TW320563B - - Google Patents

Description

Amendment! ^ -R · '/-·.' ·., Ι Bu 'II "' Supplement A 6 Π 6 320563 V. Description of the invention (1) Collection of inventions The present invention is pseudo-pro-to-round liquid preparation For infusion preparations containing sugar, amino acids, electrolytes and fat emulsions. The cracking agent has excellent stability and storage period. The present invention also relates to a container for cracking such infusion preparations, an infusion preparation containing a fat-proof emulsion and sugar, and an infusion preparation containing amino acids and electrolytes. BACKGROUND OF THE INVENTION Intravenous infusion is performed under the following circumstances to provide nutrition and maintain the patient's life: when oral or itching hunger is impossible or insufficient, the patient's digestive and absorption function is in a bad state. The same can be done when oral or Jing # bait; or when food passes through the digestive tract, will make the patient's condition or Qi disease more serious. Examples of infusion preparations available on the market include sugar infusions, which contain unrefined sugar, etc .; amino acid infusions, in which * contains mustard amino acids, etc .; electrolyte infusions, which contain electrolytes, etc .; fat emulsions, which contain Vegetable oil emulsion, etc .; and vitamin mixture. These infusion preparations can be used appropriately according to the patient's condition, and should be warm during use. However, mixing these formulations during use requires complicated handling, and in particular can cause microbial contamination problems. In order to overcome these problems, Zeng Jing broke out various liquid preparations in which several of the aforementioned ingredients were mixed in advance. Infusion preparations containing all the essential nutrients to be supplied, sucrose, amines, electrolytes, and fat emulsions are particularly useful from a clinical point of view. The stabilizing chopsticks of the liquid and the fat emulsion are different from each other. Therefore, various problems occur when mixing the slabs (please read the back of the contest first and then fill in the page). Install < the Ministry of Economic Affairs Standard Printed by the Bureau of Industry and Consumer Cooperatives 姝 浪 Λ / t 遝 鐘 home sample standard (α < 5) Ή specification (210X297; Miao 81. 4. 10,000ft. (Η) 320563 Λ 6 Π 6 V. Description of invention (2), making the mixture unusable in many situations. For example, fat emulsions are prone to generate large fat particles due to their unstable nature, and when mixed with other infusions, cause phase separation (emulsification). In particular, electrolytes Divalent cations in the infusion cause the fat emulsion particles to coagulate and disintegrate. Taking electrolyte infusion as an example, because the infusion contains calcium and phosphoric acid necessary to maintain electrolyte balance, it is easy to cause mixing due to the reaction of calcium and phosphoric acid to form calcium phosphate To prevent the formation of turbidity and Shendian, this electrolyte infusion is usually adjusted to a low pH value (lower than pH 5). When this electrolyte infusion is mixed with an amino acid infusion, due to the strong buffering effect of the amino acid , So that the pH of the mixture is increased to the pH of the amino acid, so a large amount of acidic materials (such as hydrochloric acid, acetic acid, etc.) are required to maintain the pH at a low level. However, because a large amount of acid will destroy the infusion components Balanced, so only a limited amount of acidic materials can be used. As a result, the pH value of the electrolyte and amino acid infusion mixture cannot be reduced to a satisfactory level, resulting in the mixture appearing when heated and sterilized (please read first, please pay attention Matters fill out this page) Install · Order _ Line · The Ministry of Economic Affairs, the Central Bureau of Economic Affairs, Beigong Consumer Cooperation Du Yint,, type, fat wait time, the same-sex fat period can not change the bacteria, and then eliminate, etc., It is hot at the time of mixing. The ionization is only due to the addition of the image, and the time is divided. The liquid mixture is used to find the acid, so that the lactation is based on the fat and mixed with the amine. , Like Ruchangdian and ^-! 'Liquid sugar , General information, output agent, *, quality sugar, containing the solution of the problem-solving problem and the preparation solution to ask the power transmission fluid to counter the seed and other acids, lose d) store the acid of this acid first. The amino group 11 can be deposited as an amine. The amine ai is difficult to get in the liquid, killing (M, the liquid liquid is precipitated by sugar, and the milk is described. The sugar is mixed with the outer plum or the fat, etc., the turbidity is mixed with the liquid such as the fat liquid and the transfer Ruyi Λ This paper scale is used in the middle-sleepy country (CNS) T4 specification (2〗 0 × 297 public ¢) 81. 4. U), 000 sheets (H) V. Description of the invention (3) The infusion preparation is scheduled to be stored. SUMMARY OF THE INVENTION In view of these decomposed types, and even if it contains all the properties, denaturation and coloration are repeated, it is found that the use of menstrual preparations before use is not provided with the content of excellent stability. The situation, the components of the fat emulsion and its problems. For these components, the inventors have encountered the aforementioned problems with the sugar and amino groups, and therefore, the inventors conducted a thorough study on the development of infusion preparations containing sugar, amino acids, and diazepam. Found examples of infusion preparations can also be solved by improving the modification of each group. For example, precipitation, phase separation, and infusion preparation methods are thoroughly studied. As a result, a combination of preparations can be stored safely and mixed with each preparation. Can easily get the desired loss, denaturation, color, and other problems. Acids, electrolytes, and fat emulsions, and infusion preparations with stable storage are one of the inventions (please read the back-end notes # 圸 写 此 页) Installation and Ordering-Staff of the Ministry of Economic Affairs Bureau of Standards It is another object of the present invention to provide containers filled with infusion preparations that can be used for mixing infusion preparations. It is another object of the present invention to provide an infusion preparation containing a fat emulsion and sugar. · It is another object of the present invention to provide an infusion preparation containing amino acids and electrolytes. BRIEF DESCRIPTION OF THE DRAWINGS 'Figure 1 is a cross-sectional view of an example of a container of the present invention for filling an infusion preparation. Figure 2 is a cross-section of another example of the container of the present invention for filling infusion preparations Λ 〆 * t paper-scale national standard (CNS) Ή specification (210X297 public; «:) 81. 4. 10, _ Zhang . (H)

V Printed by the Beigong Bureau of the Ministry of Economic Affairs, the Beigong Consumers ’Cooperative Society ^ 20563 Λ 6 _Π_6_ V. Description of the invention (4) 'Plan view. In figures 1 and 2, reference numbers 1 and 11 represent the container of the present invention, 2 and 12 represent the first compartment, 3 and 13 represent the second compartment, 4 and 14 represent the infusion containing fat emulsions and sugars, 5 and 15 represent infusions containing amino acids and electrolytes, 6 represents a communication device, 7 and 16 represent a partition member, and 8, 9, 10, 1 7, 18 and 19 represent openings. Figure 3 is a pseudo-graph of the relationship between the average particle size of the fat emulsion sample obtained in Example 3 and the number of times the sample passed through the emulsifier. In Figure 3, ♦ stands for glycerin, ♦ stands for glucose, ○ stands for sorbitol, □ stands for xylitol, ▽ stands for fructose, and ▲ stands for control. The details of the invention indicate that the present invention relates to an infusion preparation containing sugar, amino acids, electrolytes, and fat emulsion. The preparation contains phosphorus in the form of an ester or salt of a polyhydric alcohol or sugar. The pH value is adjusted to 5.0 to 8. The present invention also relates to a container filled with infusion, which can be used for mixing infusion preparations. Again, the present invention pseudo relates to an infusion preparation containing fat emulsion and sugar, and an infusion preparation containing amino acids and electrolytes. In particular, it is preferred to use a fat emulsion having an average particle size of 0.17 mm or less, and the phosphorus source of the electrolyte is preferably a phosphate or ester salt of a polyhydric alcohol or sugar. The container filled with infusion of the present invention is a container including first and second compartments separated by a partition member. The infusion containing fat emulsion and sugar is contained in the first compartment, and the other infusion containing amino acids and electrolytes is contained in the second compartment. Various types of sugars can be used in the present invention. · Return sugars such as glucose and fructose ·: \ (Please read the back-notes and fill in this page first) This paper scale is used in 8 sleepy homes (CNS) example specifications (210X297 公 幻 81. 4 . 10,000 sheets (H) Λ 6 Π 6 V. Description of the invention (5), maltose, etc. are particularly preferred. These reducing sugars can be used alone or in the form of a mixture of two or more. These reducing sugars can also be used. It is mixed with at least one compound selected from sorbitol, xylitol, glycerin, etc. Examples of amino acids used in the present invention include various essential and non-essential amino acids, which have been used in conventional amino acid infusion preparations To provide living nutrients, such as L-isoleucine, L-leucine, L-valine, L-lysine, L-methionine, L-phenylalanine, L-melamine , L-tryptophan, L-arginine, L-histidine, glycine, L-alanine, L-proline, L-aspartate, L-serine, L-casein Amino acids, L-glutamic acid, L-cysteine, etc. These amino acids can be used not only in the form of free amino acids, but also in many other forms, including for example: inorganic acid salts, L-ionine hydrochloride, etc .; organic acid salts, such as L-ionine acid acetate, L-ionine acid maleate, etc .; esters that can be hydrolyzed in vivo, such as L-tyrosine Methyl methionate, methyl L-methionine, ethyl L-methionine, etc .; N-substituted derivatives, such as N-ethinyl-L-tryptophan, N-acetyl-L-half Cysteine, N-acetyl-L-proline, etc .; and dipeptides generated from the same or different amino acids, such as L-tyramine-aldehyde-L-tyrosine, L-propylamine -L-tyrosine, L-spermine acetyl-L-tyrosine, L-Ministry of Economic Affairs, Central Bureau of Economic Affairs, employees of the Ministry of Economic Cooperation cooperated to produce and print other acid amine sperm IL lead group m tyramine salt hair acid sugar It is used as grapevine, salt-salt acid-soluble ethyl water, sulfur agent for various salts of acids. Before the preparation of liquefied gas delivery technology, it should be similar to the quality of the magnesium solution used in the solution. Potassium activity, Yu Na is an isotropic solution such as salt and salt, water and salt are equally divided into phosphorus groups, organic iodine is not available, various kinds of manganese, copper, etc., salt ferric acid, milk and so on. ο The person 0 must balance the quality of electricity. The paper of this kind is the Chinese standard (CN5) standard (210x297 male dragon) \ 81 10,000 pieces (Η) Ϊ »_ \\ i .. • · · · -V · · .. ........ 【...... 装 ：. · 定. ·: 线 。.... f ..... ··. * .. (Please read first, please pay attention Please fill in this page for details) Printed by Beigong Xiaoxian Cooperative of the Ministry of Economic Affairs of the Ministry of Economic Affairs ^ 320563 Λ 6 ___ Π6_ V. Description of the invention (6) In these electrolyte components, the phosphate esters of polyhydric alcohols or sugars can be used appropriately Or its salt as a source of phosphorus. Examples of phosphate esters of polyhydric alcohols include glyceryl phosphoric acid, mannitol-phosphoric acid, sorbitol-phosphoric acid, and the like. Examples of phosphate esters of sugars include glucose-6-phosphate, mannose-6-phosphate, and the like. As for the salts of these phosphate esters, alkali metal salts such as potassium salts, potassium salts, etc., and alkaline earth metal salts such as magnesium salts can be used. Preferred examples of phosphate ester salts are the sodium and potassium salts of glycerol * based phosphoric acid. The preferred electrolyte components are as follows: Sodium: sodium nitrate, sodium lactate, acetate m, sodium sulfate, and sodium glycerophosphate; potassium: potassium chloride, potassium glycerophosphate, potassium sulfate, potassium acetate, and potassium lactate;, Calcium: calcium gluconate, calcium chloride, calcium glyceryl phosphate, calcium lactate, calcium pantothenate, and calcium acetate; magnesium: magnesium sulfate, vaporized magnesium, glyceryl magnesium phosphate, magnesium acetate, and lactate m; phosphorus: glyceryl Potassium phosphate, sodium glyceryl phosphate, magnesium glyceryl phosphate, and calcium glyceryl phosphate; and zinc: zinc sulfate, vaporized zinc, zinc gluconate, zinc lactate, and zinc acetate. The fat emulsion of the present invention may be an oil-in-water emulsion. The preparation method of this emulsion pseudo-uses an emulsifier to disperse the fat in water. The fat emulsion can be prepared in any suitable manner, for example, fat and emulsifier are added to water, and the mixture is stirred to prepare a coarse emulsion, which is then emulsified by any common means, such as high-pressure emulsification. (Please read the precautions before filling in this page) The ft scale of this paper uses the Chinese National Standard (CNS) TM specifications (210X297 public) 81. 4. 10,000 sheets (H) Λ 6 Π 6 Ministry of Economic Affairs The quasi-bureau bureau co-operates with the industrial and commercial enterprises to make the printing. 5. Description of the invention (7) When the emulsion is prepared by the high-pressure emulsification method, the crude emulsion can pass through a homogenizer under a pressure condition of usually 20 to 700 kg / era2, such as Manton-Gaulin homogenizer, 5 to 50 times. Any kind of edible fat and oil can be used as fat emulsion and fat source. Preferred examples of fat sources include: vegetable oils such as soybean oil, cottonseed oil, safflower seed oil, corn oil, coconut oil, perilla oil, etc .; fish oils such as cod liver oil, etc .; medium chain fatty acid triglycerides, such as PanaceU trade name ), 0D0 (trade name), etc .; and chemical refining of triglycerides such as 2-linolein · acyl-1,3-dioctanoic acid glyceride (8L8), 2-linoleinyl-1,3--2 Glyceryl caprate (10L10), etc. These fats and oils can be used alone or as a mixture of two or more. Any emulsifier commonly used in pharmaceutical preparations can be used in the present invention. One or more chemical agents can be used, preferably selected from egg yolk phospholipids, hydrogenated egg yolk phospholipids, soybean phospholipids, hydrogenated soybean phospholipids, and nonionic surfactants, such as Plu "〇niC" F68 ( Trade name, polycyclic gas ethane polypropylene oxide block copolymer) and HC〇-60 (trade name, polyoxyethylene hydrogenated castor oil). To use soybean oil as a fat source and egg. Yellow phospholipid Fat emulsions prepared by emulsifiers are particularly preferred. According to the present invention, the preparation method of fat emulsions is preferably such that the average particle diameter becomes 0.17 wm or less. By controlling the particle diameter at this level, it is possible to obtain a comparatively current use The fat emulsion (average particle size, 0.2 to 0.3 μ π) is more stable than the fat emulsion, which can effectively prevent the phase separation of the fat emulsion caused by the difference in specific gravity., (Please read the back And the matters needing attention # fill in this page) BU3 Standard 3 Standards (CNS) Τ4 specifications (210X297 g *): α · \ 81, 4. 10,000 sheets (Η) Ministry of Economic Affairs Printed by the industrial and consumer cooperatives V. Description of invention (8) Average grain 0.17; fat emulsion of α π or below can be prepared by adding at least one compound selected from glycerin and glucose, followed by emulsification. According to this technique, glycerin and glucose have For the purpose of determining the capacity, it is convenient to prepare fat emulsions with an average particle size of 0.17 wa or less. Further examples illustrate the preparation of such fat emulsions, for example by adding fat sources and emulsifiers together with glycerol and / or glucose Stir the mixture in water to obtain a coarse emulsion, then emulsify the coarse emulsion by conventional methods, such as the aforementioned high-pressure emulsification method. In this case, glycerin and / or glucose can be added at the time of emulsification. For example, glycerin and / or glucose can be added In the coarse emulsion prepared from fat and emulsifier. The average particle size of the emulsion thus prepared can be determined by a conventional method, such as the light diffraction method. In the aforementioned emulsion preparation method, fat, emulsifier and glycerin and / or The amount of glucose is such that the composition of the resulting fat emulsion is from 0.1 to 30% fat content in terms of w / ν (unless otherwise stated, otherwise The term "%" used hereinafter means w / v%), preferably from 1 to 20%; the emulsifier content is from 0.01 to 10¾, preferably from 0.05 to 5%; the glycerin and / or glucose content is from 30 to 70 %, Preferably from 40 to 60¾; and an appropriate amount of water. The mixing ratio and concentration of the sugars, amino acids, electrolytes, and fat emulsions contained in the infusion preparation of the present invention may depend on the use of the preparation, the disease and Symptoms, and other condition adjustments. The following examples illustrate the preferred composition of the infusion preparation of the present invention: Fat emulsion and sugar: (Please read it first. Precautions before writing this page) This paper is used in SS home Standard (CNS) > H specification (210X297cm) V 81 4 10 000 sheets (H) Λ 6 Π 6 Co-authored by the quasi-bureau bureau of the Ministry of Economic Affairs, H. Co., Ltd. Printed by V. Invention description (9) Fat 5-50 g / children emulsifier 0.5-10 g / λ sugar 50-250 g / Ji base acids and electrolytes: L-isoleucine 0. 5 _ 5 g / children L-leucine 0.5-7 g / Sense L-Weinoic acid 0.5-5 g / Sense L-Ionic acid 0.5-7 g / Sense L-methionine 0.1-4 g / Sense L-phenylalanine 0 · 3- 5 g / Ai L-threonine 0.3-5 g / JL L- tryptophan 0.1-1 g / iL L- arginine 0.3-7 g / synonine 0.2-3 g / il: .v4 swill Alanine 0.2-3 g / JL-: Γ ^ ίΐί alanine 0.3 * 5 g / il 3 proline acid 0.2-5 g / il L-aspartic acid 0.03-2 g / JL L- serine 0. 2 ~ 3 g / JL L-tyrosine 0.03 ~ 0.5g / JL L-glutamic acid 0.03-2 g / iL L-cysteine 0.03-1 IB E q / JL Na 15-60 ffl E q / JL Potassium 10-50 Bl E q / JL m 3-15 ffl E q / liL This paper size is used in the middle of the S standard (CNS) A 4 specifications (210X297 public) (please read first, * · ,? (Notes on the back page of Erhu Lettuce) (Package · Line-8) .6. 10,000 sheets (Η) 320563 Λ Π 6 Printed by the β Department of the Central Bureau of Industry and Commerce β-consumer cooperation 5. The description of the invention (U )) m 2-10 Π1 Eq / Yi ammonia 8-80 ΙΠ Eq / Wen phosphorus 1-15 m Eq / Yi Fei 0-30 μταοί / iL The infusion preparation of the present invention can be prepared by; dissolving the aforementioned components In or dispersed in pure water (for example, distilled water etc. for "Notes", "internal") or preferably by making sugar liquids separately »Amino acid liquid t Electrolyte liquid and fat emulsion Sterilize t and emulsify by heating, etc. f Then aseptically mix the sterilized infusion and emulsion 9 and their mixing ratio can be adjusted to the predetermined level of each component. 0 Sugar solution t Amino acid solution> and electricity * 71 m- liquid can be prepared by conventional methods and fat emulsion can be-borrowed Prepared by the method described-Preparation 0 The infusions and emulsions prepared in this way are placed in glass or plastic containers. The atmosphere in the container is replaced with inert gas such as nitrogen krypton, etc. 1 The container is then sealed and properly sterilized. 0 This example Medium »Glass or plastic containers can be bag-shaped, bottle-shaped, etc.> The materials are polypropylene, polyethylene, ethylene-vinyl acetate copolymer. Polyvinyl chloride, etc. The sterilization process can be carried out in a common way> For example, heat sterilization Treatments such as high-pressure steam sterilization t hot water immersion sterilization > hot water spray sterilization, etc. 〇 Sterilize in a substantially oxygen-free atmosphere when using plastic containers. The container filled with infusion according to the present invention includes a sealed container It includes two compartments that can communicate with each other via a communication device. The two compartments are separated from each other by a partition member attached to the communication device. Fat contains The infusion solution of emulsion and sugar is sealed in the first compartment > and contains amino acids and electrolytes. The other infusion solution is sealed in the second compartment and then immediately added, heat--.. ι.; " (i fungus 〇 when using 9 through this paper standard for ease of use in the 8 national standard (CNS) A 4 specifications (210x297 public release) 81. 4. 10,000 sheets (H) (please read the notes before you please # Item write this page) Λ 6 Π 6 Ministry of Economic Affairs, Central Bureau of Industry and Economics, Beigong Consumer Cooperatives, Yinyu V. Description of the invention (11) Evacuation of the partition member, allowing the first and second compartments to communicate with each other, thus mixing two via the connecting device Liquid, and prepared infusion preparation. Figure 1 is a cross-sectional view showing an example of a container filled with infusion according to the present invention. In this figure, a container 1 made of plastic material has two compartments, namely a first compartment 2 and a second compartment 3, an infusion 4 containing fat emulsion and sugar is contained in the first compartment 2, and another The infusion 5 containing amino acids and electrolytes is contained in the second compartment 3. The first and second compartments 2 and 3 are separated from each other by a separating device 7 (in this example, a fastening bolt) attached to the communication device 6, so as to avoid the infusion 4 and the second compartment contained in the first compartment 2 Infusion 5 contained in 3 is mixed. In addition, the container is provided with an opening 8 for the infusion 4 to be injected into the first compartment 2, an opening 9 for the infusion 5 to be injected into the second compartment 3, and an opening 10 for the injection of the mixed preparation. If necessary, other chemical agents can be mixed through these openings. Such a container filled with infusion is obtained in the following manner. First, the communication member 6 of the container 1 is closed by a partition member (fastening bolt 7 in this example), and the first and second compartments 2 and 3 are separated from each other, and then the infusion containing fat emulsion and sugar is passed through the opening 8 Inject into the first compartment 2 and inject another solution containing amino acids and electrolytes into the second compartment 3 through the opening 9. In this case, it is better to inject the infusions 4 and 5 into the first and second compartments 2 and 3 under inert gas, such as nitrogen, argon, etc. When the infusions 4 and 5 are filled into the first and second compartments 2 and 3, the openings 8 and 9 are sealed, and the resulting container is sterilized to obtain the container with the infusion sealed in Figure 1. Sterilization can be carried out by any conventional means, for example, by heat sterilization means, such as high-pressure steam sterilization, heat permanent immersion sterilization, hot water spray sterilization, etc. When plastic containers are used in these situations, it is better to sterilize them in a substantially oxygen-free atmosphere. (Please read the precautions before filling in this page) This paper uses the 5Jc standard and uses a Η family standard (CNS) 4 specifications (210x297 public) 81. 4.] 0,000 sheets (Η) Ministry of Economic Affairs Quasi-authorized shellfish consumer cooperation Du Yin 51 320563 Λ_Π6_ V. Description of the invention α2) The thus obtained infusion sealed container of the present invention can be stored as such. Infusion preparations containing fat emulsions, sugars, amino acids, and electrolytes can be used by removing the clasp 7 to make the first and second compartments 2 and 3 communicate with each other, and make each compartment The sealed infusions 4 and 5 are mixed and aseptically mixed. Subsequently, the infusion preparation thus mixed is ejected from the opening 10 in a sterile manner, and administered to a living body through a tube (not shown). Fig. 2 is a cross-sectional view showing another example of the container filled with infusion of the present invention. In this figure, a rectangular container 11 made of plastic material and other materials has two compartments, namely a first compartment 12 and a second compartment 13, which are separated from each other by a large bolt 16. An infusion 14 containing a fat emulsion and sugar is enclosed in the first compartment 12, and another infusion 15 containing amino acids and electrolytes is enclosed in the second compartment 13. Since the first and second compartments 12 and 13 are separated from each other by bolts 16, the infusion 14 in the first compartment 12 and the infusion 15 enclosed in the second compartment 13 are not mixed . In addition, the container 11 is provided with an opening 17 for infusion 14 into the first compartment 12, an opening 18 for infusion 15 into the second compartment 13, and an opening 19 for injection of the mixed preparation . If necessary, other chemicals can be mixed through these openings. The method and usage of the container filled with infusion shown in Figure 2 is basically the same as the container shown in Figure 1. The mixed image of infusion 14, 15 is completed by unscrewing the bolt 16. The container sealed with infusion shown in Figures 1 and 2 is only one subject of the present invention and should not be considered as limiting the scope of the present invention. The shape, size, etc. of the container can be freely changed, as is the partition member. For example, in Figure 1, a clip can be used instead of the fastening bolt 7, or the first and second compartments 2 and 3 can be separated from each other by installing a ball bolt in the communication member 6. $ Can use hot-melt film or (please read the precautions before filling this page) This paper is used in the national standard (CNS) f 4 specifications (210X297 male dragon) 81. 4_ 10,000 sheets (H ) x. '»MJu \ Λ fi 1? 6 Printed by the Ministry of Economic Affairs of the Central Ministry of Industry and Consumers' Association V. Description of the invention (13) Splittable connector. . In the aforementioned process, the infusion containing fat emulsion and sugar to be sealed in the first compartment can be prepared by various methods. For example, sugar can be added to the fat emulsion prepared in advance by the aforementioned procedure, or to the fat / emulsion mixture to be emulsified. Preferably, during the preparation of the fat emulsion, 瑭 is added to the fat so that the average particle size of the fat emulsion becomes 0.17 w m or less. This fat emulsion can be prepared as described above. The composition of the infusion solution containing fat emulsion and sugar can be based on the concentration of the infusion solution to be sealed in the second compartment (in other words, the infusion solution containing amine group p and electrolytes) Any change fee such as volume ratio. The composition-preferred examples include a greaseproof content from 0.1 to 30 :, preferably from 1 to 201, more preferably from 2 to 10¾, and an emulsifier content from 0.01 to 10¾, preferably from 0.05 to 53 :, More preferably from 0.1 to 1%, reducing sugar content: from 5 to 60S :, preferably from 7 to 404, more preferably from 10 to 3.031, and the most suitable water. The infusion solution containing amino acids and electrolytes to be sealed in the second compartment meat can be prepared by various means. For example, each amino acid and electrolyte to be blended can be dissolved in pure water, such as distilled water for injection. The composition of infusions containing group-based acids and decomposables can be injected into the first and second compartments according to the degree of infusion to be sealed in the first compartment (also 6P infusion containing fat emulsion and sugar) The infusion ratio of 縹 縹 is arbitrarily changed. One of the preferred examples of the composition includes the total amount of amino acids from 1 to 15¾. Preferably from 2 to 13¾, more preferably from 3 to 12Λ; and the electrolyte is 50 to 180nEq / il sodium, 40 to 135inEq / Jl potassium, 10 Up to 50 'nEs / calcium calcium, 5 to 30oiEq / magnesium magnesium, 0 to 225nEq / clinic chloride, 3 to 40nEq / clinic phosphorus and 0 to 100 jwmol / zinc, in addition to suitable water. 、 The preferred composition is as follows: / 1¾ Please note 3R -Pl · Fill in · This / page installed η line paper paper size ϋ used in the SS home standard (CNS) T4 regulations «S (210x297 gong) sound Zheng 11 81 -4.] 0,000 ft (B) Λ 6 Π 6 Produced by Beigong Consumer Cooperation of the Bureau of Standards, Ministry of Economic Affairs. Printed by D. V. Description of Invention (14) Electrolytes-Sodium 50 -180 m E q / iL Potassium 40 -135 m E q / Calcium 10 -50 nj E q / Sense m 5 -30 Π! E q / JL Nitrogen 0 -225 rn E q / A_ Phosphorus 3 -4 0 ID E q / Sense zinc 0 -100 household mol / Sense Amino acids L-isoleucine 1-15 g / iL L-leucine 1-20 g / children L-valine 1-15 g / il L-isoamine hydrochloride 1-20 g / il L · -Methionine 0. 5-10 g / Jl L-Phenylalanine 1-15 g / il- L-Phenylalanine 1-15 g / il L-tryptophan 0 • 3-3 g / il L-arginine 1-20 g / sense group |. One Y ·! Amino acid 0.5-10 g / il l · ϋ Gan U ·. Amino acid 0.5-10 g / A. Alanine 1-15 g / iL L-proline acid 0 • 5-15 g / JL L-aspartic acid 0.1-5 g / il L _ serine acid 0.5-10 g / il

(Please read the back of the note #fill this page first) This paper standard is used in the Chinese National Standard (CNS) > F4 specification (210x297; «:) 81. 4. 10,000 sheets' (H) Economy Printed by the Ministry of Standards, Bureau A, Affordable Price Cooperative V. Description of the invention as) L) Tyrosine 0.1-1 δ / Child L-Glutamic acid 0.1-5 g / Sense L-cysteine 0.1-3 g / pH of the infusion preparation of the present invention can be adjusted from 5.0 to 8.0 t, preferably from 5.5 to 7.5 in view of the viewpoint of the safety of living body. When using phosphate or ester m of polyhydric alcohol or sugar as the source 1 Even at a relatively high pH value, it can effectively avoid the formation of precipitates. Various acidic substances t Better organic acids t As long as they are physiologically acceptable t The pH adjuster used as an infusion preparation. Examples of the pH adjuster include citric acid 9 gluconate t lactic acid > malate maleic acid and malonic acid. At least one kind of organic acids. Among these organic acids, oxycarboxylic acids can also be used in the form of lactones or lactides. When the same is used, these organic acids can be used in the form of a salt or a mixture of salts thereof. Such organic acid salts include inorganic alkali salts (such as alkali metal salts such as sodium salt, potassium salt, etc.) and organic halide salts (such as ethanolamine salt, N-methylglucosamine salt, amino acid salt, etc.). These organic acids can stabilize fat emulsions to divalent metal ions. In this way, when the fat emulsion and the solution containing divalent metal ions are warmed in the presence of these organic acids, the resulting fat emulsion is quite stable, and the aggregation of fat particles can be avoided. Organic acids that can chelate with divalent metal ions are preferred, with citric acid being particularly preferred. The pH adjuster can be added at any time. However, preferably, a predetermined amount of pH adjusting agent is added in advance to either or both infusions, such as sugar infusions. For example, taking the container in Figure 1 as an example, the pH adjusting agent may be added to one or both of the infusions in the first and second compartments. The size of this paper is used in the middle-sleepy home standard (CNS) A 4 specifications (210X297 public: ":) 81. 4. 10,000 sheets (H) (please read the precautions Sun fills in this page first)线 _ Λ 6 Π 6 The Ministry of Economic Affairs, the Central Bureau of Economics and Trade, the A-Commerce Co-production, Du Printed V. Description of the Invention (16) To avoid coloring during sterilization and storage, anti-coloring agents such as thioglycerol, disulfide Erythritol and the like are added to the infusion preparation of the present invention, and the addition amount is usually about 1% or less. The addition of the anti-coloring agent can be carried out at any time, however, it is preferable to add a predetermined amount of the anti-coloring agent to one or two infusions in advance, such as sugar infusion. For example, taking the container in Figure 1 as an example, the anti-colorant can be added to one or both infusions in the first and second compartments in advance. In addition, the infusion preparation of the present invention can be mixed with vitamins, such as vitamin A, vitamin B group, vitamin C, vitamin D group, vitamin E, and K-group. At the same time, the infusion to be sealed in the first compartment can be combined with buffering agents, such as L-histidine, ginseng (hydroxymethyl) aminomethane, etc., to 0.001 to 1.0%, preferably from 0.0 2 to 0.5%, preferably from 0.005 to 0.3 S: the quantity is mixed. L-histidine acid and ginseng (hydroxymethyl) aminomethane can be used alone or in combination. If necessary, they can be used in the form of salts. Acid addition salts such as hydrochloride can be used as salts. Taking histidine as an example, metal salts, such as potassium salts and potassium salts, can also be used. These buffers can prevent pH drop and free fatty acid production during sterilization and storage of infusion preparations. The infusion preparation thus obtained is stable, and the concentration of free fatty acids is reduced. To avoid denaturation of the components after encapsulation, the container filled with infusion according to the present invention may be wrapped with a gas-impermeable membrane. Examples of such air-impermeable membrane materials include: Three-layer laminated film in which ethylene-vinyl alcohol copolymer film, polyvinyl alcohol film, polyvinylidene chloride film, etc. are used as the inner layer (for example, the laminated film includes a polyester film, a Nylon film, stretched polypropylene film, etc. made of outer layer, and unstretched polypropylene film made of inner layer); film with aluminum layer (for example, an aluminum layer placed on polyester film and One of the f membranes between the stretched polypropylene membranes); and inorganic (please read the back and forth precautions # 蜞 写 this page) Binding · Order-line. ^ • Paper scales for the use of Η sleeper standard (CNS ) Specifications (2) 0x297 public goods) 81_ 4. 10,000 sheets (10320563 Λ 6 Β 6 Beigong Bureau of Economics, Ministry of Economic Affairs, Beigong Consumer Co., Ltd. Du Printing V. Description of the invention (17) Barrier layer of deposited film Membrane (e.g. poor), with a silicon deposited film placed between the polyester film and the unstretched polypropylene film, a barrier film 1 with a silicon deposited film placed η between the stretched nylon film and the unstretched polypropylene film The film has an aluminum deposition film placed on poly-cool film and untensioned poly The interlayer film between the propylene film and the laminated film with the polyvinylidene fluoride film placed between the vaporized aluminum deposited polyester film and the unstretched polypropylene film). Gas scavengers such as A g el es S (commodity Name) Can be placed on the left> Between the packaging material and the container, or the container wrapped with a film material can be vacuum-packed in the usual way> Or fed in an inert gas (such as nitrogen) for packaging. The fat-containing emulsion thus obtained Λ sugar amine group The infusion preparations of acid t and electrolytes have an excellent storage period »No precipitation will occur \ Denatured coloring, etc. 1 Can be stored for about a week y Infusion preparations can be used for this or after dilution with pure water * If necessary, mix with other drugs etc. Afterwards) Intravenous administration to patient 0 can also be used via other routes of administration such as via or rectal administration. The infusion preparation of the present invention including glycosamino acids-V m disintegrations and fat emulsions will not cause precipitation, phase separation and denaturation even when these components are present at the same time. An infusion preparation with excellent stability and safety. 0 In addition> The container filled with infusion according to the present invention < Infusion of one of fat emulsion and sugar t and another infusion containing amino acids and electrolytes> ; Separately pre-packed in two compartments separated from each other t The infusion preparation of the present invention can simply remove the partition member attached to the container by ασ > and encapsulate two types of fmr Μ bacteria during use The liquid is warm to get. In other words, t can be obtained simply by using the container of the present invention C3C > The infusion preparation can be easily obtained without causing microbial contamination during mixing 1 Attributed to this preparation ^ mr m Need to deal with separately prepared fat emulsion sugar solution amino acid solution $ and electrolyte installation · order-line. (Please read the back of the precautions # fill out this page) This paper standard uses the Chinese National Standard (CNS ) ΤΜ specification (210x297 g; «:) 81. 4. 10,000¾ (Η) Λ 6 Ιί 6 tcx Gongxiaozhong Duin 31 of the Central Standards Bureau of the Ministry of Economic Affairs. V. Invention Instructions (18) The steps of solution mixing. The following examples are provided for the purpose of further illustrating the present invention and should not be construed as limiting the scope of the present invention. Example 1 A mixture composed of 60 g of soybean oil, 7.2 g of egg yolk phospholipid, and an appropriate amount of distilled water for injection was stirred together using a mixer. The total volume is adjusted to 100 π with distilled water for injection to avoid coarse emulsion. Subsequently, the resulting emulsion was emulsified using a Manton-Gorlin homogenizer (15M-8TA, manufactured by Gorlin). 500πιΑ_ aliquots of the emulsion thus obtained were mixed with 250 g of glucose, and the total volume was adjusted to 1000 niil with distilled water for injection. Subsequently, the pH of the resulting emulsion was adjusted to 6 to obtain an infusion preparation. The composition of the infusion preparation thus obtained is shown in Table 1. Infusion preparations are fed into a glass container with a 50 ”volume, and the air in the container is replaced with nitrogen. Subsequently, the container filled with the infusion preparation was sealed and sterilized by high-pressure steam at 115 ° for 30 minutes. Table 2 shows the appearance, pH value, and average particle size of the infusion preparation before and after sterilization. J _L_J | _ soybean oil, yolk phospholipid, glucose, distilled water for injection, quantity U) 303.6250, and the total volume is adjusted to 1 0 0 0 m.

The size of this paper is easy to use the Chinese Standard for Sleepy Family (CNS) Grade A 4 (2Κ1χ2ί) 7 mm) 81. 4. 10,000 sheets (R) (know first read the precautions and then know this page) V. Description of the invention (19) Straight test item White homogenous emulsion before sterilization 5.60 0.22 ^ π Λ 6 Π 6 White homogenous emulsion after sterilization 5.03 0.2 2 um The average particle size of Xibuguan pH is slightly lower as shown in Table 2. Example 2 An infusion preparation shown in Table 3 below was obtained in a similar manner to the procedure of Example 1, except that fructose was used to replace glucose, and it was extinguished by high-pressure steam in the same manner as in Example 1. The infusion preparation can still maintain the emulsion in good condition after extinguishment. Table _3_ Amount (g) The infusion preparation can maintain a stable emulsion, but its p Η value is in the extinction J | _ Soybean oil yolk phospholipid fructose Distilled water for injection 30 250 The required amount and the total volume is adjusted to 1 00 niil (please first Read back and pay attention to the matter # fill out this page) Economics 4 The Central Bureau of Standards and Technology Co., Ltd. printed examples of the dispersion of soybean oil and yolk phospholipids containing glycerin or sugar (glucose, sorbitol, xylitol Or fructose) to obtain a coarse emulsion. The crude emulsion was further emulsified at a pressure of 550 kg / ciif and a temperature of 70 ¾ or below using a Manton Gorin homogenizer (15 Μ-8TA, manufactured by Kobayashi) to obtain a fat emulsion. Its composition is shown in Table 4. The paper size is returned to the Chinese standard «Zun (CNS) A 4 specifications (210x297 male dragons) lion, you 81. 4. 10,000 sheets each ⑻ repair supplement Λ 6 Π 6 V. Description of the invention (20) During the emulsification step, check The periodic change of the average particle size of the emulsion. To measure the average particle size, add 100 nil water to each 0.1 μm emulsion sample to make a sample solution, and use Ma 1 ver η automatic caliper 2 C (M a 1 ver η company cracked) to measure The average particle size of the sample solution. As for the control system, the same procedure was repeated, but glycerin or various glycopeptides were replaced with equal amounts of water. 1 The results are shown in Figure 3, where the symbols refer to glycerol, ♦ represents glucose, ○ represents sorbitol, □ represents xylitol, ▼ represents fructose, and ▲ represents control. _ 4 components (please read the notes on the back of this page first) Pack-Soybean oil 30 The Ministry of Economic Affairs is accurate and the employees work together to cooperate with the duin drum egg yolk phospholipid 3.6 glycerin or sugar 500 distilled water for injection ' It needs to be set to adjust the total volume to 1 0 0 0 ιπ, as shown in the brain 3, in the control system (without glycerol and sugar system), the average particle size after passing the wheat through the milk. It is still about 0.2 / X m. At the same time, even after repeatedly passing through the emulsifier 30 times, the average particle size of the system containing sorbitol, xylitol and fructose is still 0.1 S to 0.2 / X u. On the contrary, in the case of the system containing glycerin and inulin, the average particle size decreases rapidly as it repeatedly passes through the emulsifier. In this way, after repeating the system containing glycerin about 8 times and repeating the system containing grapevine about 20 times, the average particle size reached 0.17wni. The results show that glycerin and glucose have a high ability to reduce the particle size of the emulsion. ^ Bin Shi Example 4 ^ Threading _ MUfc standard edge with ta S home accurate (CNS) Ή specifications (210x297 cm) 81. 4. 10,000 sheets (H) 320563 A 6 15 6 V. Description of invention (21) Via Add 60g soybean oil, 7.2g egg yolk phospholipid and 500g glucose to water to prepare a crude emulsion. The total volume is adjusted to 100 mJL with water. The coarse emulsion thus obtained was emulsified using a Manton-Gauline homogenizer (15 M-8 T A, manufactured by Colin) until the particle size reached 0, 15 μm or less to prepare a fat emulsion. The fat emulsion thus obtained was mixed with 5 0 0 in aliquot and mixed with 5 0 0 u aliquot. The composition of the fat emulsion thus prepared is shown in Table 5. The glass container with a volume of 50 rail was fed with the preparation and the air in the container was replaced with nitrogen and then sealed. Subsequently, the container filled with the fat emulsion preparation thus sealed was sterilized by autoclaving at 115 5 for 30 minutes. Before and after sterilization, the appearance, pH, and average particle size of the preparation were compared. The results are shown in Table 6. • _5_ Amount (g) ϋ_ Soybean Oil Yolk Phospholipid Glucose Distilled Water Number 30 250 Needs and adjust the total volume to 1 0 0 0 mil (please read the precautions before filling in this page) Packing-Stranding . The Ministry of Economic Affairs, Central Standards Bureau, Cargo Consumers Cooperative Printed Table Test Project. Appearance of white homogeneous emulsion after sterilization. White homogeneous emulsion pH 5.60 5.01 Average particle size 0.14Wm 0.14 ^ m As shown in Table 6, after sterilization, the emulsion conditions of the preparation are stable. However, the value of P Η is slightly lowered ^ The paper size is easy to use the Chinese letter H standard (CNx) specifications (210x297; Obituary cooperation du printing 5. Description of the invention (22) Ben Example 5 After adding 42.9niil 70% glucose solution (70C) to the mixture (701) composed of 42.64g soybean oil and 6.14g egg yolk phospholipid, the total The volume was adjusted to 500 in with water to prepare a coarse emulsion. The crude emulsion thus obtained was emulsified at a pressure of 550 kg / CBf and a temperature of 70 or below using a Manton Gorin Juntong machine (15M-8TA, manufactured by Kobayashi) to obtain an average particle size of 0.17 w Fat emulsion of ra or below. Ben Example 6 1 50〇 > The fat emulsion obtained in Example 5 of the aliquots was mixed with distilled water for injection to adjust the total volume to 500 inL. This preparation was fed into a glass container with a volume of 50πι, and the air in the container was replaced with nitrogen, followed by sealing. Subsequently, the container filled with the preparation thus sealed was sterilized by autoclaving for 30 minutes. The preparation thus obtained shows that it can maintain a good emulsified state over a long period of time. Example 7 The fat emulsion obtained in Example 5 with a 200 m aliquot was mixed with 304 m distilled water for injection and 13-2mjl70% ® glucose solution. This preparation is fed into a glass container of 50IDJI volume, and the air in the container is replaced with nitrogen, followed by sealing. Subsequently, the sealed container filled with the preparation was sterilized by high-pressure steam at 115 ° C for 30 minutes. The preparation thus obtained shows that it can maintain a good emulsified state over a long period of time. 'Example 8 A mixture consisting of 60 g of soybean oil, 7.2 g of egg yolk phospholipid and an appropriate amount of water was stirred using a mixer, and the total volume was adjusted to 1000 IU with water!

(Please read the back and the precautions # fill out this page) The paper music standard uses tsa home standard (CNS) T4 specifications (210x297 ;; :) 81. 4. 10,000 sheets (H) V. Description of invention (23 ). Subsequently, the resulting coarse emulsion was obtained by using a Manton-Gauline homogenizer (1 5 Μ-8 TA, high product and total body fluid milk), and the mixture was mixed as shown in the table below. Measure and predict the sugar-making grapes Portuguese'g public 0 series 5 Lin 2 dagger / 1 milk travel Η ρ of the liquid milk gains afterwards 文 Ε 8 0 0 11 for the whole raw-distillation for injection The liquid is input as it is. After feeding, the internal container is filled with the glass and the glass is sealed. The volume is changed to 1. Set 0Π1 gas and 5 nitrogen. W0 ^ -J Ligao I, received 5 and received η V at 80. Because 0 doses »The device of the liquid volume of the device is prepared _ The liquid is dispensed. This is divided into 30 minutes. Youhe, the diameter and grain are all 70 flat table, and the pH value is measured in the value., Time-varying \ ίΕ 8} 4 periods of weeks of experience test the concentrated acid (please read the precautions before filling in This page) The Ministry of Economic Affairs, Bureau of Standards, Bureau of Industry and Commerce, cooperated with Du Gong to print this paper, and the standard is used in a Η home standard (CNS) A Ί specification 210X297 mm) 81. 4. 10,000 sheets (Η) 320563 A 6 η 6 V. Description of invention (24) Libai test concentration concentrate 'iJ slow product gy. Sample time is small (0 ° C 8 8 between C , Stored, stored, compared, compared, printed by the K5 Workers and Consumers Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs 0 12 24 48 Xj — histidine / 0.01% pH 5.85 5.65 5.49 5.23 HC1 size (μπι) ** 0.22 0.21 0.22 0,22 Free fatty acid 0.71 0.83 1.08 2.11 (mEq / l) 0.02% PH 5.89 5.81 5.7 3 5.58 Size (μπι) ** 0.22 0-21 0.21 0.22 Free fatty acid 0.83 0.83 1.20 1.71 (mEq / l) 0.05% pH 5.89 5.78 5.68 5.50 Size (Μπι) ** 0.21 0.21 0.21 0.22 free fatty acids 0.83 0.83 1.32 1.88 (mEg / 1) Tris / HC1 1 mM pH, 5.68 4.99 4 knives 5 4:55 size (μπι) ** 0.21 0.21 0.21 0.22 free fatty acids' 0.71 0.83 1.69 2.50 (mEq / l) No PH 5-29 4.68 4.58 4.38 Size (μιη) * · * 0.20 0.22 0.21 0.22 Free fatty acid 0.59 0.83 1.81 3.45 (mEq '/ l) κη2ρ〇 ": Κ2ΗΡΟή L mM PH. 5.10 4.77 4.61 4.39 Size (μπι) ** 0-22 0.22 0.21 0.21 Free fatty acid 0.71 0.83 1.93 3.45 (mEq / l) κ2ηρο4 / 1 mM. PH 5.05 4.75 4.60 4.41 citric Size (μπι) ** 0.21 0.22 0.21 0.22 Free fatty acid 1.08 0.71 1.93 3.75 (Please read the notes on the back before writing this page) (mEq / l): average particle size C Lu w) This paper uses the Chinese a Jiaju standard (CNS) A 4 specifications (210X297 mm) 8] _ 6. K), 00 £) Zhang ⑻ Binding-Strapping · Λ Λ 6 η 6 V. Description of the invention (25) The results shown in Table 7 are obviously easy to see, the preparation of the present invention has excellent efficacy and can be prevented The pH value decreased and the free fatty acid increased, while the control and comparative examples observed a more significant decrease in the pH value and a sharp increase in free fatty acid. In this way, it is confirmed that the infusion preparation of the present invention has apparently excellent stability. Example 9 A mixture composed of 60 g of soybean oil, 7.2 g of egg yolk phospholipid, and an appropriate amount of water was stirred using a mixer, and the total volume was adjusted to 100 000 with water to obtain a coarse emulsion. Subsequently, the resulting coarse emulsion was emulsified with a Manton Goolin homogenizer U 5 Μ-8TA (manufactured by Kobayashi). The emulsion thus obtained was aliquoted at 500 m, mixed with 250 g of glucose, 0.2 g of L-histidine and lg thioglycerol, and the total volume was adjusted to 1000 niil with distilled water for injection. Subsequently, the pH of the obtained emulsion was adjusted to 6 to obtain an infusion preparation. The composition of the obtained infusion preparation is shown in Table 8. A glass container with a volume of 50H1 is fed with an infusion preparation, and the air in the container is replaced with nitrogen and then sealed. Subsequently, the container filled with the infusion preparation thus sealed was autoclaved at 115 ° C for 30 minutes. Subsequently, the appearance, pH value, average particle diameter, and free fatty acid concentration before and after sterilization were measured. The results are shown in Table 9. (Please read the precautions before filling in this page) Packing. Order _ Economical and Economic Standards Bureau Bureau of Industry and Consumer Cooperation Cooperative 31

A7 B7 V. Description of the invention (26) Number of points U) Soybean oil yolk phospholipid glucose L-histidine thioglycerol distilled water for injection 30 250 The amount of fiber required to adjust the fiber volume to 1 000b & (Please read the back Note ^^ item and then fill in this page,) Install · Table test item appearance

pH Average particle size Free fatty acid concentration Before sterilization White homogeneous emulsion 5.60 0.2 2 w m 0.59mEq / fi After sterilization White homogeneous emulsion 5.03 0. 2 2 ju π 0. 71mEq / α

A Printed by the Employee Consumer Cooperative of the Central Ministry of Economic Affairs of the Ministry of Economy Μ Distilled water for injection is adjusted to 100,000 m fl. As shown in Table 9, the pH decreased slightly due to sterilization and the concentration of free fatty acids increased a little, but the formulation still maintained stable emulsifying conditions. Example 10 A mixture composed of 60 g of soybean oil, 7.2 g of egg yolk phospholipid, 500 g of glucose, and a quantity of water was stirred using a mixer, and the total volume of water was adjusted to 100 Onfl to obtain a crude emulsion. Afterwards, the resulting coarse emulsion was emulsified using a Manton Goolin homogenizer (15M-8TA, manufactured by Kobayashi). 500 · !! Emulsify the emulsion thus obtained with 0.2 g of L-histidine acid and 1 g of thioglycerol. Total volume ί 钱 lb #>, the pH of the obtained emulsion is adjusted to the paper size using the Chinese National Falcon (CNS) Λ4 specification (210X297 turbulence). It is built into a Λ 6 η 6 ^ ¾ Ministry of Central Bureau of Industry and Commerce Beigong Consumer Cooperative Print 5. Description of the invention (27) Adjust to 6 to get the infusion preparation. A glass container with a volume of 50 μm was fed with infusion preparation and the air in the container was replaced with nitrogen and then sealed. Subsequently, the container filled with the infusion preparation thus sealed was sterilized by autoclaving for 30 minutes. Subsequently, the appearance, pH value, average particle size, and free fatty acid concentration before and after sterilization were measured. The results are shown in Table 10. ^ _18 Test items Appearance of white homogeneous emulsion before sterilization after sterilization White homogeneous emulsion pH 5.71 5.32 Average particle size 0.14WB 0. 1 4 χζ m Free fatty acid concentration 0.50niEq / 义 Θ. 65a.Eq / iL As shown in Table 10, pH The value decreased slightly due to sterilization and the concentration of free fatty acids increased a little, but the preparation still maintained stable emulsifying conditions. Example 11 (A) Infusion preparation and stability test: In a similar manner to the procedure of Example 10, four infusion preparations (a total of 3 samples) sealed in glass containers were prepared, and their respective compositions are shown in Table 11. The stability test was conducted under the following conditions using these preparations. Storage temperature: 4 0 It Humidity: 75 $ Storage period: 0, 1, 2 and lunar. (Please read back to note first item 4 fill in this page) 装 · 线-

The size of this paper is used in the middle-sleepy country (CNS) Ή specification (210x297 g; «:) 81. 6. 10,000 sheets (Η) A 6 η 6 V. Description of invention (28) Table _i_L_ _i_number U) Large Soybean oil 33 Yolk phospholipid 4.8 Glucose 250 L-histidine 0,0.05, 01 or 0.15 Distilled water for injection to adjust the total volume to 1 0 0 0 m the amount required (B) Test results: As shown below, where the fat emulsion The stability of this infusion preparation like blending with reducing sugar can be significantly changed by adding L-histidine. (1) Appearance All tested preparations showed white uniform emulsification throughout the storage period. (i i) pH Table 12 shows the pH value of each formulation at the beginning of the test and during storage. In the table, the Η value is expressed as the average of 3 samples. As shown in Table 12, the pH value is proportional to the concentration of L-histidine. The concentration is inhibited (please read the precautions before reading this page). Installation · Line_ > Ministry of Economic Affairs + Central Government Printed by the Bureau ’s employees

The 51c scale of this paper is used in the letter of the Chinese letter 揳 楳 quasi (CNS) A 4 specifications (210X297 mm) 81. 4. 10,000 sheets \ Η) Fifth, the description of the invention (29) Λ 6 Π 6 Central Bureau of Economics Ministry of Economic Affairs Printed by the Explosives Cooperative Association 12 L-histidine acid concentration pH ⑴ Storage months at 40P 0 hours 1 2 3 0 4.33 4.58 4.58 4.46 0 .005 5.19 5.37 5.24 5.11 0 .01 5.64 5.65 5.54 5.43 0 .015 5.80 5.84 5.70 5.58 (i U) Average particle size Table 13 shows the average particle size of each formulation during the initial and storage periods of the test. In the table, each average particle size (unit, wm) is expressed as the average of 3 samples. As shown in Table 13, the average particle size of each formulation during the entire storage period is almost unchanged. Table 13 L-histidine concentration average particle size U m) U) Storage month at 40Ό 0 hour 1 2 3 0 0.15 0.15 0.16 0.16 0 .005 0.15 0.15 .0.16 0.17 0 .01 0.16 0.16 0.16 0.17 0 .015 0.16 0.15 0.16 0.17 (i ν) free fatty acid concentration_ Table 14 shows the free fatty acid concentration of each formulation during the initial and storage periods of the test. In the table, each free fatty acid concentration (unit, mEq / child) is expressed as the average of 3 samples. Standard-Side National Sampling (CNS) Ή Specification (2〗 0> < 297 g; ":) 81. 4. 10,000 sheets" (H) (Please read the precautions before writing this page ) Installation · Order _ Line-Printed by the Ministry of Economic Affairs, Central Standards Bureau, Monggong and Co., Ltd. V. Description of the invention (30) As shown in Table 14 »The increase in free fatty acid concentration is proportional to the concentration of L-histidine Suppressed to 0 Table 14 L-histidine concentration free fatty acid concentration UE q / nine) ⑴ At 40 months of its storage at 0 hours 1 2 3 0 1. 62 2 .26 3 .47 3.80 0 .005 0. 62 0 .91 1 .69 2.16 0 .0 1 0. 40 0 .77 1 .20 1.64 0 .0 15 0. 40 0 • 70 0 .99 1.43 Example 12 made from 79.2 g soybean oil, 9.5 The U compound composed of g egg yolk phospholipid and 600 g of inulin was adjusted to a total volume of 1000 m with water, and the resulting mixture was emulsified using a Manton Gorin homogenizer (manufactured by Kobayashi 15M-8TA t). The emulsion thus obtained Dilute and filter with 2.4 volumes of water The 50m volume glass bottle is fed with such diluted emulsion > The air in the bottle is replaced with nitrogen and then sealed. Then »The bottle filled with dilute emulsion after such sealing is extinguished by high pressure steam at 115 ° C m 30 minutes 0 The preparation thus obtained is hereinafter referred to as "sweetened fat emulsion" 0 In addition > A solution containing amino acids and electrolytes as shown in Table 15 is prepared and divided into aliquots. 0M 80mEq / Jl Citric acid was added to each solution and aliquoted separately. The resulting solution was filtered. The resulting filtrate was filtered into a glass bottle with a defined volume »The resulting filtrate» The air in the bottle was replaced with nitrogen and then sealed. Sealed bottle filled with dilute emulsion due to 1151 high-pressure steam __ standard using Chinese H home «Bi (CNS) T4 specifications (210X297 public) 81. 4. 10,000 sheets (H) (please read ift first Matters needing attention on this page) Installation-line · Λ 6 η 6 5. Description of the invention (31) Sterilize for 30 minutes. The preparation thus obtained is hereinafter referred to as "amino acid + electrolyte solution". The solutions prepared in this way are adjusted individually to pH 6.3 to 6.4. Take a 2 il aliquot of amino acid + electrolyte solution from the bottle in a sterile manner and transfer it to a sterile polystyrene tube with a volume of 15 mJl. Next, the 4id sugar-added fat emulsion was taken out of the bottle in a sterile manner and transferred into a polystyrene tube, the solution and the emulsion were mixed, and then the tube was sealed. Relative to the citric acid concentration in the amino acid + electrolyte solution, the turbidity, average particle size and appearance of the mixture thus prepared were measured in one week. The results are shown in Table 16. In this case, the average particle size of the fat emulsion is measured by the light diffraction method, and the turbidity is expressed by the absorbance of the optical tube). (Please read the back-to-back notes first and then fill out this page) Outfit · Ministry of Economic Affairs, Pyongyang Bureau C3: Printed by the Workers' Co-operative Society IV Pingyi Legg \ ": 81 ft (°° ο 10 won • ,: '; T' '', .. ': κ' supplementary A 6 Π 6 by the Ministry of Economy, Trade and Industry Central Bureau of Consumer Affairs Cooperative Printing Ai Μ V. Description of invention (32) points. Electrolyte amino acid .Gasification sodium chloride, potassium sulfate, sulfuric acid, 7H20, grapevine acid-calcium * η2〇 diglyceryl phosphate dipotassium (50%) sodium acetate, 3H2Zn sulfate, 7H20 L-isoleucine. L-. White Press acid • L- • Valine L-Iminic acid. HC1 Methionine phenylalanine L-Vulneric acid L-tryptophan L-arginine L-histidine _ Table 15 渵 度 (Each L) 1.949 3.500 2.054 6-352 gg gg 10.688 g 11.340 9.585 '8.000 14.000 g mg gg 8.000 q 10.000 g 4.000 g 8-000 q 6.000 g 1.200 g 10.500 g 5.〇〇〇g first read in. Back to t -Matters related to the use of the private standard method of late use of the taa house standard (CHS) T4 specifications (210X297 male dragons). Engine image 81. S. 10,000¾ (H) 5. Description of the invention (33) Table 15 (continued) Concentration (Glycine 5.300 g L-propylamine per liter 8- .500 g L-: proline 6_ .000 g L-aspartic acid 1, • 500 g L-. Serine 3, .000 g L- tyrosine 0. • 500 g L-. Glutamate 1.500 g Ν- 乙 Ｍ 基 -L-cysteine 1 • 100 g other components of the appropriate amount of distilled water for injection (please read the back and the precautions # fill in this page) Packing and threading.

Ministry of Economic Affairs + Central Bureau of Standards, M Industry and Consumer Cooperation, Du Yin M, the paper size of the middle use, the family of 揳 楳 quasi (CHS), 4 specifications (210x297 male dragon), 81. 6. 10,000 sheets (H) 320563 Λ 6 η 6 V. Description of the invention (34)

Table 16 Measured after the following time: Test item Citric acid concentration 0 hours 24 hours 4 8 hours 1 week. Turbidity. 0 mEq / 1 0.034 0.083 0.098 0.097 13 mEq / 1 0.033 0.055 0.063 0.080 20 mEq / 1 0.033 0.050 0 -057 0.069 27 mEq / 1 0.034 0.063 0.070 0.085 Average particle size 0 mEq / 1 0.152 0.187 0.194 0.200 (μη) 13 mEq / 1 0,152 0.170 0.173 0.177 20 mEq / 1 0.148 0.165 0.174 0.179 27 mEq / 1 0.155 0.173 0.180 0.189 Appearance θ 0 mEq / 1 NCCD 13 mEq / 1 N 1 ABD 20 mEq / 1 NNAB 2Ί mEq / 1 NNAC

And drops • »—ffl drops into _ oil-shaped, ;; formation and knot-shaped knot condensation and condensation into > but the knot width becomes slightly condensed f / / /» «AB c DN (please read first The back-to-back matters will be written on this page.) The Ministry of Economic Affairs, Ministry of Economic Affairs, Central Bureau of Industry and Commerce β-Consumer Cooperative Cooperative Printed This Paper Standard for Small Use 8® Home Sample Standard (CNS) A4 Specification (210X297) * ^- '81. 6. 10,000 sheets (H) Printed by the Consumer Cooperative Standards Bureau C5T: V. Description of invention (35) As shown in Table 16, the increase in turbidity and average particle size is affected by the addition of citric acid Suppressed, but the appearance only changed slightly. Example 13 Under a gas flow, a predetermined amount of amino acids and electrolytes shown in Table 17 and Table 18 were dissolved in distilled water for injection maintained at 80 ° C, and the resulting solution was adjusted to Η with citric acid 6 · 2. After filtering the solution, the resulting filtrate was placed in a nitrogen-replaced glass bottle and sterilized by 115t high-pressure steam for 30 minutes. The preparation after such sterilization is used for an accelerated storage test. In this way, the appearance, coloring degree, and pH value of the filtrate can be measured immediately after sterilization and after storage at 80 T: 48 hours. The results are shown in Table 19. In this example, the degree of coloring is represented by the absorbance at 4 5 0 n id (5 cm optical tube). (Please read the back-end precautions and fill in this page first) Packing · 6 paper scales for the use of the "House (CHS) specifications (210x297 male dragon) 81. 4. 10,000 sheets (B) 2 320563 Λ 6 Π 6 V. Description of the invention (36) Μ_11 component_concentration (Every time .. ·· The Ministry of Economic Affairs, Bureau of Industry and Economics, A-Consumer Co., Ltd., Du-printed L-isoleucine. 8.000 g L-.leucine 14.000 g L-. Valinic acid 8.000 g L-Iminic acid. HC1 10.000 g L-Methionine 4.000 g L-Phenylalanine, 8.000 g L- Phenylalanine 6.000 g L-Tryptophan 1.200 g L- • Arginine. 10.500 g L-histidine 5.000 g glycine 5.300 g L-alanine 8.500 g L-proline 6.000 g L-aspartic acid 1.500 g L-serine Acid 3.000 g L-tyrosine 0.500 g L-glutamic acid 1.500 g N-ethyl-L-cysteine 1.100 g (please note the matter in advance Sun Sun wrote this page) this Paper standard universal ϋ Η home sample standard (CNS) Ή specification (210X297 male dragon) V 81. 6. 10,000 sheets (Η) 5. Description of the invention (37) Μ_I! Group. Points _.. Degree (per liter) Ammoniation Sodium: 1.949 g potassium chloride 3.500 g. Magnesium sulfate * 7H20 2.054 g calcium gluconate * h2o 6 '; 352 g dipotassium glycerol phosphate. (50%) 10.688 g sodium acetate 3H20 11.340 g zinc zincate * 7H20 9.585 mg m i9 test items are just after sterilization. 4 8 hours after storage at 80 C. Appearance colorless and transparent colorless and transparent chromaticity 0-001 C .005 PH 6.23 6 .25 Read the back first, Note · Matter S 5

T-line 5i printed by the Beigong Consumer Cooperative of the Central Bureau of Economics of the Ministry of Economic Affairs. This paper is used in a national standard (CNS) Ή specification (210χ2ί) 7 male dragon) \ Amendment page 81. 6. 10,000¾ (Η)

A 6 Π 6 V. Description of the invention (38) As shown in Table 19, the sterilized infusion preparation of the present invention is colorless, transparent, free of precipitation, and coloration and changes in pH are completely suppressed. Even after being stored for 8 to 8 hours at 80, the production was still colorless, transparent, and the change in color and pH was suppressed. As such, it is clear that the infusion preparation of the present invention has a significantly high degree of stability. Example 14 An infusion preparation was obtained in the same manner as the procedure of Example 1.3, except that the electrolyte composition of Table 1 S was replaced with another composition shown in Table 20. The preparation thus obtained was used for an accelerated storage test. In this way, the appearance, color, and pH of the filtrate were measured immediately after sterilization and after 48 hours of storage at δ0Ό. As in the example of the infusion preparation in Example 13, the splitting agent in this example showed high stability. (Please read the notes on the back. Please fill in the package. The staff of the Ministry of Economic Affairs of the Central Bureau of the Ministry of Economic Affairs shall set up a cooperation. Du Yin t Table 20. The composition of each component (m -1, .9 4 9 g per atmosphere) Potassium 4.3 0 2g magnesium sulfate.7H, .0 2 .0 5 4 g calcium gluconate. HiO 6, 3 5 2 g glyceryl threonate dipotassium (50¾) 8.016g sodium acetate. 3H3〇11. 3 4 0 g zinc sulfate · 7H20 9 .585 mg Bao Shi Example 1 5 The mixture consisting of 79.2 g soybean oil, 11.4 g yolk base fat, and 600 g glucose was converted to a total of 10.0 0 n il And the resulting mixture using a Manton-Gorlin homogenizer (15 M-3 TA, manufactured by Gorlin Co., Ltd.) milk z .. 'λ The original redness of the paper is used in the asas specifications (21〇 father 297 male dragon) reduction poems: :: 81. 4 · 10, 000 sheets (η) of the line. Co-printed by EX Engineering Consumers, Bureau of Standards, Ministry of Economic Affairs, Co., Ltd. _nj_ V. Description of the invention (39). The emulsion thus obtained has a volume of 2.4 times Water dilution. A 50nijl volume glass bottle is fed with such diluted emulsion, and the air in the bottle is replaced with nitrogen, and then sealed. Then, the sealed bottle is filled with dilute emulsion Due to 115 "high-pressure steam sterilization for 30 minutes. The preparation thus obtained is hereinafter referred to as" sweetened fat emulsion ". This fat emulsion shows an average fat particle size of 0.16 um. Aseptically taken out of the 2πintegral example 13 The infusion preparation containing amino acids and electrolytes is transferred into a sterile polystyrene tube with a volume of 15m. Secondly, the 4μm Ai sugar-added fat emulsion is taken out aseptically and transferred into the polystyrene tube to mix the preparation with the emulsion , Followed by a sealed tube. The turbidity of the mixture thus prepared was measured, and the average particle size and appearance changed over 48 hours. The results are shown in Table 21. In this example, the turbidity is represented by the absorbance at 620 nra ( Ιαπ optical tube); and the average particle size of the fat emulsion is pseudo-measured by the light diffraction method. Table 21 Test items Turbidity 0.034 0.034 0.036 after 24 hours and 48 hours after mixing (please read the notes before refilling This page) The diameter and particle size are average, see 0.

The quality of W contains all of the liquid fats and fats that are intrinsically safe in the preparation of liquid preparations. When broken, it will not dissolve and then dissolve in the liquid, and the 6 types of 1 acids. For example, a basic solution of amines is prepared to prepare a liquid sugar and i liquid fat containing the paper. The paper is used on the side of the paper. China National University of Technology (CNS) ΤＭ regulations tM2] 0x297 (¢) 81. 4. 10,000 sheets (H) V. Description of the invention (40) A 6 Π 6 66g whole soybean oil, 9.5g egg yolk phospholipid, and 500g glucose are added to the appropriate volume of water, the mixture is mixed with a mixer, and then adjusted to a total volume of 1000niil with distilled water for injection Lotion. The crude emulsion thus obtained was emulsified using a Manton-Gorlin homogenizer (15M-8TA, manufactured by Korin) to obtain an emulsion having an average particle diameter of 0.17 / i m or less. Add water to the entire emulsion produced by 500πι, adjust the total volume to 1000m. The composition of the infusion thus obtained is shown in Table 22. _Table 22 Quantity of distilled water for component soybean oil, yolk phospholipid and dextrose for injection U) 334.75 2 5 0 · Required quantity and the total volume of the prepared liquid is transferred and the qualitative solution and the amido acid group contain each The display of electricity and acid amines 4 2 and 3 2 will list the downstream gas nitrogen (please read the precautions first and then write this page). Dissolve ο Intra-water distillation steam injection V 0 8 held at 20. Η 维 Ρ In order to dissolve and adjust the amount of acid number lemon paper paper standard ass standard (CHS) under 4 specifications ( 210x297 public goods) 81, 4. 10, Zhang (Η) 5. Description of the invention (41) Table 23 Sub-concentration Λ 6 Π 6 (per liter) 5 $ quasi-bureau Μ 工 consumer cooperative printed by the Ministry of Economic Affairs 51 L-iso Leucine L-Leucine L-Valine L-_ Amino Acid "HC1 L-Methionine L-Phenylalanine L-Phenylalanine L-Tryptophan 'L-Arginine L-Group Glycine Glycine L-alanine L-proline L-aspartate L-serine L-tyrosine L-glutamic acid N-acetaldehyde-L-cysteine 8.000 g 14.000 g 8.000 g 10.000 g 4.000 g 8.000 g 6.000 g 1.200 g 10.500 g 5.000 g 5.300 g 8.500 g 6.000 g 1.500 g 3.000 g 0. 500 g 1.500 g 1. 'lOO g (please read the back first and pay attention to this item # fill in this page) install, 1T line-/ ^ Paper-scale side use of a S family support standard (CNS) Ή specification (210 father 297 public release) 81. 6. 10,000 sheets (H): '-order'; Xu Cooperation Du Yin 31 fs-; Catch the Year "Month 1

Γί. M V. Description of the invention (42) Sub-table 24 Concentration (per liter) Sodium citrate 'Potassium chloride magnesium sulfate * 7Η20 ΜGarbate * η2ο Dipotassium glycerophosphate (50%) Sodium sulfate · 3Η20 sulfuric acid Zinc · 7Η20 1.949 g 4.302 g 2.054 g 6.352 g 8.016 g 11.340 g 9.585 mg (3) The extinction and preparation of the infusion preparation of the present invention ^ Use a polypropylene container with the structure shown in Figure 1 to fasten the bolt 7 After the communication member 6 is closed, 600 ml of the infusion solution containing fat emulsion and sugar obtained from the above procedure (1) is injected from the 0 port δ into the first compartment 2 with the feeding of nitrogen gas, and then the opening 8 is sealed. In a similar manner, 300 ml of the infusion solution containing amino acids and electrolytes obtained in the above procedure (2) was injected into the second compartment 3 through the opening 9 to search for nitrogen gas, and then the opening 9 was sealed. The container 1 thus prepared was sterilized by autoclaving with 11 5 for 30 minutes and then cooled to room temperature. After sterilization, the fastening bolt 7 is removed from the connecting device 6, and the infusions in the first and second compartments 2 and 3 are withdrawn through the catching device 6 and mixed to obtain the infusion preparation of the present invention. The composition of the infusion preparation thus obtained is shown in Table 25.

The MMfc scale uses the Chinese S home ft standard (CNS) IM specifications (210 father 297 ambassadors) Zhenzheng '/ U > C 81. 6. 10,000¾ (Η) Please m in the back t item and then re-binding the line

A7 B7 V. Description of the invention (43 Table 25 Infusion preparation into Example 16 (per liter) 22.OOg 3.17g Example 17 (per liter) 1 7.33g 2.49g (Please read the precautions on the back first Fill in this page) r

'1T Ministry of Economic Affairs Central Standards Bureau employee consumer cooperatives printed fat soybean oil egg yolk phospholipid glucosamine amino acids L-isoleucine L-leucine L-valine acid L-lysine · HC 1 L-methionine Acid L-Phenylalanine L-Pulmonary acid L-Tryptophan L-Arginine L-Histidine Glycine L-alanine L-proline, L-aspartic acid, L-filament Amino acid · L-tyrosine, L-glutamic acid, Ν-acetoxy-L-cysteine 1 6 6. 6 7 g 2. 67g 4. 67g 2. 67g 3. 33g 1. 33g 2 .67g 2. 0 0 g 0. 40g 3. 5 0 g 1. 6 7 g 1. 77g 2. .83g 2. 0 0 g 0. 5 0 g 1. OOg 0. 17g

122.OOg 2.67g 4.67g 2.67g 3.33g 1.33g 2.67g 2.OOg 0.40g 3.50 0g 1.6.6 7g 1.77g 2.83g 2.OOg 0.50 g 1. OOg 0. 17g 0. 5 0 g 0. 37g The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) Modified Bin 320563 Λ 6 Π 6 V. Description of the invention (44) Table 25 Infusion Formulation Composition Example 16 Example 17 (per liter) '(per liter) Electrolytes · Sodium 38.89 mEq 38-89 mEq Potassium 30.00 mEq 30.00 mEq Calcium 9.44 mEq 9.44 mEq m 5.56 mE 5.56 mEq Gas 48.60 mEq 45.17 iuEq Phosphorus 5.37 mEq 7.17 mEq Zinc 11.11 μιποί 11.11 μιηοΐ Other ingredients _ citric acid 1.401 g 1.401 g (please read the back and forth notes # 场 舄 this page) The Ministry of Economic Affairs, the Central Bureau of Industry and Commerce, the Central Committee of the Ministry of Economic Affairs and Industry Cooperative Printing (4) The stability test of the infusion preparation The infusion preparation of the present invention obtained by the procedure (3) above was stored at 25 ° C for one week, and the appearance, average fat particle size and turbidity change during storage were measured. The results are shown in Table 26. In this example, the reference infusion preparation was obtained by repeating the aforementioned procedure, but 300 B was injected for the purpose of injection. Distilled water was sealed in the second compartment 3. The average particle size of the fat emulsion is measured by the light diffraction method, and the turbidity is expressed by the absorbance at 620 nm (lcm optical tube). The size of this paper is easy to use. The standard of CN Standards (CNS) A 4 specifications (210x297 male dragons) 81. 6. 10,000 sheets ⑻ Π 6 V. Description of the invention (45) ^ 0 識 螽 闲. ¾Yushi (please read the back-to-back notes first and fill in this page) Employees from the Central Bureau of Standards of the Ministry of Economic Affairs cooperated to print

0.034 0.031 0.031 0.03S 0 · 16 μ3 0.16 μιη 0 · 16 μιη 0.16 μ3 0.0340.034 0 · 030 0.040 0.1α1μ3σ, .ισιμιη o.lcni ρισιι e ^ Φ 0 24, > Huyan 4 8, > 1¾ east One cigarette pack-, · 3Τ line. Private paper scales are used in China's national rubbing standard (CHS) 4 specifications (210x29 '/ male; tf) 81. 6. 10, 〇〇〇 张 （Η)' λ% U'h ”A copy of the work of the Ministry of Economic Affairs and the Bureau of Industry and Commerce A. The printing of the invention 5. Description of the invention (46) As shown in Table 26, there is no change in the appearance, particle size or turbidity of the preparation of the present invention during storage Thus, the stability of the preparation method of the present invention is confirmed .. Example 1 7 According to the procedure of Example 16 (1) prepare an infusion solution with the composition shown in Table 27 below. To — 27 _ number of components (g) soybean oil Distilled water for egg yolk phospholipid and glucose injection 26 3.74 183 The total volume was adjusted to 1000 m as required. An infusion preparation was obtained by repeating the method of Example 16 except that the sugar-containing fat emulsion of Table 27 was used instead of the fat emulsion of Table 22 , And use the electrolyte solution shown in Table 28 below to replace the electrolyte solution in Table 24. The infusion system thus obtained The composition is shown in Table 25. Table 23 Component concentration (per liter) Vaporized sodium 1.9 4 9, g Potassium nitride 3. 5 0 0 g Magnesium sulfate · 7Η2〇2.054g Calcium chrysanthenate · H20 ^ 6.352g dipotassium glycerol dibasic acid (50%) 1 0. 6 8 S g sodium acetate · 3H, 0 11.340g 'zinc sulfate. 7H 2 Ο 9. 5 8? 5 mg (please read the back first And weeping intentions #Fill in this page) Binding · Order _ Line t paper size side use Zhongyou a home standard (CNS) Ή specification (2) 0X297 male dragon) Precious fee 81. 4. 10,000flL (H) A 6 Π 6 V. Description of the invention (47) The stability test of the infusion preparation thus prepared was carried out in the same manner as in Example 16. It was found that the stability of this preparation is excellent as infusion preparation of Example 16. ^ Examples 28 Add an appropriate volume of distilled water for injection to a mixture of 66 g of soybean oil and 9.5 g of egg yolk phospholipid. The resulting mixture is stirred using a mixer, and then adjusted to a total volume of 100 IHJI with distilled water for injection to obtain a crude emulsion. The coarse emulsion obtained in this way is emulsified using a Manton-Gauline homogenizer (15M-8TA, manufactured by Kobayashi) to obtain a fat emulsion. 5 0 0 in the resulting emulsion and 2 5 0 g of glucose is mixed, and the total volume of the mixture is adjusted to 100 m with distilled water for injection. The composition of the fat emulsion thus obtained is shown in Table 29. _M_2_9_ Group_ Soybean Oil Yolk Phospholipid Glucose Injectable Distilled Water Quantity (s) 33 • 75 (please read the back-to-back precautions # 蜞 窝 this page) printed by the Ministry of Economic Affairs quasi-bureau employee Xiaozhong Cooperative 250 will be the total volume Adjust to the required amount of 100,000 m by repeating the method of Example 16 to obtain an infusion preparation, only using the fat emulsion of Table 29 instead of the fat emulsion of Table 22. The stability test of the infusion preparation thus prepared was conducted in the same manner as in Example 16. As in the case of the infusion preparation of Example 16, this preparation can achieve excellent stability. Although the details have been explained with reference to the pending examples, the invention of the clothing, but the industry's technical skills, paper-scale edge use in China S standard (CNS) T4 specifications (210x297 ;; :) 81_ 4. 10,000 sheets (H) A 6η 6 V. Description of the Invention (48) It is obvious to the Zhan person that various changes and modifications can be made without departing from the essence and scope of the present invention. (Please read the precautions first and then fill in this page) Install * Line Specifications (210x297 male dragon) 81. 4. 10, ⑽ Le (H)

Claims (1)

86, 6. 20 Amend this Sixth, the scope of patent application 1. Species include glycosamino acid composition 9 wherein the composition is represented by formula 9 or salt form 9 and K where the composition includes the following fats 5-50 emulsified Agent 0.5 -10 Sugar 50 -250 L-isoleucine 0.5-5 L-leucine 0.5.5-7 L-valinic acid 0.5-5 L-ionic acid 0.5.5- 7 L-Methionine 0. 1-4 L-Phenylalanine 0. 3-5 L-Glutamine 0. 3-5 L-tryptophan 0. 1-1 L-arginine 0 3-7 histidine 0.23- * glycine 0. 2-3 L _. '-· * • ιί · amino acid 0. 3-5 L- proline $ 0. 2-5 L- Aspartic acid 9 0 .03-2 L- Seric acid 9 0. 2-3 L-Broninoic acid »0 .03-0. (Please ^ Read the notes on the back before filling this page) __1—- .- h I L_ — II-^ I. Ordering paper. In the export of vegetables, electrolytes, and fat rolling liquid of the Central Standards Bureau of the Ministry of Economic Affairs, the phosphorus content of the phosphate is multi-enzyme or sugar phosphate. Adjust the pH 5.0 to 8.0, composition: g / H g / β g / ag / ϋ g / ag / ag / ag / ng / ag / fi g / ϋ g / 1 g / ng / ng / g / fl g / R g / il 5g / a -1- This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) A8 B8 C8 D8 VI. Scope of Patent Application The Central Ministry of Economic Affairs of the Ministry of Economic Affairs Beigong Consumer Cooperative Printed L-Glutamine Acid 0.03-2 g / HL-Cysteine 0.03-1 IB E q / sodium 15-60 ffl E q / 11 potassium 10-50 IB E q / il calcium 3-15 HI E q / fi . Magnesium 2-10 IS E q / fl atmosphere 0-80 ffl E q / il m 1-15 lfl E q / ft; and zinc 0-30 U ffi 0 1 / fl. Where the fat is soybean oil; The emulsifier is at least one member selected from the group consisting of egg yolk phospholipid, hydrogenated egg yolk phospholipid, soybean phospholipid, hydrogenated soybean phospholipid, and non-androgen surfactant; and the raw sugar as the sugar source is glucose and / or glycerol &lt;) 2 . If the patent scope first Item infusion composition wherein the average particle size of the fat emulsion is 0.13 ~ 0.1 7 w BI ° 3. For example, Φplease patent the first infusion composition of item 1 in which the organic acid used is sulfonic acid 0 4. An infusion composition containing fat emulsion and sugar, wherein the fat content is from 0.1 to 30¾ (V / V), the emulsifier content is from 0.01 to 10¾ (W / V), and the sugar contains M From 5 to 60¾ (W / v), the average particle size of M and the fat emulsion is 0.13 0.17 U is where the fat is soybean oil, the emulsifier is selected white egg yolk phospholipid hydrogenated egg yolk phospholipid, soybean At least one of the phospholipid, hydrogenated soybean phospholipid and nonionic surfactant and the sugar as the sugar source is grapevine and / or glycerin. (Please read the note Ϋ on the back first and then fill out this page)-Installed, tT line paper size standard Chinese national rate (CNS> A4 specification (210X297 mm) 1 2- ABCD 320563 VII. Patent application scope 5 .—An infusion composition containing amino acids and electrolytes, in which the phosphate or ester a of polyacrylase or sugar is used as the source of phosphorus and the ph of the composition is selected from the group consisting of spiro-like acid, lactic acid, malic acid * glucose The at least one organic acid of acid * oxalic acid and malonic acid is adjusted to 5.0 to 8.0, and wherein the composition contains an amino acid selected from the following although it is always 1 to 15¾: L-isoleucine Acid L-Leucine L-Valine L-Iminine L-Methionine L-Phenylalanine L-Phenylalanine L-Tryptophan L-Arginine L-Histidine Glycine L-Alanine L-Menine L-Aspartic acid L-Serine L-Brucine L-Glutamic acid N-Acetyl-L-cysteine; and the following electrolytes: 50 to 50 To 180mEq / ll, 40 to 135 sisters <ϊ / ί! This paper size is suitable for China National Standard (CNS) Α4 specifications (210 to 297 mm) (please read the precautions on the back before filling this page) Printed by Beigong Consumer Cooperative of the Central Bureau of Standards of the Ministry of Economic Affairs -3- 320563 A8 B8 C8 D8 6. Patent application Potassium, 10 to 5 0 b E g / ϋ calcium, 5 to 30 E q / α magnesium , 0 to 2 2 5 hire Eq / α atmosphere, 3 to 40mEci / il dish and 0 to 100 / i ιηοl / ϋ Zi. Participate in acid amine group 4th L-Wai self-selection, please select less If the agent contains 6. Baochongyoubuhehe group, in the item of the liquid wheel of the compound group, the alkyl methyl amine \ lx liquid of the methylmetholone formula milk fat is used to raise 17 with 0. 营 ~ For 13 preparations 0. The system is made of cofi sc seed diameter 1 grain 7. The liquid is even and M and olean, lactose, fat, fat, fat, or fat will be 0. ^ 0 S &amp; to® milk \ 1 / sugar / V grapes (W Portuguese 5¾ or to // 1 and ο. Oil ο sweetened with milk / IV% fatty milk B liquid milk crude preparation MV) W / Combined 70 to 30, mixed with oil, sugar, and sugar, and mixed sugar grapes or M (please read the notes on the back before filling this page) I Mi I-I-&quot;-- ----I--: I ^ I. To Shuhua Zhisuo Hydrogen Liquid.,, Milk Fat Crude Soya Phosphorus. Soybean milk, the first-year method of β fat, less fat a milk fat to milk 17 phosphorus pressure 0. So yellow high? The medium egg agent has 13 chemical properties of 0. Hydrogen activity is the liquid milk fat that changes the level of the grain, and the yellow fat is not selected and selected. It is the central standard of the Ministry of Economy. Printed by the Bureau Cooperative Consumer Cooperative Co., Ltd. Grape edulis' with acid liquid, fruit milk and apple fat, fatty acid including milk, including acid, 0 method to choose liquid from milk, fat liquid fat soluble Anzi SB it species A compound of 8 gold valences is mixed with dibutylene and diethylene, mixed with acid, sugar in acid dipropylene and acid stored in milk and its fat, and in this acid, there are CK species 1 which is less than PH value. For its 8 to 5 oil sugar beans or large U} and / V sugar (¥ Grape 0¾ Portuguese 3 to} 1 V • // o W Containing 60 sachets up to 5 and formulated milky paper size Happy Use China National Standard (CNS) A4 specification (210 X 297 mm) One 4 One