TW202345846A - 使用包含gdc-6036及gdc-0077之組合療法治療癌症 - Google Patents
使用包含gdc-6036及gdc-0077之組合療法治療癌症 Download PDFInfo
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US202263328149P | 2022-04-06 | 2022-04-06 | |
| US63/328,149 | 2022-04-06 |
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| TW202345846A true TW202345846A (zh) | 2023-12-01 |
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| TW112112927A TW202345846A (zh) | 2022-04-06 | 2023-04-06 | 使用包含gdc-6036及gdc-0077之組合療法治療癌症 |
Country Status (13)
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| US20250000802A1 (en) * | 2023-06-09 | 2025-01-02 | Hoffmann-La Roche Inc. | Solid formulations comprising an inhibitor of the k-ras protein having a g12c mutation, and a process for preparing |
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| CN111909173B (zh) | 2015-07-02 | 2025-03-04 | 豪夫迈·罗氏有限公司 | 苯并氧氮杂䓬噁唑烷酮化合物及其使用方法 |
| KR20210035211A (ko) * | 2018-07-23 | 2021-03-31 | 에프. 호프만-라 로슈 아게 | Pi3k 저해제인 gdc-0077로 암을 치료하는 방법 |
| WO2020097537A2 (en) | 2018-11-09 | 2020-05-14 | Genentech, Inc. | Fused ring compounds |
| TWI829003B (zh) | 2020-08-12 | 2024-01-11 | 美商建南德克公司 | 喹唑啉化合物之合成 |
| EP4243827A1 (en) | 2020-11-13 | 2023-09-20 | Genentech, Inc. | Methods and compositions comprising a krasg12c inhibitor and a pd-l1 binding antagonist for treating lung cancer |
| KR102975432B1 (ko) | 2020-11-13 | 2026-06-10 | 제넨테크, 인크. | 고형 종양 치료를 위한 krasg12c 억제제 및 vegf 억제제를 포함하는 방법 및 조성물 |
| TWI895563B (zh) | 2020-12-08 | 2025-09-01 | 美商建南德克公司 | 用於治療實性瘤之包含krasg12c抑制劑及egfr抑制劑之組成物及方法 |
| AR128449A1 (es) | 2022-02-07 | 2024-05-08 | Genentech Inc | Proceso para la síntesis de compuestos de quinazolina |
| CN118742544A (zh) | 2022-02-07 | 2024-10-01 | 基因泰克公司 | 1-((s)-4-((r)-7-(6-氨基-4-甲基-3-(三氟甲基)吡啶-2-基)-6-氯-8-氟-2-(((s)-1-甲基吡咯烷-2-基)甲氧基)喹唑啉-4-基)-3-甲基哌嗪-1-基)丙-2-烯-1-酮的固体形式 |
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2023
- 2023-04-04 PL PL23721096.8T patent/PL4504202T3/pl unknown
- 2023-04-04 CN CN202380032303.9A patent/CN119013026A/zh active Pending
- 2023-04-04 AU AU2023249068A patent/AU2023249068A1/en active Pending
- 2023-04-04 CA CA3255718A patent/CA3255718A1/en active Pending
- 2023-04-04 JP JP2024558455A patent/JP2025511352A/ja active Pending
- 2023-04-04 US US18/295,550 patent/US12383557B2/en active Active
- 2023-04-04 KR KR1020247032867A patent/KR20240167654A/ko active Pending
- 2023-04-04 ES ES23721096T patent/ES3067080T3/es active Active
- 2023-04-04 IL IL315250A patent/IL315250A/en unknown
- 2023-04-04 WO PCT/US2023/017455 patent/WO2023196329A1/en not_active Ceased
- 2023-04-04 EP EP23721096.8A patent/EP4504202B1/en active Active
- 2023-04-06 TW TW112112927A patent/TW202345846A/zh unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| US12383557B2 (en) | 2025-08-12 |
| EP4504202A1 (en) | 2025-02-12 |
| US20230321102A1 (en) | 2023-10-12 |
| IL315250A (en) | 2024-10-01 |
| CN119013026A (zh) | 2024-11-22 |
| KR20240167654A (ko) | 2024-11-27 |
| AU2023249068A1 (en) | 2024-09-05 |
| PL4504202T3 (pl) | 2026-05-04 |
| ES3067080T3 (en) | 2026-05-19 |
| CA3255718A1 (en) | 2023-10-12 |
| JP2025511352A (ja) | 2025-04-15 |
| US20260053802A1 (en) | 2026-02-26 |
| MX2024012230A (es) | 2024-11-08 |
| EP4504202B1 (en) | 2026-02-04 |
| WO2023196329A1 (en) | 2023-10-12 |
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