TW202432139A - 多巴胺d3/d2受體調節化合物 - Google Patents
多巴胺d3/d2受體調節化合物 Download PDFInfo
- Publication number
- TW202432139A TW202432139A TW113101017A TW113101017A TW202432139A TW 202432139 A TW202432139 A TW 202432139A TW 113101017 A TW113101017 A TW 113101017A TW 113101017 A TW113101017 A TW 113101017A TW 202432139 A TW202432139 A TW 202432139A
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- formula
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363479530P | 2023-01-11 | 2023-01-11 | |
| US63/479,530 | 2023-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202432139A true TW202432139A (zh) | 2024-08-16 |
Family
ID=89573273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW113101017A TW202432139A (zh) | 2023-01-11 | 2024-01-10 | 多巴胺d3/d2受體調節化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12168007B1 (enExample) |
| EP (1) | EP4400495A1 (enExample) |
| JP (2) | JP7686096B2 (enExample) |
| KR (2) | KR102921799B1 (enExample) |
| CN (2) | CN122427144A (enExample) |
| AR (1) | AR131577A1 (enExample) |
| AU (1) | AU2024208533A1 (enExample) |
| CL (2) | CL2025002035A1 (enExample) |
| CO (1) | CO2025010725A2 (enExample) |
| GE (1) | GEAP202516807A (enExample) |
| IL (1) | IL321654A (enExample) |
| JO (1) | JOP20250164A1 (enExample) |
| MX (1) | MX2025008101A (enExample) |
| PE (1) | PE20260287A1 (enExample) |
| TW (1) | TW202432139A (enExample) |
| WO (1) | WO2024150068A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2026153547A1 (zh) * | 2025-01-20 | 2026-07-23 | 上海则正医药科技股份有限公司 | D3/d2受体部分激动剂及制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227534B1 (en) | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| EP1870405A1 (en) | 2006-06-22 | 2007-12-26 | Bioprojet | Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| JP5732453B2 (ja) | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Ｎｈ酸性化合物のプロドラッグ |
| WO2020156312A1 (zh) | 2019-01-30 | 2020-08-06 | 江苏豪森药业集团有限公司 | 一种多环类衍生物调节剂、其制备方法和应用 |
| US12617759B2 (en) | 2019-10-29 | 2026-05-05 | Shanghai Hansoh Biomedical Co., Ltd. | Modifier of four-membered ring derivative, preparation method and application thereof |
| KR102947882B1 (ko) | 2019-11-05 | 2026-04-03 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 벤조티오펜 유도체 조절제, 그의 제조 방법 및 그의 용도 |
-
2024
- 2024-01-08 KR KR1020240002897A patent/KR102921799B1/ko active Active
- 2024-01-09 AR ARP240100045A patent/AR131577A1/es unknown
- 2024-01-10 US US18/409,478 patent/US12168007B1/en active Active
- 2024-01-10 IL IL321654A patent/IL321654A/en unknown
- 2024-01-10 AU AU2024208533A patent/AU2024208533A1/en active Pending
- 2024-01-10 GE GEAP202516807A patent/GEAP202516807A/en unknown
- 2024-01-10 TW TW113101017A patent/TW202432139A/zh unknown
- 2024-01-10 WO PCT/IB2024/000026 patent/WO2024150068A2/en not_active Ceased
- 2024-01-10 CN CN202610307661.1A patent/CN122427144A/zh active Pending
- 2024-01-10 PE PE2025001450A patent/PE20260287A1/es unknown
- 2024-01-10 EP EP24151077.5A patent/EP4400495A1/en active Pending
- 2024-01-10 JP JP2024001696A patent/JP7686096B2/ja active Active
- 2024-01-10 CN CN202480007498.6A patent/CN120569367A/zh active Pending
- 2024-10-29 US US18/930,023 patent/US20250049786A1/en active Pending
-
2025
- 2025-05-19 JP JP2025083110A patent/JP2025122072A/ja active Pending
- 2025-07-09 CL CL2025002035A patent/CL2025002035A1/es unknown
- 2025-07-10 MX MX2025008101A patent/MX2025008101A/es unknown
- 2025-07-10 JO JOJO/P/2025/0164A patent/JOP20250164A1/ar unknown
- 2025-08-05 CO CONC2025/0010725A patent/CO2025010725A2/es unknown
-
2026
- 2026-01-29 KR KR1020260017571A patent/KR20260019592A/ko active Pending
- 2026-02-25 CL CL2026000558A patent/CL2026000558A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2025002035A1 (es) | 2025-10-03 |
| CN120569367A (zh) | 2025-08-29 |
| EP4400495A1 (en) | 2024-07-17 |
| CO2025010725A2 (es) | 2025-08-29 |
| KR102921799B1 (ko) | 2026-02-04 |
| JP2024098972A (ja) | 2024-07-24 |
| PE20260287A1 (es) | 2026-02-10 |
| US12168007B1 (en) | 2024-12-17 |
| US20250049786A1 (en) | 2025-02-13 |
| KR20260019592A (ko) | 2026-02-10 |
| WO2024150068A3 (en) | 2024-08-22 |
| GEAP202516807A (en) | 2025-08-25 |
| AU2024208533A1 (en) | 2025-07-10 |
| AR131577A1 (es) | 2025-04-09 |
| JP7686096B2 (ja) | 2025-05-30 |
| JP2025122072A (ja) | 2025-08-20 |
| MX2025008101A (es) | 2025-08-01 |
| CL2026000558A1 (es) | 2026-06-05 |
| JOP20250164A1 (ar) | 2025-07-10 |
| IL321654A (en) | 2025-08-01 |
| KR20240112213A (ko) | 2024-07-18 |
| WO2024150068A2 (en) | 2024-07-18 |
| CN122427144A (zh) | 2026-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5437473B2 (ja) | Ａｍｐａ及びｎｍｄａ受容体モジュレーターとして使用するベンゾチアジアゼピン誘導体 | |
| US12076321B2 (en) | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4-yl)methanone citrate | |
| WO2001032615A1 (en) | 1,4 substituted piperidinyl nmda/nr2b antagonists | |
| Van der Walt et al. | 1, 3, 7-Triethyl-substituted xanthines—possess nanomolar affinity for the adenosine A1 receptor | |
| KR20260019592A (ko) | 도파민 d3/d2 수용체 조절 화합물 | |
| JP7125495B2 (ja) | テトラヒドロイソキノリン化合物、その調製方法、そのような化合物を含む医薬組成物およびその使用 | |
| US8633226B2 (en) | Piperidinyl derivative as a modulator of chemokine receptor activity | |
| WO2011159852A1 (en) | Piperidinyl compound as a modulator of chemokine receptor activity | |
| US20090312324A1 (en) | Compositions and Methods Related to RAD51 Inactivation in the Treatment of Neoplastic Diseases, and Especially CML | |
| CN113347972B (zh) | 治疗线粒体功能障碍的方法和制剂 | |
| CN111217833B (zh) | 噻吩并[2,3-d]嘧啶类HIV-1非核苷类逆转录酶抑制剂及其制备方法和应用 | |
| US20180296532A1 (en) | RNA-Focused Small Molecules for Inhibiting RNA Toxicity in Myotonic Dystrophy | |
| HK40114011A (en) | Dopamine d3/d2 receptor modulating compounds | |
| KR20140000717A (ko) | 신규한 항-혈소판 화합물의 부가염 | |
| KR102352624B1 (ko) | LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물 | |
| WO2025199564A1 (en) | Autophagy sensors | |
| Soo-Jin et al. | Antihistamine activities of iminodiacetamide derivatives | |
| US9227979B2 (en) | Fluorescent antagonists of the A3 adenosine receptor | |
| WO2021188055A1 (en) | Modulation of cxcr3 chemokine signalling for osteoporosis therapy | |
| HK1154003B (en) | Piperidinyl derivative as a modulator of chemokine receptor activity |