CN119301105A - 用于治疗癌症的基于硫链丝菌肽的化合物及其制备 - Google Patents
用于治疗癌症的基于硫链丝菌肽的化合物及其制备 Download PDFInfo
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- CN119301105A CN119301105A CN202380027720.4A CN202380027720A CN119301105A CN 119301105 A CN119301105 A CN 119301105A CN 202380027720 A CN202380027720 A CN 202380027720A CN 119301105 A CN119301105 A CN 119301105A
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
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- Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263310400P | 2022-02-15 | 2022-02-15 | |
| US63/310,400 | 2022-02-15 | ||
| US202263341238P | 2022-05-12 | 2022-05-12 | |
| US63/341,238 | 2022-05-12 | ||
| PCT/US2023/013118 WO2023158679A2 (en) | 2022-02-15 | 2023-02-15 | Thiostrepton-inspired compounds for treatment of cancer and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119301105A true CN119301105A (zh) | 2025-01-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202380027720.4A Pending CN119301105A (zh) | 2022-02-15 | 2023-02-15 | 用于治疗癌症的基于硫链丝菌肽的化合物及其制备 |
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| Country | Link |
|---|---|
| US (1) | US20250144078A1 (enExample) |
| EP (1) | EP4479390A4 (enExample) |
| JP (1) | JP2025506206A (enExample) |
| CN (1) | CN119301105A (enExample) |
| AU (1) | AU2023222756A1 (enExample) |
| CA (1) | CA3252219A1 (enExample) |
| TW (1) | TW202342492A (enExample) |
| WO (1) | WO2023158679A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024044744A2 (en) * | 2022-08-26 | 2024-02-29 | Wake Forest University Health Sciences | Peroxiredoxin 3 inhibitors and methods of use for treating cancer |
| US20260109695A1 (en) * | 2022-08-26 | 2026-04-23 | Wake Forest University Health Sciences | Peroxiredoxin 3 inhibitors and methods of use for treating cancer |
| WO2024044748A2 (en) * | 2022-08-26 | 2024-02-29 | Wake Forest University Health Sciences | Peroxiredoxin 3 inhibitors and methods of use for treating cancer |
| EP4665373A2 (en) * | 2023-02-15 | 2025-12-24 | RS Oncology, LLC | Select thiostrepton-inspired compounds for treatment of cancer and preparation thereof |
| WO2025265000A1 (en) * | 2024-06-21 | 2025-12-26 | Rs Oncology, Llc | Modified thiostrepton-inspired compounds for treatment of cancer and preparation thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017095751A1 (en) * | 2015-12-02 | 2017-06-08 | Partikula Llc | Compositions and methods for modulating cancer cell metabolism |
| EP3685846A1 (en) * | 2019-01-24 | 2020-07-29 | Genethon | Use of thiostrepton or its derivatives for the treatment of genetic diseases linked to a protein conformational disorder |
-
2023
- 2023-02-15 CA CA3252219A patent/CA3252219A1/en active Pending
- 2023-02-15 AU AU2023222756A patent/AU2023222756A1/en active Pending
- 2023-02-15 CN CN202380027720.4A patent/CN119301105A/zh active Pending
- 2023-02-15 WO PCT/US2023/013118 patent/WO2023158679A2/en not_active Ceased
- 2023-02-15 JP JP2024547861A patent/JP2025506206A/ja active Pending
- 2023-02-15 TW TW112105454A patent/TW202342492A/zh unknown
- 2023-02-15 EP EP23756836.5A patent/EP4479390A4/en active Pending
- 2023-02-15 US US18/837,725 patent/US20250144078A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3252219A1 (en) | 2023-08-24 |
| JP2025506206A (ja) | 2025-03-07 |
| TW202342492A (zh) | 2023-11-01 |
| WO2023158679A2 (en) | 2023-08-24 |
| US20250144078A1 (en) | 2025-05-08 |
| WO2023158679A3 (en) | 2023-09-28 |
| EP4479390A2 (en) | 2024-12-25 |
| EP4479390A4 (en) | 2026-02-18 |
| AU2023222756A1 (en) | 2024-08-29 |
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Inventor after: P. R. Wickhoff Inventor after: B. Daikete Inventor after: J. W.G. Messner Inventor before: G. N. Numov Inventor before: J.B. Duncan Inventor before: P. R. Wickhoff Inventor before: B. Kenniff Inventor before: B. Daikete Inventor before: J. W.G. Messner |