TW202446768A - 具有myt1抑制活性之含氮雜環化合物 - Google Patents

具有myt1抑制活性之含氮雜環化合物 Download PDF

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TW202446768A
TW202446768A TW113107016A TW113107016A TW202446768A TW 202446768 A TW202446768 A TW 202446768A TW 113107016 A TW113107016 A TW 113107016A TW 113107016 A TW113107016 A TW 113107016A TW 202446768 A TW202446768 A TW 202446768A
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amino
indazol
ring
compound
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TW113107016A
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青木紀裕
千葉高志
河内雅美
富澤正樹
村田佳久
須山英悟
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日商中外製藥股份有限公司
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TW113107016A 2023-02-28 2024-02-27 具有myt1抑制活性之含氮雜環化合物 TW202446768A (zh)

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WO2025182927A1 (ja) * 2024-02-27 2025-09-04 中外製薬株式会社 Myt1阻害剤の用途
WO2026054022A1 (ja) * 2024-09-05 2026-03-12 中外製薬株式会社 Myt1阻害活性を有する含窒素複素環化合物の製剤

Family Cites Families (12)

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US3202661A (en) * 1962-11-27 1965-08-24 Hoffmann La Roche Substituted 3-amino 4-phenyl quinolones
US4014883A (en) * 1973-09-10 1977-03-29 Hoffmann-La Roche Inc. Indoloquinolines, intermediates and processes
AU742452B2 (en) * 1997-08-28 2002-01-03 Bristol-Myers Squibb Company 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
WO2002076396A2 (en) * 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
CA2539760C (en) * 2003-09-23 2011-01-25 Merck & Co., Inc. Quinoline potassium channel inhibitors
GB0420970D0 (en) * 2004-09-21 2004-10-20 Smithkline Beecham Corp Novel triazoloquinoline compounds
WO2015088564A1 (en) * 2013-12-13 2015-06-18 Sunovion Pharmaceuticals Inc. P2x4 receptor modulating compounds
US11026937B2 (en) * 2016-09-12 2021-06-08 Padlock Therapeutics, Inc. Heteroaryl inhibitors of PAD4
CN109111426B (zh) * 2017-06-23 2021-12-14 中国科学院上海药物研究所 一类稠合双环杂芳基或芳基化合物,及其用途
US20240398799A1 (en) * 2021-08-19 2024-12-05 Engine Biosciences Pte. Ltd. Compositions and methods for generating synthetic lethality in tumors
CN114369061B (zh) * 2022-01-28 2024-05-03 济南同路医药科技发展有限公司 一种氯硝西泮有关物质b的制备方法
WO2024048687A1 (ja) * 2022-08-31 2024-03-07 中外製薬株式会社 Myt1阻害剤と化学療法剤を併用する、rb1の機能低下が生じている患者のがんの治療剤及び治療方法

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