TW202446421A - 抗b7-h3抗體-藥物結合物與atr抑制劑或atm抑制劑之組合 - Google Patents

抗b7-h3抗體-藥物結合物與atr抑制劑或atm抑制劑之組合 Download PDF

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TW202446421A
TW202446421A TW113113387A TW113113387A TW202446421A TW 202446421 A TW202446421 A TW 202446421A TW 113113387 A TW113113387 A TW 113113387A TW 113113387 A TW113113387 A TW 113113387A TW 202446421 A TW202446421 A TW 202446421A
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amino acid
acid sequence
cancer
antibody
sequence
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TW113113387A
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English (en)
Chinese (zh)
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勝又廉
長谷川純
服部千春
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日商第一三共股份有限公司
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
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    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

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  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
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  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
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  • Pulmonology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW113113387A 2023-04-10 2024-04-09 抗b7-h3抗體-藥物結合物與atr抑制劑或atm抑制劑之組合 TW202446421A (zh)

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JP2023063372 2023-04-10
JP2023-063372 2023-04-10

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TW202446421A true TW202446421A (zh) 2024-12-01

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US (1) US20260091123A1 (https=)
EP (1) EP4696332A1 (https=)
JP (1) JPWO2024214685A1 (https=)
CN (1) CN121038817A (https=)
TW (1) TW202446421A (https=)
WO (1) WO2024214685A1 (https=)

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WO2026019375A1 (en) * 2024-07-19 2026-01-22 Hummingbird Bioscience Pte. Ltd. B7h3-binding molecules

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JP2025524970A (ja) 2022-07-27 2025-08-01 明慧医藥(杭州)有限公司 抗体-薬物コンジュゲートおよびその使用
JP2025526901A (ja) 2022-08-15 2025-08-15 シャンハイ ルオトゥオ バイオサイエンシズ シーオー.,エルティーディー. 抗体-薬物コンジュゲート、医薬組成物、及び治療的応用

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