TW202342492A - 用於治療癌症之基於硫鏈絲菌肽之化合物及其製備 - Google Patents

用於治療癌症之基於硫鏈絲菌肽之化合物及其製備 Download PDF

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TW202342492A
TW202342492A TW112105454A TW112105454A TW202342492A TW 202342492 A TW202342492 A TW 202342492A TW 112105454 A TW112105454 A TW 112105454A TW 112105454 A TW112105454 A TW 112105454A TW 202342492 A TW202342492 A TW 202342492A
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compound
amino
ring
mmol
thiazole
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TW112105454A
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Chinese (zh)
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喬治 Ｎ 瑙莫
賈蕾 Ｂ 當肯
保羅 Ｒ 沃科文
巴特 迪寇特
布萊恩 柯尼夫
喬哈尼斯 Ｗ Ｇ 梅斯訥
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美商Ｒｓ腫瘤學有限責任公司
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof

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