TW202302121A - 近視之治療 - Google Patents
近視之治療 Download PDFInfo
- Publication number
- TW202302121A TW202302121A TW111104966A TW111104966A TW202302121A TW 202302121 A TW202302121 A TW 202302121A TW 111104966 A TW111104966 A TW 111104966A TW 111104966 A TW111104966 A TW 111104966A TW 202302121 A TW202302121 A TW 202302121A
- Authority
- TW
- Taiwan
- Prior art keywords
- copper
- composition
- administered
- myopia
- containing agent
- Prior art date
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- 230000004379 myopia Effects 0.000 title claims abstract description 40
- 208000001491 myopia Diseases 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 claims abstract description 136
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 92
- 229910052802 copper Inorganic materials 0.000 claims abstract description 92
- 239000010949 copper Substances 0.000 claims abstract description 92
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 83
- 238000000034 method Methods 0.000 claims abstract description 49
- YRNNKGFMTBWUGL-UHFFFAOYSA-L copper(ii) perchlorate Chemical compound [Cu+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O YRNNKGFMTBWUGL-UHFFFAOYSA-L 0.000 claims description 28
- 239000003889 eye drop Substances 0.000 claims description 13
- 229920000642 polymer Polymers 0.000 claims description 10
- 230000004515 progressive myopia Effects 0.000 claims description 9
- 239000010408 film Substances 0.000 claims description 8
- 239000000499 gel Substances 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 208000001309 degenerative myopia Diseases 0.000 claims description 4
- 230000002459 sustained effect Effects 0.000 claims description 4
- 239000002562 thickening agent Substances 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- HXUMOVKKXUVBRH-UHFFFAOYSA-L copper diperbromate Chemical compound Br(=O)(=O)(=O)[O-].[Cu+2].Br(=O)(=O)(=O)[O-] HXUMOVKKXUVBRH-UHFFFAOYSA-L 0.000 claims description 3
- KAGCXMYEBHGUDI-UHFFFAOYSA-L copper;diperiodate Chemical compound [Cu+2].[O-]I(=O)(=O)=O.[O-]I(=O)(=O)=O KAGCXMYEBHGUDI-UHFFFAOYSA-L 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims description 3
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- 210000001508 eye Anatomy 0.000 description 48
- 150000001875 compounds Chemical class 0.000 description 37
- 230000000694 effects Effects 0.000 description 23
- 238000009472 formulation Methods 0.000 description 23
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- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 description 14
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- 108010057846 lysinenorleucine Proteins 0.000 description 12
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
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- 235000005713 safflower oil Nutrition 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
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| US202163148344P | 2021-02-11 | 2021-02-11 | |
| US63/148,344 | 2021-02-11 |
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| EP (1) | EP4291163A4 (https=) |
| JP (1) | JP2024508706A (https=) |
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| CN (1) | CN118234482A (https=) |
| AU (1) | AU2022220331A1 (https=) |
| CA (1) | CA3208185A1 (https=) |
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| US20040058015A1 (en) * | 2000-06-01 | 2004-03-25 | Yuanjin Tao | Compositions and methods for treating eye discomfort and eye disease |
| US20040001791A1 (en) * | 2000-11-16 | 2004-01-01 | Zeiler Kenneth T. | Composition, method of use, and devices for the treatment of onychomycosis |
| US9504603B2 (en) * | 2012-04-02 | 2016-11-29 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
| JP6898734B2 (ja) * | 2013-10-07 | 2021-07-07 | オクジェクト, リミテッド ライアビリティー カンパニーOcuject, Llc | 針アセンブリ |
| US11065275B2 (en) * | 2016-03-08 | 2021-07-20 | University Of Utah Research Foundation | Cross-linking agents and associated methods |
| KR20250109788A (ko) * | 2018-01-05 | 2025-07-17 | 유니버시티 오브 유타 리서치 파운데이션 | 근시 진행의 치료 |
| CN109776623B (zh) * | 2019-03-05 | 2021-05-07 | 潍坊科技学院 | 一种含氟草酰胺同/异核化合物的制备方法与应用 |
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2022
- 2022-02-10 TW TW111104966A patent/TW202302121A/zh unknown
- 2022-02-11 AU AU2022220331A patent/AU2022220331A1/en active Pending
- 2022-02-11 CN CN202280027799.6A patent/CN118234482A/zh active Pending
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- 2022-02-11 US US18/546,258 patent/US20240122974A1/en active Pending
- 2022-02-11 EP EP22753451.8A patent/EP4291163A4/en active Pending
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| CN118234482A (zh) | 2024-06-21 |
| KR20240021734A (ko) | 2024-02-19 |
| US20240122974A1 (en) | 2024-04-18 |
| JP2024508706A (ja) | 2024-02-28 |
| AU2022220331A1 (en) | 2023-09-28 |
| WO2022174094A1 (en) | 2022-08-18 |
| EP4291163A1 (en) | 2023-12-20 |
| EP4291163A4 (en) | 2025-01-01 |
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