TW202446768A - 具有myt1抑制活性之含氮雜環化合物 - Google Patents
具有myt1抑制活性之含氮雜環化合物 Download PDFInfo
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- TW202446768A TW202446768A TW113107016A TW113107016A TW202446768A TW 202446768 A TW202446768 A TW 202446768A TW 113107016 A TW113107016 A TW 113107016A TW 113107016 A TW113107016 A TW 113107016A TW 202446768 A TW202446768 A TW 202446768A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/47—Quinolines; Isoquinolines
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- A61K31/47—Quinolines; Isoquinolines
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023-029673 | 2023-02-28 | ||
| JP2023029673 | 2023-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202446768A true TW202446768A (zh) | 2024-12-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW113107016A TW202446768A (zh) | 2023-02-28 | 2024-02-27 | 具有myt1抑制活性之含氮雜環化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20260062412A1 (https=) |
| EP (1) | EP4647424A1 (https=) |
| JP (2) | JP7742517B2 (https=) |
| KR (1) | KR20250153810A (https=) |
| CN (1) | CN120677145A (https=) |
| AR (1) | AR131956A1 (https=) |
| AU (1) | AU2024229746A1 (https=) |
| CL (1) | CL2025002607A1 (https=) |
| CO (1) | CO2025011476A2 (https=) |
| CR (1) | CR20250376A (https=) |
| IL (1) | IL322675A (https=) |
| MX (1) | MX2025010048A (https=) |
| PE (1) | PE20252436A1 (https=) |
| TW (1) | TW202446768A (https=) |
| WO (1) | WO2024181437A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025182927A1 (ja) * | 2024-02-27 | 2025-09-04 | 中外製薬株式会社 | Myt1阻害剤の用途 |
| WO2026054022A1 (ja) * | 2024-09-05 | 2026-03-12 | 中外製薬株式会社 | Myt1阻害活性を有する含窒素複素環化合物の製剤 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3202661A (en) * | 1962-11-27 | 1965-08-24 | Hoffmann La Roche | Substituted 3-amino 4-phenyl quinolones |
| US4014883A (en) * | 1973-09-10 | 1977-03-29 | Hoffmann-La Roche Inc. | Indoloquinolines, intermediates and processes |
| AU742452B2 (en) * | 1997-08-28 | 2002-01-03 | Bristol-Myers Squibb Company | 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators |
| WO2002076396A2 (en) * | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| CA2539760C (en) * | 2003-09-23 | 2011-01-25 | Merck & Co., Inc. | Quinoline potassium channel inhibitors |
| GB0420970D0 (en) * | 2004-09-21 | 2004-10-20 | Smithkline Beecham Corp | Novel triazoloquinoline compounds |
| WO2015088564A1 (en) * | 2013-12-13 | 2015-06-18 | Sunovion Pharmaceuticals Inc. | P2x4 receptor modulating compounds |
| US11026937B2 (en) * | 2016-09-12 | 2021-06-08 | Padlock Therapeutics, Inc. | Heteroaryl inhibitors of PAD4 |
| CN109111426B (zh) * | 2017-06-23 | 2021-12-14 | 中国科学院上海药物研究所 | 一类稠合双环杂芳基或芳基化合物,及其用途 |
| US20240398799A1 (en) * | 2021-08-19 | 2024-12-05 | Engine Biosciences Pte. Ltd. | Compositions and methods for generating synthetic lethality in tumors |
| CN114369061B (zh) * | 2022-01-28 | 2024-05-03 | 济南同路医药科技发展有限公司 | 一种氯硝西泮有关物质b的制备方法 |
| WO2024048687A1 (ja) * | 2022-08-31 | 2024-03-07 | 中外製薬株式会社 | Myt1阻害剤と化学療法剤を併用する、rb1の機能低下が生じている患者のがんの治療剤及び治療方法 |
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2024
- 2024-02-27 KR KR1020257031004A patent/KR20250153810A/ko active Pending
- 2024-02-27 PE PE2025001752A patent/PE20252436A1/es unknown
- 2024-02-27 EP EP24763916.4A patent/EP4647424A1/en active Pending
- 2024-02-27 TW TW113107016A patent/TW202446768A/zh unknown
- 2024-02-27 IL IL322675A patent/IL322675A/en unknown
- 2024-02-27 AR ARP240100443A patent/AR131956A1/es unknown
- 2024-02-27 JP JP2025503931A patent/JP7742517B2/ja active Active
- 2024-02-27 CR CR20250376A patent/CR20250376A/es unknown
- 2024-02-27 WO PCT/JP2024/007072 patent/WO2024181437A1/ja not_active Ceased
- 2024-02-27 AU AU2024229746A patent/AU2024229746A1/en active Pending
- 2024-02-27 CN CN202480012274.4A patent/CN120677145A/zh active Pending
-
2025
- 2025-08-25 US US19/308,769 patent/US20260062412A1/en active Pending
- 2025-08-26 CO CONC2025/0011476A patent/CO2025011476A2/es unknown
- 2025-08-26 MX MX2025010048A patent/MX2025010048A/es unknown
- 2025-08-27 CL CL2025002607A patent/CL2025002607A1/es unknown
- 2025-09-08 JP JP2025148435A patent/JP2026000973A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20250153810A (ko) | 2025-10-27 |
| CO2025011476A2 (es) | 2025-09-18 |
| WO2024181437A1 (ja) | 2024-09-06 |
| JP7742517B2 (ja) | 2025-09-19 |
| AU2024229746A1 (en) | 2025-08-14 |
| JPWO2024181437A1 (https=) | 2024-09-06 |
| AR131956A1 (es) | 2025-05-21 |
| CN120677145A (zh) | 2025-09-19 |
| PE20252436A1 (es) | 2025-10-20 |
| CR20250376A (es) | 2025-09-22 |
| CL2025002607A1 (es) | 2025-12-12 |
| JP2026000973A (ja) | 2026-01-06 |
| IL322675A (en) | 2025-10-01 |
| MX2025010048A (es) | 2025-10-01 |
| US20260062412A1 (en) | 2026-03-05 |
| EP4647424A1 (en) | 2025-11-12 |
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