TW202328134A - ６－胺吡唑并嘧啶化合物及其醫藥用途 - Google Patents

６－胺吡唑并嘧啶化合物及其醫藥用途 Download PDF

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TW202328134A
TW202328134A TW111132739A TW111132739A TW202328134A TW 202328134 A TW202328134 A TW 202328134A TW 111132739 A TW111132739 A TW 111132739A TW 111132739 A TW111132739 A TW 111132739A TW 202328134 A TW202328134 A TW 202328134A
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TW111132739A
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大場雄介
足達馨
西丸達也
櫻井健太朗
生越洋介
佐藤晋平
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日商日本煙草產業股份有限公司
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
TW111132739A 2021-08-31 2022-08-30 ６－胺吡唑并嘧啶化合物及其醫藥用途 TW202328134A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2021141253 2021-08-31
JP2021-141253 2021-08-31
JP2022-068967 2022-04-19
JP2022068967 2022-04-19

Publications (1)

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TW202328134A true TW202328134A (zh) 2023-07-16

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US (1) US20240287079A1 (OSRAM)
EP (1) EP4397663A4 (OSRAM)
JP (2) JP7483810B2 (OSRAM)
KR (1) KR20240055035A (OSRAM)
AR (1) AR126912A1 (OSRAM)
AU (1) AU2022340126A1 (OSRAM)
CA (1) CA3229401A1 (OSRAM)
CL (1) CL2024000581A1 (OSRAM)
CO (1) CO2024002515A2 (OSRAM)
IL (1) IL310062A (OSRAM)
MX (1) MX2024002609A (OSRAM)
PE (1) PE20240882A1 (OSRAM)
TW (1) TW202328134A (OSRAM)
WO (1) WO2023032987A1 (OSRAM)
ZA (1) ZA202400656B (OSRAM)

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TW202416965A (zh) * 2022-08-29 2024-05-01 日商日本煙草產業股份有限公司 吡唑并嘧啶化合物及其醫藥用途
WO2024177126A1 (ja) * 2023-02-24 2024-08-29 日本たばこ産業株式会社 ６－アルコキシピラゾロピリミジン化合物及びその医薬用途
KR20250151389A (ko) * 2023-02-24 2025-10-21 니뽄 다바코 산교 가부시키가이샤 치환 피라졸로피리미딘 화합물 및 그의 의약 용도
KR20250170647A (ko) 2023-04-14 2025-12-05 다케다 야쿠힌 고교 가부시키가이샤 Nlrp3 억제제로서의 피라졸로피리미딘 유도체
WO2024249539A1 (en) 2023-06-02 2024-12-05 Merck Sharp & Dohme Llc 5,6 unsaturated bicyclic heterocyles useful as inhibitors of nod-like receptor protein 3
TW202535370A (zh) * 2023-12-14 2025-09-16 美商默沙東有限責任公司 作為nod樣受體蛋白3抑制劑之吲唑衍生物
WO2025128781A1 (en) * 2023-12-14 2025-06-19 Merck Sharp & Dohme Llc Azaindazole derivatives useful as inhibitors of nod-like receptor protein 3
CN120230110A (zh) * 2023-12-31 2025-07-01 杭州百新生物医药科技有限公司 吡唑并嘧啶类化合物及其医药用途
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

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WO2012143144A1 (en) * 2011-04-21 2012-10-26 Origenis Gmbh Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
WO2017205766A1 (en) * 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
KR102815870B1 (ko) * 2019-01-14 2025-05-30 인네이트 튜머 이뮤니티, 인코포레이티드 암의 치료에 사용하기 위한 헤테로시클릭 nlrp3 조정제
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