TW202313633A - 含硫雜芳族三環kras抑制劑 - Google Patents

含硫雜芳族三環kras抑制劑 Download PDF

Info

Publication number
TW202313633A
TW202313633A TW111119490A TW111119490A TW202313633A TW 202313633 A TW202313633 A TW 202313633A TW 111119490 A TW111119490 A TW 111119490A TW 111119490 A TW111119490 A TW 111119490A TW 202313633 A TW202313633 A TW 202313633A
Authority
TW
Taiwan
Prior art keywords
trifluoromethyl
mmol
carcinoma
mixture
chloro
Prior art date
Application number
TW111119490A
Other languages
English (en)
Chinese (zh)
Inventor
馬可斯 剛薩雷洛佩茲
尚米榭 凡尼爾
軍 馮
班傑明 瓊斯
尼可拉斯 艾斯里
平 陳
Original Assignee
美商伊瑞斯卡公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商伊瑞斯卡公司 filed Critical 美商伊瑞斯卡公司
Publication of TW202313633A publication Critical patent/TW202313633A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
TW111119490A 2021-05-25 2022-05-25 含硫雜芳族三環kras抑制劑 TW202313633A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202163192991P 2021-05-25 2021-05-25
US63/192,991 2021-05-25
US202163208367P 2021-06-08 2021-06-08
US63/208,367 2021-06-08
US202263327530P 2022-04-05 2022-04-05
US63/327,530 2022-04-05

Publications (1)

Publication Number Publication Date
TW202313633A true TW202313633A (zh) 2023-04-01

Family

ID=82115821

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111119490A TW202313633A (zh) 2021-05-25 2022-05-25 含硫雜芳族三環kras抑制劑

Country Status (7)

Country Link
EP (1) EP4347603A1 (fr)
JP (1) JP2024520457A (fr)
KR (1) KR20240026948A (fr)
AU (1) AU2022280025A1 (fr)
CA (1) CA3221390A1 (fr)
TW (1) TW202313633A (fr)
WO (1) WO2022251296A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023172940A1 (fr) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Méthodes de traitement du cancer du poumon réfractaire immunitaire
WO2023240263A1 (fr) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Inhibiteurs de ras macrocycliques

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943A (en) 1847-01-26 Harness-buckle
US533A (en) 1837-12-26 Truss for hermta
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
DE69025946T2 (de) 1989-09-08 1996-10-17 Univ Duke Modifikationen der struktur des egf-rezeptor-gens in menschlichen glioma
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
DE69428764T2 (de) 1993-12-24 2002-06-20 Merck Patent Gmbh Immunokonjugate
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
WO1996003397A1 (fr) 1994-07-21 1996-02-08 Akzo Nobel N.V. Formulations de peroxides cetoniques cycliques
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
CA2216796C (fr) 1995-03-30 2003-09-02 Pfizer Inc. Derives de quinazoline
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
AU6267896A (en) 1995-06-07 1996-12-30 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth oftumors
SK398A3 (en) 1995-07-06 1998-07-08 Novartis Ag Pyrrolopyrimidines and processes for the preparation thereof
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
RO121900B1 (ro) 1996-04-12 2008-07-30 Warner-Lambert Company Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora
AR007857A1 (es) 1996-07-13 1999-11-24 Glaxo Group Ltd Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen.
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
AU7165698A (en) 1997-05-06 1998-11-27 American Cyanamid Company Use of quinazoline compounds for the treatment of polycystic kidney disease
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
PL340800A1 (en) 1997-11-06 2001-02-26 American Cyanamid Co Application of quinazoline derivatives as inhibitors of thyrosinic kinase in treating colonic polyps
WO2000031048A1 (fr) 1998-11-19 2000-06-02 Warner-Lambert Company N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholine-4-yle-propoxy)-quinazoline-6-yle]-acrylamide, un inhibiteur irreversible des tyrosine kinases
JOP20190272A1 (ar) * 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
WO2020221239A1 (fr) * 2019-04-28 2020-11-05 劲方医药科技(上海)有限公司 Composé oxaazaquinazoline-7(8h)-cétone, son procédé de préparation et son application pharmaceutique
CN114040914A (zh) * 2019-07-01 2022-02-11 江苏恒瑞医药股份有限公司 喹唑啉酮类衍生物、其制备方法及其在医药上的应用

Also Published As

Publication number Publication date
KR20240026948A (ko) 2024-02-29
JP2024520457A (ja) 2024-05-24
AU2022280025A1 (en) 2023-12-07
CA3221390A1 (fr) 2022-12-01
WO2022251296A1 (fr) 2022-12-01
EP4347603A1 (fr) 2024-04-10

Similar Documents

Publication Publication Date Title
US10022354B2 (en) Pyrrolidine amide compounds as histone demethylase inhibitors
EP2970307B1 (fr) Composés pyrazolo et leurs utilisations
WO2021127404A1 (fr) Pyridones et pyrimidones tricycliques
TW202317198A (zh) Kras抑制劑結合物
WO2021173923A1 (fr) Hétérocycles fusionnés à la pyrrolidine
AU2021347232A1 (en) Tricyclic pyridones and pyrimidones
WO2022221386A1 (fr) Inhibiteurs sélectifs de kras
US11845761B2 (en) Tricyclic pyridones and pyrimidones
EP4384522A1 (fr) Inhibiteurs sélectifs de kras
TW202313633A (zh) 含硫雜芳族三環kras抑制劑
EP3250571B1 (fr) Composés thérapeutiques et leurs utilisations
WO2022265974A1 (fr) Inhibiteurs de kras tricycliques substitués par un aminohétérocycle
WO2022266069A1 (fr) Inhibiteurs tricycliques de kras g12d
WO2022271658A1 (fr) Inhibiteurs de kras tricycliques
WO2022266167A1 (fr) Inhibiteurs de kras tricycliques contenant un amide et de l'urée
WO2015049325A1 (fr) Inhibiteurs thérapeutiques de cdk8 et utilisations de ceux-ci
EP3242872B1 (fr) Dérivés du méthanone (pipéridin-3-yl)(naphthalen-2-yl) et composés similaires en tant qu'inhibiteurs de la déméthylase de histone kdm2b pour le traitement de cancer
EP3242875A1 (fr) Dérivés 4,5-dihydroimidazole et leur utilisation comme inhibiteurs d'histone déméthylase (kdm2b)
CN118076612A (zh) 含硫杂芳族三环kras抑制剂
TW202400609A (zh) 三環吡啶酮及嘧啶酮
WO2024040080A1 (fr) Conjugués inhibiteurs de kras
WO2023183755A1 (fr) Pyrimidones tricycliques
WO2023212549A1 (fr) Pyridones et pyrimidones tricycliques
CN116323582A (zh) 杂芳环类化合物及其用途