CN117651499A - Composition containing red rice and specific components - Google Patents
Composition containing red rice and specific components Download PDFInfo
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- CN117651499A CN117651499A CN202280046143.9A CN202280046143A CN117651499A CN 117651499 A CN117651499 A CN 117651499A CN 202280046143 A CN202280046143 A CN 202280046143A CN 117651499 A CN117651499 A CN 117651499A
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Abstract
The present invention aims to provide a composition or the like having an enhanced antioxidant effect. The solution is a composition containing the following components (1) and (2): (1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed black ginger, naringin and naringenin; and (2) at least one selected from the group consisting of monascus and processed products thereof.
Description
Technical Field
The present invention relates to a composition comprising monascus and specific components, a method for enhancing antioxidation, etc.
Background
Although oxygen is important for life support, part of the oxygen taken into the body is converted into active oxygen, causing oxidative stress of cells and tissues. It is well known that oxidative stress in the body is responsible for various diseases represented by atherosclerosis, inflammation, diabetes, increased blood viscosity and reduced vascular function.
In the past, antioxidation has been attracting attention in relieving such oxidative stress, and various components such as bisdemethoxycurcumin, carotene, daidzein, hesperidin and genistein are known to have antioxidation. In order to obtain a higher antioxidant effect, for example, a cosmetic composition containing pine bark as an antioxidant substance and at least one material selected from the group consisting of herbal medicines, ceramides, and selenium is known (patent document 1). Although preparations and the like having an antioxidant effect are well known, it is still important to date to provide products having further improved antioxidant effect.
Prior art literature
Patent literature
Patent document 1: japanese patent laid-open No. 2021-54770
Disclosure of Invention
Technical problem to be solved by the invention
The present invention aims to provide a composition or the like having an enhanced antioxidant effect.
Technical means for solving the technical problems
The inventors of the present application have intensively studied to solve the above problems, and have found that combining specific components such as monascus purpureus and bisdemethoxycurcumin can enhance the antioxidant effect of a composition containing the specific components. The present invention has been completed based on this finding through further studies. For example, the present invention includes the following aspects.
Item 1, a composition comprising the following component (1) and component (2):
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed black ginger, naringin and naringenin; and
(2) At least one selected from red rice and processed product thereof.
Item 2, the composition of item 1, for oral administration.
Item 3, a method for enhancing the antioxidant effect of a composition containing component (1), comprising: a step of combining the following component (1) and component (2),
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed black ginger, naringin and naringenin; and, a step of, in the first embodiment,
(2) At least one selected from red rice and processed product thereof.
The use of at least one member selected from the group consisting of monascus and processed products thereof for enhancing the antioxidant effect of a composition comprising the following ingredient (1), wherein,
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed product of rhizoma Zingiberis recens, naringin and naringenin.
ADVANTAGEOUS EFFECTS OF INVENTION
The present invention provides a composition comprising the above component (1) and the above component (2). By combining the above component (1) and the above component (2), the antioxidant effect of the composition containing the above component (1) can be enhanced. The present invention provides the use of the above component (2) for enhancing the antioxidant effect of a composition containing the above component (1).
Detailed Description
Embodiments encompassed by the present invention will be described in more detail below.
The composition of the present invention comprises the following component (1) and component (2):
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed black ginger, naringin and naringenin; and
(2) At least one selected from red rice and processed product thereof.
Component (1)
Component (1) is described below. Bisdemethoxycurcumin is represented by formula C 19 H 16 O 4 The known substances are indicated, and the CAS numbers are known as 24939-16-0 and 33171-05-0. The bisdemethoxycurcumin may be either a natural product or a synthetic product, and may be a commercially available product or a product obtained from a commercially available product, without particular limitation. Examples of commercially available Bisdemethoxycurcumin include Bisdemethoxycurcumin (Bisdemethoxycurcumin, tokyo chemical industry co., ltd.) and the like.
The glycerin fatty acid ester is an ester formed from glycerin and a fatty acid. In the present invention, the glycerin fatty acid ester includes polyglycerin fatty acid esters and organic acid monoglycerides. The glycerin fatty acid ester may be any of monoester, diester, and triester, and the polymerization degree of glycerin is not limited. Examples of the fatty acid ester include monoglyceride, diglyceride, triglyceride, and polyglycerin fatty acid ester of glycerin and fatty acid having an average polymerization degree of 2 or more.
The number of carbon atoms of the fatty acid constituting the glycerin fatty acid ester is not particularly limited as long as the effect of the present invention can be obtained, and examples thereof are preferably 1 to 30, more preferably 10 to 25, and still more preferably 18 to 21. The fatty acid constituting the glycerin fatty acid ester may be linear or branched, and may be saturated or unsaturated. Although the present invention is not limited thereto, the average polymerization degree of glycerin in the polyglycerin fatty acid ester may be exemplified by an integer of more preferably 2 to 10, further preferably an integer of 2 to 8, particularly preferably an integer of 2 to 6. The organic acid in the organic acid monoglyceride is not limited as long as it is a conventionally known organic acid.
Examples of such fatty acids include lauric acid, myristic acid, palmitic acid, palmitoleic acid, oleic acid, iso-oleic acid, linoleic acid, stearic acid, caprylic acid, capric acid, linolenic acid, behenic acid, acetic acid, propionic acid, butyric acid, lactic acid, succinic acid, caproic acid, iso-butyric acid, iso-valeric acid, and valeric acid. More preferably exemplified are oleic acid, linoleic acid, stearic acid, butyric acid, lactic acid, succinic acid, and the like. These fatty acids may be used singly or in combination of any two or more.
Specific examples of the glycerin fatty acid ester are not particularly limited as long as the effects of the present invention can be obtained, and include: acetic acid monoglyceride, lactic acid monoglyceride, citric acid monoglyceride, diacetyl tartaric acid monoglyceride, succinic acid monoglyceride, diglyceride, polyglycerol fatty acid ester, polyglycerol condensed ricinoleate, and the like. The glycerin fatty acid ester may be used singly or in combination of two or more.
The glycerin fatty acid ester may be a natural product or a synthetic product, and may be a commercially available product or a product obtained from a commercially available product, without particular limitation. Examples of the commercially available glycerin fatty acid ester include: emax BW-36 (Riken Vitamin Co., ltd.), poem S-100 (Living Violet Co., ltd.), sunsoft Q-17D (Sunschemical Co., ltd.), and Poem J-4081V (Living Violet Co., ltd.).
Pelargonium is represented by formula C 16 H 12 O 6 The CAS number is 520-34-3 for the known substances indicated. The diosmetin may be, but is not limited to, a natural or synthetic product, and may be a commercially available product or a product obtained from a commercially available product. Examples of commercially available diosmetins include: diosmetin (AdooQ Bioscience), and the like.
Linolenic acid is represented by formula C 18 H 30 O 2 The known substances represented may be exemplified by alpha-linolenic acid and gamma-linolenic acid, and alpha-linolenic acid is preferably exemplified. Linolenic acid may be, but is not limited to, natural or synthetic and may be a commercially available product or a product obtained from a commercially available product. Examples of commercially available linolenic acid include: linolenic Acid (Linolenic Acid, tokyo chemical Co., ltd.) and the like.
The carotene is a known substance, and may be exemplified by α -carotene and β -carotene, and preferably exemplified by β -carotene. The carotenes may be, but are not limited to, natural or synthetic and may be commercially available products or products obtained from commercially available products. Examples of the commercially available carotenes include beta-carotene (Tokyo chemical Co., ltd.).
The soybean flavone is represented by chemical formula C 15 H 10 O 4 The known substance is shown, and the CAS number is known as 486-66-8. The soy flavone may be, but is not limited to, natural or synthetic, and may be a commercially available product or a product obtained from a commercially available product. Examples of commercially available soybean flavonoids include: soybean flavone (Daidzein, tokyo chemical industry co.) and the like.
Hesperidin is of the formula C 28 H 34 O 15 The known polyphenols are shown with CAS numbers 520-26-3. Hesperidin may be, but is not limited to, a natural or synthetic product, and may be a commercially available product or a product obtained from a commercially available product. Examples of the commercially available hesperidin include: hesperidin (Hesperidin, tokyo chemical industry co.) and the like.
Genistein is represented by chemical formula C 15 H 10 O 5 The CAS number for the known substances indicated is 446-72-0. Genistein may be, but is not limited to, natural or synthetic, and may be a commercially available product or a product obtained from a commercially available product. As examples of the commercially available genistein, there may be mentioned: genistein (Genistein, tokyo chemical industry co.) and the like.
The citrus extract is citrus extract. Although the present invention is not limited thereto, as Citrus, plants belonging to the genus Citrus (Citrus) of the family Rutaceae, kumquat (Fortunella) and Citrus aurantium (Poncirus) can be exemplified, and for example, citrus junos, pharbitis orange (Citrus sphaerocarpa), citrus unshiu (Citrus unshiu), citrus aurantium (Citrus depressa), citrus aurantium (Citrus japonica), citrus grandis (Citrus maxima) and Citrus erecta (Citrus tabacuna) can be exemplified. The citrus fruit used in the extract is not limited as long as the effect of the present invention can be obtained, and examples of the fruit include fruit itself, fruit juice, concentrate thereof, and concentrated dried product. The citrus can be used singly or in combination of two or more. The parts used may be used singly or in combination of two or more.
The method for producing the extract (extraction method) and conditions for extraction are not particularly limited, and the method may be carried out according to a conventionally known method. For example, the extract may be obtained by directly extracting citrus with a solvent, or by cutting, pulverizing, squeezing, drying, or the like as necessary, followed by extraction with a solvent. The solvent extraction method may be any method known in the art. For example, conventionally known extraction methods such as water (including warm water and hot water), alcohol extraction, and supercritical extraction may be used, and stirring may be performed as needed. The obtained extract may be subjected to filtration, centrifugation, or the like as necessary.
As the extraction solvent, for example, water; alcohols (anhydrous or aqueous) such as lower alcohols such as methanol, ethanol, and isopropanol, and polyhydric alcohols such as propylene glycol and 1, 3-butanediol; ketones such as acetone, esters such as diethyl ether, dioxane, acetonitrile and ethyl acetate, xylene, benzene and chloroform. The preferred solvents are water, lower alcohols, 1, 3-butanediol, etc., more preferred are water, methanol, ethanol, 1, 3-butanediol, and still more preferred are water, methanol, and aqueous ethanol. These extraction solvents may be used singly or in combination of two or more.
In the present invention, the extract thus obtained by solvent extraction is particularly referred to as a solvent extract. Further, although the present invention is not limited thereto, the solvent extract may be referred to as "water extract" when water is used as an extraction solvent, may be referred to as "lower alcohol extract" when lower alcohol is used, may be referred to as "ethanol extract" when ethanol is used, or the like, for example.
The obtained extract may be used as it is or in a solid state such as powder form or granule form after drying. The obtained extract may be subjected to ultrasonic treatment or the like, or may be subjected to separation treatment such as purification, concentration treatment, fractionation treatment of a high-activity component, or the like, if necessary. Further, for example, the obtained extract (further, dried product thereof, ultrasonic wave treated product thereof, purified treated product thereof, concentrated treated product thereof, highly active component thereof, etc.) may be formed into a powder according to a conventionally known method, for example, a method of forming a powder by subjecting to a freeze-drying treatment, etc., thereby obtaining the extract used in the present invention. The extract may be used by dissolving in water, ethanol or the like, if necessary.
The citrus extract may be, but is not particularly limited to, a commercially available product or a product obtained from a commercially available product. Examples of the commercially available citrus extract include grapefruit Polyphenol (Yuzu Polyphenol, manufactured by eastern sugar co., ltd.). The citrus extract may be used singly or in combination of two or more.
The processed product of zingiber officinale is a processed product of a plant of the family Zingiberaceae called kaempferia parvifolia (Kaempferia parviflora). The site of use may be any site such as rhizome (tuber), leaf, stem, etc., and preferably rhizome is used. The used portions may be used singly or in combination of two or more. Examples of processed products of zingiber officinale include sliced products, crushed products, dried products, pressed products (juice), ground products, and extracts of zingiber officinale.
The sliced material is not limited as long as it is obtained by slicing the ginger by a conventionally known method.
The pulverized material is not particularly limited as long as it is obtained by pulverizing the ginger by a pulverizing method known in the art such as jet milling. Powders, granules, and the like can be exemplified.
The dried product is not particularly limited as long as it is obtained by drying the black ginger, and can be obtained by a conventionally known drying method such as sun drying, far infrared irradiation, and a dryer (hot air drying, cold air drying, vacuum freeze drying, etc.). The moisture content in the dried product is preferably 12 mass% or less, more preferably 10 mass% or less. In the present invention, the dried product may be in any form, such as a dried product of the dried product itself or a pulverized product of the dried product. The pulverized dried product can be obtained in the same manner as the pulverized product described above. The dried product may be obtained by fermenting or enzyme-treating rhizoma Zingiberis recens, and drying.
The pressed product is not limited as long as it is obtained from zingiber officinale according to a conventionally known method. The form of the pressed product may be any form such as a liquid form, a paste form, or a dried product thereof, or may be a pulverized product of a dried product.
The ground product is not limited as long as it is obtained by grinding ginger according to a conventionally known method.
The extract may be any extract product obtained using zingiber officinale. The method for producing the extract (extraction method) and conditions for extraction are not particularly limited, and production can be performed by a conventionally known method. The manufacturing method is as described above. For example, the extract may be obtained by directly extracting zingiber officinale with a solvent, or by cutting, pulverizing, drying, or the like as necessary, followed by extraction with a solvent. The solvent extraction method may be, for example, water (including warm water and hot water) extraction, alcohol extraction, supercritical extraction, or the like, and if necessary, stirring or the like may be used, or the obtained extract may be filtered or centrifuged as necessary. As the extraction solvent, the same solvents as listed above can be exemplified. The extract obtained by the solvent extraction in this way is particularly referred to as "solvent extract", and the extract obtained when water is used as the extraction solvent is referred to as "water extract" or the like as described above.
As described above, the obtained extract may be used as it is or may be used in a solid state such as a powder form or a granular form after drying. The obtained extract may be subjected to ultrasonic treatment or the like, or may be subjected to separation treatment such as purification, concentration treatment, fractionation treatment of a high-activity component, or the like, if necessary. Further, for example, the obtained extract (further, dried product thereof, ultrasonic wave treated product thereof, purified treated product thereof, concentrated treated product thereof, highly active component thereof, etc.) may be formed into a powder according to a conventionally known method or the like, for example, a powder obtained by a method of freeze-drying treatment, thereby obtaining the extract used in the present invention. If necessary, the extract may be dissolved in water, ethanol, or the like.
The processed black ginger may be, but not particularly limited to, a commercially available product or a product obtained from a commercially available product. Examples of commercial processed ginger products include: black ginger extract (manufactured by kagaku corporation) and Sirtmax (manufactured by the institute of phytochemistry, TOKIWA phytochemicals, ltd.). One processed product of zingiber officinale Kirilowii Maxim may be used alone or two or more processed products of zingiber officinale Kirilowii Maxim may be used in combination.
Naringin is represented by chemical formula C 27 H 32 O 14 The known substance is shown with CAS number 10236-47-2. Naringenin is naringin aglycone, and is represented by chemical formula C 15 H 12 O 5 The known substance is shown, and the CAS number is 480-41-1. Naringin and naringenin may be natural or synthetic, and may be commercially available products or products obtained from commercially available products, without particular limitation. Examples of commercially available products include Naringenin (Cayman Chemical Company). These may be used singly or in combination of two or more.
These components (1) may be used singly or in combination of two or more.
Component (2)
Component (2) is described below. The monascus is obtained by inoculating the prior known monascus into a starter raw material and then culturing. The monascus is not limited as long as it is a bacterium conventionally used for producing monascus. Examples of the filamentous fungus include a strain belonging to the genus Monascus (Monascus). The present invention is not limited thereto, and examples of filamentous fungi belonging to the genus Monascus (Monascus) include Monascus pilosus (Monascus pilosus), monascus purpureus (Monascus purpureus), monascus anka (Monascus anka), monascus ruber (Monascus ruber), monascus pilosus (Monascus pubigerus), variants thereof, and mutants thereof. Monascus is more preferably exemplified by Cong Maoqu Monascus (Monascus pilosus), monascus purpureus (Monascus purpureus), monascus ruber (Monascus anka), etc., and Cong Maoqu Monascus pilosus (Monascus pilosus) is more preferably exemplified. The monascus may be used singly or in combination of two or more.
The starter is preferably exemplified by cereal grains. Examples of the grains include polished rice, germ brown rice, germ and other rice, beans such as soybean and bean, wheat, corn, millet and the like, although the present invention is not limited thereto. The soybean may be any soybean such as white soybean, black soybean, green soybean, etc., or any kind of defatted soybean, soybean hypocotyl, whole soybean, etc. Further, rice is more preferably exemplified as the yeast material, and polished rice is more preferably exemplified. Thus, the monascus is preferably exemplified by rice monascus. The shape of the yeast material is not particularly limited, and may be in the form of powder or granule, or may be in a crushed or pulverized state, and the size thereof is not limited. Further, the starter raw material may be heat-treated in advance. For example, the starter material may be cooked rice or wheat, steamed rice or medical rice, or cooked beans, etc. The yeast material may be used singly or in combination of two or more.
The method for producing monascus is not particularly limited, and a method of inoculating monascus to a starter material and then culturing under aerobic conditions according to a conventionally known procedure can be mentioned. Known methods for producing red yeast mainly include a solid culture method and a liquid culture method. The monascus of the present invention may be produced by any method, and is preferably produced by a solid culture method. One kind of red rice may be used alone or two or more kinds of red rice may be used in combination. The present invention is not limited thereto, and the solid culture method is generally a method of inoculating monascus into a yeast material subjected to a treatment such as steaming, and then culturing under aerobic conditions to thereby produce monascus. The liquid culture method is a method of inoculating monascus into a liquid medium containing a starter culture material added to water, and then culturing the same, thereby producing monascus. In this production, various components required for red yeast rice, such as a carbon source and a nitrogen source, can be appropriately used as needed. The starter culture may be a starter culture which has been sterilized by known techniques such as heating or pressurizing prior to contact with monascus. The temperature during the production of monascus is not limited as long as monascus can grow, and examples thereof include about 20 to 40 ℃.
The red yeast rice thus produced may be used directly or after further treatment as processed product. Examples of the processed product include dried product, mashed product (paste) and extract of red rice.
The processed product may be, for example, a dried product obtained by further subjecting the red rice produced as described above to a drying step. The drying treatment may be performed by spray drying, freeze drying, vacuum drying, or the like after concentrating or the like by vacuum concentration using a general evaporator, if necessary. In the present invention, the dried product of red rice means that the content of water in red rice is 12 mass% or less. Further, for example, the dried product may be subjected to a heat treatment to inactivate an enzyme activity or the like, or subjected to sterilization, before the drying step. After such drying, the powder, granules, or the like may be formed by crushing or pulverizing treatment. Further, for example, the mashed matter (paste) is obtained by mashing the red yeast rice obtained as described above to form a paste. The extract can be obtained by extracting the red rice, dried product thereof, paste thereof, or the like obtained as described above with an arbitrary extraction solvent. The extract may be a concentrated extract obtained by further concentrating the extract, or a dried extract obtained by drying these extracts.
The method for producing the extract (extraction method) and conditions for extraction can be described in the same manner as described above, and the method is not particularly limited and may be carried out according to a conventionally known method. The solvent extraction method may be any known in the art, and for example, known extraction methods such as water (including warm water and hot water), alcohol extraction, supercritical extraction, and the like may be used. Stirring or the like may be performed during the extraction if necessary, and the obtained extract may be subjected to filtration, centrifugation or the like if necessary. The extraction solvent may be exemplified by the same solvents listed above. As described above, the extract obtained by such solvent extraction is particularly referred to as "solvent extract", and when water is used as the extraction solvent, it is referred to as "water extract" or the like in the same manner as described above. The extract thus obtained may be used as it is, may be used as a concentrated extract obtained by concentrating the extract, or may be used as a dry extract in a solid state such as a powder form or a granule form obtained by drying. The obtained extract may be subjected to ultrasonic treatment, purification, concentration treatment, separation treatment of high-activity components, and the like, if necessary. The extract of red rice is also described above.
The red yeast may be a commercially available product or a product obtained from a commercially available product, without particular limitation. Examples of commercially available red rice include red rice flour F (Sunrich), red rice flour K-F (YAEGAKI Bio-inhibitor, inc.), red rice liquor 2000 (YAEGAKI Bio-inhibitor, inc.), and red rice flour (red rice flour) (Nicotiana ferment Co.).
The component (2) may be used singly or in combination of two or more.
In the composition of the present invention, the content of the component (1) and the content of the component (2) are not limited. The content of the component (1) in the composition may be exemplified by 0.001 to 90% by mass, preferably 1 to 85% by mass, and more preferably 2 to 80% by mass, in terms of dry matter conversion. In the case of the content described in the present invention, the dry matter conversion means that the moisture content in each of the component (1) and the component (2) is 12% or less. The dry matter conversion mentioned below applies equally.
In addition, in the composition of the present invention, the content of the component (1) and the content of the component (2) are not limited. The content of the component (2) in the composition may be exemplified by 0.01 to 95% by mass, preferably 0.1 to 90% by mass, more preferably 0.5 to 85% by mass, based on dry matter conversion.
In addition, in the composition of the present invention, the content of the component (1) and the content of the component (2) are not limited. The component (1) may be exemplified by 0.001 to 100 parts by mass (in terms of dry matter), preferably 0.1 to 10 parts by mass, more preferably 1 to 5 parts by mass, per 1 part by mass of the component (2) (in terms of dry matter). The content of the component (1) and the content of the component (2) may be any combination of values within the above numerical ranges. The following applies equally.
In addition, although the present invention is not limited thereto, when the component (1) is bisdemethoxycurcumin, the content of bisdemethoxycurcumin in the composition of the present invention is preferably exemplified by 0.01 to 10 mass%, more preferably 0.05 to 5 mass%, on a dry matter basis. Further, although the present invention is not limited thereto, when component (1) is bisdemethoxycurcumin, the content of component (2) in the composition of the present invention is preferably exemplified by 0.01 to 50% by mass, more preferably 0.1 to 30% by mass, still more preferably 1 to 15% by mass, on a dry matter basis. Further, although the present invention is not limited thereto, when the component (1) is bisdemethoxycurcumin, the content of bisdemethoxycurcumin in the composition of the present invention is preferably exemplified by 0.1 to 10 parts by mass, more preferably 0.25 to 5 parts by mass per part by mass of the component (2) in terms of dry matter conversion.
Similarly, although the present invention is not limited thereto, when the component (1) is a glycerin fatty acid ester, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention, respectively. The content of the glycerin fatty acid ester is preferably 0.1 to 10% by mass, more preferably 0.3 to 5% by mass. The content of the component (2) is preferably 0.01 to 50% by mass, more preferably 0.1 to 10% by mass, and still more preferably 0.3 to 50% by mass. The content of the glycerin fatty acid ester is preferably 0.1 to 10 parts by mass, more preferably 0.25 to 5 parts by mass, per part by mass of the component (2).
Likewise, although the present invention is not limited thereto, when component (1) is geraniin, the following contents are preferably exemplified in the composition of the present invention as calculated on a dry matter basis, respectively. The content of geraniin is preferably 0.01 to 60 mass%, more preferably 1 to 5 mass%. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of geraniin per part by mass of the component (2) is preferably 0.001 to 10 parts by mass, more preferably 0.01 to 1 part by mass.
Likewise, although the present invention is not limited thereto, when component (1) is linolenic acid, the following contents are preferably exemplified in the composition of the present invention on a dry matter basis, respectively. The content of linolenic acid is preferably 0.001 to 60% by mass, more preferably 0.01 to 30% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of the linolenic acid per mass part of the component (2) is preferably 0.1 to 20 mass parts, more preferably 1 to 10 mass parts.
Likewise, although the present invention is not limited thereto, when component (1) is carotene, the following contents are preferably exemplified in the composition of the present invention, respectively, on a dry matter basis. The content of carotene is preferably 0.1 to 20% by mass, more preferably 0.1 to 10% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of carotene in the component (2) is preferably 0.001 to 10 parts by mass, more preferably 0.1 to 1 part by mass.
Likewise, although the present invention is not limited thereto, when component (1) is soybean flavone, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention, respectively. The content of soybean flavone is preferably 1 to 30% by mass, more preferably 5 to 20% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of soybean flavone in the component (2) is preferably 0.01 to 10 parts by mass, more preferably 0.1 to 1 part by mass.
Likewise, although the present invention is not limited thereto, when the component (1) is hesperidin, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention, respectively. The content of hesperidin is preferably 0.1 to 80% by mass, more preferably 1 to 70% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of hesperidin per mass part of the component (2) is preferably 0.01 to 20 mass parts, more preferably 0.1 to 10 mass parts.
Likewise, although the present invention is not limited thereto, when component (1) is genistein, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention, respectively. The content of genistein is preferably 1 to 30 mass%, more preferably 5 to 20 mass%. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of genistein per part by mass of the component (2) is preferably 0.01 to 10 parts by mass, more preferably 0.1 to 1 part by mass.
Likewise, although the present invention is not limited thereto, when component (1) is a citrus extract, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention, respectively. The content of the citrus extract is preferably 1 to 70% by mass, more preferably 10 to 50% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of the citrus extract is preferably 0.1 to 10 parts by mass, more preferably 0.5 to 5 parts by mass, per part by mass of the component (2).
Similarly, although the present invention is not limited thereto, when the ingredient (1) is processed ginger, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention. The content of processed black ginger is preferably 1 to 70% by mass, more preferably 10 to 50% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content of processed black ginger is preferably 0.1 to 10 parts by mass, more preferably 0.5 to 5 parts by mass, per part by mass of the component (2).
Likewise, although the present invention is not limited thereto, when the component (1) is naringin and/or naringin, the following contents are preferably exemplified in terms of dry matter conversion in the composition of the present invention, respectively. The content (total amount) of naringin and/or naringin is preferably 1 to 70% by mass, more preferably 10 to 50% by mass. The content of the component (2) is preferably 1 to 50% by mass, more preferably 3.3 to 34% by mass. The content (total amount) of naringin and/or naringenin in the component (2) is preferably 0.1 to 10 parts by mass, more preferably 0.5 to 5 parts by mass.
The compositions of the present invention may be used orally or non-orally, preferably orally. The form of the composition is not limited, and may be appropriately set according to the purpose, and may be any form of solid, semisolid, or liquid. Thus, the composition may be in any form, such as powders, fine granules, granules (including dry syrups), tablets, pills, capsules (including hard and soft capsules), buccal, chewable, gel, paste, cream, liquid, suspension, emulsion, spray, and liquid form of lyophilized product. In addition, for example, when the composition of the present invention is in a solid form, it can be used by mixing with water or the like.
The manner of use of the composition is not limited, and may be appropriately set according to the purpose. The composition can be used as food composition (including beverage, health functional food (including specific health food, nutritional functional food, functional labeling food, supplement, etc.), and food for patients), pharmaceutical composition for external use, cosmetic composition, feed composition, and additive in food composition, pharmaceutical composition for external use, cosmetic composition, feed, etc.
The composition of the present invention can be produced by a conventionally known general procedure in the above-described various forms, modes of use and the like, and can be produced by mixing the component (1) and the component (2), and any component such as a pharmaceutically acceptable component, a cosmetically acceptable component, an edible component and the like, as necessary, within a range that does not affect the effect of the present invention.
Examples of the optional component include: bases (lower alcohols such as water, methanol, ethanol, and isopropanol, alcohols (anhydrous or aqueous) such as propylene glycol and polyhydric alcohols such as 1, 3-butanediol), excipients, disintegrants, diluents, lubricants, fragrances, colorants, sweeteners, flavoring agents, suspending agents, wetting agents, emulsifiers, solubilizing agents, dispersing agents, buffers, binders, permeation enhancers, stabilizers, extenders, preservatives, thickeners, pH adjusters, surfactants, coating agents, absorption enhancers, adsorbents, fillers, antioxidants, cooling agents, film formers, gelling agents, amino acids, enzymes, and various nutrients. These may be used singly or in combination of two or more, and the content thereof may be appropriately determined.
In the present invention, the subject (target animal) of the composition is not limited. Examples of the method include humans and mammals other than humans. Examples of mammals other than humans include mice, rats, guinea pigs, rabbits, dogs, cats, monkeys, pigs, cows, horses, and the like, and preferably examples thereof include mice, rats, guinea pigs, rabbits, dogs, and monkeys.
The amount of the composition of the present invention to be administered to a subject (target animal) is not limited, and may be appropriately set according to constitution, age, symptom, administration form, purpose of use, etc. of the subject (target animal). Although the present invention is not limited thereto, when the composition is orally administered, the daily administration amount (intake amount) of the component (2) (in terms of dry matter conversion) is preferably exemplified by 1 to 50000mg, more preferably 10 to 20000mg, still more preferably 20 to 10000mg, based on an adult weighing 60kg of body weight. The composition can be administered (ingested) in a single or multiple doses per day. When the composition is used for a subject other than a non-oral or human, the amount, the number of times of administration, and the like can be appropriately determined based on the instructions of the oral administration.
The composition of the present invention contains the above-mentioned component (1) and the above-mentioned component (2), and the combination of these components enhances the antioxidation effect of the composition containing the component (1). Particularly preferably, the antioxidant effect is synergistically enhanced by combining the above component (1) and the above component (2). It can thus also be said that the present invention preferably provides a composition synergistically enhanced in antioxidation by combining the above-mentioned component (1) and the above-mentioned component (2). In addition, it can be said that the present invention provides an antioxidant composition comprising the above component (1) and the above component (2).
Accordingly, the present invention also provides a method for enhancing the antioxidant effect of a composition comprising component (1), the method being characterized by comprising: combining the component (1) and the component (2). Furthermore, the present invention thus provides the use of component (2) for enhancing the antioxidant effect of a composition comprising component (1) as described above. The component (1), the component (2), the composition, the method for producing the same, other components which may be blended, and the like are as described in the description of the above composition.
Examples
Hereinafter, the present invention will be described in more detail by way of examples, however, the present invention is not limited to these examples.
Test examples
1. Test procedure
The components used
The components used in this test example are as follows.
[ component (1) ]
Di-demethoxycurcumin (trade name: di-demethoxycurcumin, CAS number 24939-16-0, manufactured by Tokyo chemical industry Co., ltd.)
Glycerol fatty acid ester (trade name: emax BW-36, manufactured by Liyangvitamin Co., ltd.)
Pelargonin (trade name: pelargonin, manufactured by AdooQ Bioscience)
Linolenic Acid (trade name: linolenic Acid, manufactured by Tokyo chemical industry Co., ltd.)
Carotene (trade name: beta-carotene, manufactured by Tokyo chemical industry Co., ltd.)
Daidzein (Daidzein), manufactured by tokyo chemical industry Co., ltd
Hesperidin (trade name: hesperidin (Hesperidin), manufactured by tokyo chemical industry Co., ltd.)
Genistein (trade name: genistein, manufactured by tokyo chemical industry Co., ltd.)
Citrus extract (commercial name: shaddock polyphenol, manufactured by Toyo Seiyang Co., ltd.)
Black ginger (trade name: extract of black ginger, manufactured by Wan shan pharmaceutical Co., ltd.)
Naringenin (trade name: naringenin (manufactured by Naringin), cayman Chemical Company)
Comparative composition
Lovastatin (trade name: lovastatin, manufactured by Tokyo chemical industry Co., ltd.)
GABA (trade name: 4-aminobutyric acid (4-Aminobutyric acid), manufactured by Fuji film and Guangdong Kogyo Co., ltd.)
Glycine (trade name: glycine, manufactured by Fuji film and Guangdong Kagaku Co., ltd.)
Fish Gelatin (trade name: gelatin FGS-230, nippi, inc.)
Pig Gelatin (trade name: gelatin AP-200, nippi, inc.)
Bovine Gelatin (trade name: gelatin HTH-175, nippi, inc.)
Adenine (trade name: adenine (Adene), manufactured by Fuji film and Wako pure chemical industries, ltd.)
D-mannose (trade name: D (+) -mannose, manufactured by Fuji film and Wako pure chemical industries, ltd.)
[ component (2) ]
Red Rice (powder (dried), 100% red rice manufactured by Xiaolin pharmaceutical Co., ltd., water content: 12% by mass), more specifically, monascus pilosus strain NITE BP-412 was inoculated into steamed rice, and then cultured, sterilized, dried, and pulverized (powder-like) to obtain
Evaluation of antioxidant Effect
Antioxidation was evaluated using an antioxidation capability test kit (DPPH Antioxidant Assay Kit, manufactured by the same-core chemical research institute) using the DPPH method.
Specifically, according to the procedure of the kit, a detection buffer (kit supply), a DPPH (1, 1-diphenyl-2-picrylhydrazine) solution, and a sample or Trolox solution were added to a 96-well microplate, and absorbance at 517nm was measured with an enzyme-labeled instrument at 25 ℃ for 30 minutes. Antioxidant effect was evaluated based on absorbance at 517nm measured at 30 minutes. In this evaluation, a calibration curve of absorbance at 517nm was drawn with Trolox as a radical scavenger (concentration: 100. Mu.g/mL, 80. Mu.g/mL, 60. Mu.g/mL, 40. Mu.g/mL, and 0. Mu.g/mL) according to the procedure of the kit. Trolox is a substance with antioxidant effect (positive control). Using the obtained calibration curve, the antioxidant activity (antioxidant capacity (%)) was calculated based on the absorbance of each well.
The samples were prepared as follows. The above components (10 mg) were weighed into a microtube (1.5 mL, manufactured by Eppendorf Co.) and water or methanol was added to each of the tubes to adjust the volume to 1mL, followed by stirring in each of the tubes with a vortex mixer. Then, the mixture was sonicated at room temperature (24 ℃) for 30 minutes, centrifuged (10,000 g,25 ℃,10 minutes), and the supernatant was collected. From the thus-obtained solution (10 mg/mL), 100. Mu.L was taken out, and the samples (5, 2.5, and 1.25mg/mL solutions) of the respective concentrations were prepared by appropriately diluting with water or methanol. The samples thus prepared were used in the mass ratios shown in the following table. In addition, among the above components, GABA, glycine, fish gelatin, pig gelatin, cow gelatin, adenine, D-mannose and monascus use water, and the other components use methanol.
The DPPH solution was prepared by adding 1mL of 99.5% methanol to a DPPH reagent (2 mL tube) provided in a kit, performing ultrasonic treatment for 60 seconds, washing the inside of the tube 3 times with 99.5% methanol, and fixing the volume to 10mL with a volumetric flask. For the Trolox solution, 1mL of 99.5% ethanol was added to a 2mL tube containing 1mg Trolox, followed by mixing with a vortex mixer. Then, ultrasonic treatment was performed for 10 minutes to completely dissolve the content. Next, the inside of the 2mL tube was washed 3 times with 99.5% methanol and the volume was fixed to 10mL. As a sample for the calibration curve, the solution was diluted with 99.5% ethanol to prepare 80. Mu.g/mL, 60. Mu.g/mL, and 40. Mu.g/mL as a 100. Mu.g/mL solution. In the reaction with the above-mentioned samples, 100. Mu.L of DPPH solution and 10. Mu.L of each sample solution were set for each well so that the total volume (DPPH solution, sample solution and detection buffer) was 200. Mu.L. For the positive control, the same procedure was followed except that 10. Mu.L of Trolox solution was used instead of the sample solution.
Results
The results are shown in tables 1 to 18.
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In the table, "5" in the column of comparative example 1 indicates that the above-prepared 5mg/mL monascus solution was used as a sample, and "10" in the column of comparative example 3 indicates that 10mg/mL bisdemethoxycurcumin solution was used as a sample, and "5" and "10" in the column of example 1 indicate that 5mg/mL monascus solution and 10mg/mL bisdemethoxycurcumin solution were used as a sample. Other examples and comparative examples are equally applicable. Further, "calculated value" in the table indicates the antioxidant activity (antioxidant capacity (%)) calculated as described above. As shown in table 1, the antioxidant capacity results of comparative examples 1 and 2 using only red yeast rice were both 0%, while the antioxidant capacity results of comparative examples 3 and 4 using only bisdemethoxycurcumin were 27.7% and 38.9%, respectively.
In contrast, in examples 1 and 2, in which monascus and bisdemethoxycurcumin are used in combination, the antioxidant effect is synergistically enhanced. In particular, in example 1, the same amount of red yeast rice as in comparative example 1 and the same amount of bisdemethoxycurcumin as in comparative example 3 were used in combination. From the results of comparative example 1 (antioxidant capacity: 0%) and comparative example 3 (antioxidant capacity: 27.7%), the results of antioxidant capacity were expected to be at most 27.7% (0% +27.7%, "theoretical antioxidant value (sum)", in the column of example 1 in the table), even when comparative example 1 and comparative example 3 were combined. However, in practice the antioxidant capacity of example 1 was synergistically improved to 32.7%. In example 2, the same amount of red yeast rice as in comparative example 1 and the same amount of bisdemethoxycurcumin as in comparative example 4 were used in combination. From the results of comparative example 1 (antioxidant capacity: 0%) and comparative example 4 (antioxidant capacity: 38.9%), the results of antioxidant capacity were expected to be at most 38.9% (0% +38.9%, "theoretical antioxidant value (sum)", in the column of example 1 in the table), even when comparative example 1 and comparative example 4 were combined. However, in practice the antioxidant capacity is synergistically improved to 48.9%. These results demonstrate that the combined use of monascus and bisdemethoxycurcumin synergistically enhances the antioxidant effect of bisdemethoxycurcumin.
The same results were obtained in tables 2 to 11, in which glycerol fatty acid ester, diosgenin, linolenic acid, carotene, soybean flavone, hesperidin, genistein, citrus extract, processed black ginger, or naringin was used instead of bisdemethoxycurcumin. These results indicate that monascus is also able to enhance the antioxidant effect of these components.
In contrast, in a composition containing lovastatin, GABA, glycine, fish gelatin, porcine gelatin, bovine gelatin, adenine and D-mannose instead of bisdemethoxycurcumin, no enhancement of antioxidant effect was confirmed in the composition even if these components were combined with monascus.
It is thus known that the antioxidant effect of compositions containing bisdemethoxycurcumin, glycerol fatty acid esters, geraniin, linolenic acid, carotenes, daidzein, hesperidin, genistein, citrus extract, processed black ginger, naringin or naringin can be enhanced by combining these components with monascus.
It is noted that, for example, table 2 using glycerin fatty acid ester shows that the antioxidant capacity results of comparative example 1 and comparative example 5 are both 0%, while the antioxidant capacity result of example 4 is 19.8%. This is presumed to be because, although glycerin fatty acid ester originally has an antioxidant effect, the antioxidant capacity of comparative example 5 is calculated to be 0% because the content of glycerin fatty acid ester in the composition is low, and because the combined use of glycerin fatty acid ester and red yeast rice in example 4 enhances the antioxidant effect and eventually improves the antioxidant capacity to 19.8% (enhances the antioxidant effect to a measurable extent). Other tables are equally applicable.
Formulation example
The combination of glycerol fatty acid ester and red rice in the composition containing the following ingredients (the content of the ingredients is 455mg based on the total amount of the composition) can also enhance the antioxidation.
Red yeast rice: 100mg of
Glycerol fatty acid ester: 25mg of
Safflower oil: 150mg
Gelatin: 130mg
Glycerol: 50mg.
Claims (4)
1. A composition comprising the following components (1) and (2):
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed black ginger, naringin and naringenin; and
(2) At least one selected from red rice and processed product thereof.
2. The composition of claim 1, wherein:
is used for oral administration.
3. A method for enhancing the antioxidant effect of a composition comprising component (1), comprising:
a step of combining the following component (1) and component (2),
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed black ginger, naringin and naringenin; and, a step of, in the first embodiment,
(2) At least one selected from red rice and processed product thereof.
4. Use of at least one selected from the group consisting of red rice and processed products thereof for enhancing the antioxidant effect of a composition comprising the following component (1),
(1) At least one selected from bisdemethoxycurcumin, glycerol fatty acid ester, geraniin, linolenic acid, carotene, daidzein, hesperidin, genistein, mandarin orange extract, processed product of rhizoma Zingiberis recens, naringin and naringenin.
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| JP2021-107058 | 2021-06-28 | ||
| JP2021107058 | 2021-06-28 | ||
| PCT/JP2022/021331 WO2023276496A1 (en) | 2021-06-28 | 2022-05-25 | Red yeast rice and composition containing specific components |
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| CN117651499A true CN117651499A (en) | 2024-03-05 |
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| CN (1) | CN117651499A (en) |
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| JP3947721B2 (en) * | 2003-03-28 | 2007-07-25 | 磐田化学工業株式会社 | A culture of koji mold containing a physiologically active substance and a method for producing the same |
| JP2022087328A (en) * | 2021-06-28 | 2022-06-09 | 小林製薬株式会社 | Composition containing ang-khak and specific component |
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