TW202337900A - 改良使用親和層析的異二聚蛋白質自雜質之解析的方法 - Google Patents

改良使用親和層析的異二聚蛋白質自雜質之解析的方法 Download PDF

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Publication number
TW202337900A
TW202337900A TW112101014A TW112101014A TW202337900A TW 202337900 A TW202337900 A TW 202337900A TW 112101014 A TW112101014 A TW 112101014A TW 112101014 A TW112101014 A TW 112101014A TW 202337900 A TW202337900 A TW 202337900A
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TW
Taiwan
Prior art keywords
value
cycles
series
protein
cycle
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TW112101014A
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English (en)
Chinese (zh)
Inventor
辛蒂 陳
安德魯 巴瑪賽
馬克 芝波羅斯基
克里斯托弗 賽文斯基
尚恩 丁
Original Assignee
美商再生元醫藥公司
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Application filed by 美商再生元醫藥公司 filed Critical 美商再生元醫藥公司
Publication of TW202337900A publication Critical patent/TW202337900A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
TW112101014A 2022-01-12 2023-01-10 改良使用親和層析的異二聚蛋白質自雜質之解析的方法 TW202337900A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202263298745P 2022-01-12 2022-01-12
US63/298,745 2022-01-12
US202263430477P 2022-12-06 2022-12-06
US63/430,477 2022-12-06

Publications (1)

Publication Number Publication Date
TW202337900A true TW202337900A (zh) 2023-10-01

Family

ID=85382626

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112101014A TW202337900A (zh) 2022-01-12 2023-01-10 改良使用親和層析的異二聚蛋白質自雜質之解析的方法

Country Status (10)

Country Link
US (1) US20230242579A1 (https=)
EP (1) EP4463463A1 (https=)
JP (1) JP2025502157A (https=)
KR (1) KR20240132357A (https=)
AU (1) AU2023207604A1 (https=)
CA (1) CA3242938A1 (https=)
IL (1) IL314032A (https=)
MX (1) MX2024008637A (https=)
TW (1) TW202337900A (https=)
WO (1) WO2023137062A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY192182A (en) 2009-06-26 2022-08-04 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
US20150093800A1 (en) * 2013-09-05 2015-04-02 Genentech, Inc. Method for chromatography reuse
GB201711481D0 (en) * 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
WO2020214792A1 (en) * 2019-04-17 2020-10-22 Bristol-Myers Squibb Company Methods for regenerating chromatography resins

Also Published As

Publication number Publication date
JP2025502157A (ja) 2025-01-24
AU2023207604A1 (en) 2024-07-25
IL314032A (en) 2024-09-01
WO2023137062A1 (en) 2023-07-20
MX2024008637A (es) 2024-08-27
EP4463463A1 (en) 2024-11-20
KR20240132357A (ko) 2024-09-03
CA3242938A1 (en) 2023-07-20
US20230242579A1 (en) 2023-08-03

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