TW217987B - - Google Patents

Info

Publication number
TW217987B
TW217987B TW081108396A TW81108396A TW217987B TW 217987 B TW217987 B TW 217987B TW 081108396 A TW081108396 A TW 081108396A TW 81108396 A TW81108396 A TW 81108396A TW 217987 B TW217987 B TW 217987B
Authority
TW
Taiwan
Prior art keywords
mesna
ifosfamide
urea
optionally
produced
Prior art date
Application number
TW081108396A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of TW217987B publication Critical patent/TW217987B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW081108396A 1991-10-23 1992-10-21 TW217987B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/781,436 US5227373A (en) 1991-10-23 1991-10-23 Lyophilized ifosfamide compositions

Publications (1)

Publication Number Publication Date
TW217987B true TW217987B (zh) 1993-12-21

Family

ID=25122737

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081108396A TW217987B (zh) 1991-10-23 1992-10-21

Country Status (24)

Country Link
US (1) US5227373A (zh)
EP (1) EP0538858B1 (zh)
JP (1) JP3576180B2 (zh)
KR (1) KR100247161B1 (zh)
CN (1) CN1046202C (zh)
AT (1) ATE175354T1 (zh)
AU (1) AU658011B2 (zh)
CA (1) CA2081061A1 (zh)
CZ (1) CZ282445B6 (zh)
DE (1) DE69228105T2 (zh)
DK (1) DK0538858T3 (zh)
EG (1) EG20114A (zh)
ES (1) ES2125880T3 (zh)
FI (1) FI107701B (zh)
GR (1) GR3029835T3 (zh)
HU (2) HU221428B (zh)
IL (1) IL103496A (zh)
MX (1) MX9206105A (zh)
MY (1) MY109794A (zh)
NZ (1) NZ244816A (zh)
RU (1) RU2106138C1 (zh)
SK (1) SK279869B6 (zh)
TW (1) TW217987B (zh)
ZA (1) ZA928104B (zh)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007083A1 (en) * 1993-09-10 1995-03-16 F.H. Faulding & Co. Limited Ifosfamide lyophilisate composition
US5789000A (en) * 1994-11-14 1998-08-04 Bionumerik Pharmaceuticals, Inc. Sterile aqueous parenteral formulations of cis-diammine dichloro platinum
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
DE19733305A1 (de) * 1997-08-01 1999-02-04 Asta Medica Ag Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin
AU1555099A (en) * 1997-10-13 1999-05-03 Stada Arzneimittel A.G. Liquid presentations of oxazaphosphorine-containing pharmaceutical products
US5972912A (en) * 1998-12-17 1999-10-26 S.P. Pharmaceuticals Method for lyophilizing ifosfamide
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
JP4077794B2 (ja) * 2002-02-22 2008-04-23 シェーリング コーポレイション 抗新生物薬剤、特にテモゾロミドの薬学的処方物、その同一物の製造方法および使用方法
BR0314068A (pt) * 2002-09-05 2005-07-05 Bharat Serums & Vaccines Ltd Processo para a preparação de uma composição estável com baixo nìvel de toxicidade; composição estável que contém oxazafosforina; uso de uma composição estável que contém oxazafosforina; e método de tratamento de uma doença maligna
US7199111B2 (en) * 2002-12-02 2007-04-03 Bharat Serums & Vaccines Ltd. Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
JP4611029B2 (ja) * 2002-12-02 2011-01-12 ブハラット セルムズ アンド ヴァクシンズ リミテッド 非経口投与用のイホスファミド組成物及びその製造方法
US8093230B2 (en) * 2003-10-01 2012-01-10 Baxter International Inc. Supersaturated aqueous ifosfamide compositions
CA2585659A1 (en) * 2004-11-05 2006-06-22 Cephalon, Inc. Cancer treatments
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
EP1973406B1 (en) 2005-12-28 2014-03-12 Advanced Bionutrition Corporation A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form
RU2470623C2 (ru) * 2006-09-29 2012-12-27 Инфа С.А. Упаковка с фармацевтической композицией и комплект для внутривенного введения
CA2673120C (en) 2006-12-18 2012-08-07 Advanced Bionutrition Corporation A dry food product containing live probiotic
JP2010526809A (ja) * 2007-05-08 2010-08-05 シェーリング コーポレイション テモゾロミドを含む静脈内処方物を用いる治療方法
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
CN102164579B (zh) * 2008-09-25 2014-10-15 赛福伦公司 苯达莫司汀的液体配制品
CN102281877B (zh) * 2009-01-15 2014-07-23 赛福伦公司 苯达莫司汀的游离碱形式
WO2010111565A2 (en) 2009-03-27 2010-09-30 Advanced Bionutrition Corporation Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
PL2435554T3 (pl) * 2009-05-26 2018-01-31 Advanced Bionutrition Corp Stabilna kompozycja suchego proszku zawierająca biologicznie aktywne mikroorganizmy i/lub materiały bioaktywne i sposoby jej wykonania
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
SG182317A1 (en) 2010-01-28 2012-08-30 Advanced Bionutrition Corp Dry glassy composition comprising a bioactive material
PL2603100T3 (pl) 2010-08-13 2019-06-28 Advanced Bionutrition Corp. Kompozycja stabilizująca przechowywanie na sucho materiałów biologicznych
PL3092009T3 (pl) 2014-01-06 2020-03-31 Auxin Surgery Sa Liofilozowane kompozycje mesny
US10342769B2 (en) 2014-11-14 2019-07-09 Navinta Iii Inc Carmustine pharmaceutical composition
CA2994112C (en) 2015-07-29 2023-08-08 Advanced Bionutrition Corp. Stable dry probiotic compositions for special dietary uses
JP6706988B2 (ja) * 2016-07-20 2020-06-10 日本化薬株式会社 ボルテゾミブを含有する医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732340A (en) * 1966-07-11 1973-05-08 Asta Werke Ag Chem Fab N',o-propylene phosphoric acid ester diamides
US4537883A (en) * 1982-11-12 1985-08-27 Mead Johnson & Company Lyophilized cyclophosphamide
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
DE3772482D1 (de) * 1986-07-11 1991-10-02 Asta Pharma Ag Loesungen von oxazaphosphorinen mit verbesserter stabilitaet und verfahren zu deren herstellung.
NO873860L (no) * 1986-10-31 1988-05-02 Asta Pharma Ag Ifosfamid-lyofilisat og fremgangsmaate til deres fremstilling.
DE3862595D1 (de) * 1987-03-06 1991-06-06 Asta Pharma Ag Verfahren zur herstellung von ifosfamid mit verbesserten eigenschaften.
ATE65402T1 (de) * 1988-03-19 1991-08-15 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
US5036060A (en) * 1988-07-25 1991-07-30 Fujisawa Usa, Inc. Cyclophosphamide

Also Published As

Publication number Publication date
MY109794A (en) 1997-06-30
GR3029835T3 (en) 1999-06-30
EP0538858A1 (en) 1993-04-28
US5227373A (en) 1993-07-13
FI924797A0 (fi) 1992-10-22
CN1046202C (zh) 1999-11-10
AU658011B2 (en) 1995-03-30
KR100247161B1 (ko) 2000-04-01
ZA928104B (en) 1993-07-20
JPH05246856A (ja) 1993-09-24
FI924797A (fi) 1993-04-24
HUT69384A (en) 1995-09-28
EP0538858B1 (en) 1999-01-07
CA2081061A1 (en) 1993-04-24
DK0538858T3 (da) 1999-08-30
RU2106138C1 (ru) 1998-03-10
JP3576180B2 (ja) 2004-10-13
MX9206105A (es) 1993-04-01
ES2125880T3 (es) 1999-03-16
IL103496A0 (en) 1993-03-15
FI107701B (fi) 2001-09-28
HU221428B (en) 2002-10-28
DE69228105D1 (de) 1999-02-18
HU211293A9 (en) 1995-11-28
CZ317692A3 (en) 1993-09-15
SK279869B6 (sk) 1999-04-13
HU9203306D0 (en) 1992-12-28
NZ244816A (en) 1994-06-27
KR930007453A (ko) 1993-05-20
DE69228105T2 (de) 1999-08-26
IL103496A (en) 1996-07-23
SK317692A3 (en) 1995-11-08
ATE175354T1 (de) 1999-01-15
CN1073358A (zh) 1993-06-23
CZ282445B6 (cs) 1997-07-16
AU2716692A (en) 1993-04-29
EG20114A (en) 1997-07-31

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees