TW202306579A - Red yeast rice and composition containing specific components - Google Patents

Abstract

To provide a composition having an enhanced antioxidant activity. This composition contains component (1) and component (2). Component (1) is at least one selected from the group consisting of bisdemethoxycurcumin, glycerine fatty acid ester, diosmetin, linolenic acid, carotene, daidzein, hesperidin, genistein, citrus fruit extract, a processed product of black ginger, naringin, and naringenin. Component (2) is at least one selected from the group consisting of red yeast rice and a processed product thereof.

Description

Compositions containing red yeast rice and specific ingredients

The present invention relates to a composition containing red yeast rice and specific components, a method for enhancing anti-oxidation and the like.

Oxygen is important for maintaining life, and a part of the oxygen taken into the body changes into active oxygen, which causes oxidative stress in cells or tissues. Oxidative stress in the body is known to cause various diseases including arteriosclerosis, anti-inflammation, diabetes, increase in blood viscosity, and decrease in vascular function.

Previously, anti-oxidation has been focused on alleviating this oxidative stress. For example, bisdemethoxycurcumin, carotene, daidzein, hesperidin ( Various ingredients including hesperidin and genistein have antioxidant effects. In addition, in order to obtain a higher antioxidant effect, for example, a beauty composition is known, which contains pine bark as an antioxidant substance, and at least one selected from the group consisting of herbs (herb), ceramide (ceramide), and selenium. Material (Patent Document 1). Previously, preparations and the like having an antioxidative effect were widely known, but in today's state, it is also important to provide a product with a further enhanced antiacid effect. [Prior art literature] [Patent Document]

[Patent Document 1] Japanese Patent Laid-Open No. 2021-54770

[Problem to be Solved by the Invention] The object of this disclosure is to provide a composition etc. which enhanced the antioxidation effect.

[Means to solve the problem] The inventors of the present invention have worked hard to solve the above-mentioned problems, and as a result, they have found that by combining specific components such as red yeast rice and bisdemethoxycurcumin, the antioxidant effect can be enhanced in a composition containing the specific components. . The present invention is based on the above findings and has been completed through further repeated studies. For example, this disclosure includes the following aspects. Item 1. A composition comprising the following components (1) and (2): (1) Bisdemethoxy curcumin, glycerin fatty acid ester, diosmetin, linoleic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black At least one selected from the group consisting of processed ginger, naringin and naringenin; (2) At least one selected from the group consisting of red yeast rice and its processed products. Item 2. The composition according to Item 1, for oral use. Item 3. A method for enhancing antioxidant action in a composition containing the following component (1), the method characterized by combining the following component (1) and component (2): (1) Processed from bis-demethoxy curcumin, glycerin fatty acid ester, diosmin, sub-linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger At least one of the group consisting of naringin, naringin and naringenin; (2) At least one selected from the group consisting of red yeast rice and its processed products. Item 4. Use of at least one selected from the group consisting of red yeast rice and its processed products, for enhancing the antioxidant effect in a composition containing the following component (1): (1) Processed from bis-demethoxy curcumin, glycerin fatty acid ester, diosmin, sub-linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger At least one of the group consisting of naringin, naringin and naringenin. [Effect of the invention]

A composition containing the component (1) and the component (2) can be provided. By combining the component (1) and the component (2), the antioxidant action can be enhanced in the composition containing the component (1). A use of the component (2) may be provided for enhancing the antioxidant effect in a composition containing the component (1).

Hereinafter, the embodiments included in the present disclosure will be described in more detail.

The composition included in this disclosure contains the following component (1) and component (2). (1) Processed from bis-demethoxy curcumin, glycerin fatty acid ester, diosmin, sub-linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger At least one of the group consisting of naringin, naringin and naringenin; (2) At least one selected from the group consisting of red yeast rice and its processed products.

Component (1) Component (1) can be demonstrated as follows. Bisdemethoxycurcumin is a known substance represented by the chemical formula C ₁₉ H ₁₆ O ₄ and is known as CAS Nos. 24939-16-0 and 33171-05-0. Bisdemethoxycurcumin may be a natural product or a synthetic product, and may be obtained commercially or from a commercially available product, and is not particularly limited. Examples of commercially available bisdemethoxycurcumin include Bisdemethoxycurcumin (Tokyo Chemical Industry Co., Ltd.).

Glycerin fatty acid esters are esters of glycerin and fatty acids. In this disclosure, glycerin fatty acid esters include polyglycerin fatty acid esters and organic acid monoglycerides. Glycerin fatty acid esters may be monoesters, diesters, or triesters, and the degree of polymerization of glycerol is not limited, and examples include: glycerin monofatty acid esters, glycerin difatty acid esters, triglycerin fatty acid esters, average degree of polymerization It is an ester of 2 or more glycerin and a fatty acid, that is, a polyglyceryl fatty acid ester, and the like.

It is not particularly limited as long as the effect of the present disclosure can be obtained, but the carbon number of the fatty acid constituting the glycerin fatty acid ester is preferably exemplified from 1 to 30, more preferably exemplified from 10 to 25, and still more preferably exemplified from 18 ~21. The fatty acid constituting glycerin fatty acid ester may be linear or branched, and may be saturated or unsaturated. Although this disclosure is not limited, in polyglycerol fatty acid esters, the average degree of polymerization of glycerin is more preferably an integer of 2 to 10, more preferably an integer of 2 to 8, particularly preferably 2 to 8. is an integer of 6, and the organic acid in the organic acid monoglyceride is not limited as long as it is a conventionally known organic acid.

Examples of such fatty acids include lauric acid, myristic acid, palmitic acid, palmitoleic acid, oleic acid, trans-11-octadecenoic acid (vaccenic acid), linoleic acid, stearic acid, caprylic acid, capric acid , Linolenic acid, behenic acid, acetic acid, propionic acid, butyric acid, lactic acid, succinic acid, caproic acid, isobutyric acid, isovaleric acid, valeric acid, etc. As fatty acid, more preferably, oleic acid, linolenic acid, stearic acid, butyric acid, lactic acid, succinic acid, etc. can be illustrated. One type of fatty acid may be used alone, or two or more types may be used in any combination.

Specific examples of fatty acid esters of glycerol are not particularly limited as long as the effect of the present disclosure can be obtained, and examples include monoglyceryl acetate, monoglyceryl lactate, monoglyceryl citric acid, and monoglyceryl diacetyl tartrate , succinic acid monoglyceride, glycerol monofatty acid ester, glyceryl diglyceride fatty acid ester, polyglycerol fatty acid ester, polyglycerol condensed ricinoleic acid ester, etc. Glycerin fatty acid esters may be used alone or in combination of two or more.

Glycerin fatty acid ester may be a natural product or a synthetic product, and may be obtained from a commercial source or obtained from a commercial source, and is not particularly limited. Examples of commercially available glycerin fatty acid esters include: EMAX BW-36 (Riken Vitamin Co., Ltd.), POEM S-100 (Riken Vitamin Co., Ltd.), Sansoft (SUNSOFT) Q-17D (Sun Chemical Co., Ltd.), POEM (POEM) J-4081V (Riken Vitamin Co., Ltd.), etc.

Dioxynignin is a known substance represented by the chemical formula C ₁₆ H ₁₂ O ₆ and is known as CAS No. 520-34-3. The diosmin may be a natural product or a synthetic product, and may be obtained from a commercial source or obtained from a commercial source, and is not particularly limited. Examples of commercially available diosmetin include Diosmetin (AdooQ Bioscience) and the like.

Linolenic acid is a known substance represented by the chemical formula C ₁₈ H ₃₀ O ₂ , and examples thereof include α-linolenic acid, γ-linolenic acid, and the like, preferably α-linolenic acid. Linolenic acid may be a natural product or a synthetic product, and may be obtained from a commercial source or obtained from a commercial source, and is not particularly limited. Examples of commercially available linolenic acid include Linolenic Acid (Tokyo Chemical Industry Co., Ltd.).

Carotene is a conventionally known substance, and examples thereof include α-carotene, β-carotene, and the like, preferably β-carotene. Carotene may be a natural product or a synthetic product, and may be obtained from a commercial source or obtained from a commercial source, and is not particularly limited. Examples of commercially available carotene include β-carotene (Tokyo Chemical Industry Co., Ltd.).

Daidzein is a known substance represented by the chemical formula C ₁₅ H ₁₀ O ₄ and is known as CAS number 486-66-8. Daidzein may be a natural product or a synthetic product, and may be obtained commercially or from a commercially available product, and is not particularly limited. Examples of commercially available daidzein include Daidzein (Tokyo Chemical Industry Co., Ltd.).

Hesperidin is one of known polyphenols represented by the chemical formula C ₂₈ H ₃₄ O ₁₅ , and is known as CAS number 520-26-3. Hesperidin may be a natural product or a synthetic product, and may be obtained from a commercial source or obtained from a commercial source, and is not particularly limited. Examples of commercially available hesperidin include Hesperidin (Tokyo Chemical Industry Co., Ltd.).

Genistein is a known substance represented by the chemical formula C ₁₅ H ₁₀ O ₅ and is known as CAS number 446-72-0. Genistein may be a natural product or a synthetic product, and may be a commercially acquired substance or a substance obtained from a commercially acquired substance, and is not particularly limited. Examples of commercially available genistein include Genistein (Tokyo Chemical Industry Co., Ltd.).

The citrus extract is an extract of citrus, and although this disclosure is not limited, examples of citrus include those belonging to the genus Satsuma, Kumquat, and Citrus belonging to the Citrus family, for example, yuzu, Kabosu , Tangerine, Taiwan lemon, kumquat, pomegranate, orange and so on. The parts of citrus fruits used in the extract are not limited as long as the effect of the present disclosure can be obtained, and fruits are mainly exemplified, for example, any of the fruit itself, fruit juice, its concentrate, and concentrated dried product. One kind of citrus fruits may be used alone, or two or more kinds may be used in combination, and the parts to be used may be used alone, or two or more kinds may be used in combination.

The method for producing the extract (extraction method), extraction conditions, and the like are not particularly limited, as long as it follows a previously known method. For example, citrus fruit can be directly, if necessary, cut, pulverized, squeezed, dried, etc., and then extracted with a solvent to obtain an extract. As the method of solvent extraction, as long as the methods known in the art can be adopted, for example, previously known extraction methods such as water (including warm water, hot water) extraction, alcohol extraction, supercritical extraction, etc. can be used, and it can also be carried out if necessary. Stir and so on. The obtained extract may be filtered, centrifuged, or the like as necessary.

Examples of extraction solvents include water; alcohols such as lower alcohols such as methanol, ethanol, and isopropanol, or polyhydric alcohols such as propylene glycol and 1,3-butanediol (either anhydrous or water-containing); ketones such as acetone Classes, diethyl ether, dioxane, acetonitrile, ethyl acetate and other esters, xylene, benzene, chloroform, etc. The solvent is preferably water, lower alcohol, 1,3-butanediol, etc., more preferably water, methanol, ethanol, 1,3-butanediol, still more preferably water, methanol, or hydrous ethanol. These extraction solvents may be used alone or in combination of two or more.

In the present disclosure, the extract obtained through solvent extraction as described above may be specifically referred to as a solvent extract. In addition, although this disclosure is not limited, regarding solvent extracts, for example, in the case of using water as the extraction solvent, it can be called a water extract, and in the case of using lower alcohols as an extraction solvent, it can be called a lower alcohol. The extract, when ethanol is used as an extraction solvent, may be called an ethanol extract or the like.

The obtained extract may be used as it is, or may be dried and used in a solid state such as powder or granule. In addition, the obtained extract may be subjected to ultrasonic treatment, etc., if necessary, and may also be subjected to purification, concentration treatment, separation treatment such as high-activity fractionation, and the like. In addition, for example, the obtained extract (and its dried product, ultrasonic treatment product, purified product, concentrated product, highly active fraction, etc.) can also be subjected to freeze-drying treatment and powdered, etc. The extracts used in this disclosure were prepared by powdering by previously known methods. Moreover, this extract can also be used dissolved in water, ethanol, etc. as needed.

The citrus extract may be commercially obtained or may be a substance obtained from a commercially obtained product, and is not particularly limited. As an example of a commercially available citrus extract, yuzu polyphenol (manufactured by Toyo Seisho Co., Ltd.) etc. are mentioned. Citrus extracts may be used alone or in combination of two or more.

The processed black ginger is a processed product of a Zingiberaceae plant called Kaempferia parviflora, and the used part may be any of rhizome (tuber), leaf, stem, etc., preferably rhizome. One type may be used alone or two or more types may be used in combination. Examples of black ginger processed products include sliced, ground, dried, squeezed, ground, and extracts of black ginger.

There are no restrictions on slices as long as black ginger is sliced by a conventionally known method.

The pulverized product is not particularly limited as long as it is obtained by pulverizing black ginger by a pulverization means known in the art such as a jet mill, and powders, granules, and the like can be exemplified.

The dried product is not particularly limited as long as it is obtained by drying black ginger, and it can be obtained by conventionally known drying methods such as sun drying, far infrared radiation, drying machine (hot air drying, cold air drying, vacuum freeze drying, etc.) . The moisture content in the dried product is preferably at most 12% by mass, more preferably at most 10% by mass. In the present invention, the form of the dried product is not limited, and may be either a dried product of black ginger itself, a pulverized product of the dried product, or the like. The dry pulverized product can be obtained by the same method as the above-mentioned pulverized product. In addition, the dried product may be obtained by drying black ginger after fermentation treatment or enzyme treatment.

The juice is not limited as long as it is obtained from black ginger by a previously known method. The form of the squeezed juice may be any of liquid, paste, and its dried product, and may also be a pulverized product of the dried product.

The ground product is not limited as long as it is obtained by grinding black ginger by a conventionally known method.

The extract may be an extract obtained by using black ginger, and its production method (extraction method) and extraction conditions are not particularly limited, as long as it follows a conventionally known method. Its production method can be described in the same manner as above. For example, the extract can be obtained by extracting black ginger as it is, optionally after cutting, pulverizing, drying, etc., by solvent extraction. As a method of solvent extraction, for example, previously known extraction methods such as water (including warm water and hot water) extraction, alcohol extraction, and supercritical extraction can be used, and stirring can also be carried out if necessary. For the obtained extract, if necessary, Filtration or centrifugation can also be performed. As the extraction solvent, the same ones as those described above can be exemplified. The extract obtained by solvent extraction as described above can be particularly referred to as a solvent extract, and when water is used as an extraction solvent, it is a water extract, etc., and can be described in the same manner as above.

In the same manner as above, the obtained extract may be used as it is, or may be dried and used in a solid state such as powder or granule. In addition, the obtained extract may be subjected to ultrasonic treatment, etc., if necessary, and may also be subjected to purification, concentration treatment, separation treatment such as high-activity fractionation, and the like. In addition, for example, the obtained extract (and its dried product, ultrasonic treatment product, purified product, concentrated product, highly active fraction, etc.) can also be subjected to freeze-drying treatment and powdered, etc. The extracts used in this disclosure were prepared by powdering by previously known methods. Moreover, this extract can also be used dissolved in water, ethanol, etc. as needed.

The processed black ginger may be a commercially acquired product or a material obtained from a commercially acquired product, and is not particularly limited. Examples of commercially available black ginger processed products include black ginger extract (Maruzen Pharmaceutical Co., Ltd.), SIRTMAX (Tokiban Phytochemical Research Institute Co., Ltd.), and the like. One kind of processed black ginger may be used alone, or two or more kinds may be used in combination.

Naringin is a known substance represented by the chemical formula C ₂₇ H ₃₂ O ₁₄ and is known as CAS No. 10236-47-2. Naringenin is a ligand of naringin, is a known substance represented by the chemical formula C ₁₅ H ₁₂ O ₅ , and is known as CAS No. 480-41-1. These may be natural products or synthetics, and may be obtained from commercial sources or obtained from commercial sources, and are not particularly limited. Naringenin (Cayman Chemical Company) etc. are mentioned as an example which can be acquired commercially. These may be used alone or in combination of two or more.

These components (1) may be used alone or in combination of two or more.

ingredients (2) Component (2) can be demonstrated as follows. Red yeast rice is the red yeast rice obtained by inoculating and culturing previously known red yeast rice fungus in the raw material of red yeast rice. The red yeast rice fungus is not limited as long as it has been used in the production of red yeast rice, and filamentous fungi belonging to the genus Monascus can be exemplified. Although this disclosure is not limited, examples of filamentous fungi belonging to the genus Monascus pilosus include Monascus pilosus, Monascus purpureus, Monascus anka, and Monascus purpureus. (Monascus ruber), Monascus pubigerus, variants of these, variants of these, etc. As the red yeast rice, more preferable examples include Rhodotorula pilosae, Rudosus purpurea, Rudos rubrum rubrum, and the like, and still more preferably, Rhodotorus pilosae can be exemplified. The red fermented yeast can be used alone or in combination of two or more.

As the raw material of koji, grains can be preferably exemplified, although this disclosure is not limited, examples of grains include rice such as polished white rice, germ rice, germinated brown rice, brown rice, and germ; beans such as soybeans and adzuki beans; wheat; Corn; Chestnut etc. The soybean may be any of white soybeans, black soybeans, lima beans, etc., and may be any of defatted soybeans, soybean hypocotyls, whole soybeans, and the like. Moreover, as a koji raw material, it is more preferable to illustrate rice, and it is more preferable to illustrate polished white rice. Accordingly, as the red yeast rice, rice red yeast rice is preferably exemplified. In addition, the shape of the koji raw material is not particularly limited, and may be powdery, granular, or crushed or pulverized, and its size is also not limited. In addition, the koji raw material may be heat-processed in advance, for example, rice or barley rice boiled with water, steamed rice or barley rice, boiled beans, etc. may be used. Koji raw materials may be used alone or in combination of two or more.

The production method of red yeast rice is not particularly limited, and a method in which red yeast rice is inoculated into a raw material of red yeast rice according to a conventionally known procedure and cultured under aerobic conditions can be mentioned. As a method for producing red yeast rice, mainly a solid culture method or a liquid culture method is known, and the red yeast rice in the present disclosure may be produced by any method, preferably, one produced by a solid culture method can be exemplified. Red yeast rice can be used alone or in combination of two or more. Although this disclosure is not limited, generally, the solid culture method refers to the method of inoculating the red yeast rice fungus in the raw material of steamed rice, and cultures it under aerobic conditions to produce the red yeast rice. A method in which red yeast rice is produced by inoculating red yeast rice bacteria into a liquid medium obtained by adding raw rice yeast ingredients and culturing it. In this production, various components such as a carbon source and a nitrogen source required for red yeast rice can also be appropriately used as needed. The koji raw material may be sterilized by known means such as heating and pressurization before being brought into contact with the red koji fungus. In addition, the temperature at the time of koji production is not limited as long as it can grow the red yeast rice, for example, about 20°C to 40°C is mentioned.

The red yeast rice produced as described above may be used as it is, or may be further processed and used as a processed product. Examples of the processed product include a dried product, a ground product (paste), an extract, and the like of red yeast rice.

Regarding the processed product, for example, red yeast rice produced as described above may be a dried product after further performing a drying step, and the drying treatment may be carried out after concentration by vacuum concentration using a normal evaporator, etc., if necessary, by Spray drying, freeze drying, vacuum drying, etc. are carried out. In the present disclosure, the dry product of red yeast rice refers to one in which the water content in red yeast rice is 12% by mass or less. In addition, for example, heat treatment may be performed before the drying step to inactivate enzyme activity or the like, or may be obtained by sterilizing. In addition, after such drying, it can also be made into powder, granule, etc. by crushing or pulverizing. In addition, for example, a ground product (paste) can be obtained by grinding the red yeast rice obtained in the above-described manner to make a paste, and the extract can be obtained by using an arbitrary extraction solvent for the obtained in the above-described manner. It is obtained by extracting red yeast rice, its dry matter, paste, etc. The extract may be a concentrated extract obtained by further concentrating the extract, or may be a dry extract obtained by drying the extract.

The method for producing the extract (extraction method), extraction conditions, and the like can be described in the same manner as above, and are not particularly limited, as long as they follow conventionally known methods. As the method of solvent extraction, any method known in the art may be used. For example, previously known extraction methods such as water (including warm water and hot water) extraction, alcohol extraction, and supercritical extraction can be used. In extraction, stirring etc. may be performed as needed, and the obtained extract may be filtered, centrifuged, etc. as needed. As the extraction solvent, the same ones as mentioned above can be exemplified. In the same manner as described above, the extract obtained through solvent extraction as described above can be specifically referred to as a solvent extract. In addition, when water is used as an extraction solvent, it is a water extract, etc., and can be used in the same manner as described above. title. In addition, the extract obtained in the above manner can be used in its original state, can also be used in the form of a concentrated extract obtained by concentrating the extract, or can be used as a dry extract in a solid state such as a dried powder or granule. form used. In addition, the obtained extract may be subjected to ultrasonic treatment, purification, concentration treatment, separation treatment of high activity fractionation, and the like as necessary. The extract of red yeast rice can also be described in the same manner as above.

Red yeast rice may be obtained commercially, or may be obtained from commercially obtained materials, and is not particularly limited. As examples of commercially available red yeast rice, available from Red yeast rice powder F (Sun Rich Co., Ltd.), Red yeast rice powder K-F (Yaegaki Yeast Technology Research Co., Ltd.), Red yeast rice liquid 2000 (Yaegaki (Yaegaki) Yeast Technology Research Co., Ltd.), rice red yeast rice (powder) (Nitto Enzyme Co., Ltd.).

Component (2) may be used alone or in combination of two or more.

In the composition disclosed in the present disclosure, the content of the component (1) and the component (2) is not limited, but for example, in the composition, the content of the component (1) is 0.001% by mass to 90% by mass in terms of dry matter, preferably It is 1 mass % - 85 mass %, More preferably, it is 2 mass % - 80 mass %. When describing the content in the present disclosure, the dry matter conversion means that the moisture content in each of the component (1) and the component (2) is 12% or less. Hereinafter, the dry matter conversion can be described similarly.

In addition, in the composition of the present disclosure, the content of the component (1) and the component (2) is not limited, and it can be exemplified that in the composition, the component (2) is 0.01% by mass to 95% by mass in terms of dry matter, Preferably it is 0.1 mass % - 90 mass %, More preferably, it is 0.5 mass % - 85 mass %.

In addition, in the composition of the present disclosure, the content of the component (1) and the component (2) is not limited, and can be exemplified: 0.001 parts by mass of the component (1) with respect to 1 part by mass of the component (2) (in terms of dry matter) - 100 parts by mass (dried matter conversion), preferably 0.1 to 10 parts by mass, more preferably 1 to 5 parts by mass. The content of component (1) and component (2) may be any combination of values within the numerical range. The following are the same.

In addition, although this disclosure is not limited, when component (1) is bisdemethoxycurcumin, in the composition of the present disclosure, bisdemethoxycurcumin is preferably exemplified in terms of dry matter. 0.01% by mass to 10% by mass, more preferably 0.05% by mass to 5% by mass. In addition, when component (1) is bisdemethoxycurcumin, although this disclosure is not limited, in the composition of this disclosure, component (2) is preferably 0.01% by mass to 0.01% by mass in terms of dry matter. 50% by mass, more preferably 0.1% by mass to 30% by mass, still more preferably 1% by mass to 15% by mass. In addition, although this disclosure is not limited, in the case where component (1) is bisdemethoxycurcumin, in the composition of the present disclosure, in terms of dry matter, relative to 1 part by mass of component (2), Bisdemethoxycurcumin is preferably 0.1 to 10 parts by mass, more preferably 0.25 to 5 parts by mass.

Similarly, although this indication is not limited, when component (1) is glycerin fatty acid ester, in the composition of this indication, the following content can be respectively illustrated preferably in conversion of a dry matter. The glycerin fatty acid ester is preferably from 0.1% by mass to 10% by mass, more preferably from 0.3% by mass to 5% by mass. The component (2) is preferably from 0.01% by mass to 50% by mass, more preferably from 0.1% by mass to 10% by mass, still more preferably from 0.3% by mass to 50% by mass. The glycerin fatty acid ester is preferably 0.1 to 10 parts by mass, more preferably 0.25 to 5 parts by mass, relative to 1 part by mass of the component (2).

Similarly, although this indication is not limited, when component (1) is diosmin, in the composition of this indication, the following content can respectively be illustrated preferably in conversion of a dry matter. The content of diosmin is preferably from 0.01% by mass to 60% by mass, more preferably from 1% by mass to 5% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The amount of diosmin is preferably from 0.001 to 10 parts by mass, more preferably from 0.01 to 1 part by mass, relative to 1 part by mass of the component (2).

Similarly, although this indication is not limited, when the component (1) is linolenic acid, in the composition of this indication, the following content can be respectively illustrated preferably in conversion of a dry matter. The amount of sublinolenic acid is preferably from 0.001% by mass to 60% by mass, more preferably from 0.01% by mass to 30% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The amount of sublinolenic acid is preferably from 0.1 to 20 parts by mass, more preferably from 1 to 10 parts by mass, relative to 1 part by mass of the component (2).

Similarly, although this indication is not limited, when component (1) is carotene, in the composition of this indication, the following content can respectively be illustrated preferably in conversion of a dry matter. Carotene is preferably in the range of 0.1% by mass to 20% by mass, more preferably in the range of 0.1% by mass to 10% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The amount of carotene is preferably from 0.001 to 10 parts by mass, more preferably from 0.01 to 1 part by mass, relative to 1 part by mass of the component (2).

Similarly, although this indication is not limited, when component (1) is daidzein, in the composition of this indication, the following content can be respectively illustrated preferably in conversion of a dry matter. As for daidzein, it is preferable that it is 1 mass % - 30 mass %, and it is more preferable that it is 5 mass % - 20 mass %. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The daidzein is preferably 0.01 to 10 parts by mass with respect to 1 part by mass of the component (2), more preferably 0.1 to 1 part by mass.

Similarly, although this indication is not limited, when component (1) is hesperidin, in the composition of this indication, the following content can respectively be illustrated preferably in conversion of a dry matter. Hesperidin is preferably 0.1% by mass to 80% by mass, more preferably 1% by mass to 70% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The amount of hesperidin is preferably from 0.01 to 20 parts by mass, more preferably from 0.1 to 10 parts by mass, relative to 1 part by mass of the component (2).

Similarly, although this disclosure is not limited, when the component (1) is genistein, in the composition of the present disclosure, the following contents can be respectively preferably illustrated in terms of dry matter. As for genistein, it is preferable that it is 1 mass % - 30 mass %, and it is more preferable that it is 5 mass % - 20 mass %. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The amount of genistein is preferably from 0.01 to 10 parts by mass, more preferably from 0.1 to 1 part by mass, relative to 1 part by mass of the component (2).

Similarly, although this indication is not limited, when component (1) is a citrus extract, in the composition of this indication, the following content can respectively be illustrated preferably in conversion of a dry matter. The citrus extract is preferably from 1% by mass to 70% by mass, more preferably from 10% by mass to 50% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The citrus extract is preferably from 0.1 to 10 parts by mass, more preferably from 0.5 to 5 parts by mass, relative to 1 part by mass of the component (2).

Similarly, although this indication is not limited, when component (1) is a black ginger processed product, in the composition of this indication, the following content can respectively be illustrated preferably in conversion of a dry matter. The black ginger processed product is preferably 1% by mass to 70% by mass, more preferably 10% by mass to 50% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The processed black ginger is preferably 0.1 to 10 parts by mass with respect to 1 part by mass of the component (2), more preferably 0.5 to 5 parts by mass.

Similarly, although this disclosure is not limited, when the component (1) is naringin and/or naringenin, as the total amount of these, in the composition of the present disclosure, in terms of dry matter, The following contents can be preferably illustrated respectively. The content of naringin and/or naringenin (total amount) is preferably from 1% by mass to 70% by mass, more preferably from 10% by mass to 50% by mass. Component (2) is preferably 1% by mass to 50% by mass, more preferably 3.3% by mass to 34% by mass. The naringin and/or naringenin (total amount) is preferably 0.1 to 10 parts by mass, more preferably 0.5 to 5 parts by mass, relative to 1 part by mass of the component (2).

The composition of the present disclosure can be either oral or parenteral, and is preferably used in an oral form. In addition, the form of the composition is not limited, as long as it is appropriately set according to the purpose, and it may be any of solid, semi-solid, and liquid. Accordingly, the composition can be powder, fine granule, granule (including dry syrup), tablet, pill, capsule (including hard capsule, soft capsule), buccal tablet, chewable tablet, gel form , paste, cream, liquid, suspension, emulsion, spray, freeze-dried product in liquid form, etc. In addition, for example, when the composition of the present disclosure is in a solid state, it can be mixed with water or the like and used.

In addition, there are no restrictions on the use of the composition, as long as it is appropriately set according to the purpose, it can be used as a food composition (including beverages, health functional foods (including specific health use foods, nutritional functional foods, functionally labeled foods) , supplements (supplement), etc.), including foods for patients), pharmaceutical compositions, quasi-drug compositions, cosmetic compositions, feed compositions, and for food compositions, pharmaceutical compositions, quasi-drug compositions, and cosmetic compositions food, feed composition] and other additives.

The composition of the present disclosure may be produced according to the previously known common procedures in the various forms, usage, etc., as long as component (1), component (2), and, if necessary, without prejudice to the present disclosure Any ingredients such as pharmaceutically acceptable ingredients, cosmetically acceptable ingredients, and edible ingredients within the range of the effect of the drug can be mixed and manufactured.

Examples of such optional components include bases (water, lower alcohols such as methanol, ethanol, and isopropanol, alcohols such as polyhydric alcohols such as propylene glycol and 1,3-butanediol (either anhydrous or water-containing), etc. ), excipients, disintegrants, diluents, lubricants, spices, colorants, sweeteners, flavoring agents, suspending agents, wetting agents, emulsifiers, solubilizers, dispersants, buffers, binders, Penetration enhancer, stabilizer, extender, preservative, thickener, pH adjuster, surfactant, coating agent, absorption enhancer, adsorbent, filler, antioxidant, cooling agent, film forming agent , gelling agent, amino acid, enzyme, various nutrients, etc. These may be used individually by 1 type, and may be used in combination of 2 or more types, and what is necessary is just to determine the content also suitably.

In the present disclosure, the subject (target animal) of the composition is also not limited, and examples include humans, mammals other than humans, and the like. Examples of mammals other than humans include animals such as mice, rats, guinea pigs, rabbits, dogs, cats, monkeys, pigs, cows, and horses, preferably mice, rats, guinea pigs, rabbits, dogs, monkeys and other animals.

The application amount of the composition disclosed herein is not particularly limited, and may be appropriately set according to the physique, age, symptom, application form, purpose of use, etc. of the subject (target animal). Although the present invention is not limited, in the case of oral application, as an example, the daily dosage (ingestion) is based on an adult with a body weight of 60 kg, component (2) (dried matter conversion) Preferably it is 1 mg-50000 mg, more preferably 10 mg-20000 mg, 20 mg-10000 mg. This composition may be administered (ingested) once per day, or may be administered (ingested) multiple times. In the case of parenteral application or application to animals other than humans, the application amount, frequency of application, and the like may be appropriately determined based on the description in the oral application.

The composition of the present disclosure contains the above-mentioned component (1) and the above-mentioned component (2), and by combining them, the antioxidant effect is enhanced in the composition containing the above-mentioned component (1). It is particularly preferred that the antioxidant action is synergistically enhanced by combining the component (1) and the component (2). Accordingly, it can also be said that the present disclosure preferably provides a composition that synergistically enhances the antioxidant effect by combining the component (1) and the component (2). Moreover, based on this, it can also be said that this disclosure provides the composition for antioxidants containing the said component (1) and the said component (2).

Accordingly, it can also be said that the present disclosure additionally provides a method for enhancing the antioxidant effect in a composition containing the component (1), and the method is characterized in that the component (1) is combined with the component (2) To be combined. In addition, according to this, it can also be said that the present disclosure additionally provides a use of component (2), which is used to enhance the antioxidant effect in a composition containing the component (1). In this method and use, component (1), component (2), composition, its production method, other components that can be formulated, and the like can be described in the same manner as the description of the above-mentioned composition. [Example]

Hereinafter, although an example is shown and this indication is demonstrated in more detail, this indication is not limited to these.

Test case 1. Test procedure ingredients used The components used in this test example are as follows. [ingredient (1)] Bisdemethoxycurcumin (trade name Bisdemethoxycurcumin, CAS number 24939-16-0, manufactured by Tokyo Chemical Industry Co., Ltd.) Glycerin fatty acid ester (trade name EMAX BW-36, manufactured by Riken Vitamin Co., Ltd.) Diosmetin (trade name Diosmetin, manufactured by AdooQ Bioscience) Linolenic acid (trade name Linolenic Acid, manufactured by Tokyo Kasei Kogyo Co., Ltd.) Carotene (trade name β-carotene, manufactured by Tokyo Chemical Industry Co., Ltd.) Daidzein (trade name Daidzein, manufactured by Tokyo Chemical Industry Co., Ltd.) Hesperidin (trade name Hesperidin, manufactured by Tokyo Chemical Industry Co., Ltd.) Genistein (trade name Genistein, manufactured by Tokyo Chemical Industry Co., Ltd.) Citrus extract (trade name Yuzu polyphenols, manufactured by Toyo Seinose Co., Ltd.) Black Ginger (trade name Black Ginger Extract, manufactured by Maruzen Pharmaceutical Co., Ltd.) Naringenin (trade name Naringenin, manufactured by Cayman Chemical Company)

[comparison ingredients] Lovastatin (trade name Lovastatin, manufactured by Tokyo Chemical Industry Co., Ltd.) GABA (trade name 4-aminobutyric acid, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Glycine (trade name Glycine, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) Fish gelatin (trade name gelatin (gelatin) FGS-230, manufactured by Nippi Co., Ltd.) Porcine gelatin (trade name gelatin (gelatin) AP-200, manufactured by Nippi Co., Ltd.) Bovine gelatin (trade name gelatin (gelatin) HTH-175, manufactured by Nippi Co., Ltd.) Adenine (trade name Adenine, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) D-mannose (trade name D(+)-Mannose, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.)

[Ingredient (2)] Red yeast rice (powdered (dried), manufactured by Kobayashi Pharmaceutical Co., Ltd., rice red yeast rice 100%, water content 12% by mass; more specifically, by inoculating steamed rice with the red yeast rice fungus Monascus pilosus NITE BP-412 strain obtained by culturing, sterilizing, drying, and crushing (powder)

Evaluation of Antioxidant Effect Antioxidant capacity assay kit using 1,1-diphenyl-2-picrylhydrazyl (l,l-diphenyl-2-picrylhydrazyl, DPPH) method (DPPH Antioxidant Assay Kit, manufactured by Dojin Chemical Research Institute Co., Ltd.) , to evaluate the antioxidant effect.

Specifically, in a 96-well microplate, add assay buffer (Assay buffer) (attached to the kit), 1,1-diphenyl-2-picrylhydrazine (l,l-diphenyl -2-picrylhydrazyl, DPPH) solution and sample or quinol dimethacrylate (Trolox) solution, the absorbance at 517 nm was measured at 25°C for 30 minutes using a plate reader. Antioxidant activity was evaluated by measuring the absorbance at 517 nm at 30 minutes. In this evaluation, Trolox was used as a free radical scavenger (concentrations 100 μg/mL, 80 μg/mL, 60 μg/mL, 40 μg/mL, 0 μg/mL) according to the kit procedure, prepared at 517 nm The absorbance calibration curve below. Trolox is a substance with antioxidant effect (positive control). Using the obtained calibration curve, the antioxidant activity (antioxidative capacity (%)) was calculated based on the absorbance in each well.

Samples were prepared in the following manner. Measure 10 mg of each of the above components into microtubes (manufactured by Eppendorf Co., Ltd., 1.5 mL), add water or methanol to each tube to make it 1 mL, and vortex each tube (vortex) for stirring. Then, ultrasonic treatment was performed at room temperature (24° C.) for 30 minutes, and after centrifugation (10,000 g, 25° C., 10 minutes), the supernatant was collected. 100 μL was aliquoted from the solution (10 mg/mL) obtained in the above manner, and appropriately diluted with water or methanol to prepare samples of each concentration (5 mg/mL, 2.5 mg/mL, 1.25 mg/mL solutions) . The samples prepared as described above were used at the mass ratios shown in the table below. In addition, among the above-mentioned components, water was used for GABA, glycine, fish gelatin, porcine gelatin, bovine gelatin, adenine, D-mannose, and red yeast rice, and methanol was used for other components.

The DPPH solution is prepared in the following manner: add 1 mL of 99.5% methanol to the DPPH Reagent (2 mL tube) attached to the kit, perform ultrasonic treatment for 60 seconds, and use 99.5% methanol to dissolve the tube Wash for 3 times, and use a volumetric flask to set the volume to 10 mL. For the Trolox solution, add 1 mL of 99.5% ethanol to a 2 mL tube containing 1 mg of Trolox, and mix by vortexing. Afterwards, ultrasonic treatment was carried out for 10 minutes to completely dissolve the contents. Next, wash the inside of the 2 mL tube three times with 99.5% methanol, and dilute to 10 mL. This was prepared to 100 μg/mL, diluted with 99.5% ethanol, and simultaneously prepared into 80 μg/mL, 60 μg/mL, and 40 μg/mL solutions to prepare the samples for the calibration curve. When reacting with the sample, the DPPH solution was 100 μL per well, each sample solution was 10 μL, and the total amount (DPPH solution, sample solution, and measurement buffer) was 200 μL. In the positive control, it was the same except that 10 μL of Trolox solution was used instead of the sample solution.

result The results are shown in Tables 1 to 18.

[Table 1] sample Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Example 1 Example 2 Example 3 red yeast rice 5 2.5 - - 5 5 2.5 Bisdemethoxycurcumin - - 10 1.25 10 1.25 10 calculated value 0 0 27.7 38.9 32.7 48.9 40.6 Antioxidant theoretical value (and) - - - - 27.7 38.9 27.7

[Table 2] sample Comparative example 1 Comparative Example 5 Comparative example 6 Comparative Example 7 Comparative Example 8 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 red yeast rice 5 - - - - 5 5 5 5 2.5 2.5 Glycerin Fatty Acid Ester - 10 5 2.5 1.25 10 5 2.5 1.25 10 5 calculated value 0 0 0 0 0 19.8 19.9 13.6 12.6 12.6 5 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0

[table 3] sample Comparative example 1 Comparative Example 9 Comparative Example 10 Comparative Example 11 Comparative Example 12 Example 10 Example 11 Example 12 Example 13 Example 14 red yeast rice 5 - - - - 5 5 2.5 2.5 2.5 diosmin - 10 5 2.5 1.25 10 1.25 10 2.5 1.25 calculated value 0 0 0 0 0 16 12.1 12.6 9.1 8.3 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0

[Table 4] sample Comparative example 1 Comparative Example 13 Comparative Example 14 Comparative Example 15 Example 15 Example 16 Example 17 Example 18 red yeast rice 5 - - - 5 5 2.5 2.5 linolenic acid - 5 2.5 1.25 2.5 1.25 10 2.5 calculated value 0 0 0 0 12.3 12.2 15 7 Antioxidant theoretical value (and) - - - - 0 0 0 0

[table 5] sample Comparative example 1 Comparative Example 16 Comparative Example 17 Comparative Example 18 Comparative Example 19 Example 19 Example 20 Example 21 Example 22 Example 23 Example 24 Example 25 red yeast rice 5 - - - - 5 5 5 5 2.5 2.5 2.5 carotene - 10 5 2.5 1.25 10 5 2.5 1.25 5 2.5 1.25 calculated value 0 0 0 0 0 23.5 18.1 13.2 14.4 5.8 5.4 5.7 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0 0

[Table 6] sample Comparative example 1 Comparative Example 20 Comparative Example 21 Comparative Example 22 Comparative Example 23 Example 26 Example 27 Example 28 Example 29 red yeast rice 5 - - - - 5 5 5 5 daidzein - 10 5 2.5 1.25 10 5 2.5 1.25 calculated value 0 0 0 0 0 8.7 8 7.8 7.8 Antioxidant theoretical value (and) - - - - - 0 0 0 0

[Table 7] sample Comparative example 1 Comparative Example 24 Comparative Example 25 Comparative Example 26 Comparative Example 27 Example 30 Example 31 Example 32 red yeast rice 5 - - - - 5 5 2.5 Hesperidin - 10 5 2.5 1.25 2.5 1.25 2.5 calculated value 0 4.3 0 0 0 8.9 6.3 4.1 Antioxidant theoretical value (and) - - - - - 0 0 0

[Table 8] sample Comparative example 1 Comparative Example 28 Comparative Example 29 Comparative Example 30 Comparative Example 31 Example 33 Example 34 Example 35 Example 36 Example 37 Example 38 red yeast rice 5 - - - - 5 5 5 5 2.5 2.5 Genistein - 10 5 2.5 1.25 10 5 2.5 1.25 10 5 calculated value 0 10.2 5.4 0 0 23.2 12.8 6.8 4.6 23.5 9.2 Antioxidant theoretical value (and) - - - - - 10.2 5.4 0 0 10.2 5.4

[Table 9] sample Comparative example 1 Comparative Example 32 Comparative Example 33 Comparative Example 34 Comparative Example 35 Example 39 Example 40 Example 41 Example 42 red yeast rice 5 - - - - 5 5 2.5 2.5 Citrus Extract - 10 5 2.5 1.25 10 5 10 5 calculated value 0 0 0 0 0 12.7 6.3 13.6 5 Antioxidant theoretical value (and) - - - - - 0 0 0 0

[Table 10] sample Comparative example 1 Comparative Example 36 Comparative Example 37 Comparative Example 38 Comparative Example 39 Example 43 Example 44 Example 45 red yeast rice 5 - - - - 5 2.5 2.5 black ginger - 10 5 2.5 1.25 5 10 5 calculated value 0 0 0 0 0 14.3 14.4 6.1 Antioxidant theoretical value (and) - - - - - 0 0 0

[Table 11] sample Comparative example 1 Comparative Example 40 Comparative Example 41 Comparative Example 42 Comparative Example 43 Example 46 Example 47 Example 48 Example 49 Example 50 Example 51 Example 52 Example 53 red yeast rice 5 - - - - 5 5 5 5 2.5 2.5 2.5 2.5 Naringenin - 10 5 2.5 1.25 10 5 2.5 1.25 10 5 2.5 1.25 calculated value 0 0 0 0 0 12.6 12.5 11.4 13 twenty two 15.7 13.6 9.1 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0 0 0

[Table 12] sample Comparative example 1 Comparative Example 44 Comparative Example 45 Example 46 Example 47 Comparative Example 48 Comparative Example 49 Comparative Example 50 Comparative Example 51 Comparative Example 52 Comparative Example 53 red yeast rice 5 - - - - 5 5 2.5 2.5 2.5 2.5 lovastatin - 10 5 2.5 1.25 10 5 10 5 2.5 1.25 calculated value 0 0 0 0 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0

[Table 13] sample Comparative example 1 Comparative Example 54 Comparative Example 55 Comparative Example 56 Comparative Example 57 Comparative Example 58 Comparative Example 59 Comparative example 60 Comparative Example 61 Comparative Example 62 Comparative Example 63 Comparative Example 64 Comparative Example 65 red yeast rice 5 - - - - 5 5 5 5 2.5 2.5 2.5 2.5 GABA - 10 5 2.5 1.25 10 5 2.5 1.25 10 5 2.5 1.25 calculated value 0 0 0 0 0 0 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0 0 0

[Table 14] sample Comparative example 1 Comparative Example 66 Comparative Example 67 Comparative Example 68 Comparative Example 69 Comparative example 70 Comparative Example 71 Comparative Example 72 Comparative Example 73 Comparative Example 74 Comparative Example 75 Comparative Example 76 red yeast rice 5 - - - - 5 5 5 2.5 2.5 2.5 2.5 Glycine - 10 5 2.5 1.25 5 2.5 1.25 10 5 2.5 1.25 calculated value 0 0 0 0 0 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0 0

[Table 15] sample Comparative example 1 Comparative Example 77 Comparative Example 78 Comparative Example 79 Comparative example 80 Comparative Example 81 Comparative Example 82 red yeast rice 5 - - - - 2.5 2.5 fish gelatin - 10 5 2.5 1.25 10 5 calculated value 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - - - - 0 0

[Table 16] sample Comparative example 1 Comparative Example 83 Comparative Example 84 Comparative example 85 Comparative Example 86 Comparative Example 87 Comparative Example 88 Comparative Example 89 Comparative example 90 red yeast rice 5 - 2.5 - - - 2.5 2.5 2.5 Porcine Gelatin - 5 5 - - - - - - bovine gelatin - - - 5 2.5 1.25 5 2.5 1.25 calculated value 0 0 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - 0 - - - 0 0 0

[Table 17] sample Comparative example 1 Comparative Example 91 Comparative Example 92 Comparative example 93 Comparative example 94 Comparative example 95 Comparative example 96 Comparative Example 97 Comparative example 98 Comparative Example 99 Comparative example 100 Comparative Example 101 red yeast rice 5 - - - - 5 5 5 2.5 2.5 2.5 2.5 adenine - 10 5 2.5 1.25 10 5 2.5 10 5 2.5 1.25 calculated value 0 0 0 0 0 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0 0

[Table 18] sample Comparative example 1 Comparative Example 102 Comparative Example 103 Comparative Example 104 Comparative Example 105 Comparative Example 106 Comparative Example 107 Comparative Example 108 Comparative Example 109 Comparative Example 110 Comparative Example 111 Comparative Example 112 red yeast rice 5 - - - - 5 5 5 2.5 2.5 2.5 2.5 D-Mannose - 10 5 2.5 1.25 10 5 2.5 10 5 2.5 1.25 calculated value 0 0 0 0 0 0 0 0 0 0 0 0 Antioxidant theoretical value (and) - - - - - 0 0 0 0 0 0 0

In the table, in Comparative Example 1, "5" means that the 5 mg/mL red yeast rice solution prepared as above was used as a sample, and in Comparative Example 3, "10" means that 10 mg/mL The bisdemethoxycurcumin solution of 10 mg/mL of bisdemethoxycurcumin is used as a sample. solution was used as a sample. The same applies to other Examples and Comparative Examples. In addition, in the table, "calculated value" represents the antioxidant activity (antioxidative capacity (%)) calculated as mentioned above. As shown in Table 1, in Comparative Example 1 and Comparative Example 2 that only use red yeast rice, the antioxidant capacity is 0%, and in Comparative Example 3 and Comparative Example 4 that only use bisdemethoxycurcumin, Antioxidant capacity were 27.7%, 38.9%.

In contrast, in Example 1 and Example 2 in which red yeast rice and bisdemethoxycurcumin were used in combination, the antioxidant effect was synergistically enhanced. Specifically, Example 1 is an example in which the same amount of red yeast rice as in Comparative Example 1 and the same amount of bisdemethoxycurcumin as in Comparative Example 3 are used in combination. ) and Comparative Example 3 (antioxidant capacity 27.7%), although it is expected that even if Comparative Example 1 and Comparative Example 3 are combined, the antioxidant capacity is at most 27.7% (0% + 27.7%, in the table, the implementation Example 1 "theoretical value of antioxidant (and)"), but actually in Example 1, the antioxidant capacity synergistically increased to 32.7%. In addition, Example 2 is an example in which the same amount of red yeast rice as in Comparative Example 1 and the same amount of bisdemethoxycurcumin as in Comparative Example 4 were used in combination. When judging from Comparative Example 4 (antioxidant capacity 38.9%), it is expected that even when Comparative Example 1 and Comparative Example 4 are combined, the antioxidant capacity is at most 38.9% (0% + 38.9%, in the table, Example 1 "Antioxidant theoretical value (and)"), but actually said antioxidant capacity synergistically increased to 48.9%. Accordingly, it was found that the antioxidant effect of bisdemethoxycurcumin can be enhanced synergistically by using red yeast rice and bisdemethoxycurcumin in combination.

In addition, when using fatty acid esters of glycerol, diosmin, linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger processed product or naringenin instead of bis In Tables 2 to 11 of demethoxycurcumin, the same result was obtained. Accordingly, it is known that red yeast rice can also enhance the antioxidant effect on these components.

In contrast, in a composition containing lovastatin, GABA, glycine, fish gelatin, porcine gelatin, bovine gelatin, adenine, and D-mannose instead of bisdemethoxycurcumin, even if these The ingredients were combined with red yeast rice, and the enhancement of the antioxidant effect was not confirmed in this composition.

As mentioned above, it is found that: containing bisdemethoxy curcumin, glycerin fatty acid ester, diosmin, linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, In the composition of processed black ginger, naringin or naringenin, the antioxidation effect can be enhanced by combining these components with red yeast rice.

Furthermore, for example, in Table 2 using glycerin fatty acid ester, in Comparative Example 1 and Comparative Example 5, the antioxidant capacity was 0%, and in Example 4, the antioxidant capacity was 19.8%. It is speculated that the reason is that although glycerin fatty acid ester originally has an antioxidant effect, in Comparative Example 5, since the content of glycerin fatty acid ester in the composition is small, the antioxidant capacity is calculated as 0%, and in Example 4 Among them, the antioxidant effect was enhanced by using fatty acid esters of glycerol and red yeast rice together, and as a result, the antioxidant capacity was increased to 19.8% (enhanced to the extent that the antioxidant effect can be measured). The same can be said for other tables.

Prescription In the composition containing the following ingredients (total composition amount per 455 mg of ingredient content), the antioxidant effect can also be enhanced by combining red yeast rice with glycerin fatty acid ester. Rice red yeast rice: 100 mg Glycerin fatty acid esters: 25 mg Safflower oil: 150 mg Gelatin: 130 mg Glycerin: 50 mg

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Claims (4)

A composition comprising the following component (1) and component (2): (1) Processed from bis-demethoxy curcumin, glycerin fatty acid ester, diosmin, sub-linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger At least one of the group consisting of naringin, naringin and naringenin; (2) At least one selected from the group consisting of red yeast rice and its processed products. The composition as described in Claim 1, for oral use. A method for enhancing antioxidation in a composition containing the following component (1), the method characterized by combining the following component (1) and component (2): (1) Processed from bis-demethoxy curcumin, glycerin fatty acid ester, diosmin, sub-linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger At least one of the group consisting of naringin, naringin and naringenin; (2) At least one selected from the group consisting of red yeast rice and its processed products. A use of at least one selected from the group consisting of red yeast rice and its processed products, for enhancing the antioxidant effect in a composition containing the following component (1): (1) Processed from bis-demethoxy curcumin, glycerin fatty acid ester, diosmin, sub-linolenic acid, carotene, daidzein, hesperidin, genistein, citrus extract, black ginger At least one of the group consisting of naringin, naringin and naringenin.