TW202539656A - 投與抗纖維化療法之方法 - Google Patents

投與抗纖維化療法之方法

Info

Publication number
TW202539656A
TW202539656A TW114123565A TW114123565A TW202539656A TW 202539656 A TW202539656 A TW 202539656A TW 114123565 A TW114123565 A TW 114123565A TW 114123565 A TW114123565 A TW 114123565A TW 202539656 A TW202539656 A TW 202539656A
Authority
TW
Taiwan
Prior art keywords
compound
individual
auc
administration
hours
Prior art date
Application number
TW114123565A
Other languages
English (en)
Chinese (zh)
Inventor
林 潘
桃樂絲 紫芸 鐘
傑佛瑞 馬克 哈里斯
印第安娜 史東布
Original Assignee
美商基因科技公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商基因科技公司 filed Critical 美商基因科技公司
Publication of TW202539656A publication Critical patent/TW202539656A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW114123565A 2016-11-30 2017-11-29 投與抗纖維化療法之方法 TW202539656A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662428163P 2016-11-30 2016-11-30
US62/428,163 2016-11-30
US201662432425P 2016-12-09 2016-12-09
US62/432,425 2016-12-09

Publications (1)

Publication Number Publication Date
TW202539656A true TW202539656A (zh) 2025-10-16

Family

ID=60655162

Family Applications (3)

Application Number Title Priority Date Filing Date
TW114123565A TW202539656A (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法
TW106141628A TWI826361B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法
TW112145288A TWI891129B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW106141628A TWI826361B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法
TW112145288A TWI891129B (zh) 2016-11-30 2017-11-29 投與抗纖維化療法之方法

Country Status (11)

Country Link
US (3) US11207304B2 (https=)
EP (2) EP4470624A3 (https=)
JP (3) JP2020502054A (https=)
KR (3) KR20230129628A (https=)
CN (1) CN110087651A (https=)
AU (3) AU2017366881A1 (https=)
CA (2) CA3247781A1 (https=)
IL (3) IL299447A (https=)
MX (3) MX2019006143A (https=)
TW (3) TW202539656A (https=)
WO (1) WO2018102323A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207304B2 (en) 2016-11-30 2021-12-28 Genentech, Inc. Methods of administering anti-fibrotic therapy
CN114129517A (zh) * 2020-09-03 2022-03-04 苏州爱科百发生物医药技术有限公司 一种ak3287制剂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
US11207304B2 (en) 2016-11-30 2021-12-28 Genentech, Inc. Methods of administering anti-fibrotic therapy

Also Published As

Publication number Publication date
TW202412795A (zh) 2024-04-01
US11925624B2 (en) 2024-03-12
JP2023139157A (ja) 2023-10-03
CA3247781A1 (en) 2025-07-09
IL266480A (en) 2019-07-31
TWI826361B (zh) 2023-12-21
IL289544A (en) 2022-03-01
IL299447A (en) 2023-02-01
CA3045455A1 (en) 2018-06-07
AU2023263548B2 (en) 2025-10-16
KR20190089862A (ko) 2019-07-31
CN110087651A (zh) 2019-08-02
AU2017366881A1 (en) 2019-05-30
AU2025238129A1 (en) 2025-10-23
JP2022058873A (ja) 2022-04-12
JP2020502054A (ja) 2020-01-23
MX2020011766A (es) 2020-11-24
IL289544B2 (en) 2023-06-01
US20240197693A1 (en) 2024-06-20
KR20230129628A (ko) 2023-09-08
KR20220139450A (ko) 2022-10-14
EP4470624A2 (en) 2024-12-04
TW201825093A (zh) 2018-07-16
EP4470624A3 (en) 2025-01-08
US11207304B2 (en) 2021-12-28
JP7495951B2 (ja) 2024-06-05
MX2023003924A (es) 2023-04-26
TWI891129B (zh) 2025-07-21
US12310951B2 (en) 2025-05-27
KR102575344B1 (ko) 2023-09-06
AU2023263548A1 (en) 2023-11-30
US20220184046A1 (en) 2022-06-16
WO2018102323A1 (en) 2018-06-07
US20190321344A1 (en) 2019-10-24
MX2019006143A (es) 2019-10-17
EP3548025A1 (en) 2019-10-09

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