係使用Machi仙股份有限公司 製油壓式多層錠打錠機所調製。集合有舌苔者“名,以呼 氣袋收取其呼氣。將這些人分爲2組,每組各7人。服用表3 的兩種三層錠3小時後,再度以呼氣袋收取其呼氣。三層錠 使用七後口臭之有無,由2名評審員加以評價。評價基準爲 :口臭消失◎、部分口臭消失〇、沒有變化父。結果如表4 g,15 mm直徑、重量 (請先閲讀背面之注意事項再填寫本頁) ••I裝 訂 14 - 本紙張尺度適财關家標準(CNS ) A4規格(21()><297公後 492874Example 1 2 According to the same method as in Example 1, I, ', Ben < Wanfa, a variety of bonding agents having the composition shown below were prepared. This keying agent has a long-term bad breath prevention effect and a cool feeling. (Ingredients) Corn Palace Powder (% by weight) 43.02 12 4 4 4 30 0.5 1 0.12 0.06 0.8 0.5 Printed by the Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs ¾ Bicarbonate steel citrate malate ascorbyl maltitol saccharin sodium sucrose fatty acid ester copper leaf Natto green phytate Natitol chlorophyllol spice (thyme) Example 1 3 Has various three-layer bonds not composed as shown in Table 3 One ... ^ One king to king ratio · Outer layer / Inner layer / Outer layer = 丨 / 丨 / j) It is prepared by hydraulic multi-layer ingot beater manufactured by Machi Sen Co., Ltd. The names of those with tongue coating were collected, and their breath was collected by exhalation bags. These people were divided into 2 groups of 7 people each. After taking the two three-layer tablets of Table 3 for 3 hours, they were collected again in an exhalation bag. Exhale. The presence or absence of halitosis after using the three-layer ingot was evaluated by 2 reviewers. The evaluation criteria were: halitosis disappeared ◎, some halitosis disappeared 〇, no change. The results are shown in Table 4 g, 15 mm diameter, weight ( Please read the precautions on the back before filling out this page) •• I Binding 14-This paper size is suitable for financial and family care standards (CNS) A4 specifications (21 () > < 297 Queen 492874

第86118226號專利申請案 中文說明書修正頁(91年3月) ^ 五、發明説明(12 ) 所示。 表3Patent Application No. 86118226 Chinese Revised Page of the Specification (March 91) ^ V. Description of the Invention (12). table 3

由表4及表5可明顯地看出,口腔内先溶解部分中成八 的相對濃度高且後溶解部分中(b)成分的相對濃度高之本^ 明製劑,藥效成分的持續性也非常優良。 表4 評審員A 評審員B 評價 實例1 3 比較例3 評價 實例1 3 比較例3 ◎ 5 〇 〇 2 1 X 〇 6 ◎ 6 0 〇 1 2 x 0 5 -15- 本紙張尺度適用中國國家標準(CNS) A4規格(210 X 297公釐) 492874 A7 B7 •五、發明説明( 13 實例1 4 使用橘水製作所股份有限公司所製有核迴轉式打鍵機, 調製直徑15 mm、厚度5 mm的有_。(還有,須先使用 油壓式加壓打錢調製直徑1Q mm、厚度3咖做爲核的旋 劑)。調製後的錠劑,以實例13的外部層做爲有核錠的外部 層,而以實例13的内部層做爲有核錠的核心部份。 再者,與實例丨3同樣地,集合有舌苔者7名,以呼氣袋收 取其呼氣,而服用有核錠3小時後,再度以呼氣袋收取其呼 氣,錠劑使用前後口臭之有無,由2名評審員加以評價。評 價基準爲:口臭消失◎、部分口溴消失〇、沒有變化乂。 結果如表5所示。 —_______ 表 5 評價It can be clearly seen from Tables 4 and 5 that the relative concentration of eighteen in the first dissolved portion in the oral cavity is high and the relative concentration of the component (b) in the later dissolved portion is high. Very good. Table 4 Evaluator A Evaluator B Evaluation Example 1 3 Comparative Example 3 Evaluation Example 1 3 Comparative Example 3 ◎ 5 〇〇2 1 X 〇6 ◎ 6 0 〇1 2 x 0 5 -15- This paper size applies Chinese national standards (CNS) A4 size (210 X 297 mm) 492874 A7 B7 • V. Description of the invention (13 Example 1 4 A nuclear rotary key press manufactured by Orange Water Manufacturing Co., Ltd. was used to modulate a diameter of 15 mm and a thickness of 5 mm. Yes. (Also, you must first use hydraulic pressure to make money to prepare a spinner with a diameter of 1Q mm and a thickness of 3 coffee.) After the preparation, use the outer layer of Example 13 as the cored ingot. The inner layer of Example 13 was taken as the core part of the cored ingot. Furthermore, as in Example 3, 7 persons with tongue coating were collected, and their breath was collected in an exhalation bag. After 3 hours, the core tablets were again exhaled in an exhalation bag, and the presence or absence of bad breath before and after the tablet was used was evaluated by two reviewers. The evaluation criteria were: bad breath disappeared ◎, some bromine disappeared 0, no change 乂. The results are shown in Table 5. —_______ Table 5 Evaluation

評審員AReviewer A

評審員BReviewer B

◎ 〇 X 5 2 0 4 3 0 經濟部中央標準局員工消費合作社印製 實例1 5表6所示爲藥效成分配合好的各種三^層鍵(丨g、瓜瓜直 徑、重量比:外層/内層/外層=1/1/1),係以與實例13$樣的方法所調製。這些錠層無論是口臭預防效果,或其持 續性,均非常優異。 _ 16 _ Μ氏張尺度適财關家縣(CNS ) A4規格(21()χ 297公酱 (請先閱讀背面之注意事項再填寫本頁}◎ 〇X 5 2 0 4 3 0 Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 1 5 Table 6 shows various three-layered bonds (丨 g, melon diameter, weight ratio: outer layer) with good medicinal ingredients. / Inner layer / outer layer = 1/1/1), which is modulated in the same way as in Example 13 $. These ingot layers are excellent in both the bad breath prevention effect and the durability. _ 16 _ Zhang Zhang scale Shicai Guanjia County (CNS) A4 specification (21 () χ 297 male sauce (Please read the precautions on the back before filling in this page)

492874 A7 B7 i、發明説明(14 玉米澱粉 碳鼠鋼 抗壞血酸 檸檬酸 酒石酸 麥芽糖醇 糖精鈉 蔗糖脂肪酸酯 50.5 9 3 3 3 30 0.5 1 氣化芊乙氧銨 異丙甲基酚 曰扁柏醇 丁香粉 桂皮粉 甘草粉 0 0 0 0 0 0 表6 (重量%) 外層 内 層 ① ② ③ ④ ⑤ ⑥ 68.4 68.4 68.4 68.4 68.4 68.4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 30 30 30 30 30 30 0.5 0.5 0.5 0.5 0.5 0.5 1 1 1 1 1 1 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 (請先閱讀背面之注意事項再填寫本頁)492874 A7 B7 i. Description of the invention (14 corn starch carbon rat steel ascorbic acid citrate tartrate maltitol saccharin sodium sucrose fatty acid ester 50.5 9 3 3 3 30 0.5 1 gasification ethoxyammonium isopropyl phenol called linalool clove powder Cinnamon powder and licorice powder 0 0 0 0 30 30 30 30 30 30 0.5 0.5 0.5 0.5 0.5 0.5 1 1 1 1 1 1 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0.1 (Please read the notes on the back before filling this page)

、1T 經濟部中央榡準局員工消費合作社印掣 實例1 6 表7所示係配合有薄荷醇之兰層錠(f g、15 mm直徑、重 量比:外層/内層/外層=1/1/1),係以與實例13同樣的方 法所調製。·用以評價口中之、爽‘度。使用本錠劑之後,無 論是爽快度’或爽快感之持續性,均非常價異。 -17 - ‘紙張尺度適用中國國家標準(CNS ) A4規格(210X297公羡) 492874 A7 B7 五、發明説明(15 ) 表7 實例16 外層 内層 玉米澱粉 48.4 67.89 碳酸氫納 10 0 檸檬酸 5 0 蘋果酸 5 0 麥芽糖醇 30 30 糖精鈉 0.5 0.5 蔗糖脂肪酸酯 1 1 銅葉綠酸鋼 0 0.2 1 薄荷醇 0.1 0.4 (請先閲讀背面之注意事項再填寫本頁) 經濟部中央標準局員工消費合作社印製 實例1 7 表8所示爲配合有銅葉綠酸鋼及鐵葉綠酸鋼以做爲藥效成 分配合之三層鍵(1 g、15 mm直徑、重量比:外層/内層 /外層=1 /1 /1 ),係以與實例1 3同樣的方法所調製。這些錠 劑無論是口臭預防效果,或其持續性,均非常>異。 本纸張尺度適用中國國家標準(CNS ) A4規格(210X29*7公釐) 492874 A7 五 、發明説明(16, 1T Example of the printing of consumer cooperatives by the Central Government Bureau of the Ministry of Economic Affairs of the People's Republic of China 16 Table 7 shows a blue-layered ingot with menthol (fg, 15 mm diameter, weight ratio: outer layer / inner layer / outer layer = 1/1/1 ) Was prepared in the same manner as in Example 13. · Used to evaluate the degree of coolness in the mouth. After using this lozenge, both the refreshment 'and the persistence of refreshment are very valuable. -17-'The paper size applies the Chinese National Standard (CNS) A4 specification (210X297 public envy) 492874 A7 B7 V. Description of the invention (15) Table 7 Example 16 Outer inner corn starch 48.4 67.89 Sodium bicarbonate 10 0 Citric acid 5 0 Apple Acid 5 0 Maltitol 30 30 Saccharin sodium 0.5 0.5 Sucrose fatty acid ester 1 1 Copper chlorophyllic acid steel 0 0.2 1 Menthol 0.1 0.4 (Please read the precautions on the back before filling this page) Staff Consumer Cooperatives, Central Bureau of Standards, Ministry of Economic Affairs Printing example 17 Table 8 shows a three-layer bond (1 g, 15 mm diameter, weight ratio: outer layer / inner layer / outer layer) with copper chlorophyllic acid steel and iron chlorophyllic acid steel as a medicinal ingredient. = 1/1/1), which is modulated in the same way as in Example 13. These tablets are very different from each other in terms of their bad breath prevention effect or their persistence. This paper size applies to Chinese National Standard (CNS) A4 (210X29 * 7mm) 492874 A7 V. Description of the invention (16

48.4 10 5 5 30 0.5 1 0 0 0 67.89 0 0 0 3〇 經濟、邺中央榡準局員工消費合作社印製 玉米澱粉 碳酸氫鈉 檸檬酸 蘋果酸 麥芽糖醇 糖精鈉 蔗糖脂肪酸酯 銅葉綠酸鈉 鐵葉綠酸鈉 薄荷醇 tjH 1 8 表9所示爲配合有銅葉綠酸 分之三層錠Ug、15_直經、編以做爲藥效成 層⑴,其係以與實例13同二比:外 A、 只1冋樣的万法所調製。這些錠劑 無論是口臭預防效果,或其持續性,均非常優異。 0.5 1 0.11 0.1 0.4 (請先閲讀背面之注意事項再填寫本頁) r裝· 、11 19 - 本纸張尺度適用中國國家標準(CNS ) A4規格(210X;297公釐) 7^ 8 2 9 4 A7 B7 五、發明説明(17 表9 實例18 外層 内層 玉米澱粉 48. 1 67.39 碳酸氮納 10 0 檸檬酸 5 0 蘋果酸 5 0 麥芽糖醇 30 30 糖精鈉 0.5 0.5 蔗糖脂肪酸酯 1 1 銅葉綠酸鈉 0 0.11 鐵葉綠酸鈉 0 0. 1 薄荷醇 0. 1 0.4 香料(荷蘭薄荷) 0.3 0.5 請 閱 讀 背 之 注 意 項 再 填 寫 本 頁 經濟部中央標準局員工消費合作社印繁 試驗例1 製造依實例1 3所得之三層錠及下述之錠劑,並評價口臭 之有無。其結果,實例1 3之錠劑,在口臭防止效果及其持 續性方面均最優。 -20 本纸張尺度適用中國國家標準(CNS ) A4規格(210X297公釐) 492874 經濟部中央標準局員工消費合作社印^ A7 B7 五、發明説明(18 ) 表10 無發泡單層鍵 發泡單層鍵 玉米澱粉 68.43 56.43 碳酸氫鋼 0 6 抗壞血酸 0 2 檸檬酸 0 2 酒石酸 0 2 麥芽糖醇 30 30 糖精鈉 0.5 0.5 蔑糖脂肪酸酯 1 1 銅葉綠酸鈉 0.07 0.07 (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準(CNS ) A4規格(210X 297公釐)48.4 10 5 5 30 0.5 1 0 0 0 67.89 0 0 3 0 Printed by the Economic and Social Organization of the Central People's Republic of China Employees' Cooperative to produce corn starch, sodium bicarbonate, citrate, malate, maltitol, saccharin, sucrose fatty acid ester, sodium copper chlorophyll Sodium iron chlorophyll menthol tjH 1 8 Table 9 shows a three-layer ingot Ug, 15_ straight warp and braided with copper chlorophyll acid, which is used as a medicated layered tincture. It is the same as Example 13 Ratio: Outside A, only 1 sample of modulation. These lozenges are excellent in both the bad breath prevention effect and the persistence. 0.5 1 0.11 0.1 0.4 (Please read the precautions on the back before filling out this page) r Pack · , 11 19-This paper size applies to China National Standard (CNS) A4 (210X; 297 mm) 7 ^ 8 2 9 4 A7 B7 5. Description of the invention (17 Table 9 Example 18 Outer inner corn starch 48.1 67.39 Sodium nitrate 10 0 Citric acid 5 0 Malic acid 5 0 Maltitol 30 30 Saccharin sodium 0.5 0.5 Sucrose fatty acid ester 1 1 Copper leaf Sodium chlorate 0 0.11 Sodium iron chlorophyll 0 0. 1 menthol 0.1. 1 0.4 Spices (Dutch Mint) 0.3 0.5 Please read the note on the back and fill in this page again. Test example 1 printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs The three-layered tablet obtained according to Example 13 and the following tablets were produced, and the presence or absence of bad breath was evaluated. As a result, the tablets of Example 13 were optimal in terms of the effect of preventing bad breath and its persistence. -20 paper Zhang scale is applicable to China National Standard (CNS) A4 specification (210X297 mm) 492874 Printed by the Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs ^ A7 B7 V. Description of the invention (18) Table 10 Non-foaming single-layer key Foaming single-layer key corn Starch 68.4 3 56.43 hydrogen carbonate steel 0 6 ascorbic acid 0 2 citric acid 0 2 tartaric acid 0 2 maltitol 30 30 saccharin sodium 0.5 0.5 sugar fatty acid ester 1 1 sodium copper chlorophyll 0.07 0.07 (please read the precautions on the back before filling in this (Page) This paper size applies to Chinese National Standard (CNS) A4 (210X 297 mm)

Claims (1)

492874 第86118226號專利申請案 g 終V卜: 中文申請專利範圍修正本(91年3月)C8 六、申請專利範圍 1· 一種口腔衛生用固形製劑,其含有下列成分(a)、了七)及 (〇): Ο)發泡成分 15〜90重量°/〇 (b) 口腔用藥效成分 0.001〜1〇重量% (c) 賦形劑 8 4.9 9 9重量。/。以下 且(a) : (b)= 1 〇 : 1 〜1 〇〇〇 : 1, 其為溶於口腔而使用之固形製劑,該製劑之(a)成分與(b) 成分的相對濃度因所在部分不同而有差異,在口腔内先行 -溶解的邵分中(a)成分濃度高,而在較遲溶解的部分中(b) 成分濃度高。 2·根據申请專利範圍第1項之口腔衛生用固形製劑,具有二 層以上(a):(b)之組成比有差異之層。 3·根據申請專利範圍第2項之口腔衛生用固形製劑,具有三 層以上之積層構造,或者具有二層以上之内層及外層者。 4. 根據申請專利範圍第1至3項中任一項之口腔用固形製劑, 其中該(a)成分係碳酸鹽及有機酸。 ~ 5. 根據申請專利範圍第1至3項中任一項之口腔衛生用固形 製劑,其中該(b)成分係選自口臭防止成分、抗菌劑、消炎 劑、血行促進劑、氟化合物及酵素中之一種或二種以上。 6. 根據申μ專利範圍弟1至3項中任一項之口腔衛生用固形 製劑,其中該(b )成分係銅葉綠酸鈉及/或鐵葉綠酸鈉。 7. 根據申請專利範圍第丨至3項中任_項之口腔衛生用固形製 劑,其尚配合有薄荷醇者。 本紙張尺度適用中國國家標準(CNS) A4規格(210X297公釐)— ------—_ 492874 A8 B8 C8 D8 、申請專利範圍 8. 根據申請專利範圍第1至3項中任一項之口腔衛生用固形製 劑,其中該(a)成分配合層及(b)成分配合層中,配合有薄 荷醇,且該薄荷醇之配合濃度,在(b)成分配合層之濃度 高於(a)成分配合層之濃度。 9. 根據申請專利範圍第1至3項中任一項之口腔衛生用固形製 劑,其中尚配合有一種或二種以上選自百里香、芽菜、肉 桂、鼠尾草、胡椒、香菜、荷蘭薄荷、肉莖蔻、茴香醚、 丁子香、墨角蘭、薄荷油、羅樂及迷迭香中者。 裝 -2 本纸張尺果逋用中國理家標準(CNS) A4規格(210 X 297公釐)492874 No. 86118226 Patent Application g Final V: Chinese Patent Application Scope Amendment (March 91) C8 VI. Application Scope 1. A solid preparation for oral hygiene, which contains the following ingredients (a), (7) And (〇): 〇) Foaming ingredients 15 to 90% by weight / 〇 (b) Oral medicinal ingredients 0.001 to 10% by weight (c) Excipients 8 4.9 9 9%. /. The following and (a): (b) = 1 0: 1 to 1 000: 1 is a solid preparation used for dissolution in the oral cavity. The relative concentration of (a) component and (b) component of the preparation depends on Some of them are different, and the concentration of (a) component is high in the pre-dissolved shaw in the oral cavity, and the concentration of (b) component is high in the later dissolved portion. 2. The solid preparation for oral hygiene according to item 1 of the scope of patent application, having more than two layers (a): (b) having a different composition ratio. 3. The solid preparation for oral hygiene according to item 2 of the scope of patent application, which has a laminated structure of three or more layers, or an inner layer and an outer layer of two or more layers. 4. The oral solid preparation according to any one of claims 1 to 3, wherein the component (a) is a carbonate and an organic acid. ~ 5. The solid preparation for oral hygiene according to any one of claims 1 to 3, wherein the component (b) is selected from the group consisting of a halitosis preventive component, an antibacterial agent, an anti-inflammatory agent, a bloodstream promoter, a fluorine compound, and an enzyme. One or more of them. 6. The solid preparation for oral hygiene according to any one of claims 1 to 3, wherein the component (b) is sodium copper chlorophyll and / or sodium iron chlorophyll. 7. According to any of the items in the scope of the applied patent, any one of the solid preparations for oral hygiene, which are still formulated with menthol. This paper size applies to China National Standard (CNS) A4 specifications (210X297 mm) — ------ — 492874 A8 B8 C8 D8, patent application scope 8. According to any one of the scope of patent applications 1 to 3 A solid preparation for oral hygiene, wherein the (a) component blending layer and (b) component blending layer are blended with menthol, and the blending concentration of the menthol is higher than (a) ) Concentration of component blending layer. 9. The solid preparation for oral hygiene according to any one of claims 1 to 3, wherein one or two or more kinds are selected from the group consisting of thyme, sprouts, cinnamon, sage, pepper, parsley, and mint , Nutmeg, fennel ether, gerbera, marjoram, peppermint oil, ralle and rosemary. Packing-2 paper ruler for Chinese paper standard (CNS) A4 (210 X 297 mm)
TW86118226A 1996-08-09 1997-12-04 Solid preparation for oral hygiene TW492874B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP21126696A JP3706204B2 (en) 1996-08-09 1996-08-09 Oral solid formulation
JP34993696 1996-12-27
JP34993796 1996-12-27
JP20900897A JPH10236948A (en) 1996-08-09 1997-08-04 Solid pharmaceutical preparation for oral cavity
JP9209009A JPH10236935A (en) 1996-08-02 1997-08-04 Oral solid preparation

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TW492874B true TW492874B (en) 2002-07-01

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