TW202317611A - 與困難梭狀芽孢桿菌結合之抗體 - Google Patents

與困難梭狀芽孢桿菌結合之抗體 Download PDF

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TW202317611A
TW202317611A TW111124616A TW111124616A TW202317611A TW 202317611 A TW202317611 A TW 202317611A TW 111124616 A TW111124616 A TW 111124616A TW 111124616 A TW111124616 A TW 111124616A TW 202317611 A TW202317611 A TW 202317611A
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amino acid
acid sequence
ser
light chain
variable region
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TW111124616A
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Chinese (zh)
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新藏礼子
森智行
玉野竜太郎
堂前直
箱嶋敏雄
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國立大學法人東京大學
國立大學法人奈良先端科學技術大學院大學
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Publication of TW202317611A publication Critical patent/TW202317611A/zh

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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TW111124616A 2021-07-01 2022-06-30 與困難梭狀芽孢桿菌結合之抗體 TW202317611A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021-110421 2021-07-01
JP2021110421 2021-07-01

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TW202317611A true TW202317611A (zh) 2023-05-01

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US (1) US20250188157A1 (https=)
EP (1) EP4365293A4 (https=)
JP (3) JP7425452B2 (https=)
KR (1) KR20240026999A (https=)
CN (1) CN117716035A (https=)
AU (1) AU2022305377A1 (https=)
CA (1) CA3224497A1 (https=)
TW (1) TW202317611A (https=)
WO (1) WO2023277142A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202440928A (zh) 2023-03-03 2024-10-16 國立大學法人東京大學 免疫球蛋白
CN121127591A (zh) 2023-05-12 2025-12-12 国立大学法人东京大学 与艰难梭菌结合的抗体
WO2025134928A1 (ja) * 2023-12-21 2025-06-26 国立大学法人 東京大学 結腸直腸がんを治療するための組成物
WO2025220732A1 (ja) * 2024-04-17 2025-10-23 国立研究開発法人国立循環器病研究センター 肺高血圧症の予防又は治療薬
WO2025225737A1 (ja) * 2024-04-26 2025-10-30 国立大学法人 東京大学 微生物と抗体の組み合わせおよび使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030003104A1 (en) * 2001-07-02 2003-01-02 John Mottola Method for removal of pathogens from a localized environment
JP5916946B2 (ja) * 2013-03-11 2016-05-11 学校法人関西文理総合学園 モノクローナルＩｇＡ抗体の製造方法
JP2017001987A (ja) * 2015-06-11 2017-01-05 学校法人関西文理総合学園 ポリペプチド

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Publication number Publication date
KR20240026999A (ko) 2024-02-29
AU2022305377A1 (en) 2024-02-15
JP2023123746A (ja) 2023-09-05
EP4365293A4 (en) 2026-03-11
CA3224497A1 (en) 2023-01-05
JPWO2023277142A1 (https=) 2023-01-05
US20250188157A1 (en) 2025-06-12
JP2024041901A (ja) 2024-03-27
JP7405386B2 (ja) 2023-12-26
EP4365293A1 (en) 2024-05-08
JP7425452B2 (ja) 2024-01-31
CN117716035A (zh) 2024-03-15
WO2023277142A1 (ja) 2023-01-05

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