TW202312998A - Composition for improving or suppressing decline of social healthiness - Google Patents

Abstract

The purpose of the present invention is to provide a composition for improving or suppressing decline of social healthiness and a method for improving or suppressing decline of social healthiness. The present invention pertains to a composition that is for improving or suppressing decline of social healthiness and that contains, as an active ingredient, quercetin or a glycoside thereof.

Description

Composition for inhibiting or improving social health decline

The present invention relates to compositions for inhibiting or improving social health decline. Furthermore, the present invention relates to a method for suppressing or improving social health decline, and the like.

In recent years, QOL (Quality of Life) has received attention not only in medical and nursing care, but also in daily life. QOL not only affects physical and mental health, but also affects social health. For example, through everyday life, people interact with the society to which each individual belongs. Therefore, maintaining social health such as communication with others is considered to be related to the improvement of satisfaction and happiness in life and life.

As a method for measuring personal QOL, SF-36 (MOS Short-Form 36-Item Health Survey: MOS Short-Form 36-Item Health Survey) was used. SF-36 was made in the United States. From the full review of the concept construction stage to the quantitative psychological evaluation, it has been translated and widely used in Japan and other countries in the world.

Quercetin is a kind of flavonol, which is contained in plants such as onions directly or as a glycoside. For example, in Patent Document 1, it is described that the visual assessment scale (VAS) is used to evaluate the effects of neck, shoulder stiffness and waist stiffness caused by VDT (Visual Display Terminals) operations. VAS scales were significantly improved compared to the control food group. [Prior Art Literature] [Patent Document]

[Patent Document 1] Japanese Patent Laid-Open No. 2019-43862

[Problem to be solved by the invention]

However, Patent Document 1 does not examine the effect of suppressing or improving the decline in social health.

The object of the present invention is to provide a composition for inhibiting or improving the decline of social health. Furthermore, the object of the present invention is to provide a method for suppressing or improving the decline in social health. [Means to solve the problem]

The inventors of the present invention have found that quercetin or its glycoside is effective in suppressing or improving social health decline.

That is, although not limited thereto, the present invention relates to the following compositions for suppressing or improving social health decline, methods for suppressing or improving social health decline, and the like. [1] A composition for inhibiting or improving the decline in social health, which contains quercetin or its glycoside as an active ingredient. [2] The composition of the above [1], which is the score of suppressing at least one item selected from the group consisting of daily role function (body), overall health and social life function evaluated by SF-36v2 and and/or a decrease in or improvement in the component summary score of social health. [3] The composition according to the above [1] or [2], which is used to suppress the decline in social health of healthy people or improve social health. [4] The composition according to any one of the above-mentioned [1] to [3], which is for oral use. [5] The composition according to any one of the above-mentioned [1] to [4], which is a food or drink. [6] The composition according to any one of the above [1] to [5], which is accompanied by a compound selected from "can work as one wishes", "can maintain communication with others", "can maintain sociality", "does not hinder Communicating with people", "Maintaining active time", "Fluent activities", "Maintaining confidence in health", "Maintaining sociability", "Maintaining interpersonal relationship building", "Maintaining communication", "Enjoying being with others Communication", "Deepen the bond with people", "Maintain cooperation with others", "Go out with motivation", "Positive life", "Won't be lazy to communicate with others", "Play your own part role", "no health barriers in work and life", "daily life is not irrational", "work-life balance can be maintained", "living a life as it is now", "living a normal life", "not Display of at least one function in the group consisting of feeling the troubles of daily life", "maintaining vitality" and "feeling healthy at all times". [7] A method for inhibiting or improving the decline in social health, comprising administering quercetin or its glycoside. [8] A use of quercetin or its glycoside for inhibiting the reduction of social health or improving social health. [Invention effect]

According to the present invention, a composition for inhibiting or improving the decline in social health can be provided. According to the present invention, there can be provided a method for inhibiting or improving the decline in social health.

The composition for inhibiting or improving the decline in social health of the present invention contains quercetin or its glycoside as an active ingredient. The composition of the present invention for inhibiting or improving the decline in social health is also referred to as the composition of the present invention hereinafter.

In this specification, "quercetin" is also called vitamin P, and means a compound of flavonol which is a kind of polyphenol. Quercetin is a compound represented by the following formula (1).

In the present invention, the so-called "quircetin glycoside" means the glycoside of quercetin mentioned above, specifically, a series of compounds in which one or more sugars are bonded to the 3-hydroxy glycoside of quercetin general term. The quercetin glycoside system is a compound represented by the following general formula (2). The quercetin glycoside may be one type of compound, or two or more types of compounds.

(X)n in the above general formula represents a sugar chain. X represents sugar (monosaccharide), and n is an integer of 1 or more.

The sugar constituting the sugar chain represented by X glycosidically bonded to quercetin is, for example, glucose, rhamnose, galactose, glucuronic acid, etc., preferably glucose and rhamnose. In addition, n is not particularly limited if it is 1 or more, but is preferably 1-16, and more preferably 1-8. When n is 2 or more, part X may consist of one type of sugar, or may consist of multiple types of sugars. In other words, when n is 2 or more, (X)n may be a sugar chain composed of one type of sugar, or may be a sugar chain composed of multiple types of sugars. The quercetin glycosides in the present invention also include the existing quercetin glycosides that have been treated with enzymes to transfer sugar. The quercitrin glycoside in the present invention specifically includes Rutin, enzyme-treated Rutin (an enzyme-treated product of Rutin), quercitrin, and isoquinone. In the present invention, as the quercetin glycoside, it is particularly preferable to use enzyme-treated rutin. As a preferred example of enzyme treatment of rutin, for example, rutin is treated with enzymes to remove the rhamnose sugar chain part of isoginseng, which has a certain effect on the isoginseng obtained by treating rutin with glycotransferase. Sugar chains composed of ~7 glucose and their mixtures are the main components. In one aspect, the quercetin glycoside is preferably a compound having more than one (preferably 1 to 8) glucose bonded to the 3-hydroxy glycoside of quercetin (such as isoquinone, para There are 1 to 7 glucose glycosides bonded to isoginseng) and so on. The ingested quercetin glycoside is absorbed by the body after the sugar is cut off into aglycone (quircetin) in the intestinal tract.

In the present invention, the source and production method for obtaining quercetin or its glycoside are not particularly limited. For example, as plants containing a large amount of quercetin or its glycosides, buckwheat, locust tree, pepper, apple, tea, onion, grape, cauliflower, long-capsulated jute, raspberry, lingonberry, cranberry, Cactus, leafy vegetables, citrus, etc., quercetin or its glycosides can be obtained from these plants. In the present invention, as long as the effect of the present invention can be exerted, extracts from natural products such as the above-mentioned plants can be used to increase the content of quercetin or its glycosides through operations such as concentration and purification. For example, extracts containing quercetin can be used. Concentrate or purified product of corticosteroid or its glycoside extract. As the concentration method or purification method, known methods can be used. In one aspect of the present invention, purified or isolated quercetin or its glycosides can also be used. Quercetin or its glycosides can also be chemically synthesized.

Quercetin or its glycosides are contained in natural products or food products, and are compounds with dietary experience. Therefore, from the viewpoint of safety, quercetin or its glycoside is considered to be less of a problem even if it is ingested every day, for example. According to the present invention, it is possible to provide a composition containing a highly safe substance as an active ingredient for suppressing or improving the decline in social health.

In the present invention, the so-called social health (social health) is based on social health (health). Social health includes social, physical and spiritual daily role functions, overall sense of well-being, etc. The social health degree in the present invention can be evaluated using SF-36 (MOS Short Form 36-Item Health Survey). SF-36 is based on 36 questions, which are evaluated in 3~5 stages, including physical function (PF), daily role function (body) (RP), body pain (BP), general sense of health (GH), and vitality (VT). , QOL evaluation method of 8 sub-scale evaluations of social life function (SF), daily role function (mental) (RE), and mental health (MH). Based on the measurement results of the 8 sub-scales, the component summary (CS) for each of physical health, mental health, and role/social health can be calculated and evaluated. In the present invention, the so-called inhibition or improvement of social health reduction refers to the inhibition or improvement of daily role function (body), overall sense of health, daily role function (mental) and social life function evaluated by SF-36. The score of at least one of the selected items and/or the composite score of the components of the role/social health degree (social health degree) is lowered.

In SF-36, the component composite score of role/social health is based on daily role function (body), body pain (BP), general sense of health (GH), social life function (SF), daily role function (mental) (RE) five lower scales and comprehensive evaluation. It is recorded in the SF-36 manual that among the above-mentioned sub-scales, daily role function (body), daily role function (spirit), and social life function contribute more to "role/social health". The adequacy of this model has been demonstrated in a paper (Suzukamo et al., J Clin Epidemiol., 2011 Mar;64(3):301-308). For example, high scores on "Role of Everyday Functioning (Physical)" and "Role of Functioning Everyday (Mental)" indicate that performing work or general activities is not a problem for physical or psychological reasons. A high score on "Social Life Functioning" indicates that general communication with family, friends, neighbors, and other peers is not hindered for physical or psychological reasons. Therefore, it can be said that a high score of "social life function" means that the work can be carried out according to the mind, the communication with others can be maintained, and the sociality can be maintained.

In one aspect, the composition of the present invention can be preferably used to inhibit or improve at least one of the group of daily role function (body), overall health and social life function evaluated by SF-36. The score of 1 item and/or the component composite score of the social health degree is lowered. The composition of the present invention is especially suitable for inhibiting or improving the daily role function (body), overall sense of health and social life function scores evaluated by SF-36, and the reduction of the comprehensive score of components of social health.

Inhibiting the reduction of social health includes maintaining social health, slowing down the progress of social health reduction, stopping social health reduction, and the like. Improving social health includes improving social health, alleviating (slowing down) the degree of decline in social health, restoring the reduced social health, etc. Restoration also includes at least partial restoration.

As shown in the examples described below, quercetin glycosides improved the component composite score of character/social health in the evaluation based on SF-36v2. In the evaluation of quercetin glycoside based on SF-36v2, daily role function (body), body pain (BP), general sense of health (GH), social life function (SF), daily role function (mental) (RE ) of the 5 items have been improved. Quercetin or its glycosides have the effect of inhibiting or improving the decline in character/social health evaluated by SF-36, and can be used as an active ingredient in a composition for inhibiting or improving the decline in social health. Quencetin or its glycosides have the effect of inhibiting or improving the decline in social health, but so far it has not been reported.

Since quercetin or its glycosides can increase (improve) the scores of daily role function (body), general sense of health (GH) and social life function (SF) evaluated by SF-36, it can, for example, work like mind, Have a healthy self-awareness (sense of health), be able to work like a mind, be able to maintain communication with others, be able to maintain sociality, not hinder communication with others, be able to maintain activity time, be able to move smoothly, maintain confidence in health, be able to maintain sociality, Can maintain the construction of interpersonal relationships, maintain communication, deepen the fetters with others, maintain cooperation with others, be able to go out with motivation, can live a positive life, will not be lazy to communicate with others, play their own role, and Work and life without health barriers, daily life is not irrational, can maintain work-life balance, live a life as it is now, live a normal life, do not feel the troubles of daily life, can maintain vitality and feel at any time A sense of fulfillment and/or satisfaction in social life, such as health.

The compositions of the present invention may be used for any therapeutic or non-therapeutic use. The so-called non-treatment refers to the concept that does not include medical behavior, that is, does not include artificial surgery, treatment or diagnosis. The composition of the present invention can be in the form of food and drink, medicine, quasi-drug, cosmetic, etc. The composition of the present invention itself can be foodstuffs, medicines, quasi-drugs, cosmetics, etc. used to suppress or improve the decline in social health, and can also be formulated into materials or preparations used in these. The composition for suppressing or improving social health decline of the present invention can be provided in the form of a dose as an example, but is not limited to this form. The agent can also be provided directly as a composition, or as a composition containing the agent. In one aspect, the composition for inhibiting or improving the decline in social health of the present invention may also be called an agent for inhibiting or improving social decline in health. The composition of the present invention may be either an oral composition or a non-oral composition, and is preferably an oral composition. Examples of the oral composition include food and beverages, oral pharmaceuticals, and oral quasi-drugs, preferably food and beverages or oral quasi-medicines, more preferably food and beverages. Examples of parenteral compositions include parenteral pharmaceuticals, parenteral quasi-drugs, and cosmetics. It is preferably a cosmetic or a quasi-drug for parenteral use.

The composition of the present invention may contain any additives or components other than quercetin or its glycosides, as long as the effect of the present invention is not impaired. These additives and ingredients can be selected according to the form of the composition, etc., and can also be used in general food and beverages, pharmaceuticals, quasi-drugs, cosmetics, etc. When the composition of the present invention is used as food and drink, pharmaceuticals, quasi-drugs, cosmetics, etc., the production method is not particularly limited, and can be produced by common methods.

For example, when the composition of the present invention is made into food and drink, quercetin or its glycosides can be mixed with ingredients that can be used in food and drink (such as food materials, food additives used as needed, etc.) to make various food and drink. The food and drink are not particularly limited, and examples thereof include general food and drink, health food, health drink, food exhibiting functional properties, food for specific health use, health supplement food, food and drink for patients, and the like. The above-mentioned health food, food displaying functional properties, food for specific health use, health supplement food, etc. can be used as, for example, fine granules, lozenges, granules, powders, capsules, chewables, dry syrups, syrups, liquids , beverages, liquid foods, etc. in various preparation forms. In one aspect, the composition of the present invention may be provided in the form of a drink. The beverage is not particularly limited, but is preferably a tea-based beverage such as barley tea beverage, green tea beverage, mixed tea, black tea beverage, or oolong tea beverage.

When the composition of the present invention is made into a medicine or a quasi-drug, for example, quercetin or its glycoside can be formulated with a pharmacologically acceptable carrier, and additives added as needed to make a medicine or a quasi-drug in various dosage forms. Such carriers, additives, etc. should be pharmacologically acceptable as long as they can be used in pharmaceuticals or quasi-drugs, such as excipients, binders, disintegrants, lubricants, antioxidants, coloring agents, etc. or 2 or more. Examples of administration (ingestion) forms of pharmaceuticals or quasi-drugs include oral or parenteral (transdermal, transmucosal, enteral, injection, etc.) administration forms. When the composition of the present invention is used as a pharmaceutical or quasi-drug, it is preferably used as an oral (orally administered) pharmaceutical or quasi-drug. The dosage forms for oral administration include liquids, tablets, powders, fine granules, granules, sugar-coated agents, capsules, suspensions, emulsions, chewables and the like. Examples of dosage forms for parenteral administration include injections, drips, and external preparations for skin (patches, creams, ointments, etc.) and the like.

When the composition of the present invention is made into cosmetics, acceptable carriers, additives, etc. for cosmetics can be formulated in quercetin or its glycosides. The product form of the cosmetic is not particularly limited.

The content of quercetin or its glycoside contained in the composition of the present invention is not particularly limited, and can be set according to its form and the like. The content of quercetin or its glycosides in the composition of the present invention is preferably at least 0.0001% by weight, more preferably at least 0.01% by weight, and still more preferably at least 0.1% by weight as a quercetin-converted value. , and preferably less than 99.9% by weight, more preferably less than 95% by weight, more preferably less than 80% by weight, particularly preferably less than 45% by weight. In one aspect, the content of quercetin or its glycosides is preferably 0.0001 to 99.9% by weight, more preferably 0.001 to 95% by weight, and even more preferably 0.01% in terms of quercetin conversion. ~80% by weight, especially preferably 0.01~45% by weight. Moreover, in one aspect, when the composition of the present invention is made into food and drink, the content of quercetin or its glycoside in the food and drink is preferably 0.0001 to 99.9% by weight, more preferably 0.001 to 45% by weight. The content of quercetin or its glycosides can be determined according to known methods, for example, high-speed liquid chromatography (HPLC) can be used.

The composition of the present invention is usually ingested or administered to a subject. The route of administration of the composition of the present invention is not particularly limited, and it can be ingested or administered by an appropriate method according to its form. In one aspect, the composition of the present invention is preferably ingested orally (oral administration). The administration amount (also referred to as intake) of the composition of the present invention is not particularly limited, as long as it is an amount (also referred to as an effective amount) to obtain the effect of inhibiting or improving the decline in social health, as long as it is based on the administration form , the method of administration, and the like may be appropriately set.

In one aspect, when the composition of the present invention is ingested or administered to an adult, the dose of quercetin or its glycoside is preferably 0.1 mg or more per day, more preferably 0.3 mg or more, as a quercetin conversion value. mg or more, more preferably 1.0 mg or more, particularly preferably 10 mg or more, and preferably 8000 mg or less, more preferably 4000 mg or less, more preferably 1000 mg or less, still more preferably 500 mg or less, most preferably 200 mg or less. In one aspect, the dose of quercetin or its glycosides, as the converted value of quercetin, is preferably 0.1 mg to 8000 mg per day for adults, more preferably 0.3 mg to 4000 mg, and even more preferably 1.0mg~1000mg, more preferably 10mg~500mg, especially preferably 10mg~200mg. In one aspect, the above-mentioned amount is preferably ingested or administered, for example, once a day or divided into several times (for example, 2 to 3 times). In one aspect, the aforementioned amount of quercetin or its glycoside is preferably orally ingested or administered to humans. The dosage of the above-mentioned quercetin or its glycosides can be the dosage per 60 kg of body weight. In one aspect of the present invention, the composition of the present invention can be used to ingest or administer the above-mentioned amount of quercetin or its glycosides to humans every day.

The composition of the present invention is preferably continuously ingested or administered. By continuously taking or administering quercetin or its glycosides, it is expected to obtain a high effect of inhibiting or improving the decline in social health. In one aspect, the composition of the present invention is preferably continuously ingested or administered for more than 1 week, more preferably for more than 4 weeks, and more preferably for more than 8 weeks.

If the composition of the present invention is used, it is possible to suppress a decrease in social health or improve social health. For example, suppressing or ameliorating socially-based declines in well-being may help suppress or ameliorate socially-based QOL declines. In one aspect, the composition of the present invention can be used to suppress QOL decline or improve QOL by suppressing or improving social health decline. Inhibiting QOL reduction includes maintaining QOL, delaying progression of QOL reduction, stopping QOL reduction, and the like. The improvement of QOL includes improving QOL, alleviating (slowing down) the reduction degree of QOL, recovering the QOL that has been reduced, etc. In one aspect, the composition of the present invention can be used, for example, to prevent or improve a state or disease caused by a decrease in social health, or to prevent or improve a state or disease accompanied by a decrease in social health. Prevention of a condition or disease includes preventing the onset of the condition or disease, delaying the onset of the condition or disease, reducing the incidence of the condition or disease, mitigating the risk of developing the condition or disease. Amelioration of a state or disease includes recovering a subject from a state or disease, ameliorating the symptoms of the state or disease, alleviating the symptoms of the state or disease, delaying, preventing the progression of the state or disease, and the like.

The subjects who ingest or administer the composition of the present invention (also referred to as administration subjects) are usually human beings. The subject of administration of the present invention includes, for example, subjects who need or wish to suppress or improve social health decline.

The compositions of the present invention can be used on subjects of a wide range of ages. Preferably, the compositions of the present invention are administered to adults (eg, 18 years of age or older). In one aspect, the subject of the present invention is preferably middle-aged or elderly. Middle-aged and elderly people include elderly people. Among middle-aged and elderly people, it is preferable to target the elderly. In the present invention, middle-aged and elderly people may be, for example, people over 40 years old. An elderly person may be, for example, a person over 60 years old. In one aspect, the composition of the present invention can be suitably used as a composition for middle-aged and elderly people to suppress or improve social health decline. The subject of administration of the composition of the present invention may be, for example, a person aged 60 to 80, preferably a person aged 60 to 75. In one aspect, the subject of administration of the composition of the present invention is preferably a healthy person, more preferably a healthy middle-aged or elderly person. The composition of the present invention is preferably used for inhibiting the reduction of social health of healthy people or improving social health. "Healthy person" in the present invention refers to a person who has no disease and does not use medicine frequently (about 6 days or more a week).

The composition of the present invention may also be accompanied by indications of functions exerted by inhibiting or improving social health decline. The composition of the present invention can also be accompanied by such as "can work as intended", "can maintain communication with people", "can maintain sociality", "does not hinder communication with people", "can maintain activity time", "can be fluent activities", "maintain confidence in health", "maintain sociability", "maintain relationship building", "maintain communication", "enjoy communication with others", "deepen ties with people", "maintain and Cooperation between people", "Going out with motivation", "Positive life", "Don't be lazy to communicate with others", "Play your own role", "No health obstacles in work and life", " Daily life is not irrational", "can maintain work-life balance", "live life as it is now", "live a normal life", "do not feel troublesome in daily life", "can maintain vitality" and " One or two or more functional displays such as "I feel healthy at any time". The display of the above functions can also be described as the function of obtaining the above functions by inhibiting or improving the decline in social health. In one aspect, the composition of the present invention is preferably a food or drink with the above indications. And the above-mentioned display may be a display for obtaining the above-mentioned function. The display can be attached to the composition itself, or to the container or package of the composition.

The present invention also includes the following methods and uses. A method for inhibiting or improving the decline of social health, which is to administer quercetin or its glycoside. A use of quercetin or its glycoside for inhibiting the reduction of social health or improving social health. The above methods and uses can be therapeutic methods or uses, or non-therapeutic methods or uses. Administration (ingestion) of quercetin or its glycoside suppresses the decline in social health or improves social health. Quercetin or its glycosides can be used to inhibit or improve QOL decline by inhibiting or improving the decline in social health.

In the above methods and uses, it is preferable to administer quercetin or its glycosides to the subject more than once a day, for example, once to several times (eg, 2 to 3 times) a day. In one aspect, the drink containing quercetin or its glycoside is preferably ingested or administered at least once a day. The above uses are generally for human use. Quercetin or its glycosides are as above.

In the above methods and uses, quercetin or its glycosides may be used in an amount capable of suppressing or improving the effect of reducing social health. The preferred dosage, administration object, and administration method of quercetin or its glycosides are the same as the above-mentioned composition for inhibiting or improving social health decline of the present invention. Quercetin or its glycoside can be administered directly or as a composition containing it. For example, the composition of the present invention described above can also be used. Quercetin or its glycosides are preferably administered orally.

Quercetin or its glycosides can be used in the manufacture of foods, pharmaceuticals, quasi-medicines, cosmetics, etc. to inhibit or improve the decline in social health. In one aspect, the present invention also includes the use of quercetin or its glycosides for the manufacture of compositions for inhibiting or improving the decline in social health. The composition for suppressing or improving the decline in social health and its preferred aspects are the same as those of the above-mentioned composition of the present invention.

The academic documents and patent documents described in this specification are incorporated in this specification by reference. When stated for clarity, the numerical range represented by the lower limit and the upper limit in this specification, that is, "lower limit ~ upper limit" includes the lower limit and the upper limit. For example, the range represented by "1~2" means 1 to 2, including 1 and 2. [Example]

Hereinafter, based on an Example, this invention is demonstrated more concretely. Also, the present invention is not limited by these embodiments.

<Example 1> (Tested food and control food) The quercetin glycoside system uses SUNEMIC (trade name, Sanrongyuan FFI Co., Ltd.). SUNEMIC is a mixture of two or more quercetin glycosides in which 1~7 glucose is added to quercetin. The test food is a 500mL barley tea drink containing 110mg (71.6mg in terms of quercetin) of quercetin glycoside as isoquinone (quercetin glycoside with 1 glucose added to quercetin) , the control food is 500mL barley tea drink without quercetin glycoside.

(Test summary) 80 healthy Japanese males and females aged 60 to 80 without diseases and not taking medicines were used as objects, and the comfort food intake group (40 people) and the control food intake group (40 people) were implemented. Dose-controlled randomized double-blind parallel group comparison trial. The subjects took 500mL test food or control food every day for 40 weeks. Before and after the intervention, the QOL measurement examination was carried out. The QOL measurement examination was carried out using the SF-36v2 (MOS short-form 36-item health survey version 2) (references 1~3 below) of the QOL questionnaire consisting of ten thousand people's common concepts of health. The 36 questions are evaluated in stages from 3 to 5, with physical function (PF), daily role function (body) (RP), body pain (BP), general sense of health (GH), vitality (VT), social life Eight sub-scales of functioning (SF), daily role functioning (spiritual) (RE), and mental health (MH) were evaluated. In addition, the composite scores of the components of physical health, mental health, and role/social health are calculated and evaluated. The data of 68 people were analyzed by removing those who were omitted and those who were excluded from analysis. The details include the test food intake group (33 persons) and the control food intake group (35 persons). The analysis method is to perform a corresponding t-test (*: P<0.05, **: P<0.01) by comparing each group before the ingestion (before ingestion) and after ingestion for 40 weeks.

(test results) Subscales of SF-36v2 (Routine Role Function (Physical) (RP), Body Pain (BP), General Health (GH), Vitality (VT), Social Life Function (SF), Daily Role Function (Spiritual) (RE ), Mental Health (MH)) and Mental Health, Role/Social Health The changes (mean ± standard error) of the comprehensive scores of the respective components after intake for 40 weeks are shown in Table 1 (*: P<0.05). In Fig. 1, it shows the change amount (average ± standard error). The amount of change in the score was calculated by subtracting the score before the start of ingestion (before ingestion) from the score at each time point.

Compared with the control food intake group, the test food intake group saw score improvement items including daily role function (body), body pain (BP), general sense of health (GH), vitality (VT), social life function (SF ), Daily Role Functioning (Spiritual) (RE), Mental Health (MH), Role/Social Health, Mental Health.

Among them, role/social health is composed of 5 sub-levels of daily role function (body), body pain (BP), general sense of health (GH), social life function (SF), and daily role function (spiritual) (RE). All the sub-items have been improved. As shown in Figure 1, the component composite score of the role/social health degree also saw improvement. Therefore, it can be seen that by ingesting quercetin or its glycoside, it is possible to suppress a decrease in character/social health or improve character/social health.

＜References＞ (Reference 1) Fukuhara S, et al.,: Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. Journal of Clinical Epidemiology, 51(11), 1037-1044, 1998 (Reference 2) Fukuhara S, et al.,: Psychometric and clinical tests of validity of the Japanese SF-36 Health Survey, Journal of Clinical Epidemiology, 51, 11, 1045-1053, 1998 (Reference 3) Fukuhara et al., Manual of SF-36v2 Japanese version: iHope International Co., Ltd., Kyoto, 2004, 2015 (English publication: Fukuhara et al., Manual of SF-36v2 Japanese version: iHope International Inc., Kyoto, 2004, 2015)

[Fig. 1] It shows the effect of the group of people who ingested the test food containing quercetin glycoside and the group who ingested the control food without quercetin glycoside/changes in the composite score of social health (mean ± standard error) graph.

Claims (8)

A composition for inhibiting or improving the decline of social health, which contains quercetin or its glycoside as an active ingredient. The composition of claim 1, which is to suppress the score and/or sociality of at least one item selected from the group consisting of daily role function (body), overall health and social life function evaluated by SF-36v2 A decrease in the component summary score of the health degree or an improvement in the score. The composition of claim 1 or 2, which is used to inhibit the decline of social health of healthy people or improve social health. The composition of claim 1 or 2 is an oral composition. As in the composition of claim 1 or 2, it is a food or drink. Such as the composition of claim 1 or 2, it is attached with a choice of "can work as desired", "can maintain communication with people", "can maintain sociality", "does not hinder communication with people", "can maintain activity time ", "Smooth activities", "Maintain confidence in health", "Maintain sociability", "Maintain relationship building", "Maintain communication", "Enjoy communication with others", "Deepen ties with people" , "Maintain cooperation with others", "Go out with motivation", "Positive life", "Won't be lazy to communicate with others", "Play your own role", "No need for work and life Health barriers", "Daily life is not irrational", "Work-life balance can be maintained", "Living life as it is now", "Live a normal life normally", "Do not feel troublesome in daily life", "Can maintain The display of at least one function in the group formed by "vigorous" and "feeling healthy at all times". A method for inhibiting or improving the decline of social health, which is to administer quercetin or its glycoside. A use of quercetin or its glycoside for inhibiting the reduction of social health or improving social health.

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