30S5 A7 B7 五、發明説明（1 ) 本發明有關一種泡殼包裝，尤其有關一種提供藥劑凹槽 與乾燥劑凹搢的泡殼包裝，用以包裝懼濕性固體或半固體 藥劑。 本文中使用的「泡殼包裝」一詞爲一般意義，亦即，代 表任何類型的薄片狀包裝，最好使用塑膠和鋁製成。這種 包裝具有凹槽，容置欲包裝在底盤片（通常爲塑膠薄片製 成）内的固體；並用第二薄片密封。第二薄片通常稱爲覆 蓋片，最好是經披覆處理的鋁箔製成，藉此，要取出產品 時，可在底盤片上施力，椎擠產品穿出覆蓋片。 技術背景： 今曰，泡殼包裝已成爲固體或半固體藥劑的較佳包裝形 式，它們的優點是，藥劑在使用前，可以一直保持清潔的 包裝；此外，由於標示通常位於背侧及/或頂侧，所以混 淆的風險大爲減少。泡殼包裝還有其他優點，例如，產品 •的摩擦減少，可以從原始包裝的容置狀態下取出一單位藥 劑，抵抗水蒸汽等。 今日使用的泡殼包裝，由於使用塑膠薄片製造之故，因 此具有某種程度的水汽滲透性，使泡殼包裝不適於懼濕性 的產品。若使用加厚的箔料來減少水汽滲透性，由於技術 實用性及處理上的因素（推擠穿出），只有極小的可能。 因此，要改進今曰常用包裝中的濕氣滲透性，只有靠材 料的選擇，亦即，儘可能選擇不滲水氣的積層片。關於這 方面，複層的片料經證明尤其適合使用。 然而，這些已知的包裝，並不適於非常懼濕性或中等懼 本紙張尺度適用中國國家橾準（CNS ) A4規格（210x 297公缝） ---^-------装------訂---^--丨東 (請先閲讀背面之注意事項再填寫本頁) 經濟部中央標隼局員工消費合作杜印梦 經濟部中央標準局員工消費合作社印取 A7 B7 五、發明説明（2 ) 濕性卻要用在濕熱氣候國度裡的藥劑。 已-有數種嘗試’擬提供可以乾燥儲存藥劑的包裝。 有—種已知的程序，完全使用鋁合成物膜作爲底盤片與 覆蓋片。兩個彼此相通可流通空氣的凹槽，其中一個包含 乾燥劑’另一個包含禁劑，如此可以提供额外的乾燥作用 。此種包裝的缺點是，償格相當昂貴，尤其是，因爲欠缺 透明性’所以有可能危險地誤食乾燥劑而不是包含藥劑的 有效物質。除了某些乾燥劑可能發生副作用外，未服用有 效的禁劑可能對病患的健康產生不良的影響。 也有人嘗試減少泡殼包裝的透濕性，但不放棄至少包裝 一侧箔料的透明性。30S5 A7 B7 V. Description of the invention (1) The present invention relates to a blister package, in particular to a blister package that provides medicament grooves and desiccant recesses, used to package moisture-resistant solid or semi-solid medicament. The term "blister pack" as used in this article has a general meaning, that is, to represent any type of sheet-like packaging, preferably made of plastic and aluminum. This kind of package has a groove to accommodate the solid to be packed in the chassis sheet (usually made of plastic sheet); it is sealed with a second sheet. The second sheet is usually called a cover sheet, and is preferably made of coated aluminum foil, so that when the product is to be taken out, a force can be applied to the chassis sheet to squeeze the product out of the cover sheet. Technical background: Today, blister packaging has become the preferred form of packaging for solid or semi-solid medicinal products. Their advantage is that the medicinal product can be kept in a clean packaging before use; in addition, because the label is usually located on the back and / or The top side, so the risk of confusion is greatly reduced. The blister pack has other advantages, for example, the friction of the product is reduced, and a unit of the drug can be taken out of the original packaging in the contained state to resist water vapor. The blister packaging used today is made of plastic sheets, so it has a certain degree of water vapor permeability, making the blister packaging unsuitable for products that are afraid of moisture. If thicker foil is used to reduce water vapor permeability, due to technical practicability and processing factors (pushing out), there is only a very small possibility. Therefore, to improve the moisture permeability in today's commonly used packaging, only the choice of materials, that is, as far as possible, choose a laminate that does not penetrate moisture. In this regard, multi-layered sheets have proven to be particularly suitable for use. However, these known packages are not suitable for very wet or medium fear of paper size. Applicable to China National Standard (CNS) A4 specification (210x297 male seam) --- ^ ------- installed- ----- Subscribe --- ^-丨 East (please read the precautions on the back before filling out this page) Employee Consumer Cooperation of the Central Standard Falcon Bureau of the Ministry of Economic Affairs Du Yinmeng A7 Employee Consumer Cooperative of the Central Standard Bureau of the Ministry of Economic Affairs Printed A7 B7 V. Description of the invention (2) Moisture is a medicine to be used in a hot and humid climate country. Already-there have been several attempts to provide packages that can be stored dry. There is a known procedure that completely uses aluminum composite films as the chassis and cover sheets. Two grooves that communicate with each other to circulate air, one of which contains a desiccant 'and the other contains a forbidden agent, which provides additional drying. The disadvantage of this type of packaging is that the compensation is quite expensive, especially because of lack of transparency, it is possible to dangerously ingest the desiccant instead of the effective substance containing the medicament. In addition to the possible side effects of certain desiccants, failure to take an effective contraindication may adversely affect the patient's health. There are also attempts to reduce the moisture permeability of blister packaging, but do not give up the transparency of the foil on at least one side of the packaging.
Ep-A-〇 466 068説明的泡殼包裝中，每一容置藥劑的凹 槽與一容置乾燥劑的凹槽相連。另外可以加設針孔，以分 開藥劑與乾燥劑的每一组合。 此*種泡殼包裝的缺點是，很容易意外地服用乾燥劑，尤 其是以分離的單元包裝時。 FR~A-2 593 152也説明一種含乾燥劑的泡殼包裝，其中 ’數個容置禁劑的凹槽與一個容置乾燥劑的凹槽相連。 這種包裝雖然囡爲乾燥劑的位置外露及/或增大，所以 意外誤食乾燥劑的危險減少，但是，其缺點在於，如果服 用蔡劑的順序錯誤，乾燥效果將受不良影響。 FR-A-2 660 634揭示一種包括乾燥劑的包裝，其中，在 乾燥劑與覆蓋片之間放置一薄膜，以使乾燥劑保持在所要 的位置。服用禁劑時，不是用推擠樂劑穿出覆蓋片，而是 本紙張尺度適用中國國家標準（CNS ) A4規格（2!OX297公鏠） ---------裝------訂---.--，丨線 (請先閱讀背面之注意事項再填寫本頁) A7 3〇«577 ---- B7 i'發明説明（3 ) 剝掉覆蓋片。利用额外的密封，使乾燥劑部分的覆蓋片較 難剝除。 此外還有已知的兒童防護包裝。 DE-0S-24 04 232揭示一種兒童防護包裝，然而沒有任 何裝置可保持藥劑的乾燥。除了覆蓋片上有一層可除去的 防撕除薄片，防止椎擠藥劑穿出覆蓋片外，凹槽形成時， 並使兒童無法經由咬泡殼而打開凹槽。 US-5 172 812揭示一種兒童防護包裝，其中具有可戮破 的覆蓋片與可剝除的紙板材料；紙板材料並與可戳破材料 片黏合。此外，設一截割模，與開口不完全對正，此便只 有一部份紙板材料從開口剝除，除非以特定方式施力時， 才能取出藥片。此一文件未揭示包括乾燥劑的包裝。 US-3 780 856及US-3 835 995二者都揭示泡殼包裝，其 中具有要剝除的覆蓋片。在這兩種包裝中，都設有一條撕 •除帶，覆蓋片在此部份未與容置層密封。 發明概要説明 因此，本發明的問題在於提供一種可乾燥儲存禁劑的泡 殼包裝，並防止意外誤食乾燥劑。 凹槽與乾燥劑凹槽的底盤片及—覆蓋片構 成泡殼包裝，可以解決這個問題。此種泡殼包裝的 特徵在於，泡殼包裝在乾燥劑凹搢的部位，予以增強因 此，可以防止使用一般的手指壓力取出藥劑，同時，無法 用-般的方法除去乾職凹槽上方的㈣物。在本發明之 泡殼包裝中，包含藥劑的每一凹槽，與至少一個包含乾燥 本紙張尺度ϋ财酬家 (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部中央標隼局員工消費合作社印聚 A7In the blister pack described in Ep-A-〇 466 068, each recess containing a medicament is connected to a recess containing a desiccant. In addition, pinholes can be added to separate each combination of medicament and desiccant. The disadvantage of this type of blister packaging is that it is easy to accidentally take the desiccant, especially when packaged in separate units. FR ~ A-2 593 152 also describes a blister pack containing a desiccant, in which ‘several recesses containing a forbidden agent are connected to a recess containing a desiccant. Although this kind of packaging exposes and / or enlarges the position of the desiccant, the risk of accidentally ingesting the desiccant is reduced. However, the disadvantage is that if the order of the Tsai agent is wrong, the drying effect will be adversely affected. FR-A-2 660 634 discloses a package including a desiccant, in which a film is placed between the desiccant and the cover sheet to keep the desiccant in the desired position. When taking the forbidden drug, it is not a push-out agent to wear out the cover sheet, but the paper standard is applicable to the Chinese National Standard (CNS) A4 specification (2! OX297) ------------- --- Subscribe ---.--, line (please read the precautions on the back before filling in this page) A7 3〇 «577 ---- B7 i'instructions for invention (3) Peel off the cover sheet. The additional seal makes it difficult to remove the cover sheet of the desiccant part. There are also known child protection packages. DE-0S-24 04 232 discloses a childproof packaging, however there is no device to keep the medicine dry. In addition to a removable anti-tear sheet on the cover sheet, to prevent the vertebral squeezing agent from penetrating the cover sheet, the groove is formed and prevents children from opening the groove through the bite shell. US-5 172 812 discloses a child-resistant packaging, which has a smashable cover sheet and a peelable cardboard material; the cardboard material is bonded to the pierceable material sheet. In addition, a cutting die is set, which is not completely aligned with the opening, so that only a part of the cardboard material is peeled from the opening, and the tablets can only be taken out unless a specific force is applied. This document does not disclose packaging including desiccant. Both US-3 780 856 and US-3 835 995 disclose blister packs with a cover sheet to be peeled off. In both types of packaging, there is a tear-off tape where the cover sheet is not sealed from the containment layer. SUMMARY OF THE INVENTION Therefore, the problem of the present invention is to provide a blister pack capable of drying a storage-inhibiting agent, and to prevent accidental ingestion of the desiccant. The bottom plate and the cover plate of the groove and the desiccant groove constitute a blister package, which can solve this problem. The feature of this kind of blister packaging is that the blister packaging is reinforced in the concave portion of the desiccant, so it can prevent the use of general finger pressure to remove the medicine, and at the same time, it is impossible to remove the upper part of the dry groove by a general method Thing. In the blister packaging of the present invention, each groove containing the medicament, and at least one containing the dried paper size ϋ financial rewarder (please read the precautions on the back before filling out this page) Consumer Cooperative Printed Poly A7
經濟部中央標隼局員工消费合作社印製 而且，至少有一片料，尤其是覆蓋片，在 乾燥，=加以補強，使乾燥劑凹搢上方的補強物，無 法以一般方式，例如，时指或指甲按壓' 推择或剝除。 利用：種，不但可以考慮氣候情況，在整個所要的服 禁期間，確：相當乾燥地错存樂劑，並可同時防止經常危 險地意外誤食乾_。若未服用眞正有效的_，以及在 乾燥劑的副作用下，身體已經很衰弱的病人，可能會更加 衰弱。 圖1至圈6類示本發明泡殼包裝之範例。 圖式簡要説明 圖1爲一泡殼包裝之俯視圖，其中，每一藥劑凹槽與一 乾燥劑凹槽藉-連接通道㈣，且乾域内的覆蓋片 上，另外加置保護片。 圖2爲圖1之泡殼包裝沿π-ι線之剖視圖。 '圖3類示防止取出並作爲兒童防護之特殊保護片的結構 〇 圖4爲根據圖3具有防止取出特殊保護片的泡殼包裝俯 視圖。 圖5爲圖4之泡殼包裝沿V-V線之剖視圖’其中，保 護片正從藥劑側剝除。 圖6顯示一泡殼包裝，其中，兩個殡劑凹槽與一乾燥劑 凹槽相連。 本發明之泡殼包裝有一底盤片⑷及一覆蓋片⑸；底盤片 —----^----β------ir---.--1^ (請先閱讀背面之注意事項存填寫本頁) 本紙張尺歧财國岭料（CNS )八4麟（210X 297公f ) A7 A7 經濟部中央樣隼局員工消t合作社印裝 B7 五、發明説明（5 ) ⑷設有多數容置有效禁劑物質的凹槽⑴及多數容置乾操劑 的凹，⑵。其特徵在於，泡殼包裝在乾燥劑凹槽⑵的區域 内，加以補強，因此，可以防止用一般的手指壓力取出樂 劑’以及，乾燥劑凹槽⑵上方的補強物，不能用一般的方 式除去。通常’每一凹槽⑴藉一連接裝置⑶，與至少一個 凹槽(2)相連，因此，當然容許空氣交流，但是乾燥劑不直 接接觸有效之藥劑物質。該連接裝置⑶較佳是泡殼包裝成 型之塑膠底盤片⑷内，像一連接通道的凹搢。 包裝的生命期可由所用的乾燥劑量來控制，視環境狀況 而定。 乾燥劑的份量，由乾燥劑的吸水能量、泡殼設計、使用 的猪料品質、所提供的儲存條件及產品所要的（儲藏）有 效期間來決定。 爲了節省空間，如果一個以上的藥劑凹槽⑴與一個乾燥 劑凹槽⑵相連（亦即圖6所示的情況），較爲有利。因爲 乾燥劑最好也使用片劑形式，以便利於確定劑量及放入凹 槽⑵’並消除或避免鬆散微粒阻塞通道，所以，對於這種 實施例，可以使用較大的乾燥劑。 乾燥劑適於全爲固體，最好是對藥理無害的物質，例如分 子篩與|凝膠體。因此，最重要的考慮因素是，包裝中包 括额外 _全元件’防止意外呑食乾燥劑而未服用有效的 藥劑物質。此種安全措施諸如可爲乾燥劑區域内，额外的 塑膠薄片密封’尤其是在覆蓋片(5)上。此種额外的薄片可 防止推擠乾燥劑穿透覆蓋片⑸。較佳是多加一片同時覆蓋 本紙狀度4财_ --Lr n) n n - - I I I I II I n Λ-ν (請先聞讀背面之注意事項再填寫本頁) A7 A7 經濟部中央標準局員工消f合作社印製 B7 五、發明説明（6 ) 數個包含乾燥劑的凹槽⑵’以產生改進的黏著力。此種锅 料可爲透明的或著色的。在底盤片⑷那—側，可以採用讀 如局部著色、局部補強底盤片或加單等方法，但是技術上 而言，費用昂貴得多。 尤其是，如果一片额外的保護片要同時覆蓋數個乾燥劑 凹樯⑵時，乾燥劑凹槽最好位置彼此相鄰，尤其是在一列 或數列相鄰的列中。 本發明較佳之泡殼包裝，具有防止取出乾燥劑的增強型 安全措施，係在覆蓋片上至少於容置乾燥劑的凹槽⑵的區 域内，設一保護片⑹。 保護片⑹的形狀不拘，只要可以確實防止取出乾燥劑。 塑膠猪等，由於其勒性可阻止推掛穿透，所以是適合的材 料。而衆乙#(PE)膜或衆乙稀合成物的薄膜，例如衆乙稀 (PE)與衆對壯酸乙二時（pET)膜（pET/pE膜），由於具有 -韌性’所以是較佳的材料。 覆蓋片⑸如爲包括保護片⑹的多層積層片時（請與圖3 比較），亦很適合。例如，這種市面有 ⑷::的，設，層，例如-層熱: i 有—層料，—層黏劑，—層衆脂膜（例如 聚對S太酸乙二g旨，pet、 a _ )，一層膠σ増強劑（例如另一廣 固態黏著劑），一層紐r Λ嘴 層紙（或許可爲印花紙）。瑞士Neher 公司出βα的「剝擠箔（p 度2〇❹的銘層，厚扪二二ί〇ΐ1)，可提供具有厚 劑共同積層形成的薄片;^的聚㈣及限定黏著力的點著 國國 CNS ) (210x M7公鏠） --i-------装------訂---：--.—'^ (請先閱讀背面之注意事項再填寫本f ) A7 B7 305577 五、發明説明（7 ) 黏著劑可爲僅提供限定積層黏著力的黏著劑，以便可用 手分離覆蓋片⑸與保護片⑹，或者，勒著劑在積層間的黏 著力極強，足以使多層積層片（亦即，覆蓋片⑸與保護片 ⑹）必須一同剝除。 使用限定積層黏著力的多層積層圬時，整個覆蓋片區域 ，也就是藥劑區域，都用它覆蓋。此種覆蓋被視爲一種兒 童防護方法，用一般壓擠藥錠法，是不可能穿透積層片的 〇 關於本發明之泡殼包装’必須確定的是，多層積層片的 保護片部份’只能從有效藥劑物質處制離，而不能從乾燥 劑處剝離。 確定此一條件的方法是，例如，如阖4及圖5所示，在 包含有效藥劑物質的部份，設置開啓補助裝置，例如，設 置未搶封區⑺，以及破都乾燥劑區設針孔或橫切口⑻。利 用針孔或橫切口⑻，可以確保多層锖層片中保護片的部份 ’只存在有效藥劑物質區域内’從未密封區⑺開始，才能 剝開。未密封區⑺最好直接於位針孔或橫切口⑻上，或位 於針孔（或橫切口）⑻與針孔（或橫切口）⑼的交點上， 以使剝除方向必然偏離乾燥劑。形成未密封區⑺的方法是 ，例如，在密封工具（例如壓印器）上設置各個"冷作"部 份；及/或在各個區域内拉制包裝形狀，阻止接觸，並同 時利於抓緊鬆弛片部；或在密封底盤片與覆蓋片之前，從 底盤片沖出各個區域。最好在兩個藥劑凹槽間及/或兩個 乾燥劑凹搢間，也設置一道針孔或橫切口⑼。針孔或橫切 -9 ~ 本紙張尺度逍用中國國家榡準（CNS ) A4規格（210X 297公釐 --L-------壯衣------訂------—線 (請先閱請背面之注意事項再填寫本頁) 經濟部中央標隼局員工消费合作社印聚 經濟部中央標準局員工消費合作社印製 A7 B7 五、發明説明（8 ) 口⑻與針孔或橫切口⑼最好至少與多層積層片中的保護箔 部份相關。尤其是，最好能設置穿過整個泡殼包裝的針孔 ⑼，以便可以取下一個單元。由於保護箔的緣故，乾燥劑 區域在1 : 1组合（每一片乾燥劑配一個有效禁劑物質 > 的 情況時，也可以安全地免於被取出，沒有被取出的危險存 在。 然而，重要的是，紙張與PET的複合體，只能從禁劑區 域剝除。將開啓輔助裝置⑺完全設在藥劑區域内，即可達 到這個目的。如果使用的片料所含的黏著劑在覆蓋片⑸與 保護片⑹之間提供相當強的積層黏著力，則須設置針孔或 橫切口⑻及針孔或橫切口⑼，以確保僅能從一個有效禁劑 物質上剝除多層積層片，然後露出禁劑。 尤其是在多層積層片的情沉中，紙層可以作爲進一步的 保護措施，尤其是在乾燥劑上方的區域内。紙層可以著色 •或提供警告圖案。最好在產品區域内，亦設置一標籤，例 如，應服用各個藥錠的曰期表。有了這種標籤可進而消除 下列服用順序的可能性：例如包裝含有數個單元，每一單 元中，每一乾燥劑凹槽⑵搭紀一個以上的藥劑凹槽時’如 果除了一個單元中的一片藥片外，所有禁片都要在開始服 用時就服用，但是餘下的一片，是所有單元中最後服用的 一片。由於過多濕氣經過藥片凹搢⑴上方覆蓋片⑸被戮破 的部份因而使乾燥劑使用過度。 此外，此種包裝可設一監視裝置，指示乾燥劑已完全耗 用，或指示濕度增加。這方面的已知技術例如含有指示器 -10〜 张尺度適用中—國國CNS ) Λ4規格（~~ - 裝------訂-------竦 (請先閱讀背面之注意事項再填寫本頁) 經濟部中央標隼局員工消費合作社印製 A7 _____ B7____ 五、發明説明（9 ) 的矽凝膠體一 一種用C〇Cl 2著色的矽凝膠體，用以顯示水 份吸收的情況。由於誤食CoCl 2可能產生副作用，所以本 發明之泡殼包裝最好僅在設有额外保護裝置以防止誤食乾 燥劑時，才能使用含有顯示器的矽凝膠體。 如上所述，底盤片本身的濕氣滲透性應該儘可能地小。 此外，它應該可以密封，並與產品也有極佳的相容性。今 曰常用作此種用途的片料，是一種PVC(聚氣乙烯）、PE (衆乙烯）及PVDC (聚偏二氣乙烯）的組合片料。這種片 料的市售品牌有Alfoil⑧，Tristar⑧，Aclar⑧等，並廣 泛用於藥劑。 還有一種常見的片料可作爲覆蓋片，尤其是包括鋁層或 銘箔的片料，諸如一般使用的聚合物披覆銘箔，或上述的 多層積層片。 底盤片是以一般的方法依照泡殼設計而形成的，並於裝 •入乾燥劑與產品後，以泡殼包裝常用的方式，與覆蓋落連 接，尤其是密封。 泡殼包裝的取出防護方法 在覆蓋片上（通常爲一銘薄片）需要防範取出之區域（ 乾燥劑區域）内，以大約120〜130*c之溫度，密封一層 PET/PE保護片（厚度約6〇um)。由於PET/PE片的勒度， 所以不可能推擠乾燥劑穿出保護片。經過如此加強安全的 泡殼包裝，然後可以按需要形成針孔，最好在每—單元之 間形成針孔。 2 :以多層積層片防範取出的方法 本紙張尺度適用中國國家橾率（CNS) A4規格（210x 297公釐） --U-------Λ------IT (請先閱讀背面之注意事項再填寫本頁) 308577 A7 B7 五、發明説明（ίο ) 充填後的底盤片在大約200·〇下，根據圖3，用多層積 層片_ (瑞士Neher出品的「剝擠箔」）密封，取代鋁薄片 作爲覆蓋片與保護片，然後，在產品區域内位於毗鄰乾燥 劑區域的針孔線處，及位於兩單元間的針孔線處，對每一 單元至少形成一個未密封區。如果是用壓印器密封時，則 可在壓印器本身上形成"冷作"區而達成這個目的。 然後，在藥劑區凹槽與乾燥劑凹槽間形成針孔。 取出產品的步骤如下： 一沿針孔線選擇性地分開泡殼片。 -在未密封角落_外_覆蓋片各層，此處爲紙層加 PET複合物。 -廢择產品穿透經由熱黏密封方式固著在下部的紹猪。 其中，未密封區係位於乾燥劑區域與產品區域間的邊緣 線’以使剝_偏離乾㈣區域，多層積 •部::在產品區域内完全剝除。若在乾燥劑區 ^刺除保護片，因爲沒有任何諸如未密封區的開啓輔助裝 (請先閲讀背面之注意事項再填寫本頁) 經濟部中央標準局員Μ消費合作社印製 本紙张尺度適用中CNS ) Μ規格（Printed by the Employee Consumer Cooperative of the Central Standard Falcon Bureau of the Ministry of Economic Affairs and, at least one piece of material, especially the cover sheet, is reinforced when dry, = so that the reinforcement above the desiccant can not be reinforced in a general way, for example, when referring to Nail pressing 'push or peel. Utilization: Species, not only can consider the climatic conditions, throughout the required period of confinement, indeed: miserably store the medicaments, and at the same time prevent accidental accidental ingestion of dry food. Patients who are already weakened due to the side effects of desiccant without taking _Zhengzheng_, may be even weaker. Figures 1 to 6 show examples of blister packaging of the present invention. Brief description of the drawings Figure 1 is a top view of a blister pack, in which each medicament groove is connected to a desiccant groove by a connecting channel (iv), and a protective sheet is additionally placed on the cover sheet in the dry area. 2 is a cross-sectional view of the blister package of FIG. 1 taken along the line π-ι. 'Figure 3 shows the structure of a special protective sheet that prevents removal and serves as a child protection. Figure 4 is a top view of a blister package with a special protective sheet that prevents removal according to Figure 3. Fig. 5 is a cross-sectional view of the blister pack of Fig. 4 taken along line V-V ', wherein the protective sheet is being peeled off from the medicine side. Figure 6 shows a blister pack in which two fungicide grooves are connected to a desiccant groove. The blister of the present invention is packed with a chassis sheet ⑷ and a cover sheet ⑸; chassis sheet —---- ^ ---- β ------ ir ---.-- 1 ^ (please read the back Note and fill in this page) This paper Chichi Finance National Ridge Material (CNS) Ba 4 Lin (210X 297 gf) A7 A7 Printed and printed by the staff of the Central Falcon Bureau of the Ministry of Economic Affairs B7 V. Invention Instructions (5) ⑷ There are many grooves (1) containing most effective agent-inhibiting substances and many concaves containing dry-handling agents (2). It is characterized in that the blister pack is packed in the area of the desiccant groove ⑵ to be reinforced. Therefore, it can be prevented that the music agent is taken out with general finger pressure and the reinforcement above the desiccant groove ⑵ cannot be used in the general way Remove. Normally, each groove (1) is connected to at least one groove (2) by means of a connecting device (3). Therefore, of course, air exchange is allowed, but the desiccant does not directly contact the effective chemical substance. The connecting device (CD) is preferably in a plastic chassis sheet (4) in the form of a blister pack, like a recess in a connecting channel. The lifetime of the packaging can be controlled by the amount of drying agent used, depending on the environmental conditions. The amount of desiccant is determined by the water absorption energy of the desiccant, the design of the blister, the quality of the pig feed used, the storage conditions provided, and the required (storage) effective period of the product. In order to save space, it is more advantageous if more than one medicament groove (1) is connected to a desiccant groove (2) (that is, the situation shown in Figure 6). Since the desiccant is preferably also in the form of a tablet to facilitate dose determination and placement in the recess ⑵ 'and eliminate or avoid loose particles blocking the channel, for this embodiment, a larger desiccant can be used. The desiccant is suitable for all solids, preferably substances that are not harmful to pharmacology, such as molecular sieves and gels. Therefore, the most important consideration is that the package includes an extra _full element ’to prevent accidental swallowing of the desiccant without taking an effective pharmaceutical substance. Such safety measures can be, for example, in the area of desiccant, additional plastic foil seals' especially on the cover sheet (5). This extra sheet prevents the pushing desiccant from penetrating the cover sheet ⑸. It is better to add one more sheet and cover the paper at the same time. -Lr n) nn--IIII II I n Λ-ν (please read the precautions on the back before filling this page) A7 A7 Employee of Central Bureau of Standards, Ministry of Economic Affairs Printed by the cooperative in cooperation B7 V. Description of the invention (6) Several grooves containing desiccant ⑵ 'to produce improved adhesion. Such pot materials can be transparent or colored. On the side of the chassis ⑷, you can use methods such as partial coloring, local reinforcement of the chassis, or adding orders, but technically, the cost is much more expensive. In particular, if an additional protective sheet is to cover several desiccant recesses at the same time, the desiccant grooves are preferably located next to each other, especially in one or several adjacent rows. The preferred blister pack of the present invention has enhanced safety measures to prevent the desiccant from being taken out. A protective sheet ⑹ is provided on the cover sheet at least in the area of the recess ⑵ containing the desiccant. The shape of the protective sheet ⑹ is not limited, as long as it can reliably prevent the desiccant from being taken out. Plastic pigs, etc., are suitable materials because they can prevent push-through penetration. And the public ethyl # (PE) film or the film of the public vinyl compound, such as public vinyl (PE) and public para-acid ethylene dichloride (pET) film (pET / pE film), because it has-toughness', it is Better material. The cover sheet ⑸ is also suitable if it is a multi-layer laminate including a protective sheet ⑹ (please compare with Figure 3). For example, this kind of market has ⑷ ::, set, layer, for example-layer heat: i have-layer material,-layer adhesive,-layer of public film (such as polyethylene terephthalate, pet, a _), a layer of glue σ increase agent (such as another wide solid adhesive), a layer of button r Λ mouth layer paper (or may be printed paper). Switzerland's Neher company released βα's "peeled foil (p-degree 2〇❹ inscription layer, thickness of 22%), which can provide a thin layer formed by thick layer co-lamination; ^ poly ㈣ and limit the point of adhesion Zhu Guoguo CNS) (210x M7 male version) --i ------- installed ------ order ---: --.-- '^ (Please read the precautions on the back before filling in this f) A7 B7 305577 V. Description of the invention (7) The adhesive can be an adhesive that provides only limited build-up adhesion, so that the cover sheet ⑸ and the protective sheet ⑹ can be separated by hand, or the adhesion between the build-up agent is extremely high It is strong enough that the multi-layer laminate (that is, the cover sheet ⑸ and the protective sheet ⑹) must be peeled together. When using a multi-layer laminate with limited build-up adhesion, the entire cover sheet area, that is, the drug area, is covered with it. This kind of covering is regarded as a child protection method, and it is impossible to penetrate the laminated sheet by the general squeeze tablet method. With regard to the blister package of the present invention, it must be determined that the protective sheet portion of the multilayer laminated sheet It can only be separated from the effective medicinal substance, but cannot be peeled from the desiccant. Determine this condition The method is, for example, as shown in Fig. 4 and Fig. 5, in the part containing the effective medicinal substance, an opening assistance device is provided, for example, an unsealed area ⑺, and a pinhole or transverse cut in the desiccant area of Podu ⑻. The use of pinholes or transverse cuts ⑻ can ensure that the part of the protective sheet in the multi-layered layer sheet 'only exists in the effective drug substance area' can be peeled off from the unsealed area ⑺. The unsealed area ⑺ is best directly Position the pinhole or crosscut ⑻, or at the intersection of the pinhole (or crosscut) ⑻ and the pinhole (or crosscut) ⑼, so that the stripping direction must deviate from the desiccant. The method of forming the unsealed area ⑺ is , For example, providing various " cold work " parts on a sealing tool (such as an imprinter); and / or drawing the packaging shape in various areas to prevent contact and at the same time help to grasp the slack portion; or during sealing Before the chassis sheet and the cover sheet, punch out various areas from the chassis sheet. It is better to set a pinhole or transverse cut between the two medicament grooves and / or the two desiccant recesses. The pinhole or crosscut -9 ~ This paper scale is easy to use in China National Standard (CNS) A4 specification (210X 297mm--L ------- Strong clothes ------ ordered -------- line (please read the precautions on the back first (Fill in this page) Printed by the Central Standard Falcon Bureau Employee Consumer Cooperative of the Ministry of Economic Affairs Printed by the Central Standard Bureau Employee Consumer Cooperative of the Ministry of Economic Affairs A7 B7 V. Description of the invention (8) Port ⑻ and pinhole or transverse cut ⑼ at least preferably with multilayer laminates The protective foil in the part is related. In particular, it is best to provide a pinhole through the entire blister pack ⑼, so that one unit can be removed. Due to the protective foil, the desiccant area is combined in 1: 1 (each piece When the desiccant is mixed with an effective forbidden substance>, it can be safely removed from it, and there is no danger of it being removed. However, it is important that the composite of paper and PET can only be stripped from the prohibited area. This goal can be achieved by setting the opening aid ⑺ completely in the area of the medicine. If the adhesive used in the sheet material provides a considerable build-up adhesive force between the cover sheet ⑸ and the protective sheet ⑹, a pinhole or transverse cut ⑻ and a pinhole or transverse cut ⑼ must be provided to ensure that only An effective forbidden substance is peeled off the multilayer laminate, and then the forbidden substance is exposed. Especially in the case of multilayer laminates, the paper layer can be used as a further protective measure, especially in the area above the desiccant. The paper layer can be colored • or provide a warning pattern. It is better to set up a label in the product area, for example, the schedule for taking each tablet. With this label, the possibility of taking the following order can be eliminated: for example, the package contains several units, each unit, each desiccant groove ⑵ when more than one medicament groove is used, if you remove the Except for one tablet, all prohibited tablets should be taken at the beginning, but the remaining one is the last one in all units. The desiccant is overused due to excessive moisture passing through the tablet depression (1) and the broken part of the cover sheet (5). In addition, such packaging may be provided with a monitoring device to indicate that the desiccant has been completely consumed, or to indicate an increase in humidity. Known technologies in this area include, for example, an indicator -10 ~ Zhang scale is applicable in-Guoguo CNS) Λ4 specifications (~~-loaded ------ ordered ------- 竦 (please read the back of the first (Notes to fill out this page) A7 _____ B7____ printed by the Employees ’Consumer Cooperative of the Central Standard Falcon Bureau of the Ministry of Economic Affairs 5. The Silicone Gel of the Invention Description (9) —a kind of silicon gel colored with C〇Cl 2 for Shows the absorption of water. Due to the possible side effects of ingestion of CoCl 2, the blister pack of the present invention is best to use the silicone gel containing the display only when an additional protective device is provided to prevent ingestion of the desiccant. As mentioned above, the moisture permeability of the chassis sheet itself should be as small as possible. In addition, it should be sealable and have excellent compatibility with the product. The sheet commonly used for this purpose today is a kind of PVC (Polyethylene), PE (Ethylene) and PVDC (Polyvinylidene Diethylene) combined sheet materials. The commercially available brands of this sheet material are Alfoil⑧, Tristar⑧, Aclar⑧, etc., and are widely used in pharmaceuticals. There is also a Common sheets can be used as cover sheets, especially including aluminum layers Sheet material of Ming Foil, such as the commonly used polymer coated Ming Foil, or the above-mentioned multi-layer laminate. The chassis sheet is formed according to the blister design in a general method, and after the desiccant and product are loaded In the usual way of blister packaging, it is connected to the cover, especially sealed. The blister packaging removal protection method is on the cover sheet (usually a Ming sheet) in the area that needs to be prevented from being removed (desiccant area), about 120 ~ At a temperature of 130 * c, a layer of PET / PE protective sheet (thickness about 60um) is sealed. Due to the tightness of the PET / PE sheet, it is impossible to push the desiccant through the protective sheet. After such enhanced safety, the blister packaging Then, pinholes can be formed as needed, preferably between each unit. 2: Using multi-layer laminates to prevent removal. This paper size is applicable to China National Atomic Rate (CNS) A4 specification (210x 297 mm) --U ------- Λ ------ IT (Please read the precautions on the back before filling in this page) 308577 A7 B7 5. Description of the invention (ίο) The filled chassis is about 200 · 〇Next, according to FIG. 3, use a multi-layer laminate_ (瑞Neher's "peeled foil") seal, replacing the aluminum foil as a cover sheet and a protective sheet, and then located in the product area at the pinhole line adjacent to the desiccant area and at the pinhole line between the two units, At least one unsealed area is formed for each unit. If it is sealed with an imprinter, a " cold work " area can be formed on the imprinter itself to achieve this purpose. Then, the groove and the drying in the medicine area Pinholes are formed between the agent grooves. The steps for taking out the product are as follows: 1. Selectively separate the blister sheet along the pinhole line. -In the unsealed corner_outer_covering sheet layers, here is the paper layer plus PET compound. -The waste product penetrates through the hot-seal sealing method in the lower part of the pig. Among them, the unsealed area is located at the edge line between the desiccant area and the product area so that the peeling is deviated from the dry area, the multi-layer product :: completely peeled off in the product area. If the protective sheet is pierced in the desiccant area, because there is no opening auxiliary equipment such as an unsealed area (please read the precautions on the back before filling in this page). The member of the Central Bureau of Standards of the Ministry of Economic Affairs MM Consumer Cooperative printed this paper. The standard is applicable. CNS) Μ specifications (