TW202402748A - 兩性離子抗菌化合物 - Google Patents

兩性離子抗菌化合物 Download PDF

Info

Publication number
TW202402748A
TW202402748A TW112107104A TW112107104A TW202402748A TW 202402748 A TW202402748 A TW 202402748A TW 112107104 A TW112107104 A TW 112107104A TW 112107104 A TW112107104 A TW 112107104A TW 202402748 A TW202402748 A TW 202402748A
Authority
TW
Taiwan
Prior art keywords
carbonyl
amino
methyl
imidazole
trifluoromethyl
Prior art date
Application number
TW112107104A
Other languages
English (en)
Chinese (zh)
Inventor
珊卓 瑪麗 喬瑟夫 奧斯摩爾
克里斯俊 連納
帕雷茲歐 麥堤
席巴斯提恩 西米特
羅倫茲 麥可 爾納
珍 貝普提史特 伊曼紐爾 布朗克
雅各 威廉 波瓦
席爾朵 華特 雅各 史鐸
史蒂芬 赫爾曼 溫莫爾
Original Assignee
瑞士商赫孚孟拉羅股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 瑞士商赫孚孟拉羅股份公司 filed Critical 瑞士商赫孚孟拉羅股份公司
Publication of TW202402748A publication Critical patent/TW202402748A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW112107104A 2022-02-25 2023-02-24 兩性離子抗菌化合物 TW202402748A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22158739.7 2022-02-25
EP22158739 2022-02-25

Publications (1)

Publication Number Publication Date
TW202402748A true TW202402748A (zh) 2024-01-16

Family

ID=80461664

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112107104A TW202402748A (zh) 2022-02-25 2023-02-24 兩性離子抗菌化合物

Country Status (7)

Country Link
US (1) US20250179066A1 (https=)
EP (1) EP4482583B1 (https=)
JP (1) JP2025508473A (https=)
CN (1) CN118632842A (https=)
AR (1) AR128612A1 (https=)
TW (1) TW202402748A (https=)
WO (1) WO2023161316A1 (https=)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
WO2020182648A1 (en) 2019-03-08 2020-09-17 F. Hoffmann-La Roche Ag Novel imidazole-pyrazole derivatives
CN114981259B (zh) * 2020-01-22 2024-06-18 豪夫迈·罗氏有限公司 新型杂环化合物

Also Published As

Publication number Publication date
WO2023161316A1 (en) 2023-08-31
CN118632842A (zh) 2024-09-10
AR128612A1 (es) 2024-05-29
US20250179066A1 (en) 2025-06-05
JP2025508473A (ja) 2025-03-26
EP4482583A1 (en) 2025-01-01
EP4482583B1 (en) 2026-04-01

Similar Documents

Publication Publication Date Title
JP7846819B2 (ja) Ikaros及びAiolosの三環式分解誘導薬
US12195445B2 (en) 2-amino-N-heteroaryl-nicotinamides as Nav1.8 inhibitors
ES2990061T3 (es) Degronímeros espirocíclicos para la degradación de proteínas diana
JP2022548095A (ja) 接着分解剤及びその使用方法
WO2017197056A1 (en) Bromodomain targeting degronimers for target protein degradation
JP2018519302A (ja) 抗菌化合物
BR112016012262B1 (pt) Acrilamidas heterocíclicas farmaceuticamente ativas e composições para tratar e prevenir condições mediadas por jac
MX2014002482A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit.
WO2025007074A9 (en) Chemical compounds
KR20140097118A (ko) 항균 화합물 및 이의 사용 방법
KR20250021314A (ko) 비시클릭-치환된 글루타르이미드 세레블론 결합제
WO2013117645A1 (en) Imidazo [4, 5 -c] pyridine derivatives useful for the treatment of degenerative and inflammatory diseases
JP2022547777A (ja) ヒダントイン誘導体
TW202402748A (zh) 兩性離子抗菌化合物
EA017808B1 (ru) Производные трициклических n-гетероарилкарбоксамидов, их получение и их применение в терапии
CA3012567A1 (en) Antibacterial compounds
CA3059773C (en) Compounds and methods for treating bacterial infections
CA3012583A1 (en) Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds